{"id":"https://openalex.org/W7225658166","doi":"https://doi.org/10.64898/2026.11.05.764691","title":"Programmable interphyla communication for Staphylococcus aureus by transferability of homoserine lactone sensors between Bacillales bacteria","display_name":"Programmable interphyla communication for Staphylococcus aureus by transferability of homoserine lactone sensors between Bacillales bacteria","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225658166","doi":"https://doi.org/10.64898/2026.11.05.764691"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.05.764691","doi":"https://doi.org/10.64898/2026.11.05.764691","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764691","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.05.764691.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.05.764691.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104227072","display_name":"Biprodev Sarker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Biprodev Sarker","raw_affiliation_strings":["University of Massachusetts Amherst"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Amherst","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092808988","display_name":"Stephen N. Rondthaler","orcid":"https://orcid.org/0009-0006-7568-0209","observed_orcids":["https://orcid.org/0009-0006-7568-0209"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen N Rondthaler","raw_affiliation_strings":["University of Massachusetts Amherst"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Amherst","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103041263","display_name":"Min Zeng","orcid":"https://orcid.org/0009-0007-9611-1272","observed_orcids":["https://orcid.org/0009-0007-9611-1272"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Zeng","raw_affiliation_strings":["University of Massachusetts Amherst"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Amherst","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036971797","display_name":"Lauren B. Andrews","orcid":"https://orcid.org/0000-0003-1627-1430","observed_orcids":["https://orcid.org/0000-0003-1627-1430"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lauren B Andrews","raw_affiliation_strings":["University of Massachusetts Amherst"],"raw_orcid":"https://orcid.org/0000-0003-1627-1430","affiliations":[{"raw_affiliation_string":"University of Massachusetts Amherst","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036971797"],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.6542999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.6542999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.14259999990463257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.09160000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.996999979019165},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.781000018119812},{"id":"https://openalex.org/keywords/bacillales","display_name":"Bacillales","score":0.6690000295639038},{"id":"https://openalex.org/keywords/synthetic-gene-circuits","display_name":"synthetic gene circuits","score":0.5299999713897705},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7699999809265137},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.527999997138977},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7574999928474426},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.7440000176429749},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5515000224113464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4934999942779541},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.4675999879837036},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4375999867916107},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.397599995136261},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.3917999863624573},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.3808000087738037},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.3723999857902527},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3619000017642975},{"id":"https://openalex.org/C194051981","wikidata":"https://www.wikidata.org/wiki/Q1337691","display_name":"Economic shortage","level":3,"score":0.3271999955177307},{"id":"https://openalex.org/C61272859","wikidata":"https://www.wikidata.org/wiki/Q7834031","display_name":"Transferability","level":3,"score":0.32269999384880066},{"id":"https://openalex.org/C2779150676","wikidata":"https://www.wikidata.org/wiki/Q2091405","display_name":"Bacillus (shape)","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.322299987077713},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.3075000047683716},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.30720001459121704},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.3050999939441681},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.287200003862381},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.28529998660087585},{"id":"https://openalex.org/C2779840497","wikidata":"https://www.wikidata.org/wiki/Q418214","display_name":"Homoserine","level":5,"score":0.2851000130176544},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.27900001406669617},{"id":"https://openalex.org/C2779134421","wikidata":"https://www.wikidata.org/wiki/Q1949025","display_name":"Paenibacillus polymyxa","level":3,"score":0.2630000114440918},{"id":"https://openalex.org/C2777655017","wikidata":"https://www.wikidata.org/wiki/Q1501161","display_name":"Toolbox","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C180223184","wikidata":"https://www.wikidata.org/wiki/Q4839986","display_name":"Bacterial genetics","level":4,"score":0.2606000006198883},{"id":"https://openalex.org/C2778039104","wikidata":"https://www.wikidata.org/wiki/Q149088","display_name":"Bacillales","level":4,"score":0.2524999976158142},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.05.764691","doi":"https://doi.org/10.64898/2026.11.05.764691","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764691","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.05.764691.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.05.764691","doi":"https://doi.org/10.64898/2026.11.05.764691","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764691","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.05.764691.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225658166.pdf","grobid_xml":"https://content.openalex.org/works/W7225658166.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2110763275","https://openalex.org/W2169614539","https://openalex.org/W3023758810"],"related_works":["https://openalex.org/W4389574618","https://openalex.org/W2171629640","https://openalex.org/W2951103967","https://openalex.org/W4390739368","https://openalex.org/W2888130320","https://openalex.org/W2165895054","https://openalex.org/W1992050565","https://openalex.org/W1922733429","https://openalex.org/W2937567255","https://openalex.org/W2043340731"],"abstract_inverted_index":{"Staphylococcus":[0],"aureus":[1,24,90,126,140,165],"is":[2],"a":[3,12,33,104,172,181],"Gram-positive":[4,99],"opportunistic":[5],"pathogen":[6],"of":[7,15,35,42,147],"the":[8,26,98,113,133,144],"order":[9],"Bacillales":[10],"and":[11,25,45,68,110,136,163,179],"frequent":[13],"member":[14],"human-associated":[16],"microbiomes.":[17],"Despite":[18],"its":[19],"clinical":[20],"relevance,":[21],"engineering":[22,176],"S.":[23,89,125,139,164],"communities":[27],"it":[28],"inhabits":[29],"remains":[30],"limited":[31],"by":[32],"shortage":[34],"well-characterized":[36],"genetic":[37,114],"tools":[38],"for":[39,49,67,97,120,175],"precise":[40],"control":[41],"gene":[43],"expression":[44],"intercellular":[46],"signaling.":[47,168],"Biosensors":[48],"homoserine":[50],"lactones":[51],"(HSLs)":[52],"are":[53,61,71,85],"widely":[54],"used":[55],"in":[56,88,138],"Gram-negative":[57,160],"bacteria,":[58],"as":[59,116],"HSLs":[60],"small,":[62],"passively":[63],"diffusible":[64],"signaling":[65,187],"molecules":[66],"their":[69],"sensors":[70,81],"tightly":[72,154],"regulated.":[73],"Here,":[74],"we":[75],"show":[76],"that":[77],"synthetically":[78],"designed":[79],"HSL":[80,167,186],"using":[82],"LuxR-family":[83],"regulators":[84],"highly":[86],"functional":[87],".":[91,127],"Notably,":[92],"synthetic":[93],"designs":[94],"previously":[95],"built":[96],"model":[100],"Bacillus":[101],"subtilis":[102],",":[103],"distantly":[105],"related":[106],"Bacillales,":[107,135],"transferred":[108],"functionally":[109],"establish":[111],"repurposing":[112],"toolbox":[115],"an":[117],"effective":[118],"strategy":[119],"importing":[121],"these":[122],"functions":[123],"into":[124],"Sensor":[128],"performance":[129],"correlated":[130],"strongly":[131],"between":[132,159],"two":[134],"activation":[137],"reached":[141],"55-fold,":[142],"exceeding":[143],"dynamic":[145],"range":[146],"reported":[148],"inducible":[149],"systems.":[150],"We":[151],"further":[152],"demonstrate":[153],"regulated,":[155],"programmable":[156,185],"interphyla":[157],"communication":[158,178],"Escherichia":[161],"coli":[162],"via":[166],"These":[169],"results":[170],"provide":[171],"new":[173],"toolset":[174],"interbacterial":[177],"open":[180],"route":[182],"to":[183,188],"extending":[184],"other":[189],"tough-to-engineer":[190],"bacteria.":[191]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
