{"id":"https://openalex.org/W7225647541","doi":"https://doi.org/10.1177/22313354261495782","title":"Xanthine Oxidase\u2013Targeted and Antioxidant Effects of the PASA Polyherbal Formulation in Hyperuricemia: An Integrated in Silico and Experimental Study","display_name":"Xanthine Oxidase\u2013Targeted and Antioxidant Effects of the PASA Polyherbal Formulation in Hyperuricemia: An Integrated in Silico and Experimental Study","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225647541","doi":"https://doi.org/10.1177/22313354261495782"},"language":"en","primary_location":{"id":"doi:10.1177/22313354261495782","doi":"https://doi.org/10.1177/22313354261495782","is_oa":true,"landing_page_url":"https://doi.org/10.1177/22313354261495782","pdf_url":null,"source":{"id":"https://openalex.org/S2764844132","display_name":"Journal of Applied Pharmaceutical Science","issn_l":"2231-3354","issn":["2231-3354"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4327876862","host_organization_name":"Open Science Publishers LLP","host_organization_lineage":["https://openalex.org/P4327876862"],"host_organization_lineage_names":["Open Science Publishers LLP"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1177/22313354261495782","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091802631","display_name":"Oanh Hoang Hua","orcid":"https://orcid.org/0009-0005-4823-0977","observed_orcids":["https://orcid.org/0009-0005-4823-0977"]},"institutions":[{"id":"https://openalex.org/I2802508454","display_name":"University of Medicine and Pharmacy at Ho Chi Minh City","ror":"https://ror.org/025kb2624","country_code":"VN","type":"education","lineage":["https://openalex.org/I2802508454"]}],"countries":["VN"],"is_corresponding":true,"raw_author_name":"Hua Hoang Oanh","raw_affiliation_strings":["Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam"],"raw_orcid":"https://orcid.org/0009-0005-4823-0977","affiliations":[{"raw_affiliation_string":"Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam","institution_ids":["https://openalex.org/I2802508454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161330529","display_name":"Pham Ngoc Nhu Quynh","orcid":"https://orcid.org/0009-0008-5020-194X","observed_orcids":["https://orcid.org/0009-0008-5020-194X"]},"institutions":[{"id":"https://openalex.org/I2802508454","display_name":"University of Medicine and Pharmacy at Ho Chi Minh City","ror":"https://ror.org/025kb2624","country_code":"VN","type":"education","lineage":["https://openalex.org/I2802508454"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Pham Ngoc Nhu Quynh","raw_affiliation_strings":["Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam"],"raw_orcid":"https://orcid.org/0009-0008-5020-194X","affiliations":[{"raw_affiliation_string":"Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam","institution_ids":["https://openalex.org/I2802508454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161329894","display_name":"Nguyen Ngoc Nha Thien","orcid":"https://orcid.org/0009-0005-1234-8340","observed_orcids":["https://orcid.org/0009-0005-1234-8340"]},"institutions":[{"id":"https://openalex.org/I2802508454","display_name":"University of Medicine and Pharmacy at Ho Chi Minh City","ror":"https://ror.org/025kb2624","country_code":"VN","type":"education","lineage":["https://openalex.org/I2802508454"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Nguyen Ngoc Nha Thien","raw_affiliation_strings":["Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam"],"raw_orcid":"https://orcid.org/0009-0005-1234-8340","affiliations":[{"raw_affiliation_string":"Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam","institution_ids":["https://openalex.org/I2802508454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091802631"],"corresponding_institution_ids":["https://openalex.org/I2802508454"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12346","display_name":"Phytochemistry and biological activity of medicinal plants","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pasa","display_name":"PASA","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.8740000128746033},{"id":"https://openalex.org/keywords/xanthine-oxidase-inhibition","display_name":"xanthine oxidase inhibition","score":0.9950000047683716},{"id":"https://openalex.org/keywords/polyherbal-formulation","display_name":"polyherbal formulation","score":0.890999972820282},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/plasma-uric-acid","display_name":"plasma uric acid","score":0.8270000219345093},{"id":"https://openalex.org/keywords/potassium-oxonate-induced-hyperuricemia","display_name":"potassium oxonate-induced hyperuricemia","score":0.8769999742507935},{"id":"https://openalex.org/keywords/phellodendri-cortex","display_name":"Cortex Phellodendri","score":0.847000002861023},{"id":"https://openalex.org/keywords/atractylodis-rhizoma","display_name":"Atractylodis Rhizoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/alkaloids","display_name":"alkaloids","score":0.6169999837875366},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":1.0},{"id":"https://openalex.org/keywords/acute-oral-toxicity","display_name":"acute oral toxicity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/traditional-vietnamese-medicine","display_name":"traditional Vietnamese medicine","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.8363999724388123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8263999819755554},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.8054999709129333},{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.7685999870300293},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7646999955177307},{"id":"https://openalex.org/C2779470414","wikidata":"https://www.wikidata.org/wiki/Q50980","display_name":"Xanthine","level":3,"score":0.6904000043869019},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5562999844551086},{"id":"https://openalex.org/C2780261098","wikidata":"https://www.wikidata.org/wiki/Q412486","display_name":"Allopurinol","level":2,"score":0.5257999897003174},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5202999711036682},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5184000134468079},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44839999079704285},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4154999852180481},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3411000072956085},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3061000108718872},{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.30309998989105225},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.28299999237060547}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1177/22313354261495782","doi":"https://doi.org/10.1177/22313354261495782","is_oa":true,"landing_page_url":"https://doi.org/10.1177/22313354261495782","pdf_url":null,"source":{"id":"https://openalex.org/S2764844132","display_name":"Journal of Applied Pharmaceutical Science","issn_l":"2231-3354","issn":["2231-3354"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4327876862","host_organization_name":"Open Science Publishers LLP","host_organization_lineage":["https://openalex.org/P4327876862"],"host_organization_lineage_names":["Open Science Publishers LLP"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1177/22313354261495782","doi":"https://doi.org/10.1177/22313354261495782","is_oa":true,"landing_page_url":"https://doi.org/10.1177/22313354261495782","pdf_url":null,"source":{"id":"https://openalex.org/S2764844132","display_name":"Journal of Applied Pharmaceutical Science","issn_l":"2231-3354","issn":["2231-3354"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4327876862","host_organization_name":"Open Science Publishers LLP","host_organization_lineage":["https://openalex.org/P4327876862"],"host_organization_lineage_names":["Open Science Publishers LLP"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W2015592047","https://openalex.org/W2042932003","https://openalex.org/W2077041474","https://openalex.org/W2078663947","https://openalex.org/W2105317528","https://openalex.org/W2134967712","https://openalex.org/W2325474125","https://openalex.org/W2545583561","https://openalex.org/W2762198415","https://openalex.org/W2783927412","https://openalex.org/W2896802316","https://openalex.org/W2964395106","https://openalex.org/W3084043695","https://openalex.org/W3091850792","https://openalex.org/W3155684781","https://openalex.org/W3186506122","https://openalex.org/W3208319202","https://openalex.org/W3211775389","https://openalex.org/W4210535879","https://openalex.org/W4296457088","https://openalex.org/W4361206171","https://openalex.org/W4380372894","https://openalex.org/W4383263092","https://openalex.org/W4389253618","https://openalex.org/W4392052742","https://openalex.org/W4396922079","https://openalex.org/W4401153866","https://openalex.org/W4401753793","https://openalex.org/W4405077917","https://openalex.org/W4407265051","https://openalex.org/W4407901197","https://openalex.org/W4409585430","https://openalex.org/W4411433909","https://openalex.org/W4412951526","https://openalex.org/W4414617863","https://openalex.org/W7128311504","https://openalex.org/W7161120800"],"related_works":["https://openalex.org/W2789847684","https://openalex.org/W7204667870","https://openalex.org/W1988108439","https://openalex.org/W3007029501","https://openalex.org/W2008607828","https://openalex.org/W2128387777","https://openalex.org/W4414263719","https://openalex.org/W7210270664","https://openalex.org/W3015666742","https://openalex.org/W4410124779"],"abstract_inverted_index":{"Hyperuricemia":[0],"is":[1,25],"a":[2,21,26,263],"metabolic":[3],"condition":[4],"characterized":[5,130],"by":[6,71],"abnormally":[7],"elevated":[8],"uric":[9,165,207,244],"acid":[10,166,208,245],"levels":[11],"in":[12,15,58,60,64,107,110,134,171,238,247],"the":[13,52,85,135,210,218],"body,":[14],"which":[16],"xanthine":[17],"oxidase":[18],"(XO)":[19],"plays":[20],"key":[22],"role.":[23],"PASA":[24,56,136,138,176,198,231,261],"traditional":[27],"Vietnamese":[28],"polyherbal":[29],"formulation":[30],"comprising":[31],"Cortex":[32],"Phellodendri,":[33],"Rhizoma":[34],"Atractylodis,":[35],"Herba":[36,40],"Sarcandrae":[37],",":[38,62],"and":[39,63,88,102,109,120,147,156,188,201,235,240],"Achyranthis":[41],"asperae":[42],".":[43],"The":[44],"aim":[45],"of":[46,55,185,252,260],"this":[47],"study":[48],"was":[49,81],"to":[50,83],"evaluate":[51],"anti-hyperuricemic":[53,103],"activity":[54,104,141,150],"using":[57],"silico,":[59],"vitro":[61,108,239],"vivo":[65],"approaches.":[66],"Reported":[67],"phytochemicals":[68],"were":[69,105,168],"screened":[70],"molecular":[72],"docking":[73,116],"against":[74],"XO":[75,96,148,233],"(PDB":[76],"ID:":[77],"3NVY).":[78],"UPLC-QTOF/MS":[79,128],"(ESI+)":[80],"used":[82],"profile":[84],"aqueous":[86],"extract":[87],"tentatively":[89,129],"characterize":[90],"its":[91],"major":[92,132],"constituents.":[93],"Antioxidant":[94],"activity,":[95,98],"inhibitory":[97,149,234],"acute":[99,159,253],"oral":[100],"toxicity,":[101],"evaluated":[106],"potassium":[111],"oxonate-induced":[112],"hyperuricemic":[113,172,211,248],"mice.":[114],"Molecular":[115],"identified":[117],"several":[118],"alkaloids":[119],"flavonoids":[121],"with":[122],"high":[123],"predicted":[124],"affinity":[125],"for":[126,266],"XO.":[127],"11":[131],"constituents":[133],"extract.":[137],"exhibited":[139,232],"antioxidant":[140,236],"(IC":[142,151],"50":[143,152],"=":[144,153],"58.00":[145],"\u00b5g/mL)":[146,155],"44.43":[154],"showed":[157,221],"no":[158,222],"toxicity":[160],"at":[161],"27.8":[162],"g/kg.":[163],"Plasma":[164],"concentrations":[167,246],"significantly":[169,204,241],"reduced":[170,205,242],"mice":[173,249],"following":[174],"repeated":[175],"administration.":[177],"Linear":[178],"mixed-effects":[179],"model":[180,212],"analysis":[181],"demonstrated":[182],"significant":[183,223],"effects":[184],"treatment,":[186],"time,":[187],"treatment":[189],"\u00d7":[190],"time":[191],"interaction":[192],"(all":[193],"p":[194],"<":[195],"0.001).":[196],"Both":[197],"doses":[199],"(0.695":[200],"1.39":[202],"g/kg)":[203],"plasma":[206,243],"versus":[209],"from":[213,225,227],"Day":[214,228],"7":[215,229],"onward,":[216],"while":[217],"higher":[219],"dose":[220],"difference":[224],"allopurinol":[226],"onward.":[230],"activities":[237],"without":[250],"evidence":[251],"toxicity.":[254],"These":[255],"findings":[256],"support":[257],"further":[258],"investigation":[259],"as":[262],"potential":[264],"intervention":[265],"hyperuricemia.":[267]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}