{"id":"https://openalex.org/W7225652909","doi":"https://doi.org/10.3390/biology15212034","title":"Integrative Single-Cell and Bulk Transcriptomic Analysis Reveals Ribosome Biogenesis-Associated Molecular Subtypes and Immune Characteristics in Hepatocellular Carcinoma","display_name":"Integrative Single-Cell and Bulk Transcriptomic Analysis Reveals Ribosome Biogenesis-Associated Molecular Subtypes and Immune Characteristics in Hepatocellular Carcinoma","publication_year":2026,"publication_date":"2026-11-08","ids":{"openalex":"https://openalex.org/W7225652909","doi":"https://doi.org/10.3390/biology15212034"},"language":"en","primary_location":{"id":"doi:10.3390/biology15212034","doi":"https://doi.org/10.3390/biology15212034","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15212034","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biology15212034","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5156601567","display_name":"Zejing Liu","orcid":"https://orcid.org/0009-0002-9849-1620","observed_orcids":["https://orcid.org/0009-0002-9849-1620"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zejing Liu","raw_affiliation_strings":["Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China"],"raw_orcid":"https://orcid.org/0009-0002-9849-1620","affiliations":[{"raw_affiliation_string":"Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China","institution_ids":["https://openalex.org/I4210124531","https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080288244","display_name":"Shangdi Zhang","orcid":"https://orcid.org/0000-0003-0729-717X","observed_orcids":["https://orcid.org/0000-0003-0729-717X"]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shangdi Zhang","raw_affiliation_strings":["Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China"],"raw_orcid":"https://orcid.org/0000-0003-0729-717X","affiliations":[{"raw_affiliation_string":"Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China","institution_ids":["https://openalex.org/I4210124531","https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161323509","display_name":"Hongwei Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongwei Gao","raw_affiliation_strings":["Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China","institution_ids":["https://openalex.org/I4210124531","https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136083559","display_name":"Yicheng Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yicheng Ma","raw_affiliation_strings":["Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China","institution_ids":["https://openalex.org/I4210124531","https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161335650","display_name":"Shan Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Gao","raw_affiliation_strings":["Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China","institution_ids":["https://openalex.org/I4210124531","https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161306483","display_name":"Jing Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Yang","raw_affiliation_strings":["Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China","institution_ids":["https://openalex.org/I4210124531","https://openalex.org/I76214153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161359605","display_name":"Linjing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linjing Li","raw_affiliation_strings":["Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacogenomics Laboratory, Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City 730030, China","institution_ids":["https://openalex.org/I4210124531","https://openalex.org/I76214153"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5161359605"],"corresponding_institution_ids":["https://openalex.org/I4210124531","https://openalex.org/I76214153"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"21","first_page":"2034","last_page":"2034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hepatocyte-heterogeneity","display_name":"hepatocyte heterogeneity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/glutamine-synthetase","display_name":"glutamine synthetase","score":0.8109999895095825},{"id":"https://openalex.org/keywords/aldolase-a","display_name":"aldolase A","score":0.9629999995231628},{"id":"https://openalex.org/keywords/bop1","display_name":"BOP1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8510000109672546},{"id":"https://openalex.org/keywords/immune-checkpoint-genes","display_name":"immune checkpoint genes","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tide-score","display_name":"TIDE score","score":0.8709999918937683},{"id":"https://openalex.org/keywords/hbv-related-liver-cancer","display_name":"HBV-related liver cancer","score":0.8489999771118164},{"id":"https://openalex.org/keywords/immunotherapy-targets","display_name":"immunotherapy targets","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9358000159263611},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7558000087738037},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6877999901771545},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6323000192642212},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5713000297546387},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4440000057220459},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4406000077724457},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.41999998688697815},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4153999984264374},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4025000035762787},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.39660000801086426},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3716000020503998},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34279999136924744},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3343000113964081},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.31200000643730164},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2987000048160553},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.29510000348091125},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.2888000011444092},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2809999883174896},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2784000039100647},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.27399998903274536},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.27379998564720154},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.260699987411499},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2590999901294708},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2587999999523163},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/biology15212034","doi":"https://doi.org/10.3390/biology15212034","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15212034","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/biology15212034","doi":"https://doi.org/10.3390/biology15212034","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15212034","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322880","display_name":"Natural Science Foundation of Gansu Province","ror":null},{"id":"https://openalex.org/F4320329850","display_name":"Innovation and Entrepreneurship Talent Project of Lanzhou","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1895643351","https://openalex.org/W1970622792","https://openalex.org/W2010457001","https://openalex.org/W2067490682","https://openalex.org/W2146512944","https://openalex.org/W2169353806","https://openalex.org/W2230320310","https://openalex.org/W2616922646","https://openalex.org/W2747877289","https://openalex.org/W2753467283","https://openalex.org/W2791483720","https://openalex.org/W2794480084","https://openalex.org/W2886498337","https://openalex.org/W2896872272","https://openalex.org/W2909679049","https://openalex.org/W2937441321","https://openalex.org/W2974569074","https://openalex.org/W3036206386","https://openalex.org/W3093296160","https://openalex.org/W3094276961","https://openalex.org/W3122359993","https://openalex.org/W3164864812","https://openalex.org/W3175114505","https://openalex.org/W3182293965","https://openalex.org/W3211956115","https://openalex.org/W3213277274","https://openalex.org/W4200261341","https://openalex.org/W4205099813","https://openalex.org/W4221000712","https://openalex.org/W4235027475","https://openalex.org/W4378549752","https://openalex.org/W4386726864","https://openalex.org/W4391758618","https://openalex.org/W4394063358","https://openalex.org/W4401247596","https://openalex.org/W4401335593","https://openalex.org/W4403097690","https://openalex.org/W4403586183","https://openalex.org/W4403983136","https://openalex.org/W4403990643","https://openalex.org/W4407591703","https://openalex.org/W4408176652","https://openalex.org/W4409866189"],"related_works":["https://openalex.org/W7131884856","https://openalex.org/W4391401621","https://openalex.org/W4408734500","https://openalex.org/W7161981067","https://openalex.org/W4384120666","https://openalex.org/W4417055047","https://openalex.org/W4412685416","https://openalex.org/W4399671981","https://openalex.org/W2767965002","https://openalex.org/W4407642443"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"exhibits":[3],"substantial":[4],"molecular":[5,25,70,124],"heterogeneity.":[6],"We":[7],"integrated":[8],"single-cell":[9],"and":[10,23,26,42,51,66,86,93,125,139,145],"bulk":[11],"transcriptomic":[12],"data":[13],"to":[14],"investigate":[15],"associations":[16],"between":[17,49],"ribosome":[18],"biogenesis-related":[19],"(RiboSis-related)":[20],"gene":[21,75,84],"expression":[22,121],"the":[24,34,114,140],"immune":[27,77,127],"characteristics":[28],"of":[29,134,143],"HCC.":[30,130],"GLUL+":[31,52],"hepatocytes":[32],"had":[33],"highest":[35],"RiboSis-related":[36,74,120],"gene-set":[37],"score":[38],"among":[39],"hepatocyte":[40],"subpopulations,":[41],"ligand\u2013receptor":[43],"analysis":[44,63],"inferred":[45,126],"an":[46],"MDK\u2013SDC2":[47],"interaction":[48],"ALDOA+":[50],"hepatocytes.":[53],"Feature":[54],"selection":[55],"identified":[56],"four":[57],"candidate":[58],"genes,":[59],"with":[60,122],"subsequent":[61],"subtype":[62],"highlighting":[64],"BOP1":[65,92,144],"EXOSC4.":[67],"The":[68,131],"two":[69],"subtypes":[71,136],"differed":[72],"in":[73,96,99,107,110,129],"expression,":[76,85],"cell":[78],"signature":[79],"scores,":[80],"mutation":[81],"profiles,":[82],"checkpoint":[83],"TIDE":[87],"scores.":[88],"Immunohistochemistry":[89],"showed":[90],"higher":[91],"EXOSC4":[94,103,146],"staining":[95,104],"HCC":[97,112],"than":[98,109],"paired":[100],"adjacent":[101],"tissues.":[102],"was":[105],"lower":[106],"HBV-associated":[108],"non-viral":[111],"within":[113],"tissue":[115],"microarray.":[116],"These":[117],"findings":[118],"associate":[119],"distinct":[123],"features":[128],"clinical":[132],"relevance":[133],"these":[135],"for":[137],"immunotherapy":[138],"functional":[141],"roles":[142],"require":[147],"further":[148],"validation.":[149]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
