{"id":"https://openalex.org/W7225655651","doi":"https://doi.org/10.3390/metabo16110866","title":"Nonlinear Association Between Lithocholic Acid-Related Metabolism and Dysglycemia in Pediatric Obesity","display_name":"Nonlinear Association Between Lithocholic Acid-Related Metabolism and Dysglycemia in Pediatric Obesity","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225655651","doi":"https://doi.org/10.3390/metabo16110866"},"language":"en","primary_location":{"id":"doi:10.3390/metabo16110866","doi":"https://doi.org/10.3390/metabo16110866","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo16110866","pdf_url":null,"source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/metabo16110866","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036975207","display_name":"Lingwen Ying","orcid":"https://orcid.org/0000-0001-6240-9221","observed_orcids":["https://orcid.org/0000-0001-6240-9221"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingwen Ying","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115602259","display_name":"Fan Yang","orcid":"https://orcid.org/0000-0002-9693-4099","observed_orcids":["https://orcid.org/0000-0002-9693-4099","https://orcid.org/0009-0005-2609-2681","https://orcid.org/0000-0001-6841-1605","https://orcid.org/0009-0007-6097-0622"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Yang","raw_affiliation_strings":["Department of Clinical Research Ward, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research Ward, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122039640","display_name":"Jiayue Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayue Hu","raw_affiliation_strings":["Department of Clinical Research Ward, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research Ward, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146345145","display_name":"JiaXiao She","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxiao She","raw_affiliation_strings":["Department of Clinical Research Ward, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research Ward, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013862085","display_name":"Biyun Feng","orcid":"https://orcid.org/0000-0003-0828-3036","observed_orcids":["https://orcid.org/0000-0003-0828-3036"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Biyun Feng","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065053054","display_name":"Qianwen Zhang","orcid":"https://orcid.org/0000-0001-8115-982X","observed_orcids":["https://orcid.org/0000-0001-8115-982X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianwen Zhang","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161353519","display_name":"Yiguo Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiguo Huang","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031813761","display_name":"Libo Wang","orcid":"https://orcid.org/0009-0001-3192-1115","observed_orcids":["https://orcid.org/0009-0001-3192-1115"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Libo Wang","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":"https://orcid.org/0009-0001-3192-1115","affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067901140","display_name":"Juan Li","orcid":"https://orcid.org/0000-0003-4841-1186","observed_orcids":["https://orcid.org/0000-0003-4841-1186"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Li","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121366724","display_name":"Yu Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Ding","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045258881","display_name":"Yunman Liu","orcid":"https://orcid.org/0009-0006-4795-767X","observed_orcids":["https://orcid.org/0009-0006-4795-767X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunman Liu","raw_affiliation_strings":["Department of Clinical Nutrition, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Nutrition, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014743881","display_name":"Zhiyan Zhan","orcid":"https://orcid.org/0000-0003-1381-0136","observed_orcids":["https://orcid.org/0000-0003-1381-0136"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyan Zhan","raw_affiliation_strings":["Clinical Research Center, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","Department of Clinical Nutrition, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":"https://orcid.org/0000-0003-1381-0136","affiliations":[{"raw_affiliation_string":"Clinical Research Center, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]},{"raw_affiliation_string":"Department of Clinical Nutrition, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006351883","display_name":"Danping Su","orcid":"https://orcid.org/0000-0002-6532-0772","observed_orcids":["https://orcid.org/0000-0002-6532-0772"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danping Su","raw_affiliation_strings":["Department of Clinical Nutrition, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Nutrition, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066215279","display_name":"Hong Li","orcid":"https://orcid.org/0000-0002-9192-1213","observed_orcids":["https://orcid.org/0000-0002-9192-1213"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Hong","raw_affiliation_strings":["Department of Clinical Nutrition, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":"https://orcid.org/0000-0002-9192-1213","affiliations":[{"raw_affiliation_string":"Department of Clinical Nutrition, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148569603","display_name":"Xiumin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiumin Wang","raw_affiliation_strings":["Department of Clinical Research Ward, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research Ward, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]},{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025064125","display_name":"Guoying Chang","orcid":"https://orcid.org/0000-0003-0701-3544","observed_orcids":["https://orcid.org/0000-0003-0701-3544"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guoying Chang","raw_affiliation_strings":["Department of Clinical Research Ward, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":"https://orcid.org/0000-0003-0701-3544","affiliations":[{"raw_affiliation_string":"Department of Clinical Research Ward, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]},{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025064125","https://openalex.org/A5066215279","https://openalex.org/A5148569603"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"11","first_page":"866","last_page":"866"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7598000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7598000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.031300000846385956,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.031099999323487282,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lithocholic-acid","display_name":"lithocholic acid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.8700000047683716},{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dysglycemia","display_name":"dysglycemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7760000228881836},{"id":"https://openalex.org/keywords/insulin-dynamics","display_name":"insulin dynamics","score":0.753000020980835},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.7889999747276306},{"id":"https://openalex.org/keywords/oral-glucose-tolerance-test","display_name":"oral glucose tolerance test","score":0.6600000262260437},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6489999890327454},{"id":"https://openalex.org/keywords/enterohepatic-circulation","display_name":"enterohepatic circulation","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5891000032424927},{"id":"https://openalex.org/C2779668308","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Prediabetes","level":4,"score":0.5529999732971191},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5511999726295471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5157999992370605},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.5029000043869019},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.48809999227523804},{"id":"https://openalex.org/C2780420665","wikidata":"https://www.wikidata.org/wiki/Q3323035","display_name":"Lithocholic acid","level":3,"score":0.4634999930858612},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.43650001287460327},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4325000047683716},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.42879998683929443},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.41119998693466187},{"id":"https://openalex.org/C2778620825","wikidata":"https://www.wikidata.org/wiki/Q1344633","display_name":"Enterohepatic circulation","level":3,"score":0.36820000410079956},{"id":"https://openalex.org/C76923068","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Blood sugar regulation","level":3,"score":0.35019999742507935},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.34610000252723694},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.33250001072883606},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.32710000872612},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.32089999318122864},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C2780833929","wikidata":"https://www.wikidata.org/wiki/Q1501412","display_name":"Glucose tolerance test","level":4,"score":0.31520000100135803},{"id":"https://openalex.org/C2781089062","wikidata":"https://www.wikidata.org/wiki/Q419028","display_name":"Chenodeoxycholic acid","level":3,"score":0.2937999963760376},{"id":"https://openalex.org/C203862802","wikidata":"https://www.wikidata.org/wiki/Q14905041","display_name":"Farnesoid X receptor","level":5,"score":0.27090001106262207},{"id":"https://openalex.org/C2777185836","wikidata":"https://www.wikidata.org/wiki/Q3306264","display_name":"Impaired fasting glucose","level":5,"score":0.2612999975681305},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2556000053882599}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/metabo16110866","doi":"https://doi.org/10.3390/metabo16110866","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo16110866","pdf_url":null,"source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/metabo16110866","doi":"https://doi.org/10.3390/metabo16110866","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo16110866","pdf_url":null,"source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W2013209482","https://openalex.org/W2026160870","https://openalex.org/W2052390133","https://openalex.org/W2062808581","https://openalex.org/W2066898102","https://openalex.org/W2074399756","https://openalex.org/W2099673318","https://openalex.org/W2121848003","https://openalex.org/W2139425275","https://openalex.org/W2151013011","https://openalex.org/W2170469583","https://openalex.org/W2382765172","https://openalex.org/W2468692184","https://openalex.org/W2596624061","https://openalex.org/W2806196874","https://openalex.org/W2924422341","https://openalex.org/W2953324747","https://openalex.org/W2996401508","https://openalex.org/W3002924774","https://openalex.org/W3009496837","https://openalex.org/W4221131751","https://openalex.org/W4283766901","https://openalex.org/W4383187169","https://openalex.org/W4407837320","https://openalex.org/W4408208700","https://openalex.org/W4409457453","https://openalex.org/W4410608327"],"related_works":["https://openalex.org/W2614032291","https://openalex.org/W4224261340","https://openalex.org/W2996401508","https://openalex.org/W4414607220","https://openalex.org/W3100989347","https://openalex.org/W2155128881","https://openalex.org/W7203600192","https://openalex.org/W7225105669","https://openalex.org/W2614093500","https://openalex.org/W2417695074"],"abstract_inverted_index":{"Background:":[0],"Bile":[1,67,250],"acids":[2],"regulate":[3],"glucose":[4,51,93],"metabolism":[5,263],"through":[6],"enterohepatic":[7],"signaling":[8],"and":[9,25,55,83,113,116,145,177,269,287],"gut":[10],"microbiota-mediated":[11],"transformations.":[12],"However,":[13],"the":[14,160,174,181,212,232,235,279],"role":[15],"of":[16,231,240,281],"specific":[17],"bile":[18,58,126,149,261,283,292],"acid":[19,23,59,150,262,284],"subtypes,":[20],"particularly":[21],"lithocholic":[22],"(LCA)":[24],"its":[26],"derivatives,":[27],"in":[28,142,257,290],"pediatric":[29,258],"obesity":[30,42],"remains":[31],"incompletely":[32],"understood.":[33],"Methods:":[34],"In":[35],"this":[36],"cross-sectional":[37],"study,":[38],"149":[39],"children":[40],"with":[41,129,159,267],"underwent":[43],"comprehensive":[44],"metabolic":[45,77,131,255,274,288],"assessment,":[46],"including":[47],"a":[48,153,227],"75-g":[49],"oral":[50],"tolerance":[52],"test":[53],"(OGTT)":[54],"fasting":[56],"serum":[57],"profiling":[60],"using":[61,99,110],"liquid":[62],"chromatography\u2013tandem":[63],"mass":[64],"spectrometry":[65],"(LC\u2013MS/MS).":[66],"acid-derived":[68,127],"indices":[69,82,151],"were":[70,97,121,133,168],"used":[71],"for":[72,166,173,180,234],"unsupervised":[73],"clustering":[74,252],"to":[75],"identify":[76],"phenotypes.":[78,275],"Associations":[79],"between":[80,219],"LCA-related":[81,148,260],"dysglycemia":[84,167,268],"(defined":[85],"as":[86],"HbA1c":[87],"\u2265":[88,94],"5.7%":[89],"and/or":[90],"2-h":[91],"plasma":[92],"7.8":[95],"mmol/L)":[96],"evaluated":[98],"multivariable":[100],"regression":[101],"models.":[102,118],"The":[103,184],"LCA":[104],"derivative":[105],"sum":[106],"was":[107],"analyzed":[108],"separately":[109],"tertile":[111,176,220],"categories":[112],"continuous":[114,185,200,213,241],"linear":[115,186],"quadratic":[117,201],"Cluster-stratified":[119],"patterns":[120],"further":[122],"assessed.":[123],"Results:":[124],"Three":[125],"clusters":[128,139],"distinct":[130,254],"profiles":[132],"identified.":[134],"Despite":[135],"similar":[136],"anthropometric":[137],"characteristics,":[138],"differed":[140],"significantly":[141],"glycemic":[143,242],"status":[144],"insulin":[146],"dynamics.":[147],"showed":[152,188],"non-monotonic":[154],"redistribution":[155],"across":[156,211,247,273],"clusters.":[157,248],"Compared":[158],"lowest":[161],"tertile,":[162],"adjusted":[163],"odds":[164],"ratios":[165],"1.44":[169],"(95%":[170],"CI:":[171],"0.62\u20133.37)":[172],"intermediate":[175],"0.33":[178],"(0.13\u20130.83)":[179],"highest":[182],"tertile.":[183],"model":[187,202],"an":[189,204],"inverse":[190],"association":[191,233],"per":[192],"SD":[193],"increase":[194],"(OR":[195],"0.646":[196],"[0.441\u20130.946]).":[197],"A":[198],"separate":[199],"suggested":[203,244],"inverted":[205],"U-shaped":[206],"exposure\u2013response":[207],"pattern,":[208],"describing":[209],"variation":[210],"exposure":[214],"range":[215],"rather":[216],"than":[217],"comparisons":[218],"categories.":[221],"Interaction":[222],"analyses":[223,239],"did":[224],"not":[225],"demonstrate":[226],"statistically":[228],"significant":[229],"modification":[230],"primary":[236],"outcome,":[237],"although":[238],"traits":[243],"potential":[245],"heterogeneity":[246,272],"Conclusions:":[249],"acid-based":[251],"identifies":[253],"phenotypes":[256],"obesity.":[259],"shows":[264],"nonlinear":[265],"associations":[266],"may":[270],"exhibit":[271],"These":[276],"findings":[277],"highlight":[278],"importance":[280],"considering":[282],"subtype":[285],"specificity":[286],"context":[289],"understanding":[291],"acid\u2013glucose":[293],"interactions.":[294]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
