{"id":"https://openalex.org/W7225649237","doi":"https://doi.org/10.64898/2026.11.05.764667","title":"Nutrient Availability as a Driver of Transcriptome Reprogramming in Osteosarcoma","display_name":"Nutrient Availability as a Driver of Transcriptome Reprogramming in Osteosarcoma","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225649237","doi":"https://doi.org/10.64898/2026.11.05.764667"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.05.764667","doi":"https://doi.org/10.64898/2026.11.05.764667","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764667","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.05.764667.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.05.764667.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004385039","display_name":"Jakub M. Tomczak","orcid":"https://orcid.org/0000-0001-8634-694X","observed_orcids":["https://orcid.org/0000-0001-8634-694X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jakub Mikolaj Tomczak","raw_affiliation_strings":["GenSiLab Inc"],"raw_orcid":"https://orcid.org/0000-0001-8634-694X","affiliations":[{"raw_affiliation_string":"GenSiLab Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119760635","display_name":"Zuzanna Senkowska","orcid":"https://orcid.org/0009-0006-1243-721X","observed_orcids":["https://orcid.org/0009-0006-1243-721X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zuzanna Senkowska","raw_affiliation_strings":["GenSiLab Inc"],"raw_orcid":"https://orcid.org/0009-0006-1243-721X","affiliations":[{"raw_affiliation_string":"GenSiLab Inc","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063868367","display_name":"Ewelina W\u0119glarz\u2010Tomczak","orcid":"https://orcid.org/0000-0001-8080-2801","observed_orcids":["https://orcid.org/0000-0001-8080-2801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ewelina Weglarz-Tomczak","raw_affiliation_strings":["GenSiLab Inc"],"raw_orcid":"https://orcid.org/0000-0001-8080-2801","affiliations":[{"raw_affiliation_string":"GenSiLab Inc","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004385039"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.08839999884366989,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":1.0},{"id":"https://openalex.org/keywords/nutrient-availability","display_name":"nutrient availability","score":0.9580000042915344},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.824999988079071},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":1.0},{"id":"https://openalex.org/keywords/transcriptional-reprogramming","display_name":"transcriptional reprogramming","score":0.878000020980835},{"id":"https://openalex.org/keywords/fos","display_name":"FOS","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5839999914169312},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cell-growth-rate","display_name":"cell growth rate","score":0.8809999823570251},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.8070999979972839},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8012999892234802},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7437999844551086},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.6607000231742859},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6398000121116638},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5946000218391418},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5164999961853027},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47440001368522644},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42489999532699585},{"id":"https://openalex.org/C97633540","wikidata":"https://www.wikidata.org/wiki/Q4328195","display_name":"Nutrigenomics","level":3,"score":0.4106999933719635},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.38929998874664307},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.388700008392334},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.37529999017715454},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3495999872684479},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34540000557899475},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3434000015258789},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3386000096797943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3368000090122223},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3310000002384186},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3050999939441681},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2922999858856201},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2791999876499176},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.2750999927520752},{"id":"https://openalex.org/C2776030549","wikidata":"https://www.wikidata.org/wiki/Q7829395","display_name":"Nutrient sensing","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27390000224113464},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.2736999988555908},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.2680000066757202},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26089999079704285}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.05.764667","doi":"https://doi.org/10.64898/2026.11.05.764667","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764667","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.05.764667.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.05.764667","doi":"https://doi.org/10.64898/2026.11.05.764667","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764667","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.05.764667.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.40450000762939453}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225649237.pdf","grobid_xml":"https://content.openalex.org/works/W7225649237.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3128776424","https://openalex.org/W4312113604","https://openalex.org/W7139066323","https://openalex.org/W4385988021","https://openalex.org/W7161990271","https://openalex.org/W4385271590","https://openalex.org/W3015213712","https://openalex.org/W7130642747","https://openalex.org/W7131256132","https://openalex.org/W7019796883"],"abstract_inverted_index":{"Background:":[0],"Gene":[1],"expression":[2,74,132,165,198,213,285],"in":[3,75,149,233],"mammalian":[4],"cells":[5],"is":[6],"intricately":[7],"regulated":[8],"by":[9],"environmental":[10],"and":[11,26,58,94,105,128,158,178,193,235,263],"metabolic":[12,100,231,275],"cues.":[13],"Among":[14],"these,":[15],"nutrient":[16,69,207],"availability":[17,208],"represents":[18],"a":[19,31,43,48,67,79,135,171,180,195,242,278],"key":[20,125],"feature":[21],"of":[22,34,46,66,99,113,123,168,206,215,230,245,274,283],"the":[23,64,96,185,190,211,272],"tumor":[24,247],"microenvironment":[25],"has":[27],"recently":[28],"emerged":[29],"as":[30,277],"potent":[32],"modulator":[33],"oncogenic":[35],"signaling":[36],"networks.":[37],"In":[38],"this":[39,269],"study,":[40],"we":[41],"employed":[42],"cell-line":[44],"model":[45],"osteosarcoma,":[47],"rare":[49],"but":[50],"highly":[51],"aggressive":[52],"bone":[53],"malignancy":[54],"affecting":[55],"both":[56],"humans":[57],"dogs.":[59],"We":[60,108,161],"demonstrate":[61,203],"that":[62,204,237],"altering":[63],"concentration":[65],"single":[68],"can":[70],"profoundly":[71,209],"reprogram":[72],"gene":[73,84,131,212,284],"osteosarcoma":[76,116,216],"cells,":[77,217],"revealing":[78,218],"previously":[80],"underexplored":[81],"phenomenon:":[82],"nutrient-dependent":[83,137],"regulation.":[85],"This":[86,225],"finding":[87],"highlights":[88,271],"potential":[89,222,273],"opportunities":[90],"for":[91,102,258,280],"therapeutic":[92,223],"intervention":[93],"underscores":[95],"broader":[97,256],"implications":[98,257],"regulation":[101,232],"personalized":[103],"medicine":[104],"nutrition.":[106],"Methods/Results:":[107],"performed":[109],"bulk":[110],"RNA":[111],"sequencing":[112],"an":[114],"established":[115],"cell":[117,175],"line":[118],"cultured":[119],"under":[120],"varying":[121],"concentrations":[122],"two":[124],"nutrients,":[126],"glucose":[127],"glutamine.":[129],"Differential":[130],"analysis":[133],"revealed":[134],"pronounced":[136],"transcriptional":[138,182],"response.":[139],"The":[140],"identified":[141,162,191],"genes":[142,192],"were":[143],"functionally":[144],"associated":[145],"with":[146,174,221],"pathways":[147],"involved":[148],"cancer,":[150],"development,":[151],"nervous":[152,264],"system":[153,265],"regulation,":[154],"metabolism,":[155],"cellular":[156],"signaling,":[157],"immune":[159],"responses.":[160],"seven":[163],"distinct":[164],"patterns,":[166],"one":[167],"which":[169],"exhibited":[170],"striking":[172],"correlation":[173],"growth":[176],"rate":[177],"resembled":[179],"FOS-like":[181],"signature.":[183],"Notably,":[184],"proto-oncogene":[186],"FOS":[187],"was":[188],"among":[189],"displayed":[194],"strong":[196],"growth-rate-dependent":[197],"pattern.":[199],"Conclusion/Impact:":[200],"Our":[201],"findings":[202],"modulation":[205,282],"reshapes":[210],"landscape":[214],"nutrient-responsive":[219],"targets":[220],"relevance.":[224],"work":[226],"expands":[227],"our":[228],"understanding":[229],"cancer":[234],"suggests":[236],"nutrient-based":[238],"interventions":[239,276],"may":[240,253],"provide":[241],"controllable":[243],"means":[244],"influencing":[246],"progression.":[248],"Beyond":[249],"oncology,":[250],"such":[251],"approaches":[252],"also":[254],"have":[255],"developmental":[259],"biology,":[260],"autoimmune":[261],"disorders,":[262],"function.":[266],"More":[267],"broadly,":[268],"study":[270],"strategy":[279],"targeted":[281],"programs.":[286]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
