{"id":"https://openalex.org/W7225655979","doi":"https://doi.org/10.3389/fonc.2026.1961205","title":"Primary rectal malignant melanoma: a rare case report","display_name":"Primary rectal malignant melanoma: a rare case report","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225655979","doi":"https://doi.org/10.3389/fonc.2026.1961205"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1961205","doi":"https://doi.org/10.3389/fonc.2026.1961205","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1961205","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1961205/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1961205/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161319784","display_name":"Yang Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Xiao","raw_affiliation_strings":["Department of Gastrointestinal Surgery,Zhejiang Provincial People\u2019s Hospital Bijie Hospital (The First People\u2019s Hospital of Bijie)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery,Zhejiang Provincial People\u2019s Hospital Bijie Hospital (The First People\u2019s Hospital of Bijie)","institution_ids":["https://openalex.org/I4210131061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161323537","display_name":"MingWang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"MingWang Li","raw_affiliation_strings":["Department of Gastrointestinal Surgery,Zhejiang Provincial People\u2019s Hospital Bijie Hospital (The First People\u2019s Hospital of Bijie)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery,Zhejiang Provincial People\u2019s Hospital Bijie Hospital (The First People\u2019s Hospital of Bijie)","institution_ids":["https://openalex.org/I4210131061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008104415","display_name":"Xia Ye","orcid":"https://orcid.org/0000-0002-7692-3595","observed_orcids":["https://orcid.org/0000-0002-7692-3595"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Ye","raw_affiliation_strings":["Department of Gastrointestinal Surgery,Zhejiang Provincial People\u2019s Hospital Bijie Hospital (The First People\u2019s Hospital of Bijie)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery,Zhejiang Provincial People\u2019s Hospital Bijie Hospital (The First People\u2019s Hospital of Bijie)","institution_ids":["https://openalex.org/I4210131061"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161340836","display_name":"Ming Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Nie","raw_affiliation_strings":["Department of Gastrointestinal Surgery,Zhejiang Provincial People\u2019s Hospital Bijie Hospital (The First People\u2019s Hospital of Bijie)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery,Zhejiang Provincial People\u2019s Hospital Bijie Hospital (The First People\u2019s Hospital of Bijie)","institution_ids":["https://openalex.org/I4210131061"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5161340836"],"corresponding_institution_ids":["https://openalex.org/I4210131061"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-melanoma","display_name":"rectal melanoma","score":0.7799999713897705},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7950000166893005},{"id":"https://openalex.org/keywords/melan-a","display_name":"Melan-A","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hmb-45","display_name":"HMB-45","score":1.0},{"id":"https://openalex.org/keywords/sox10","display_name":"SOX10","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ki-67-proliferation-index","display_name":"Ki-67 proliferation index","score":0.8999999761581421},{"id":"https://openalex.org/keywords/miles-operation","display_name":"Miles operation","score":0.878000020980835},{"id":"https://openalex.org/keywords/hematochezia","display_name":"hematochezia","score":0.7210000157356262},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.6959999799728394},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9544000029563904},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6503000259399414},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.578000009059906},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5555999875068665},{"id":"https://openalex.org/C2781171867","wikidata":"https://www.wikidata.org/wiki/Q3933360","display_name":"Abdominoperineal resection","level":4,"score":0.5188999772071838},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4745999872684479},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4636000096797943},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4339999854564667},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4316999912261963},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4011000096797943},{"id":"https://openalex.org/C2779701055","wikidata":"https://www.wikidata.org/wiki/Q929833","display_name":"Rare disease","level":3,"score":0.39399999380111694},{"id":"https://openalex.org/C2779797108","wikidata":"https://www.wikidata.org/wiki/Q41478","display_name":"Hemorrhoids","level":2,"score":0.37869998812675476},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3499999940395355},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.3463999927043915},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.29260000586509705},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.26750001311302185},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.26190000772476196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26109999418258667},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.2590000033378601},{"id":"https://openalex.org/C2780101318","wikidata":"https://www.wikidata.org/wiki/Q594341","display_name":"Rectal examination","level":4,"score":0.257099986076355},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2529999911785126},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fonc.2026.1961205","doi":"https://doi.org/10.3389/fonc.2026.1961205","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1961205","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1961205/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1961205","doi":"https://doi.org/10.3389/fonc.2026.1961205","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1961205","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1961205/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225655979.pdf","grobid_xml":"https://content.openalex.org/works/W7225655979.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W2161366013","https://openalex.org/W2332298895","https://openalex.org/W2883114130","https://openalex.org/W2885898493","https://openalex.org/W2913383852","https://openalex.org/W3035972043","https://openalex.org/W3162024349","https://openalex.org/W4200587443","https://openalex.org/W4210587714","https://openalex.org/W4210842907","https://openalex.org/W4234660273","https://openalex.org/W4238312088","https://openalex.org/W4380590072","https://openalex.org/W4399871556","https://openalex.org/W4401099762","https://openalex.org/W4402759855","https://openalex.org/W4403009946","https://openalex.org/W4403096271","https://openalex.org/W4404861281","https://openalex.org/W4408154785","https://openalex.org/W4411300917","https://openalex.org/W7124693911","https://openalex.org/W7161646880"],"related_works":["https://openalex.org/W2044753021","https://openalex.org/W2005637369","https://openalex.org/W4411121295","https://openalex.org/W2120296293","https://openalex.org/W82567081","https://openalex.org/W4321189961","https://openalex.org/W4385332364","https://openalex.org/W1978000550","https://openalex.org/W7142985917","https://openalex.org/W7163749735"],"abstract_inverted_index":{"Primary":[0],"malignant":[1,12,62,108,143],"melanoma":[2,63,144],"of":[3,39,60,64,101,107,141,150,175],"the":[4,58,65,73,80,139,148,169],"rectum":[5],"is":[6,21],"a":[7,30,37,40,77,97,126],"rare":[8],"and":[9,19,51,55,83,86,94,119,155,182],"highly":[10],"aggressive":[11],"tumor.":[13],"Its":[14],"clinical":[15,173],"manifestations":[16],"lack":[17],"specificity":[18],"it":[20],"often":[22],"misdiagnosed":[23],"as":[24],"hemorrhoids":[25],"or":[26,131],"rectal":[27,142],"polyps,":[28],"with":[29,46,67,96,105],"very":[31],"poor":[32],"prognosis.":[33,190],"This":[34,166],"article":[35],"reported":[36],"case":[38,167],"71-year-old":[41],"Asian":[42],"female":[43],"who":[44],"presented":[45],"changes":[47],"in":[48,79,163],"bowel":[49],"habits":[50],"hematochezia.":[52],"Colonoscopic":[53],"biopsy":[54],"immunohistochemistry":[56,87],"confirmed":[57],"diagnosis":[59,140,181],"primary":[61,69],"rectum,":[66,82],"no":[68,129],"lesions":[70],"found":[71],"on":[72,146],"skin.":[74],"Imaging":[75],"suggested":[76],"lesion":[78],"lower":[81],"postoperative":[84,123],"pathology":[85],"showed":[88],"positivity":[89],"for":[90],"Melan":[91],"A,":[92],"HMB45,":[93],"SOX10,":[95],"Ki-67":[98],"proliferation":[99],"index":[100],"approximately":[102],"45%,":[103],"consistent":[104],"characteristics":[106],"melanoma.":[109],"The":[110],"patient":[111,189],"underwent":[112],"robot-assisted":[113],"laparoscopic":[114],"abdominoperineal":[115],"resection":[116],"(Miles":[117],"operation)":[118],"did":[120],"not":[121],"receive":[122],"immunotherapy;":[124],"during":[125],"6-month":[127],"follow-up,":[128],"recurrence":[130],"metastasis":[132],"was":[133],"observed.":[134],"Literature":[135],"review":[136],"indicates":[137],"that":[138],"relies":[145],"immunohistochemistry,":[147],"choice":[149],"surgical":[151],"approach":[152],"remains":[153],"controversial,":[154],"immune":[156],"checkpoint":[157],"inhibitors":[158],"have":[159],"shown":[160],"good":[161],"efficacy":[162],"advanced":[164],"patients.":[165],"highlights":[168],"need":[170],"to":[171,178],"raise":[172],"awareness":[174],"this":[176],"disease":[177],"achieve":[179],"early":[180],"individualized":[183],"treatment":[184],"selection,":[185],"which":[186],"may":[187],"improve":[188]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
