{"id":"https://openalex.org/W7225656141","doi":"https://doi.org/10.3389/fmed.2026.1919416","title":"Sarcopenia in older adults: pharmacological targets, trial evidence, and function-centered translational priorities","display_name":"Sarcopenia in older adults: pharmacological targets, trial evidence, and function-centered translational priorities","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225656141","doi":"https://doi.org/10.3389/fmed.2026.1919416"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2026.1919416","doi":"https://doi.org/10.3389/fmed.2026.1919416","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1919416","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1919416/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1919416/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147081068","display_name":"Xinxin Shao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinxin Shao","raw_affiliation_strings":["Anhui University of Chinese Medicine","Department of Nursing, Shanghai Tenth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anhui University of Chinese Medicine","institution_ids":["https://openalex.org/I253932293"]},{"raw_affiliation_string":"Department of Nursing, Shanghai Tenth People\u2019s Hospital","institution_ids":["https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153498797","display_name":"Xinyi Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Gao","raw_affiliation_strings":["Department of Nursing, Shanghai Tenth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Shanghai Tenth People\u2019s Hospital","institution_ids":["https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045942","display_name":"Yanbo Di","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunzheng Di","raw_affiliation_strings":["Anhui University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anhui University of Chinese Medicine","institution_ids":["https://openalex.org/I253932293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100324873","display_name":"Rong Wang","orcid":"https://orcid.org/0000-0001-8599-9850","observed_orcids":["https://orcid.org/0000-0001-8599-9850","https://orcid.org/0009-0001-6105-0568"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Wang","raw_affiliation_strings":["Tongji University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tongji University School of Medicine","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161310196","display_name":"Yin Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin Gu","raw_affiliation_strings":["Tongji University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tongji University School of Medicine","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147121247","display_name":"Qiuying Jiang","orcid":"https://orcid.org/0009-0004-6278-0775","observed_orcids":["https://orcid.org/0009-0004-6278-0775"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiuying Jiang","raw_affiliation_strings":["Tongji University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tongji University School of Medicine","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161311575","display_name":"Yamei Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yamei Chen","raw_affiliation_strings":["Department of Nursing, Shanghai Tenth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Shanghai Tenth People\u2019s Hospital","institution_ids":["https://openalex.org/I4210132741"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5161311575"],"corresponding_institution_ids":["https://openalex.org/I4210132741"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.652999997138977},{"id":"https://openalex.org/keywords/lean-body-mass","display_name":"lean body mass","score":0.40700000524520874},{"id":"https://openalex.org/keywords/muscle-strength","display_name":"muscle strength","score":0.7020000219345093},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.8859999775886536},{"id":"https://openalex.org/keywords/anabolic-signaling","display_name":"anabolic signaling","score":0.9269999861717224},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/redox-modulation","display_name":"redox modulation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.6639999747276306},{"id":"https://openalex.org/keywords/gut-muscle-axis","display_name":"gut-muscle axis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/multimorbidity","display_name":"multimorbidity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/energy-and-protein-intake","display_name":"energy and protein intake","score":0.7950000166893005},{"id":"https://openalex.org/keywords/resistance-training","display_name":"resistance training","score":0.9819999933242798},{"id":"https://openalex.org/keywords/medication-reconciliation","display_name":"medication reconciliation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.6060000061988831},{"id":"https://openalex.org/keywords/pragmatic-trial-design","display_name":"pragmatic trial design","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.9455999732017517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6503999829292297},{"id":"https://openalex.org/C120863210","wikidata":"https://www.wikidata.org/wiki/Q17064264","display_name":"Lean body mass","level":3,"score":0.5532000064849854},{"id":"https://openalex.org/C2992343062","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Muscle mass","level":2,"score":0.5059999823570251},{"id":"https://openalex.org/C2909273474","wikidata":"https://www.wikidata.org/wiki/Q1952420","display_name":"Multimorbidity","level":3,"score":0.4878000020980835},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4244999885559082},{"id":"https://openalex.org/C2988147884","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy expenditure","level":2,"score":0.41940000653266907},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41679999232292175},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.4000000059604645},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3815000057220459},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.3718000054359436},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3625999987125397},{"id":"https://openalex.org/C3017819807","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy aging","level":2,"score":0.34279999136924744},{"id":"https://openalex.org/C3019887659","wikidata":"https://www.wikidata.org/wiki/Q191089","display_name":"Older people","level":2,"score":0.33799999952316284},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.33180001378059387},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.3240000009536743},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3237000107765198},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.29989999532699585},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2962000072002411},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.2840000092983246},{"id":"https://openalex.org/C2910186798","wikidata":"https://www.wikidata.org/wiki/Q309438","display_name":"Anabolic Agents","level":3,"score":0.2547000050544739},{"id":"https://openalex.org/C2993503589","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Fat mass","level":3,"score":0.25429999828338623},{"id":"https://openalex.org/C2908924572","wikidata":"https://www.wikidata.org/wiki/Q645858","display_name":"Nutritional Supplementation","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fmed.2026.1919416","doi":"https://doi.org/10.3389/fmed.2026.1919416","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1919416","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1919416/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2026.1919416","doi":"https://doi.org/10.3389/fmed.2026.1919416","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1919416","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1919416/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225656141.pdf","grobid_xml":"https://content.openalex.org/works/W7225656141.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W2020213864","https://openalex.org/W2731310808","https://openalex.org/W2765375372","https://openalex.org/W2800029051","https://openalex.org/W2883879428","https://openalex.org/W2906721882","https://openalex.org/W2981414419","https://openalex.org/W3005437800","https://openalex.org/W3018955305","https://openalex.org/W3092041124","https://openalex.org/W3092694780","https://openalex.org/W3109391513","https://openalex.org/W3120042166","https://openalex.org/W3121032204","https://openalex.org/W3134877230","https://openalex.org/W3202133882","https://openalex.org/W4205510409","https://openalex.org/W4212972763","https://openalex.org/W4223616061","https://openalex.org/W4307112113","https://openalex.org/W4308680130","https://openalex.org/W4321216784","https://openalex.org/W4323923461","https://openalex.org/W4366245917","https://openalex.org/W4381325817","https://openalex.org/W4390666865","https://openalex.org/W4390892825","https://openalex.org/W4391160917","https://openalex.org/W4391173159","https://openalex.org/W4391434082","https://openalex.org/W4392765139","https://openalex.org/W4392864556","https://openalex.org/W4393120004","https://openalex.org/W4394008431","https://openalex.org/W4394748651","https://openalex.org/W4396744339","https://openalex.org/W4398780397","https://openalex.org/W4399301804","https://openalex.org/W4401161652","https://openalex.org/W4402462892","https://openalex.org/W4404515351","https://openalex.org/W4405989867","https://openalex.org/W4406717012","https://openalex.org/W4407141522","https://openalex.org/W4408059703","https://openalex.org/W4408136137","https://openalex.org/W4408426597","https://openalex.org/W4408531092","https://openalex.org/W4408744532","https://openalex.org/W4409351516","https://openalex.org/W4409590905","https://openalex.org/W4411240344","https://openalex.org/W4411417946","https://openalex.org/W4412110695","https://openalex.org/W4413034963","https://openalex.org/W4413323940","https://openalex.org/W4414960442","https://openalex.org/W4415227110","https://openalex.org/W4415849352"],"related_works":["https://openalex.org/W7154104842","https://openalex.org/W7223020196","https://openalex.org/W2941076520","https://openalex.org/W2953709313","https://openalex.org/W2592258424","https://openalex.org/W7128722221","https://openalex.org/W2946755051","https://openalex.org/W4399706268","https://openalex.org/W2146779186","https://openalex.org/W2564670940"],"abstract_inverted_index":{"Introduction":[0],"Sarcopenia":[1],"in":[2,47,100,110],"older":[3,173],"adults":[4],"is":[5],"a":[6,25,42],"progressive":[7],"disorder":[8],"of":[9,15],"skeletal":[10],"muscle":[11,20],"characterized":[12],"by":[13,34],"loss":[14],"strength,":[16,111],"function,":[17],"and,":[18],"variably,":[19],"quantity":[21],"and":[22,41,50,65,67,84,88,91,121,128,135,144],"quality.":[23],"Despite":[24],"rapidly":[26],"expanding":[27],"mechanistic":[28],"literature,":[29],"pharmacological":[30,66],"translation":[31],"remains":[32],"constrained":[33],"heterogeneous":[35],"definitions,":[36],"multimorbidity,":[37],"short":[38],"trial":[39,147],"duration,":[40],"recurrent":[43],"mismatch":[44],"between":[45],"gains":[46],"lean":[48,101],"mass":[49,102],"patient-centered":[51,115],"functional":[52],"outcomes.":[53,116],"Methods":[54],"We":[55],"synthesized":[56],"published":[57],"literature":[58],"on":[59],"contemporary":[60],"diagnostic":[61],"frameworks,":[62],"trial-enrichment":[63],"concepts,":[64],"pharmacology-adjacent":[68],"strategies.":[69],"The":[70],"evidence":[71,97],"was":[72,119],"organized":[73],"around":[74],"key":[75],"biological":[76,165],"pathways,":[77],"including":[78,125],"anabolic":[79],"signaling,":[80],"myostatin-activin":[81],"inhibition,":[82],"inflammation":[83],"redox":[85],"modulation,":[86],"mitochondrial":[87],"metabolic":[89],"targets,":[90],"gut-muscle":[92],"interactions.":[93],"Results":[94],"Across":[95],"the":[96],"reviewed,":[98],"changes":[99],"did":[103],"not":[104],"consistently":[105],"translate":[106],"into":[107],"meaningful":[108],"improvements":[109],"mobility,":[112],"or":[113],"other":[114],"Treatment":[117],"response":[118],"phenotype-dependent":[120],"often":[122],"required":[123],"co-interventions,":[124],"adequate":[126],"protein":[127],"energy":[129],"intake,":[130],"resistance":[131],"training":[132],"when":[133],"feasible,":[134],"careful":[136],"medication":[137],"reconciliation.":[138],"Discussion":[139],"Biomarker-informed":[140],"enrichment,":[141],"function-centered":[142],"endpoints,":[143],"pragmatic":[145],"geriatric":[146],"designs":[148],"are":[149],"priorities":[150],"for":[151],"improving":[152],"translation.":[153],"Pharmacological":[154],"strategies":[155],"should":[156],"be":[157],"evaluated":[158],"within":[159],"multimodal":[160],"care":[161],"to":[162,172],"better":[163],"connect":[164],"target":[166],"engagement":[167],"with":[168],"outcomes":[169],"that":[170],"matter":[171],"adults.":[174]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
