{"id":"https://openalex.org/W7225657109","doi":"https://doi.org/10.1021/acs.analchem.6c06917","title":"An Asymmetric Input Precondition-Gated AND DNA Circuit for Dual-Mutation Analysis","display_name":"An Asymmetric Input Precondition-Gated AND DNA Circuit for Dual-Mutation Analysis","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225657109","doi":"https://doi.org/10.1021/acs.analchem.6c06917"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.6c06917","doi":"https://doi.org/10.1021/acs.analchem.6c06917","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.6c06917","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161353657","display_name":"Linmin Zhong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linmin Zhong","raw_affiliation_strings":["*Email: ","COI Statement: The authors declare no competing financial interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Email: ","institution_ids":[]},{"raw_affiliation_string":"COI Statement: The authors declare no competing financial interest","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147827971","display_name":"Chunmin Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunmin Li","raw_affiliation_strings":["*Email: ","COI Statement: The authors declare no competing financial interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Email: ","institution_ids":[]},{"raw_affiliation_string":"COI Statement: The authors declare no competing financial interest","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018222202","display_name":"\u8d56\u5a77\u5a77","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tingting Lai","raw_affiliation_strings":["*Email: ","COI Statement: The authors declare no competing financial interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Email: ","institution_ids":[]},{"raw_affiliation_string":"COI Statement: The authors declare no competing financial interest","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136345297","display_name":"Huiping Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huiping Chen","raw_affiliation_strings":["*Email: ","COI Statement: The authors declare no competing financial interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Email: ","institution_ids":[]},{"raw_affiliation_string":"COI Statement: The authors declare no competing financial interest","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080909510","display_name":"Shanwen Hu","orcid":"https://orcid.org/0000-0001-8138-9537","observed_orcids":["https://orcid.org/0000-0001-8138-9537"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shanwen Hu","raw_affiliation_strings":["*Email: ","COI Statement: The authors declare no competing financial interest"],"raw_orcid":"https://orcid.org/0000-0001-8138-9537","affiliations":[{"raw_affiliation_string":"*Email: ","institution_ids":[]},{"raw_affiliation_string":"COI Statement: The authors declare no competing financial interest","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.09809999912977219,"subfield":{"id":"https://openalex.org/subfields/2614","display_name":"Theoretical Computer Science"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynamic-logic","display_name":"dynamic logic","score":0.546999990940094},{"id":"https://openalex.org/keywords/amoxicillin-resistance","display_name":"amoxicillin resistance","score":0.781000018119812},{"id":"https://openalex.org/keywords/clarithromycin-resistance","display_name":"clarithromycin resistance","score":1.0},{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.9900000095367432},{"id":"https://openalex.org/keywords/antibiotic-resistance-mutations","display_name":"antibiotic resistance mutations","score":0.7120000123977661},{"id":"https://openalex.org/keywords/signal-priority","display_name":"signal priority","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C131017901","wikidata":"https://www.wikidata.org/wiki/Q170451","display_name":"Logic gate","level":2,"score":0.7045999765396118},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5627999901771545},{"id":"https://openalex.org/C81409106","wikidata":"https://www.wikidata.org/wiki/Q76505","display_name":"Combinational logic","level":3,"score":0.48089998960494995},{"id":"https://openalex.org/C187075797","wikidata":"https://www.wikidata.org/wiki/Q173245","display_name":"Sequential logic","level":3,"score":0.46219998598098755},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4465000033378601},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.41920000314712524},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.41499999165534973},{"id":"https://openalex.org/C199822604","wikidata":"https://www.wikidata.org/wiki/Q557120","display_name":"Duty cycle","level":3,"score":0.38420000672340393},{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.3668999969959259},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3418000042438507},{"id":"https://openalex.org/C10418432","wikidata":"https://www.wikidata.org/wiki/Q560370","display_name":"AND gate","level":3,"score":0.3368000090122223},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.32670000195503235},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.325300008058548},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.321399986743927},{"id":"https://openalex.org/C142465778","wikidata":"https://www.wikidata.org/wiki/Q2502619","display_name":"Toffoli gate","level":5,"score":0.31940001249313354},{"id":"https://openalex.org/C99692599","wikidata":"https://www.wikidata.org/wiki/Q596577","display_name":"Dissipative system","level":2,"score":0.31279999017715454},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3028999865055084},{"id":"https://openalex.org/C198521697","wikidata":"https://www.wikidata.org/wiki/Q7142438","display_name":"Pass transistor logic","level":4,"score":0.2980000078678131},{"id":"https://openalex.org/C189645446","wikidata":"https://www.wikidata.org/wiki/Q350865","display_name":"Mirroring","level":2,"score":0.2971000075340271},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2944999933242798},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.2937000095844269},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C34854456","wikidata":"https://www.wikidata.org/wiki/Q1484552","display_name":"Register-transfer level","level":4,"score":0.2922999858856201},{"id":"https://openalex.org/C191961535","wikidata":"https://www.wikidata.org/wiki/Q2360205","display_name":"A-DNA","level":3,"score":0.27880001068115234},{"id":"https://openalex.org/C32123652","wikidata":"https://www.wikidata.org/wiki/Q2451605","display_name":"Molecular switch","level":3,"score":0.2768000066280365},{"id":"https://openalex.org/C190560348","wikidata":"https://www.wikidata.org/wiki/Q3245116","display_name":"Circuit design","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C41112130","wikidata":"https://www.wikidata.org/wiki/Q2146175","display_name":"Retiming","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.257999986410141}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.analchem.6c06917","doi":"https://doi.org/10.1021/acs.analchem.6c06917","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.6c06917","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1964850787","https://openalex.org/W1980301976","https://openalex.org/W2047155236","https://openalex.org/W2069755600","https://openalex.org/W2810268565","https://openalex.org/W2889140275","https://openalex.org/W3010098676","https://openalex.org/W3083703986","https://openalex.org/W3108592521","https://openalex.org/W3203592626","https://openalex.org/W4220661141","https://openalex.org/W4220712052","https://openalex.org/W4223955932","https://openalex.org/W4283778205","https://openalex.org/W4291016468","https://openalex.org/W4322619649","https://openalex.org/W4361275207","https://openalex.org/W4366503476","https://openalex.org/W4378715144","https://openalex.org/W4386799865","https://openalex.org/W4387844270","https://openalex.org/W4390761918","https://openalex.org/W4401218574","https://openalex.org/W4403865664","https://openalex.org/W4412351360","https://openalex.org/W4412845078","https://openalex.org/W4413840416","https://openalex.org/W4414517821","https://openalex.org/W4415122181","https://openalex.org/W4415267234","https://openalex.org/W4415929980","https://openalex.org/W4417178357","https://openalex.org/W7125648023","https://openalex.org/W7127980658","https://openalex.org/W7131231505","https://openalex.org/W7136642020","https://openalex.org/W7147210481"],"related_works":["https://openalex.org/W4292239280","https://openalex.org/W2069755600","https://openalex.org/W1976086519","https://openalex.org/W3126565387","https://openalex.org/W2124587650","https://openalex.org/W4220690432","https://openalex.org/W2766757267","https://openalex.org/W4411134617","https://openalex.org/W2791317004","https://openalex.org/W1779343208"],"abstract_inverted_index":{"Abstract":[0],"DNA":[1,192],"molecular":[2,38,188,193],"logic":[3,42,120,175,198],"gates":[4],"typically":[5],"treat":[6],"multiple":[7],"inputs":[8,47],"as":[9,153],"equal-status":[10],"Boolean":[11],"variables,":[12],"making":[13],"it":[14],"difficult":[15],"to":[16,71,85,127],"handle":[17],"the":[18,64,72,82,86,91,101,106,136,159,173],"inherent":[19],"temporal":[20],"priorities":[21],"and":[22,63,144],"weight":[23],"disparities":[24],"of":[25,44,124,139],"signals":[26],"in":[27,100,149,155],"real":[28],"biological":[29],"networks.":[30],"Here":[31],"we":[32],"report":[33],"a":[34,49,77,112,122,162],"precondition-gated":[35,181],"asymmetric":[36,182],"AND":[37,119,183],"circuit":[39,107,134,184],"that":[40,81],"achieves":[41],"discrimination":[43],"two":[45],"unequal-weight":[46],"within":[48],"dual-DNAzyme":[50],"cascade":[51],"framework.":[52],"A":[53,96],"prerequisite":[54,92],"input":[55,74,88],"undergoes":[56],"signal":[57],"accumulation":[58],"through":[59],"autocatalytic":[60],"positive":[61,163],"feedback,":[62],"resulting":[65],"gating":[66],"molecule":[67],"grants":[68],"detection":[69,138],"access":[70],"secondary":[73,87,102],"pathway":[75,103],"via":[76],"de-inhibition":[78],"mechanism,":[79],"ensuring":[80],"system":[83,160],"responds":[84],"only":[89,165],"after":[90,111],"condition":[93,123],"is":[94],"satisfied.":[95],"dissipative":[97],"cycle":[98],"embedded":[99],"further":[104],"endows":[105],"with":[108],"chemical":[109],"renewability":[110],"single":[113],"response.":[114],"This":[115,180],"design":[116],"extends":[117],"conventional":[118],"from":[121,195],"spatial":[125],"co-existence":[126],"one":[128],"governed":[129],"by":[130],"priority.":[131],"Using":[132],"this":[133],"for":[135,176,190],"combined":[137],"low-prevalence":[140],"amoxicillin":[141],"resistance-associated":[142,147,168],"mutations":[143,148,169],"high-prevalence":[145],"clarithromycin":[146],"Helicobacter":[150],"pylori":[151],"infection,":[152],"demonstrated":[154],"simulated":[156],"clinical":[157],"specimens,":[158],"produces":[161],"output":[164],"when":[166],"both":[167],"are":[170],"present,":[171],"mirroring":[172],"decision":[174],"dual":[177],"resistance":[178],"status.":[179],"provides":[185],"an":[186],"expandable":[187],"platform":[189],"advancing":[191],"computation":[194],"static":[196],"combinational":[197],"toward":[199],"dynamic":[200],"logic.":[201]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
