{"id":"https://openalex.org/W7225654063","doi":"https://doi.org/10.64898/2026.11.06.764874","title":"Enhanced hypoxic ventilatory response is accompanied by a decrease in carotid body mitochondrial oxygen affinity in heart failure","display_name":"Enhanced hypoxic ventilatory response is accompanied by a decrease in carotid body mitochondrial oxygen affinity in heart failure","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225654063","doi":"https://doi.org/10.64898/2026.11.06.764874"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.06.764874","doi":"https://doi.org/10.64898/2026.11.06.764874","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.06.764874","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.06.764874.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.06.764874.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054950089","display_name":"Agnieszka Swiderska","orcid":"https://orcid.org/0000-0001-6968-965X","observed_orcids":["https://orcid.org/0000-0001-6968-965X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Agnieszka Swiderska","raw_affiliation_strings":["University of Manchester;"],"raw_orcid":"https://orcid.org/0000-0001-6968-965X","affiliations":[{"raw_affiliation_string":"University of Manchester;","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062659005","display_name":"Mohammed Obeidat","orcid":"https://orcid.org/0000-0002-8934-3004","observed_orcids":["https://orcid.org/0000-0002-8934-3004"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mohammed Obeidat","raw_affiliation_strings":["University of Manchester;"],"raw_orcid":"https://orcid.org/0000-0002-8934-3004","affiliations":[{"raw_affiliation_string":"University of Manchester;","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087753753","display_name":"George W. P. Madders","orcid":"https://orcid.org/0000-0003-1409-133X","observed_orcids":["https://orcid.org/0000-0003-1409-133X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"George WP Madders","raw_affiliation_strings":["University of Manchester;"],"raw_orcid":"https://orcid.org/0000-0003-1409-133X","affiliations":[{"raw_affiliation_string":"University of Manchester;","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079950421","display_name":"Alice S. Whitley","orcid":"https://orcid.org/0000-0003-3836-3512","observed_orcids":["https://orcid.org/0000-0003-3836-3512"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alice S Whitley","raw_affiliation_strings":["University of Manchester;"],"raw_orcid":"https://orcid.org/0000-0003-3836-3512","affiliations":[{"raw_affiliation_string":"University of Manchester;","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161342051","display_name":"Jagen C Burke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jagen C Burke","raw_affiliation_strings":["University of Manchester;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester;","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130058851","display_name":"Menglu Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Menglu Lin","raw_affiliation_strings":["University of Manchester;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester;","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016964309","display_name":"Gina L. J. Galli","orcid":"https://orcid.org/0000-0002-1023-915X","observed_orcids":["https://orcid.org/0000-0002-1023-915X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gina Lucia Jane Galli","raw_affiliation_strings":["The University of Manchester"],"raw_orcid":"https://orcid.org/0000-0002-1023-915X","affiliations":[{"raw_affiliation_string":"The University of Manchester","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073540592","display_name":"Andrew W. Trafford","orcid":"https://orcid.org/0000-0002-2770-445X","observed_orcids":["https://orcid.org/0000-0002-2770-445X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrew W Trafford","raw_affiliation_strings":["University of Manchester;"],"raw_orcid":"https://orcid.org/0000-0002-2770-445X","affiliations":[{"raw_affiliation_string":"University of Manchester;","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073540592"],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.05590000003576279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carotid-body","display_name":"carotid body","score":0.8679999709129333},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hypoxic-ventilatory-response","display_name":"hypoxic ventilatory response","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mitochondrial-complex-iv","display_name":"mitochondrial complex IV","score":0.8159999847412109},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9639999866485596},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9409999847412109},{"id":"https://openalex.org/keywords/aconitase","display_name":"aconitase","score":0.8569999933242798},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":1.0},{"id":"https://openalex.org/keywords/sympathetic-overdrive","display_name":"sympathetic overdrive","score":0.7590000033378601},{"id":"https://openalex.org/keywords/autonomic-imbalance","display_name":"autonomic imbalance","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.5569999814033508},{"id":"https://openalex.org/keywords/hydrogen-peroxide-production","display_name":"hydrogen peroxide production","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6460000276565552},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6456999778747559},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6345000267028809},{"id":"https://openalex.org/C2778113364","wikidata":"https://www.wikidata.org/wiki/Q1532008","display_name":"Carotid body","level":3,"score":0.6323999762535095},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.6223999857902527},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.5631999969482422},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5178999900817871},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5141000151634216},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.48179998993873596},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4510999917984009},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4440999925136566},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3959999978542328},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.39079999923706055},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.37599998712539673},{"id":"https://openalex.org/C195677412","wikidata":"https://www.wikidata.org/wiki/Q4780928","display_name":"Apparent oxygen utilisation","level":3,"score":0.34389999508857727},{"id":"https://openalex.org/C200886947","wikidata":"https://www.wikidata.org/wiki/Q342083","display_name":"Aconitase","level":3,"score":0.3382999897003174},{"id":"https://openalex.org/C2780157289","wikidata":"https://www.wikidata.org/wiki/Q16918363","display_name":"Hypoxic ventilatory response","level":3,"score":0.33559998869895935},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.32190001010894775},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30869999527931213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30469998717308044},{"id":"https://openalex.org/C136511781","wikidata":"https://www.wikidata.org/wiki/Q7168702","display_name":"Peripheral chemoreceptors","level":4,"score":0.29600000381469727},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2799000144004822},{"id":"https://openalex.org/C3020761558","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Mitochondrial respiratory chain","level":3,"score":0.27649998664855957},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C14471203","wikidata":"https://www.wikidata.org/wiki/Q412832","display_name":"Coenzyme Q \u2013 cytochrome c reductase","level":4,"score":0.26269999146461487},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.25440001487731934},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.06.764874","doi":"https://doi.org/10.64898/2026.11.06.764874","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.06.764874","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.06.764874.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.06.764874","doi":"https://doi.org/10.64898/2026.11.06.764874","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.06.764874","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.06.764874.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225654063.pdf","grobid_xml":"https://content.openalex.org/works/W7225654063.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1539665155","https://openalex.org/W1574790479","https://openalex.org/W1597306962","https://openalex.org/W1965312593","https://openalex.org/W1972388086","https://openalex.org/W1979048203","https://openalex.org/W1990758062","https://openalex.org/W2002606850","https://openalex.org/W2006649747","https://openalex.org/W2011348831","https://openalex.org/W2028900652","https://openalex.org/W2051476652","https://openalex.org/W2060727108","https://openalex.org/W2087004550","https://openalex.org/W2093889998","https://openalex.org/W2097433357","https://openalex.org/W2097757382","https://openalex.org/W2106645421","https://openalex.org/W2109223610","https://openalex.org/W2111773661","https://openalex.org/W2116355373","https://openalex.org/W2125893767","https://openalex.org/W2125945433","https://openalex.org/W2127031045","https://openalex.org/W2135757495","https://openalex.org/W2139200038","https://openalex.org/W2142784061","https://openalex.org/W2147200652","https://openalex.org/W2150918467","https://openalex.org/W2165547205","https://openalex.org/W2281780984","https://openalex.org/W2524897358","https://openalex.org/W2617303046","https://openalex.org/W2743088679","https://openalex.org/W2799937394","https://openalex.org/W2804335534","https://openalex.org/W2805325535","https://openalex.org/W2910130222","https://openalex.org/W2942786244","https://openalex.org/W3002452051","https://openalex.org/W3006038284","https://openalex.org/W3131917202","https://openalex.org/W4210321112","https://openalex.org/W4236357753","https://openalex.org/W4290739774","https://openalex.org/W4411576719","https://openalex.org/W4416427388","https://openalex.org/W7118129526","https://openalex.org/W7166354838"],"related_works":["https://openalex.org/W7166354838","https://openalex.org/W3164576722","https://openalex.org/W2195026301","https://openalex.org/W4389025639","https://openalex.org/W4306698261","https://openalex.org/W2799937394","https://openalex.org/W2743088679","https://openalex.org/W4389027469","https://openalex.org/W2029170061","https://openalex.org/W2747095934"],"abstract_inverted_index":{"Carotid":[0],"bodies":[1],"(CBs),":[2],"the":[3,31,41,54,74,205],"main":[4],"peripheral":[5],"oxygen":[6,42,55,65,75,146,167,217,225,228],"sensors,":[7],"play":[8],"a":[9,70,106,221],"significant":[10],"role":[11,72],"in":[12,15,20,73,88,174,181,198,211,247],"sympathetic":[13,160],"overdrive":[14],"heart":[16],"failure":[17],"(HF),":[18],"resulting":[19],"worse":[21],"clinical":[22],"outcomes.":[23],"Whilst":[24],"CBs":[25,134],"are":[26],"an":[27,172,232],"attractive":[28],"therapeutic":[29],"target,":[30],"development":[32],"of":[33,59,111,144,176,240],"CB":[34,81,99,206,215,241],"focused":[35],"therapies":[36],"has":[37,50],"been":[38,51,86],"limited":[39],"as":[40],"sensing":[43,76],"mechanism":[44],"is":[45,57,209],"not":[46],"fully":[47],"understood.":[48],"It":[49],"hypothesised":[52],"that":[53,204],"sensor":[56],"part":[58],"mitochondrial":[60,82,100,145,177,182,207,216],"complex":[61,165,223],"IV,":[62],"and":[63,102,118,124,137,139,149,159,192,213,243],"reactive":[64],"species":[66],"(ROS)":[67],"signalling":[68],"plays":[69],"crucial":[71],"cascade.":[77],"However,":[78,189],"changes":[79,180],"to":[80,93,141],"function":[83,101,120,208],"have":[84],"never":[85],"determined":[87],"HF.":[89,112,199,248],"Hence,":[90],"we":[91],"aimed":[92],"address":[94],"this":[95],"gap":[96],"by":[97,153,231],"characterising":[98],"ROS":[103],"production":[104,151,186],"using":[105],"rapid":[107],"pacing":[108],"ovine":[109],"model":[110],"The":[113],"hypoxic":[114],"ventilatory":[115],"response":[116],"(HVR)":[117],"autonomic":[119,245],"were":[121,130,162,187,196],"assessed":[122],"pre-":[123],"post":[125],"HF":[126,138],"induction.":[127],"Tissue":[128],"homogenates":[129],"prepared":[131],"from":[132,135],"whole":[133],"control":[136],"utilised":[140],"measure":[142],"kinetics":[143],"affinity,":[147],"respiration":[148,183],"H2O2":[150,185],"rates":[152],"high-resolution":[154],"respirometry.":[155],"In":[156],"HF,":[157,212],"HVR":[158],"drive":[161],"increased,":[163],"while":[164],"IV":[166,224],"affinity":[168,218],"was":[169],"decreased.":[170],"Despite":[171],"increase":[173],"abundance":[175],"complexes,":[178],"no":[179],"or":[184],"observed.":[188],"aconitase":[190],"activity":[191],"lipid":[193],"peroxidation":[194],"level":[195],"increased":[197,233],"Overall,":[200],"these":[201],"results":[202],"suggest":[203,220],"altered":[210],"decreased":[214],"may":[219,236],"higher":[222],"sensitivity.":[226],"Higher":[227],"sensitivity":[229],"accompanied":[230],"oxidative":[234],"stress":[235],"be":[237],"key":[238],"drivers":[239],"overactivity":[242],"therefore":[244],"imbalance":[246]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
