{"id":"https://openalex.org/W7225650746","doi":"https://doi.org/10.21203/rs.3.rs-11643734/v1","title":"Adipocyte-derived FABP4 Drives Pancreatic Cancer Radioresistance via FABP4- eIF3a Axis","display_name":"Adipocyte-derived FABP4 Drives Pancreatic Cancer Radioresistance via FABP4- eIF3a Axis","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225650746","doi":"https://doi.org/10.21203/rs.3.rs-11643734/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11643734/v1","doi":"https://doi.org/10.21203/rs.3.rs-11643734/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11643734/v1","pdf_url":"https://www.researchsquare.com/article/rs-11643734/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11643734/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065653136","display_name":"Wei Mo","orcid":"https://orcid.org/0000-0002-8165-4473","observed_orcids":["https://orcid.org/0000-0002-8165-4473"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei MO","raw_affiliation_strings":["Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085111130","display_name":"Yuji Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuji Xiao","raw_affiliation_strings":["Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161310453","display_name":"Di Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Chen","raw_affiliation_strings":["Changhai Hospital affiliated to Naval Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changhai Hospital affiliated to Naval Medical University","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008067300","display_name":"Lunjie Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lunjie Lu","raw_affiliation_strings":["Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161309033","display_name":"Wei Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhu","raw_affiliation_strings":["Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017484928","display_name":"Jianping Cao","orcid":"https://orcid.org/0000-0002-1974-0047","observed_orcids":["https://orcid.org/0000-0002-1974-0047"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianping Cao","raw_affiliation_strings":["Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161339195","display_name":"Huojun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huojun Zhang","raw_affiliation_strings":["Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161307007","display_name":"Yang Jiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Jiao","raw_affiliation_strings":["Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.17990000545978546,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8050000071525574},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.9729999899864197},{"id":"https://openalex.org/keywords/fabp4","display_name":"FABP4","score":0.9760000109672546},{"id":"https://openalex.org/keywords/eif3a","display_name":"eIF3a","score":0.9570000171661377},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.9079999923706055},{"id":"https://openalex.org/keywords/peritumoral-adipose-tissue","display_name":"peritumoral adipose tissue","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9120000004768372},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8410000205039978},{"id":"https://openalex.org/keywords/ku80","display_name":"Ku80","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mre11","display_name":"MRE11","score":1.0},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mrna-binding","display_name":"mRNA binding","score":0.5040000081062317},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.5759999752044678},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.7700999975204468},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7440999746322632},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7117999792098999},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.6470000147819519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5672000050544739},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5547999739646912},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5264000296592712},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5063999891281128},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.46950000524520874},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.438400000333786},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.41839998960494995},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3637999892234802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33480000495910645},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32199999690055847},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.31279999017715454},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.29339998960494995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29280000925064087},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.28600001335144043},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.28540000319480896},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.2766999900341034},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2703000009059906},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.2621999979019165}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11643734/v1","doi":"https://doi.org/10.21203/rs.3.rs-11643734/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11643734/v1","pdf_url":"https://www.researchsquare.com/article/rs-11643734/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11643734/v1","doi":"https://doi.org/10.21203/rs.3.rs-11643734/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11643734/v1","pdf_url":"https://www.researchsquare.com/article/rs-11643734/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225650746.pdf","grobid_xml":"https://content.openalex.org/works/W7225650746.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W2140034636","https://openalex.org/W2164995160","https://openalex.org/W2415557067","https://openalex.org/W2499387342","https://openalex.org/W2579809204","https://openalex.org/W2602521450","https://openalex.org/W2764185501","https://openalex.org/W2774607552","https://openalex.org/W3000534695","https://openalex.org/W3003086165","https://openalex.org/W3006458539","https://openalex.org/W3013907718","https://openalex.org/W3041456489","https://openalex.org/W3051105556","https://openalex.org/W3089967154","https://openalex.org/W3131031307","https://openalex.org/W3161495487","https://openalex.org/W3180003559","https://openalex.org/W3193437905","https://openalex.org/W3199899759","https://openalex.org/W4284677685","https://openalex.org/W4285009445","https://openalex.org/W4365483307","https://openalex.org/W4386928797","https://openalex.org/W4388035189","https://openalex.org/W4398774246","https://openalex.org/W4400241067","https://openalex.org/W4402577215","https://openalex.org/W4412522260","https://openalex.org/W4412690739","https://openalex.org/W4414158286","https://openalex.org/W4414299977","https://openalex.org/W4417497364","https://openalex.org/W7123452202","https://openalex.org/W7130504397","https://openalex.org/W7211968091"],"related_works":["https://openalex.org/W2794847062","https://openalex.org/W2765325388","https://openalex.org/W4402945430","https://openalex.org/W7213450199","https://openalex.org/W2564797339","https://openalex.org/W2593064468","https://openalex.org/W2071539626","https://openalex.org/W1975232516","https://openalex.org/W2997526573","https://openalex.org/W7154717091"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Radiotherapy":[2],"is":[3,21],"a":[4,34,68,123,276,289],"common":[5],"treatment":[6],"modality":[7],"for":[8,293],"patients":[9],"with":[10,72,174],"locally":[11],"advanced":[12],"or":[13,211],"metastatic":[14],"pancreatic":[15,50,165,181,280],"cancer,":[16],"but":[17],"the":[18,137,160,164,227,238,285],"therapeutic":[19,42,291],"efficacy":[20],"constrained":[22],"by":[23,54,96,149,169,196,265],"intrinsic":[24],"radioresistance.":[25],"The":[26,57,105,157],"tumor":[27],"microenvironment,":[28],"particularly":[29],"peritumoral":[30],"adipose":[31,46,171],"tissue,":[32],"plays":[33],"critical":[35],"yet":[36],"poorly":[37],"understood":[38],"role":[39,106,244],"in":[40,49,90,109,202,217,220,245],"modulating":[41],"responses.":[43],"Methods":[44],"Peritumoral":[45],"tissue":[47],"distribution":[48],"cancer":[51,62,92,127,166,182,281],"was":[52,113,167],"assessed":[53],"H&E":[55],"staining.":[56],"effects":[58,138],"of":[59,107,139,159,180,200,279],"adipocytes":[60,175,203],"on":[61,141],"cell":[63],"radiosensitivity":[64,111,282],"were":[65,94,133,145],"evaluated":[66],"using":[67,115],"co-culture":[69],"system":[70],"combined":[71],"colony":[73],"formation,":[74],"alkaline":[75],"comet,":[76],"and":[77,85,103,122,129,147,153,190,219,252,255,262,283],"flow":[78],"cytometry":[79],"assays.":[80],"Energy":[81],"metabolism,":[82],"lipid":[83],"accumulation,":[84],"fatty":[86],"acid":[87],"transporter":[88],"levels":[89],"co-cultured":[91],"cells":[93,128,183],"examined":[95],"Seahorse":[97],"analysis,":[98],"BODIPY":[99],"staining,":[100],"real-time":[101],"PCR,":[102],"immunofluorescence.":[104],"FABP4":[108,120,124,140,201,209,259,274],"adipocyte-mediated":[110],"regulation":[112],"tested":[114],"FABP4-knockout":[116],"3T3-L1":[117],"cells,":[118],"exogenous":[119,208],"protein,":[121],"inhibitor.":[125],"FABP4-overexpressing":[126],"nude":[130],"mouse":[131],"xenografts":[132],"used":[134],"to":[135],"determine":[136],"radiosensitivity.":[142],"Underlying":[143],"mechanisms":[144],"explored":[146],"validated":[148],"Co-IP,":[150],"LC-MS/MS,":[151],"RIP,":[152],"other":[154],"approaches.":[155],"Results":[156],"results":[158],"pathology":[161],"showed":[162],"that":[163,234],"surrounded":[168],"peripancreatic":[170],"tissue.":[172],"Co-culture":[173],"significantly":[176],"enhancing":[177,266],"clonogenic":[178],"survival":[179],"while":[184],"attenuated":[185],"radiation-induced":[186],"DNA":[187],"damage,":[188],"apoptosis,":[189],"G2/M":[191],"arrest,":[192],"an":[193],"effect":[194],"mediated":[195],"FABP4.":[197],"Genetic":[198],"ablation":[199],"abolished":[204],"this":[205,246],"radioprotection,":[206],"whereas":[207,258],"supplementation":[210],"its":[212,242],"overexpression":[213],"recapitulated":[214],"radioresistance":[215],"both":[216],"vitro":[218],"vivo.":[221],"Proteomic":[222],"screening":[223],"identified":[224],"eIF3a":[225,235],"as":[226,275,288],"predominant":[228],"FABP4-interacting":[229],"protein.":[230],"Functional":[231],"validation":[232],"demonstrated":[233],"knockdown":[236,249],"abrogated":[237],"FABP4-enhanced":[239],"radioresistance,":[240,257],"confirming":[241],"essential":[243],"process.":[247],"EIF3a":[248],"increased":[250],"KU80":[251,261],"MRE11":[253,263],"expression":[254,264],"promoted":[256],"suppressed":[260],"eIF3a\u2013mRNA":[267],"binding.":[268],"Conclusions":[269],"This":[270],"study":[271],"identify":[272],"adipocyte\u2011derived":[273],"pivotal":[277],"regulator":[278],"unveil":[284],"FABP4\u2013eIF3a":[286],"axis":[287],"potential":[290],"target":[292],"radiosensitization.":[294]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
