{"id":"https://openalex.org/W7225649150","doi":"https://doi.org/10.1007/s00204-026-04623-5","title":"CYP450 quantification and metabolic activation capacity of rat and hamster liver S9 fractions: implications for nitrosamine mutagenicity testing","display_name":"CYP450 quantification and metabolic activation capacity of rat and hamster liver S9 fractions: implications for nitrosamine mutagenicity testing","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225649150","doi":"https://doi.org/10.1007/s00204-026-04623-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/43002211"},"language":"en","primary_location":{"id":"doi:10.1007/s00204-026-04623-5","doi":"https://doi.org/10.1007/s00204-026-04623-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00204-026-04623-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00204-026-04623-5.pdf","source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00204-026-04623-5.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110388379","display_name":"Jessica Dieckhoff","orcid":"https://orcid.org/0009-0009-1908-5351","observed_orcids":["https://orcid.org/0009-0009-1908-5351"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I4405266695","display_name":"Merck Healthcare KGaA, Darmstadt (Germany)","ror":"https://ror.org/04vpzfb52","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4405266695"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jessica Dieckhoff","raw_affiliation_strings":["Discovery Development Technologies, Chemical and Preclinical Safety, Merck Healthcare KGaA, Global Research & Development, Frankfurter Stra\u00dfe 250, 64293, Darmstadt, Germany"],"raw_orcid":"https://orcid.org/0009-0009-1908-5351","affiliations":[{"raw_affiliation_string":"Discovery Development Technologies, Chemical and Preclinical Safety, Merck Healthcare KGaA, Global Research & Development, Frankfurter Stra\u00dfe 250, 64293, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I4405266695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059885874","display_name":"Frank Bringezu","orcid":"https://orcid.org/0000-0002-3628-6317","observed_orcids":["https://orcid.org/0000-0002-3628-6317"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I4405266695","display_name":"Merck Healthcare KGaA, Darmstadt (Germany)","ror":"https://ror.org/04vpzfb52","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4405266695"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Bringezu","raw_affiliation_strings":["Discovery Development Technologies, Chemical and Preclinical Safety, Merck Healthcare KGaA, Global Research & Development, Frankfurter Stra\u00dfe 250, 64293, Darmstadt, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3628-6317","affiliations":[{"raw_affiliation_string":"Discovery Development Technologies, Chemical and Preclinical Safety, Merck Healthcare KGaA, Global Research & Development, Frankfurter Stra\u00dfe 250, 64293, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I4405266695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082458795","display_name":"Jasjot Singh","orcid":"https://orcid.org/0000-0002-9203-2047","observed_orcids":["https://orcid.org/0000-0002-9203-2047"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jasjot Singh","raw_affiliation_strings":["LC-MS Quantification Small Molecule & Bioanalytics, Site Management Analytical Lab Services, Merck KGaA, 64293, Darmstadt, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9203-2047","affiliations":[{"raw_affiliation_string":"LC-MS Quantification Small Molecule & Bioanalytics, Site Management Analytical Lab Services, Merck KGaA, 64293, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027714121","display_name":"S. Moniot","orcid":"https://orcid.org/0000-0002-2890-8075","observed_orcids":["https://orcid.org/0000-0002-2890-8075"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Moniot","raw_affiliation_strings":["Analytics Healthcare - Biomolecule Analytics & Proteomics, Site Management Analytical Lab Services, Merck KGaA, Frankfurter Stra\u00dfe 250, 64293, Darmstadt, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2890-8075","affiliations":[{"raw_affiliation_string":"Analytics Healthcare - Biomolecule Analytics & Proteomics, Site Management Analytical Lab Services, Merck KGaA, Frankfurter Stra\u00dfe 250, 64293, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065021034","display_name":"St\u00e9phanie Simon","orcid":"https://orcid.org/0000-0002-2497-5211","observed_orcids":["https://orcid.org/0000-0002-2497-5211"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I4405266695","display_name":"Merck Healthcare KGaA, Darmstadt (Germany)","ror":"https://ror.org/04vpzfb52","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4405266695"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stephanie Simon","raw_affiliation_strings":["Discovery Development Technologies, Chemical and Preclinical Safety, Merck Healthcare KGaA, Global Research & Development, Frankfurter Stra\u00dfe 250, 64293, Darmstadt, Germany. stephanie.simon@merckgroup.com"],"raw_orcid":"https://orcid.org/0000-0002-2497-5211","affiliations":[{"raw_affiliation_string":"Discovery Development Technologies, Chemical and Preclinical Safety, Merck Healthcare KGaA, Global Research & Development, Frankfurter Stra\u00dfe 250, 64293, Darmstadt, Germany. stephanie.simon@merckgroup.com","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I4405266695"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065021034"],"corresponding_institution_ids":["https://openalex.org/I164928964","https://openalex.org/I4405266695"],"apc_list":{"value":5690,"currency":"USD","value_usd":5690},"apc_paid":{"value":5690,"currency":"USD","value_usd":5690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.060600001364946365,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrosamines","display_name":"nitrosamines","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.8040000200271606},{"id":"https://openalex.org/keywords/metabolic-activation","display_name":"metabolic activation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/liver-s9-fraction","display_name":"liver S9 fraction","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.8460000157356262},{"id":"https://openalex.org/keywords/enzyme-induction","display_name":"enzyme induction","score":0.6579999923706055},{"id":"https://openalex.org/keywords/aroclor-1254","display_name":"Aroclor 1254","score":0.9610000252723694},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.43299999833106995},{"id":"https://openalex.org/keywords/targeted-proteomics","display_name":"targeted proteomics","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.929099977016449},{"id":"https://openalex.org/C86745063","wikidata":"https://www.wikidata.org/wiki/Q3737406","display_name":"CYP1A2","level":4,"score":0.8323000073432922},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.65829998254776},{"id":"https://openalex.org/C117632636","wikidata":"https://www.wikidata.org/wiki/Q30912","display_name":"Ames test","level":4,"score":0.646399974822998},{"id":"https://openalex.org/C2777755551","wikidata":"https://www.wikidata.org/wiki/Q2539773","display_name":"Chinese hamster","level":3,"score":0.6371999979019165},{"id":"https://openalex.org/C2779525107","wikidata":"https://www.wikidata.org/wiki/Q389919","display_name":"Mesocricetus","level":3,"score":0.5170999765396118},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5163999795913696},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5148000121116638},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.48030000925064087},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.46459999680519104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.462799996137619},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3995000123977661},{"id":"https://openalex.org/C2776678776","wikidata":"https://www.wikidata.org/wiki/Q2204663","display_name":"S9 fraction","level":4,"score":0.3905999958515167},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3813999891281128},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.3765999972820282},{"id":"https://openalex.org/C2777395278","wikidata":"https://www.wikidata.org/wiki/Q413779","display_name":"Nitrosamine","level":3,"score":0.36010000109672546},{"id":"https://openalex.org/C140027455","wikidata":"https://www.wikidata.org/wiki/Q14864434","display_name":"CYP2E1","level":4,"score":0.3386000096797943},{"id":"https://openalex.org/C2777066959","wikidata":"https://www.wikidata.org/wiki/Q869711","display_name":"Cricetulus","level":4,"score":0.33570000529289246},{"id":"https://openalex.org/C132154277","wikidata":"https://www.wikidata.org/wiki/Q5381545","display_name":"Enzyme inducer","level":3,"score":0.32899999618530273},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.32749998569488525},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2784000039100647},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.2678999900817871},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.26249998807907104},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25949999690055847},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.25519999861717224}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s00204-026-04623-5","doi":"https://doi.org/10.1007/s00204-026-04623-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00204-026-04623-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00204-026-04623-5.pdf","source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},{"id":"pmid:43002211","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43002211","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00204-026-04623-5","doi":"https://doi.org/10.1007/s00204-026-04623-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00204-026-04623-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00204-026-04623-5.pdf","source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225649150.pdf","grobid_xml":"https://content.openalex.org/works/W7225649150.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1536089744","https://openalex.org/W1973195696","https://openalex.org/W1973879072","https://openalex.org/W1994059131","https://openalex.org/W2000237365","https://openalex.org/W2004678494","https://openalex.org/W2044282573","https://openalex.org/W2055994283","https://openalex.org/W2061001060","https://openalex.org/W2064181764","https://openalex.org/W2066947531","https://openalex.org/W2067080504","https://openalex.org/W2068288884","https://openalex.org/W2073840836","https://openalex.org/W2075903510","https://openalex.org/W2092707120","https://openalex.org/W2094932400","https://openalex.org/W2096565553","https://openalex.org/W2109326791","https://openalex.org/W2111329465","https://openalex.org/W2132777822","https://openalex.org/W2143871691","https://openalex.org/W2319704017","https://openalex.org/W2399237148","https://openalex.org/W2403999120","https://openalex.org/W2414768696","https://openalex.org/W2499793886","https://openalex.org/W2884273662","https://openalex.org/W2921574161","https://openalex.org/W2985411097","https://openalex.org/W3101984651","https://openalex.org/W3135198452","https://openalex.org/W3199494003","https://openalex.org/W4210825187","https://openalex.org/W4243813731","https://openalex.org/W4251483345","https://openalex.org/W4252693454","https://openalex.org/W4379197405","https://openalex.org/W4391264963","https://openalex.org/W4391544148","https://openalex.org/W4400229231","https://openalex.org/W4402909972","https://openalex.org/W4407269379","https://openalex.org/W4409907075","https://openalex.org/W4411203805","https://openalex.org/W4415743478","https://openalex.org/W4415962113","https://openalex.org/W7163182742"],"related_works":["https://openalex.org/W4407269379","https://openalex.org/W7203825546","https://openalex.org/W4391264963","https://openalex.org/W2071596003","https://openalex.org/W2345749253","https://openalex.org/W2401367174","https://openalex.org/W4415743478","https://openalex.org/W2024801864","https://openalex.org/W4411967245","https://openalex.org/W2019582647"],"abstract_inverted_index":{"N-nitrosamine":[0],"impurities":[1],"are":[2],"a":[3,92,249,263],"major":[4],"concern":[5],"in":[6,77,95,120,142,173,192,229,257],"the":[7,26,39,78,96,105,114,165,201,267],"pharmaceutical":[8],"industry":[9],"and":[10,47,56,112,135,139,146,149,160,207,254,260],"public":[11],"safety.":[12],"The":[13],"assessment":[14],"of":[15,81,98,137,168,266,271],"this":[16],"chemically":[17],"diverse":[18],"group":[19],"using":[20],"conventional":[21],"regulatory":[22,50],"test":[23,28],"batteries,":[24],"including":[25],"Ames":[27,41,203],"(OECD":[29],"TG":[30],"471),":[31],"remains":[32],"challenging.":[33],"Consequently,":[34],"refined":[35],"strategies":[36],"such":[37],"as":[38],"Enhanced":[40],"Test":[42],"(EAT)":[43],"have":[44],"been":[45],"developed":[46],"recommended":[48],"by":[49,86],"authorities,":[51],"requiring":[52],"30%":[53],"induced":[54,197,233],"rat":[55,71,138,148,154,194,224],"hamster":[57,63,140,150,174,198,234],"S9.":[58,152,195,272],"Recently,":[59],"we":[60],"showed":[61],"that":[62,210,237],"S9":[64,175,199,225],"metabolizes":[65],"short-chain":[66],"N-nitrosamines":[67],"more":[68],"efficiently":[69],"than":[70,190],"S9,":[72,155,235],"likely":[73],"due":[74],"to":[75,262],"differences":[76,256],"induction":[79,156,211],"pattern":[80],"metabolizing":[82],"enzymes.":[83],"Metabolic":[84],"activation":[85,269],"cytochrome":[87],"P450":[88],"isoenzymes":[89],"(CYP)":[90],"is":[91],"critical":[93],"step":[94],"bioactivation":[97],"N-nitrosamines.":[99,126],"Building":[100],"on":[101,109],"our":[102],"previous":[103],"publication,":[104],"present":[106],"work":[107],"focusses":[108],"key":[110],"CYPs":[111],"sets":[113],"proteome":[115],"data":[116,123],"into":[117],"perspective":[118],"with":[119,232],"vitro":[121],"mutagenicity":[122,258],"for":[124,205,244,252],"selected":[125,166],"Targeted":[127],"proteomics":[128],"quantified":[129],"CYP1A2,":[130],"2A6,":[131],"2C8/9/19,":[132],"2D6,":[133],"2E1,":[134],"3A4":[136],"orthologs":[141],"uninduced,":[143],"Aroclor":[144],"1254-,":[145],"PB/NF-induced":[147],"liver":[151],"In":[153],"markedly":[157],"increased":[158,178],"CYP1A2":[159],"CYP3A1":[161],"(>":[162],"40-fold).":[163],"For":[164],"set":[167],"CYPs,":[169],"most":[170],"protein":[171,216],"levels":[172,187],"decreased":[176],"or":[177],"only":[179,231],"slightly":[180],"(<":[181],"6-fold)":[182],"following":[183],"induction,":[184],"although":[185],"baseline":[186],"were":[188],"higher":[189],"those":[191],"uninduced":[193],"Nevertheless,":[196],"generated":[200],"strongest":[202],"responses":[204],"NDBA":[206],"1-CPNP,":[208],"indicating":[209,236],"enhances":[212],"CYP":[213],"activity":[214,243],"beyond":[215],"quantity":[217],"alone.":[218],"N-nitroso-atenolol":[219],"was":[220],"negative":[221],"under":[222],"all":[223],"conditions":[226],"but":[227],"positive":[228],"TA1535":[230],"larger":[238],"NDSRIs":[239],"require":[240],"elevated":[241],"metabolic":[242,268],"detection.":[245],"These":[246],"findings":[247],"provide":[248],"mechanistic":[250],"basis":[251],"species-":[253],"induction-specific":[255],"detection":[259],"contribute":[261],"better":[264],"understanding":[265],"capacity":[270]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
