{"id":"https://openalex.org/W7225655436","doi":"https://doi.org/10.1002/ijc.70821","title":"Stratification of Gastric Cancer Based on Methylation Status of Enhancer Regions and Effects on Transcriptional Regulation","display_name":"Stratification of Gastric Cancer Based on Methylation Status of Enhancer Regions and Effects on Transcriptional Regulation","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225655436","doi":"https://doi.org/10.1002/ijc.70821","pmid":"https://pubmed.ncbi.nlm.nih.gov/43001335"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.70821","doi":"https://doi.org/10.1002/ijc.70821","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.70821","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110652799","display_name":"Tomoka Okada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoka Okada","raw_affiliation_strings":["Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000586304","display_name":"Genki Usui","orcid":"https://orcid.org/0000-0002-6615-8674","observed_orcids":["https://orcid.org/0000-0002-6615-8674"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257820","display_name":"Institute of Molecular Health Sciences","ror":"https://ror.org/05q2cwx50","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257820"]}],"countries":["CH","JP"],"is_corresponding":false,"raw_author_name":"Genki Usui","raw_affiliation_strings":["Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan","Department of Quantitative Biomedicine University of Zurich  Zurich Switzerland","Institute for Molecular Health Sciences ETH Zurich  Zurich Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Quantitative Biomedicine University of Zurich  Zurich Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Institute for Molecular Health Sciences ETH Zurich  Zurich Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006229702","display_name":"Atsushi Okabe","orcid":"https://orcid.org/0000-0001-7748-6078","observed_orcids":["https://orcid.org/0000-0001-7748-6078"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4405287122","display_name":"Health and Disease Omics Center, Chiba University","ror":"https://ror.org/045r0ya67","country_code":"JP","type":"facility","lineage":["https://openalex.org/I159385669","https://openalex.org/I4405287122"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Okabe","raw_affiliation_strings":["Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan","Health and Disease Omics Center Chiba University  Chiba Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Health and Disease Omics Center Chiba University  Chiba Japan","institution_ids":["https://openalex.org/I4405287122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024950554","display_name":"M. Seki","orcid":"https://orcid.org/0000-0003-4207-1408","observed_orcids":["https://orcid.org/0000-0003-4207-1408"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoaki Seki","raw_affiliation_strings":["Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110022853","display_name":"Ryoji Fujiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryoji Fujiki","raw_affiliation_strings":["Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010943454","display_name":"Hiroyuki Ab\u00e9","orcid":"https://orcid.org/0000-0003-4513-1007","observed_orcids":["https://orcid.org/0000-0003-4513-1007"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Abe","raw_affiliation_strings":["Department of Pathology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Graduate School of Medicine The University of Tokyo  Tokyo Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161341395","display_name":"Bahityar Rahmutulla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Bahityar Rahmutulla","raw_affiliation_strings":["Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041668258","display_name":"Masaki Fukuyo","orcid":"https://orcid.org/0000-0003-2320-1529","observed_orcids":["https://orcid.org/0000-0003-2320-1529"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Fukuyo","raw_affiliation_strings":["Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022741402","display_name":"Teppei Morikawa","orcid":"https://orcid.org/0000-0002-4945-6207","observed_orcids":["https://orcid.org/0000-0002-4945-6207"]},"institutions":[{"id":"https://openalex.org/I2801547476","display_name":"NTT Medical Center","ror":"https://ror.org/0285prp25","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2801547476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Teppei Morikawa","raw_affiliation_strings":["Department of Diagnostic Pathology NTT Medical Center Tokyo  Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Pathology NTT Medical Center Tokyo  Tokyo Japan","institution_ids":["https://openalex.org/I2801547476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011690214","display_name":"Tetsuo Ushiku","orcid":"https://orcid.org/0000-0002-1763-8380","observed_orcids":["https://orcid.org/0000-0002-1763-8380"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Ushiku","raw_affiliation_strings":["Department of Pathology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"],"raw_orcid":"https://orcid.org/0000-0002-1763-8380","affiliations":[{"raw_affiliation_string":"Department of Pathology, Graduate School of Medicine The University of Tokyo  Tokyo Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081519082","display_name":"Atsushi Kaneda","orcid":"https://orcid.org/0000-0002-6980-5515","observed_orcids":["https://orcid.org/0000-0002-6980-5515"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4405287122","display_name":"Health and Disease Omics Center, Chiba University","ror":"https://ror.org/045r0ya67","country_code":"JP","type":"facility","lineage":["https://openalex.org/I159385669","https://openalex.org/I4405287122"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsushi Kaneda","raw_affiliation_strings":["Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan","Health and Disease Omics Center Chiba University  Chiba Japan"],"raw_orcid":"https://orcid.org/0000-0002-6980-5515","affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, School of Medicine Chiba University  Chiba Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Health and Disease Omics Center Chiba University  Chiba Japan","institution_ids":["https://openalex.org/I4405287122"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5081519082"],"corresponding_institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4405287122"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dna-hypermethylation","display_name":"DNA hypermethylation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/phosphoinositide-3-kinase-akt-signaling","display_name":"phosphatidylinositol 3-kinase/Akt signaling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tumor-suppressor-inactivation","display_name":"tumor suppressor inactivation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/gastric-carcinogenesis","display_name":"gastric carcinogenesis","score":0.6110000014305115},{"id":"https://openalex.org/keywords/dna-methylome","display_name":"methylome","score":0.6380000114440918},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/epstein-barr-virus-infection","display_name":"Epstein-Barr virus infection","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.8809000253677368},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.868399977684021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7287999987602234},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6446999907493591},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5878000259399414},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5307999849319458},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.508899986743927},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.498199999332428},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4424999952316284},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42980000376701355},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.4025000035762787},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3968000113964081},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.3953000009059906},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3799999952316284},{"id":"https://openalex.org/C189235521","wikidata":"https://www.wikidata.org/wiki/Q4087270","display_name":"Bisulfite sequencing","level":5,"score":0.35589998960494995},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.35409998893737793},{"id":"https://openalex.org/C154253233","wikidata":"https://www.wikidata.org/wiki/Q14862240","display_name":"Differentially methylated regions","level":5,"score":0.34459999203681946},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3409999907016754},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.3352000117301941},{"id":"https://openalex.org/C116114238","wikidata":"https://www.wikidata.org/wiki/Q6823960","display_name":"Methylated DNA immunoprecipitation","level":5,"score":0.32100000977516174},{"id":"https://openalex.org/C21784809","wikidata":"https://www.wikidata.org/wiki/Q17119097","display_name":"Enhancer RNAs","level":5,"score":0.30219998955726624},{"id":"https://openalex.org/C37080517","wikidata":"https://www.wikidata.org/wiki/Q18353747","display_name":"Epigenetics of physical exercise","level":5,"score":0.3010999858379364},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2973000109195709},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.25049999356269836}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.70821","doi":"https://doi.org/10.1002/ijc.70821","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.70821","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:43001335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43001335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320325182","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1578954095","https://openalex.org/W1902615984","https://openalex.org/W1955052620","https://openalex.org/W1970744631","https://openalex.org/W1979594866","https://openalex.org/W1983347147","https://openalex.org/W1985621639","https://openalex.org/W1988850909","https://openalex.org/W2014677321","https://openalex.org/W2036619779","https://openalex.org/W2043033879","https://openalex.org/W2044433401","https://openalex.org/W2057749060","https://openalex.org/W2073001950","https://openalex.org/W2073577792","https://openalex.org/W2093741667","https://openalex.org/W2104181329","https://openalex.org/W2119393622","https://openalex.org/W2126547130","https://openalex.org/W2133223718","https://openalex.org/W2139077902","https://openalex.org/W2160703133","https://openalex.org/W2167996825","https://openalex.org/W2170551349","https://openalex.org/W2259938310","https://openalex.org/W2281867871","https://openalex.org/W2321006835","https://openalex.org/W2321415533","https://openalex.org/W2549050625","https://openalex.org/W2605422674","https://openalex.org/W2615883294","https://openalex.org/W2739139903","https://openalex.org/W2743865413","https://openalex.org/W2969542839","https://openalex.org/W2972352323","https://openalex.org/W2982646774","https://openalex.org/W3044410956","https://openalex.org/W3045759143","https://openalex.org/W3049187117","https://openalex.org/W3163834190","https://openalex.org/W4205403772","https://openalex.org/W4241577617","https://openalex.org/W4281633224","https://openalex.org/W4310333656","https://openalex.org/W4315754639","https://openalex.org/W4385721650","https://openalex.org/W4387957323","https://openalex.org/W4410999989","https://openalex.org/W7138950263"],"related_works":["https://openalex.org/W2160703133","https://openalex.org/W2035542544","https://openalex.org/W2000010384","https://openalex.org/W2069252124","https://openalex.org/W1545141073","https://openalex.org/W2331141406","https://openalex.org/W2120436117","https://openalex.org/W2743239593","https://openalex.org/W3185060537","https://openalex.org/W2739139903"],"abstract_inverted_index":{"Epstein-Barr":[0],"virus-positive":[1],"gastric":[2,61,163,209],"cancer":[3],"(EBV(+)":[4],"GC)":[5],"shows":[6],"extensive":[7],"DNA":[8,14,30,51,177,199,214],"hypermethylation":[9,200],"in":[10,32,73,117,147,169,179,202,208,216],"gene":[11,26,223],"promoter":[12],"regions.":[13,76],"methylation":[15,31,91,178,215],"induced":[16],"by":[17],"EBV":[18,168,206],"infection":[19,207],"contributes":[20],"to":[21,38,69],"carcinogenesis":[22],"through":[23],"tumor":[24],"suppressor":[25],"inactivation.":[27],"Whereas":[28],"aberrant":[29,176,213],"enhancer":[33,75,94,182,203,217],"regions":[34],"might":[35],"reportedly":[36],"contribute":[37],"carcinogenesis,":[39],"its":[40,188],"impact":[41],"has":[42],"not":[43],"been":[44],"fully":[45],"elucidated.":[46],"Therefore,":[47],"we":[48],"here":[49],"performed":[50],"methylome":[52],"analysis":[53,87],"on":[54,89],"clinical":[55],"samples,":[56],"including":[57],"GC":[58,79,97,149,156,195],"and":[59,137,140,142,154,171,184,205],"normal":[60,152],"mucosa,":[62],"using":[63,84],"the":[64,71,74,90,102,132,173,180,185],"Infinium":[65],"MethylationEPIC":[66],"BeadChip":[67],"array":[68],"evaluate":[70],"epigenome":[72],"We":[77,107,158],"stratified":[78],"cases":[80],"into":[81,101],"three":[82],"subclusters":[83],"hierarchical":[85],"clustering":[86],"based":[88],"status":[92],"of":[93,175,187,221],"regions;":[95],"EBV(+)":[96,118,148,194],"samples":[98],"were":[99],"classified":[100],"most":[103],"extensively":[104],"methylated":[105,116,121],"subcluster.":[106],"identified":[108],"genes":[109,122],"with":[110,131,151,167],"promoters":[111],"unmethylated":[112],"but":[113],"enhancers":[114],"aberrantly":[115],"GC.":[119],"Such":[120],"included":[123],"Inositol":[124],"polyphosphate-5-phosphatase":[125],"A":[126],"(INPP5A),":[127],"which":[128],"is":[129],"associated":[130],"phosphoinositide":[133],"3-kinase/Akt":[134],"signaling":[135],"pathway":[136],"cell":[138,165],"proliferation":[139],"survival,":[141],"showed":[143],"lower":[144],"expression":[145],"levels":[146],"compared":[150],"mucosa":[153],"other":[155],"samples.":[157],"infected":[159],"GES1,":[160],"an":[161],"immortalized":[162],"epithelial":[164],"line,":[166],"vitro,":[170],"demonstrated":[172],"induction":[174],"INPP5A":[181],"region":[183],"downregulation":[186],"expression.":[189,224],"These":[190],"findings":[191],"indicate":[192],"that":[193],"exhibits":[196],"a":[197],"specific":[198],"phenotype":[201],"regions,":[204,218],"cells":[210],"could":[211],"induce":[212],"involving":[219],"dysregulation":[220],"cancer-related":[222]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
