{"id":"https://openalex.org/W7225656134","doi":"https://doi.org/10.21203/rs.3.rs-11469637/v1","title":"Modulation of cellular bioenergetics enhances CFTR-dependent chloride transport in human bronchial epithelium","display_name":"Modulation of cellular bioenergetics enhances CFTR-dependent chloride transport in human bronchial epithelium","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225656134","doi":"https://doi.org/10.21203/rs.3.rs-11469637/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11469637/v1","doi":"https://doi.org/10.21203/rs.3.rs-11469637/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11469637/v1","pdf_url":"https://www.researchsquare.com/article/rs-11469637/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11469637/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092711828","display_name":"Jakub Hoser","orcid":"https://orcid.org/0000-0002-3095-162X","observed_orcids":["https://orcid.org/0000-0002-3095-162X"]},"institutions":[{"id":"https://openalex.org/I170230895","display_name":"Warsaw University of Life Sciences","ror":"https://ror.org/05srvzs48","country_code":"PL","type":"education","lineage":["https://openalex.org/I170230895"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jakub Hoser","raw_affiliation_strings":["Warsaw University of Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warsaw University of Life Sciences","institution_ids":["https://openalex.org/I170230895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003001023","display_name":"Marta J\u0119drzejczyk","orcid":"https://orcid.org/0000-0003-4214-569X","observed_orcids":["https://orcid.org/0000-0003-4214-569X"]},"institutions":[{"id":"https://openalex.org/I59411706","display_name":"Adam Mickiewicz University in Pozna\u0144","ror":"https://ror.org/04g6bbq64","country_code":"PL","type":"education","lineage":["https://openalex.org/I59411706"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marta J\u0119drzejczyk","raw_affiliation_strings":["Adam Mickiewicz University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adam Mickiewicz University","institution_ids":["https://openalex.org/I59411706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028053146","display_name":"Adam Huczy\u0144ski","orcid":"https://orcid.org/0000-0003-4770-215X","observed_orcids":["https://orcid.org/0000-0003-4770-215X"]},"institutions":[{"id":"https://openalex.org/I59411706","display_name":"Adam Mickiewicz University in Pozna\u0144","ror":"https://ror.org/04g6bbq64","country_code":"PL","type":"education","lineage":["https://openalex.org/I59411706"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Adam Huczy\u0144ski","raw_affiliation_strings":["Adam Mickiewicz University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adam Mickiewicz University","institution_ids":["https://openalex.org/I59411706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014390413","display_name":"Miros\u0142aw Zaj\u0105c","orcid":"https://orcid.org/0000-0002-4287-4377","observed_orcids":["https://orcid.org/0000-0002-4287-4377"]},"institutions":[{"id":"https://openalex.org/I170230895","display_name":"Warsaw University of Life Sciences","ror":"https://ror.org/05srvzs48","country_code":"PL","type":"education","lineage":["https://openalex.org/I170230895"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Miros\u0142aw Zaj\u0105c","raw_affiliation_strings":["Warsaw University of Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warsaw University of Life Sciences","institution_ids":["https://openalex.org/I170230895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049349366","display_name":"Piotr Bednarczyk","orcid":"https://orcid.org/0000-0002-7125-0715","observed_orcids":["https://orcid.org/0000-0002-7125-0715"]},"institutions":[{"id":"https://openalex.org/I170230895","display_name":"Warsaw University of Life Sciences","ror":"https://ror.org/05srvzs48","country_code":"PL","type":"education","lineage":["https://openalex.org/I170230895"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr Bednarczyk","raw_affiliation_strings":["Warsaw University of Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warsaw University of Life Sciences","institution_ids":["https://openalex.org/I170230895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.968999981880188},{"id":"https://openalex.org/keywords/chloride-transport","display_name":"chloride transport","score":0.8199999928474426},{"id":"https://openalex.org/keywords/airway-surface-liquid","display_name":"airway surface liquid","score":0.8479999899864197},{"id":"https://openalex.org/keywords/bronchial-epithelium","display_name":"bronchial epithelium","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mitochondrial-bioenergetics","display_name":"mitochondrial bioenergetics","score":0.7279999852180481},{"id":"https://openalex.org/keywords/salinomycin","display_name":"salinomycin","score":0.878000020980835},{"id":"https://openalex.org/keywords/luteolin","display_name":"luteolin","score":1.0},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8980000019073486},{"id":"https://openalex.org/keywords/intracellular-atp","display_name":"intracellular ATP","score":0.8640000224113464},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8100000023841858},{"id":"https://openalex.org/keywords/epithelial-barrier-integrity","display_name":"epithelial barrier integrity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/mucociliary-clearance","display_name":"mucociliary clearance","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7781999707221985},{"id":"https://openalex.org/C2778428886","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"Cystic fibrosis transmembrane conductance regulator","level":3,"score":0.7645999789237976},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.640500009059906},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.6269999742507935},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6258999705314636},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5806999802589417},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5365999937057495},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.49059998989105225},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.48410001397132874},{"id":"https://openalex.org/C28938303","wikidata":"https://www.wikidata.org/wiki/Q17122952","display_name":"Transepithelial potential difference","level":4,"score":0.4779999852180481},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4706000089645386},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.44020000100135803},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.4253999888896942},{"id":"https://openalex.org/C145822097","wikidata":"https://www.wikidata.org/wiki/Q106916978","display_name":"Chloride channel","level":2,"score":0.3725000023841858},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36880001425743103},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.3490000069141388},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.33340001106262207},{"id":"https://openalex.org/C3018436504","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Apical membrane","level":3,"score":0.3327000141143799},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3276999890804291},{"id":"https://openalex.org/C2779932011","wikidata":"https://www.wikidata.org/wiki/Q581885","display_name":"Ussing chamber","level":3,"score":0.31520000100135803},{"id":"https://openalex.org/C57947595","wikidata":"https://www.wikidata.org/wiki/Q7886088","display_name":"Membrane transport","level":3,"score":0.3102000057697296},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.3084999918937683},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.29750001430511475},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.2847999930381775},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.27880001068115234},{"id":"https://openalex.org/C2779533339","wikidata":"https://www.wikidata.org/wiki/Q4036893","display_name":"DIDS","level":3,"score":0.27619999647140503},{"id":"https://openalex.org/C2778695967","wikidata":"https://www.wikidata.org/wiki/Q44791900","display_name":"Chloride","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C39587587","wikidata":"https://www.wikidata.org/wiki/Q5383698","display_name":"Epithelial polarity","level":3,"score":0.2741999924182892},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26969999074935913},{"id":"https://openalex.org/C2778643788","wikidata":"https://www.wikidata.org/wiki/Q411840","display_name":"Cadmium chloride","level":3,"score":0.2696000039577484},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C114682108","wikidata":"https://www.wikidata.org/wiki/Q1952044","display_name":"Mucociliary clearance","level":3,"score":0.2533999979496002}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11469637/v1","doi":"https://doi.org/10.21203/rs.3.rs-11469637/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11469637/v1","pdf_url":"https://www.researchsquare.com/article/rs-11469637/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11469637/v1","doi":"https://doi.org/10.21203/rs.3.rs-11469637/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11469637/v1","pdf_url":"https://www.researchsquare.com/article/rs-11469637/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225656134.pdf","grobid_xml":"https://content.openalex.org/works/W7225656134.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1498807305","https://openalex.org/W1821144537","https://openalex.org/W1985842881","https://openalex.org/W1987294972","https://openalex.org/W2004844038","https://openalex.org/W2006307101","https://openalex.org/W2032986953","https://openalex.org/W2038842598","https://openalex.org/W2046465695","https://openalex.org/W2047233384","https://openalex.org/W2058456997","https://openalex.org/W2075070043","https://openalex.org/W2094969755","https://openalex.org/W2152939397","https://openalex.org/W2181100149","https://openalex.org/W2232970380","https://openalex.org/W2337762305","https://openalex.org/W2559623350","https://openalex.org/W2591328463","https://openalex.org/W2593854881","https://openalex.org/W2737731334","https://openalex.org/W2806123391","https://openalex.org/W2890642338","https://openalex.org/W2952212183","https://openalex.org/W2978407315","https://openalex.org/W2985405196","https://openalex.org/W2989171950","https://openalex.org/W3036202249","https://openalex.org/W3111464951","https://openalex.org/W3137453670","https://openalex.org/W3141624153","https://openalex.org/W3163174891","https://openalex.org/W3171749013","https://openalex.org/W3174818577","https://openalex.org/W3185687082","https://openalex.org/W3186483066","https://openalex.org/W3214462184","https://openalex.org/W4211144794","https://openalex.org/W4213056068","https://openalex.org/W4225104635","https://openalex.org/W4311881860","https://openalex.org/W4389386829","https://openalex.org/W4404192402","https://openalex.org/W4404387135","https://openalex.org/W4407419841","https://openalex.org/W4408906656","https://openalex.org/W4415041627","https://openalex.org/W4415746471","https://openalex.org/W4416344534","https://openalex.org/W7134245106"],"related_works":["https://openalex.org/W3138811744","https://openalex.org/W4393950056","https://openalex.org/W2182177768","https://openalex.org/W4410998889","https://openalex.org/W63993757","https://openalex.org/W4415356844","https://openalex.org/W2160054775","https://openalex.org/W7160933163","https://openalex.org/W7213275156","https://openalex.org/W3154033850"],"abstract_inverted_index":{"Abstract":[0],"Airway":[1],"surface":[2,202],"liquid":[3],"(ASL)":[4],"homeostasis":[5],"depends":[6],"on":[7],"coordinated":[8],"epithelial":[9,68,127,196],"ion":[10,197],"transport,":[11],"with":[12,207],"the":[13,42,58,102,148],"cystic":[14],"fibrosis":[15],"transmembrane":[16],"conductance":[17],"regulator":[18],"(CFTR)":[19],"playing":[20],"a":[21,53,173,191],"central":[22],"role":[23],"in":[24,65,204],"chloride":[25,63,145],"secretion.":[26],"Reduced":[27],"CFTR":[28,71,159,209],"activity":[29,72,160],"contributes":[30],"to":[31,100,105,194],"ASL":[32],"dehydration,":[33],"impaired":[34,208],"mucociliary":[35],"clearance,":[36],"and":[37,57,83,93,125,143,161,164,199],"chronic":[38],"airway":[39,201],"inflammation.":[40],"In":[41],"present":[43],"study,":[44],"we":[45],"investigated":[46],"whether":[47],"modulation":[48,185],"of":[49,176,186],"cellular":[50,103],"bioenergetics":[51],"by":[52,75],"mitochondria-targeted":[54],"conjugate":[55,110],"3a":[56,111,131],"flavonoid":[59],"luteolin":[60,119],"enhances":[61],"CFTR-mediated":[62,144],"transport":[64,198],"human":[66],"bronchial":[67],"HBE":[69],"cells.":[70],"was":[73],"evaluated":[74],"Ussing":[76],"chamber,":[77],"while":[78,147],"mitochondrial":[79,134,170,187],"respiration,":[80,171],"intracellular":[81,122,137,165],"ATP":[82,138,163],"Ca\u00b2\u207a":[84,141,166],"levels,":[85,139],"reactive":[86],"oxygen":[87,135],"species":[88],"(ROS)":[89],"production,":[90,117],"cell":[91,113],"viability,":[92],"transepithelial":[94],"electrical":[95],"resistance":[96],"(TEER)":[97],"were":[98],"assessed":[99],"characterize":[101],"responses":[104],"treatment.":[106],"Neither":[107],"salinomycin":[108,151],"nor":[109],"affected":[112],"viability":[114],"or":[115],"ROS":[116,123],"whereas":[118],"significantly":[120],"reduced":[121],"levels":[124,167],"enhanced":[126,158,177],"barrier":[128],"integrity.":[129],"Conjugate":[130],"markedly":[132],"increased":[133,162],"consumption,":[136],"cytosolic":[140],"concentration,":[142],"secretion,":[146],"parent":[149],"compound":[150],"produced":[152],"no":[153],"significant":[154],"effects.":[155],"Luteolin":[156],"also":[157],"without":[168],"stimulating":[169],"suggesting":[172],"mechanism":[174],"independent":[175],"oxidative":[178],"metabolism.":[179],"Our":[180],"findings":[181],"demonstrate":[182],"that":[183],"pharmacological":[184],"function":[188],"may":[189],"represent":[190],"complementary":[192],"strategy":[193],"improve":[195],"restore":[200],"hydration":[203],"diseases":[205],"associated":[206],"function.":[210]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
