{"id":"https://openalex.org/W7225648946","doi":"https://doi.org/10.3389/fcell.2026.1998983","title":"Artificial intelligence and multi-omics integration for cardiac regeneration: from cell fate decoding to clinical translation","display_name":"Artificial intelligence and multi-omics integration for cardiac regeneration: from cell fate decoding to clinical translation","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225648946","doi":"https://doi.org/10.3389/fcell.2026.1998983"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2026.1998983","doi":"https://doi.org/10.3389/fcell.2026.1998983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1998983","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1998983/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1998983/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100387843","display_name":"Yue Li","orcid":"https://orcid.org/0000-0003-0994-8714","observed_orcids":["https://orcid.org/0000-0003-0994-8714"]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Li","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University","Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140916967","display_name":"Siyi Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyi Wu","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University","Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083048670","display_name":"Lanxian Mai","orcid":"https://orcid.org/0000-0001-6403-497X","observed_orcids":["https://orcid.org/0000-0001-6403-497X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lanxian Mai","raw_affiliation_strings":["Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161340755","display_name":"Chuanghong Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chuanghong Lu","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University","Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5161340755"],"corresponding_institution_ids":["https://openalex.org/I4210126060"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"artificial intelligence","score":0.8619999885559082},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cardiac-lineage","display_name":"cardiac lineage","score":0.5329999923706055},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.9089999794960022},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":1.0},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/zebrafish-regeneration","display_name":"zebrafish regeneration","score":0.7170000076293945},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.6507999897003174},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6388999819755554},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.6187000274658203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.597000002861023},{"id":"https://openalex.org/C63101894","wikidata":"https://www.wikidata.org/wiki/Q604095","display_name":"Fate mapping","level":4,"score":0.5364000201225281},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.44519999623298645},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4390999972820282},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4390000104904175},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4212000072002411},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.38510000705718994},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.3781999945640564},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3765999972820282},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3598000109195709},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3580000102519989},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35740000009536743},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.3402999937534332},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.33739998936653137},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32089999318122864},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.3140999972820282},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.31380000710487366},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.31369999051094055},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.31130000948905945},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.28360000252723694},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.2766000032424927},{"id":"https://openalex.org/C191141034","wikidata":"https://www.wikidata.org/wiki/Q3087369","display_name":"Cell physiology","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.26750001311302185},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.26269999146461487},{"id":"https://openalex.org/C57273362","wikidata":"https://www.wikidata.org/wiki/Q576722","display_name":"Decoding methods","level":2,"score":0.25699999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fcell.2026.1998983","doi":"https://doi.org/10.3389/fcell.2026.1998983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1998983","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1998983/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2026.1998983","doi":"https://doi.org/10.3389/fcell.2026.1998983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1998983","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1998983/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225648946.pdf","grobid_xml":"https://content.openalex.org/works/W7225648946.grobid-xml"},"referenced_works_count":151,"referenced_works":["https://openalex.org/W1016059894","https://openalex.org/W1671213273","https://openalex.org/W1835655851","https://openalex.org/W1969038150","https://openalex.org/W1969210272","https://openalex.org/W1977374662","https://openalex.org/W1984883254","https://openalex.org/W1985644650","https://openalex.org/W2018050443","https://openalex.org/W2022689242","https://openalex.org/W2037036397","https://openalex.org/W2048178709","https://openalex.org/W2048839385","https://openalex.org/W2067335193","https://openalex.org/W2071765960","https://openalex.org/W2086294280","https://openalex.org/W2092756213","https://openalex.org/W2095059099","https://openalex.org/W2116500923","https://openalex.org/W2121072573","https://openalex.org/W2123771262","https://openalex.org/W2123950519","https://openalex.org/W2124396531","https://openalex.org/W2133685977","https://openalex.org/W2143837955","https://openalex.org/W2143892509","https://openalex.org/W2144327104","https://openalex.org/W2156140279","https://openalex.org/W2157995113","https://openalex.org/W2166040185","https://openalex.org/W2167202160","https://openalex.org/W2196404391","https://openalex.org/W2258573009","https://openalex.org/W2267597338","https://openalex.org/W2462759503","https://openalex.org/W2509957998","https://openalex.org/W2556548281","https://openalex.org/W2566116513","https://openalex.org/W2598326928","https://openalex.org/W2617110182","https://openalex.org/W2618870156","https://openalex.org/W2747877289","https://openalex.org/W2761436661","https://openalex.org/W2766437506","https://openalex.org/W2767983921","https://openalex.org/W2772624269","https://openalex.org/W2793216206","https://openalex.org/W2794521141","https://openalex.org/W2795867722","https://openalex.org/W2803499747","https://openalex.org/W2807588107","https://openalex.org/W2807593075","https://openalex.org/W2815133411","https://openalex.org/W2901182248","https://openalex.org/W2901226889","https://openalex.org/W2901677030","https://openalex.org/W2902652978","https://openalex.org/W2903777941","https://openalex.org/W2906295032","https://openalex.org/W2907783748","https://openalex.org/W2908201961","https://openalex.org/W2911685613","https://openalex.org/W2921173483","https://openalex.org/W2924188812","https://openalex.org/W2925075625","https://openalex.org/W2927507212","https://openalex.org/W2942880491","https://openalex.org/W2947763854","https://openalex.org/W2953751486","https://openalex.org/W2963567221","https://openalex.org/W2981890739","https://openalex.org/W2982367920","https://openalex.org/W2988889252","https://openalex.org/W2995410603","https://openalex.org/W2996171578","https://openalex.org/W2999577865","https://openalex.org/W3002219094","https://openalex.org/W3004299218","https://openalex.org/W3012501605","https://openalex.org/W3014807564","https://openalex.org/W3045651959","https://openalex.org/W3047141442","https://openalex.org/W3047163763","https://openalex.org/W3048152017","https://openalex.org/W3088401235","https://openalex.org/W3093858607","https://openalex.org/W3099810371","https://openalex.org/W3112563877","https://openalex.org/W3119671877","https://openalex.org/W3121368818","https://openalex.org/W3127657277","https://openalex.org/W3132661792","https://openalex.org/W3138479716","https://openalex.org/W3159800610","https://openalex.org/W3161494350","https://openalex.org/W3163897922","https://openalex.org/W3164573547","https://openalex.org/W3164692211","https://openalex.org/W3165120573","https://openalex.org/W3176661463","https://openalex.org/W3195038684","https://openalex.org/W3199206152","https://openalex.org/W3200928356","https://openalex.org/W3202226602","https://openalex.org/W3208940117","https://openalex.org/W3215273257","https://openalex.org/W3215794551","https://openalex.org/W4205496949","https://openalex.org/W4211016865","https://openalex.org/W4211240480","https://openalex.org/W4225278475","https://openalex.org/W4225598893","https://openalex.org/W4229033508","https://openalex.org/W4281716326","https://openalex.org/W4283390936","https://openalex.org/W4284897468","https://openalex.org/W4289793679","https://openalex.org/W4290989128","https://openalex.org/W4294042823","https://openalex.org/W4294884148","https://openalex.org/W4295951577","https://openalex.org/W4308834893","https://openalex.org/W4310701303","https://openalex.org/W4311662347","https://openalex.org/W4322505506","https://openalex.org/W4322738920","https://openalex.org/W4322768301","https://openalex.org/W4362521490","https://openalex.org/W4367322635","https://openalex.org/W4378212544","https://openalex.org/W4379537327","https://openalex.org/W4382022265","https://openalex.org/W4383346782","https://openalex.org/W4383480858","https://openalex.org/W4384023988","https://openalex.org/W4387095456","https://openalex.org/W4389391124","https://openalex.org/W4392168151","https://openalex.org/W4395026179","https://openalex.org/W4399387478","https://openalex.org/W4403680192","https://openalex.org/W4403680473","https://openalex.org/W4404568868","https://openalex.org/W4405364772","https://openalex.org/W4413506068","https://openalex.org/W4414621342","https://openalex.org/W4415126302","https://openalex.org/W4417117769","https://openalex.org/W7127351961","https://openalex.org/W7130642068","https://openalex.org/W7207825289"],"related_works":["https://openalex.org/W4414183094","https://openalex.org/W4414810029","https://openalex.org/W2785547001","https://openalex.org/W3011959400","https://openalex.org/W3048641110","https://openalex.org/W2982007054","https://openalex.org/W2560051790","https://openalex.org/W3205392289","https://openalex.org/W4383620144","https://openalex.org/W2737232808"],"abstract_inverted_index":{"Heart":[0],"failure":[1],"remains":[2],"among":[3],"the":[4,35,39,67,75,79,96,117,164,187,224,230,234,237,246,249,261,268,282,313,326],"leading":[5],"causes":[6],"of":[7,127,135,236,260,309],"death":[8],"worldwide,":[9],"and":[10,38,108,116,147,170,198,203,209,222,233,270,301,312],"its":[11,99,160],"burden":[12],"is":[13,42,53,86,138,244,278,290,295,319],"increasing":[14],"as":[15,297],"populations":[16],"age.":[17],"The":[18,132,241,293],"adult":[19,72],"mammalian":[20],"heart":[21,269,327],"has":[22,102,264],"almost":[23],"no":[24,152],"capacity":[25,76],"to":[26,30,94,328],"replace":[27],"cardiomyocytes":[28,33],"lost":[29],"injury:":[31],"most":[32,259],"leave":[34],"cell":[36,215],"cycle,":[37],"infarcted":[40],"muscle":[41],"replaced":[43],"by":[44],"scar,":[45],"so":[46,150],"that":[47,64,151,190],"function":[48],"declines":[49],"progressively.":[50],"This":[51,173],"constraint":[52],"not":[54],"fixed.":[55],"Neonatal":[56],"mice":[57],"regenerate":[58],"myocardium":[59],"for":[60,81,182,239,285],"a":[61,128,298,302,307],"brief":[62],"window":[63],"closes":[65],"within":[66],"first":[68],"postnatal":[69],"week,":[70],"whereas":[71,258],"zebrafish":[73],"retain":[74],"throughout":[77],"life;":[78],"machinery":[80],"regeneration":[82,137,219,289],"therefore":[83,279],"exists,":[84],"but":[85],"held":[87],"in":[88,156,287,325],"check.":[89],"Cell-based":[90],"therapy":[91],"was":[92],"expected":[93],"circumvent":[95],"problem,":[97],"yet":[98],"clinical":[100],"benefit":[101],"remained":[103],"modest:":[104],"transplanted":[105],"cells":[106],"survive":[107],"engraft":[109],"poorly,":[110],"their":[111],"fate":[112,216],"resists":[113],"precise":[114],"control,":[115,142],"host":[118],"microenvironment":[119,251],"actively":[120],"suppresses":[121],"regeneration.":[122,184],"These":[123],"shortcomings":[124],"are":[125,200],"symptoms":[126],"single":[129],"underlying":[130],"difficulty\u2014scale.":[131],"regulatory":[133],"logic":[134],"cardiac":[136,183,213,256,288],"distributed":[139],"across":[140],"transcriptional":[141],"intercellular":[143],"communication,":[144],"spatial":[145,196],"microenvironments":[146],"protein":[148],"interactions,":[149],"omics":[153],"layer":[154],"examined":[155],"isolation,":[157],"however":[158],"high":[159],"resolution,":[161],"can":[162,208],"recover":[163],"integrated":[165],"picture":[166],"from":[167,321],"high-dimensional,":[168],"sparse":[169],"heterogeneous":[171],"data.":[172],"review":[174,294],"proposes":[175],"an":[176],"artificial":[177],"intelligence":[178],"(AI)\u2013multi-omics":[179],"integration":[180],"framework":[181,300],"We":[185,227],"survey":[186],"methodological":[188,262,299],"progress":[189,263],"becomes":[191],"available":[192],"when":[193],"single-cell":[194],"transcriptomics,":[195],"transcriptomics":[197],"proteomics":[199],"modelled":[201],"jointly,":[202],"examine":[204],"what":[205],"these":[206],"approaches":[207],"cannot":[210],"establish":[211],"about":[212,218,223],"lineage":[214],"determination,":[217],"trajectory":[220],"reconstruction,":[221],"failing-heart":[225,250],"microenvironment.":[226],"then":[228],"consider":[229],"translational":[231],"pathways,":[232],"limits":[235],"evidence":[238,243,284,314,324],"each.":[240],"resulting":[242],"uneven:":[245],"sections":[247],"on":[248,254],"rest":[252],"largely":[253],"direct":[255,322],"data,":[257],"been":[265],"made":[266],"outside":[267],"transfers":[271],"only":[272],"under":[273],"additional":[274],"assumptions.":[275],"One":[276],"qualification":[277],"stated":[280],"at":[281],"outset:":[283],"AI":[286],"still":[291],"scarce.":[292],"positioned":[296],"forward-looking":[303],"perspective":[304],"rather":[305],"than":[306],"synthesis":[308],"established":[310],"conclusions,":[311],"supporting":[315],"each":[316],"principal":[317],"claim":[318],"graded,":[320],"experimental":[323],"methodology.":[329]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
