{"id":"https://openalex.org/W7225654615","doi":"https://doi.org/10.3390/genes17111417","title":"Genetic and Epigenetic Determinants of Endometrial LIF Expression and the Potential Role of Human Papillomavirus E6-Mediated p53 Degradation","display_name":"Genetic and Epigenetic Determinants of Endometrial LIF Expression and the Potential Role of Human Papillomavirus E6-Mediated p53 Degradation","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225654615","doi":"https://doi.org/10.3390/genes17111417"},"language":"en","primary_location":{"id":"doi:10.3390/genes17111417","doi":"https://doi.org/10.3390/genes17111417","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes17111417","pdf_url":null,"source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/genes17111417","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081206570","display_name":"Charalampos Voros","orcid":"https://orcid.org/0000-0001-9477-7619","observed_orcids":["https://orcid.org/0000-0001-9477-7619"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210113950","display_name":"Alexandra Hospital","ror":"https://ror.org/029hept94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210113950"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Charalampos Voros","raw_affiliation_strings":["Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0001-9477-7619","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210113950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084051901","display_name":"Stylianos Makrydimas","orcid":"https://orcid.org/0009-0001-9981-7488","observed_orcids":["https://orcid.org/0009-0001-9981-7488"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Stylianos Makrydimas","raw_affiliation_strings":["Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012285230","display_name":"Fotios G. Chatzinikolaou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Fotios Chatzinikolaou","raw_affiliation_strings":["Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115617216","display_name":"Diamantis Athanasiou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diamantis Athanasiou","raw_affiliation_strings":["IVF Athens Reproduction Center, 15123 Maroussi, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IVF Athens Reproduction Center, 15123 Maroussi, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136860271","display_name":"Antonia Athanasiou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonia Athanasiou","raw_affiliation_strings":["IVF Athens Reproduction Center, 15123 Maroussi, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IVF Athens Reproduction Center, 15123 Maroussi, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112422732","display_name":"Aikaterini V. Athanasiou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aikaterini Athanasiou","raw_affiliation_strings":["IVF Athens Reproduction Center, 15123 Maroussi, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IVF Athens Reproduction Center, 15123 Maroussi, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058131651","display_name":"Nikolaos Thomakos","orcid":"https://orcid.org/0000-0003-0962-3549","observed_orcids":["https://orcid.org/0000-0003-0962-3549"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210113950","display_name":"Alexandra Hospital","ror":"https://ror.org/029hept94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210113950"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolaos Thomakos","raw_affiliation_strings":["Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210113950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014863415","display_name":"Panagiotis G. Antsaklis","orcid":"https://orcid.org/0000-0003-2106-5922","observed_orcids":["https://orcid.org/0000-0003-2106-5922","https://orcid.org/0000-0002-6836-5028"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210113950","display_name":"Alexandra Hospital","ror":"https://ror.org/029hept94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210113950"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Antsaklis","raw_affiliation_strings":["Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0003-2106-5922","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210113950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101796153","display_name":"G. Daskalakis","orcid":"https://orcid.org/0000-0001-7108-211X","observed_orcids":["https://orcid.org/0000-0001-7108-211X"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210113950","display_name":"Alexandra Hospital","ror":"https://ror.org/029hept94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210113950"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgios Daskalakis","raw_affiliation_strings":["Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0001-7108-211X","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210113950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070992331","display_name":"George Makrydimas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Makrydimas","raw_affiliation_strings":["Department of Obstetrics & Gynecology, University Hospital of Ioannina, 45500 Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynecology, University Hospital of Ioannina, 45500 Ioannina, Greece","institution_ids":["https://openalex.org/I4210141877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012285230","https://openalex.org/A5081206570"],"corresponding_institution_ids":["https://openalex.org/I200777214","https://openalex.org/I21370196","https://openalex.org/I4210113950"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"11","first_page":"1417","last_page":"1417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukemia-inhibitory-factor","display_name":"leukemia inhibitory factor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/endometrium","display_name":"endometrium","score":0.8880000114440918},{"id":"https://openalex.org/keywords/embryo-implantation","display_name":"embryo implantation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hpv-e6","display_name":"E6 oncoprotein","score":0.6349999904632568},{"id":"https://openalex.org/keywords/p53-degradation","display_name":"p53 degradation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/p53-codon-72-polymorphism","display_name":"p53 codon 72 polymorphism","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.7120000123977661},{"id":"https://openalex.org/keywords/mdm4","display_name":"MDM4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/usp7","display_name":"USP7","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.7879999876022339},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.765999972820282},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/implantation-failure","display_name":"implantation failure","score":0.777999997138977},{"id":"https://openalex.org/keywords/pregnancy-maintenance","display_name":"pregnancy maintenance","score":0.7590000033378601},{"id":"https://openalex.org/keywords/high-risk-hpv","display_name":"high-risk HPV","score":0.8259999752044678},{"id":"https://openalex.org/keywords/endometrial-gene-expression","display_name":"endometrial gene expression","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8008000254631042},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6730999946594238},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.6621999740600586},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45170000195503235},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.451200008392334},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.43639999628067017},{"id":"https://openalex.org/C175211621","wikidata":"https://www.wikidata.org/wiki/Q14907998","display_name":"DNMT1","level":5,"score":0.4154999852180481},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4052000045776367},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3919000029563904},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.3797000050544739},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.37560001015663147},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.35670000314712524},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.35530000925064087},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.3544999957084656},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3481999933719635},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3212999999523163},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.2973000109195709},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.2971999943256378},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.2957000136375427},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.295199990272522},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29510000348091125},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2856000065803528},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2734000086784363},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2727999985218048},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.27160000801086426},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.26969999074935913},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.25609999895095825},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.25609999895095825}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/genes17111417","doi":"https://doi.org/10.3390/genes17111417","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes17111417","pdf_url":null,"source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/genes17111417","doi":"https://doi.org/10.3390/genes17111417","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes17111417","pdf_url":null,"source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1512539933","https://openalex.org/W1544336828","https://openalex.org/W1572149133","https://openalex.org/W1577885672","https://openalex.org/W1643155728","https://openalex.org/W1816656028","https://openalex.org/W1970642302","https://openalex.org/W1970811664","https://openalex.org/W1971750179","https://openalex.org/W1972013614","https://openalex.org/W1972447322","https://openalex.org/W1977518691","https://openalex.org/W1989567420","https://openalex.org/W1991281779","https://openalex.org/W1995559307","https://openalex.org/W1995895857","https://openalex.org/W2012468170","https://openalex.org/W2013801759","https://openalex.org/W2020512831","https://openalex.org/W2023599593","https://openalex.org/W2028868332","https://openalex.org/W2029679807","https://openalex.org/W2033133818","https://openalex.org/W2036263889","https://openalex.org/W2039382131","https://openalex.org/W2051606353","https://openalex.org/W2064850779","https://openalex.org/W2066385030","https://openalex.org/W2068965703","https://openalex.org/W2083297125","https://openalex.org/W2091147168","https://openalex.org/W2103680668","https://openalex.org/W2109892705","https://openalex.org/W2111279378","https://openalex.org/W2120388677","https://openalex.org/W2121629468","https://openalex.org/W2125910222","https://openalex.org/W2130713787","https://openalex.org/W2132087311","https://openalex.org/W2133638137","https://openalex.org/W2135779855","https://openalex.org/W2140192506","https://openalex.org/W2157223292","https://openalex.org/W2162811754","https://openalex.org/W2167917245","https://openalex.org/W2170918168","https://openalex.org/W2170939558","https://openalex.org/W2262285906","https://openalex.org/W2435143021","https://openalex.org/W2559269101","https://openalex.org/W2616736570","https://openalex.org/W2624885275","https://openalex.org/W2751977084","https://openalex.org/W2891455487","https://openalex.org/W2907552428","https://openalex.org/W2922298027","https://openalex.org/W2981437601","https://openalex.org/W2984985719","https://openalex.org/W3036106812","https://openalex.org/W3086909323","https://openalex.org/W3109957549","https://openalex.org/W3165519339","https://openalex.org/W3198361313","https://openalex.org/W3202957493","https://openalex.org/W3204381006","https://openalex.org/W3206313099","https://openalex.org/W3217622393","https://openalex.org/W4210356210","https://openalex.org/W4280520979","https://openalex.org/W4366826128","https://openalex.org/W4392234043","https://openalex.org/W4400736595","https://openalex.org/W4402076682","https://openalex.org/W4403514512","https://openalex.org/W4404196708","https://openalex.org/W4404667922","https://openalex.org/W4406385231","https://openalex.org/W4407895556","https://openalex.org/W4414795964","https://openalex.org/W4417435853"],"related_works":["https://openalex.org/W2019166715","https://openalex.org/W2140192506","https://openalex.org/W2077700968","https://openalex.org/W1987617191","https://openalex.org/W1996003820","https://openalex.org/W2140014254","https://openalex.org/W2050586330","https://openalex.org/W1976270126","https://openalex.org/W1660660796","https://openalex.org/W2071542590"],"abstract_inverted_index":{"Our":[0],"review":[1],"develops":[2],"a":[3,66,142],"mechanistic":[4],"hypothesis":[5],"and":[6,28,52,99,122,126,133,159,165,182,197],"does":[7],"not":[8,35],"describe":[9],"an":[10],"established":[11],"pathway.":[12],"The":[13,90,150],"empirical":[14],"premise":[15],"on":[16],"which":[17,201],"it":[18,56],"rests,":[19],"that":[20,32,72,169],"HPV":[21],"E6":[22,151],"is":[23,47,57,73,85],"expressed":[24],"in":[25,38,53,69,75,106,113,117,123],"endometrial":[26],"tissue":[27],"degrades":[29],"p53":[30,63,161,193],"at":[31,65,120],"site,":[33],"has":[34,100,128],"been":[36,101,129],"demonstrated":[37],"humans.":[39],"Endometrial":[40],"expression":[41],"of":[42,62,168,177,188,192,209],"leukaemia":[43],"inhibitory":[44],"factor":[45],"(LIF)":[46],"required":[48],"for":[49,81],"blastocyst":[50],"implantation,":[51],"the":[54,60,76,82,114,146,154,166,203,206,210],"mouse":[55],"transcribed":[58],"under":[59],"control":[61],"acting":[64],"response":[67],"element":[68],"intron":[70],"1":[71],"conserved":[74],"human":[77,139],"gene.":[78],"Human":[79],"support":[80],"same":[83,147],"relationship":[84],"genetic":[86],"rather":[87],"than":[88,174],"biochemical.":[89],"TP53":[91],"codon":[92],"72":[93],"polymorphism":[94],"rs1042522":[95],"alters":[96],"LIF":[97,118],"transactivation":[98],"associated":[102,130],"with":[103,131,134],"implantation":[104,132],"failure":[105],"several":[107],"cohorts":[108],"while":[109],"showing":[110],"no":[111],"effect":[112],"largest.":[115],"Variation":[116],"itself":[119],"rs929271,":[121],"MDM2,":[124],"MDM4":[125],"USP7,":[127],"later":[135],"pregnancy":[136],"maintenance.":[137],"High-risk":[138],"papillomavirus":[140],"brings":[141],"second":[143],"genome":[144],"into":[145],"regulatory":[148],"problem.":[149],"oncoprotein":[152],"recruits":[153],"E6-associated":[155],"protein":[156],"ubiquitin":[157],"ligase":[158],"directs":[160],"to":[162],"proteasomal":[163],"degradation,":[164],"efficiency":[167],"reaction":[170],"varies":[171],"by":[172],"more":[173],"two":[175],"orders":[176],"magnitude":[178],"across":[179],"high-risk":[180],"genotypes":[181],"again":[183],"between":[184],"natural":[185],"sequence":[186],"variants":[187],"HPV16":[189],"E6.":[190],"Loss":[191],"also":[194],"raises":[195],"DNMT1":[196],"removes":[198],"p53-dependent":[199],"microRNAs,":[200],"places":[202],"axis":[204],"inside":[205],"epigenetic":[207],"programme":[208],"cycling":[211],"endometrium.":[212]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
