{"id":"https://openalex.org/W7225647337","doi":"https://doi.org/10.3390/nu18213717","title":"Effects of Omega-3 Supplementation on Inflammatory Biomarkers and Ambulatory and Central Blood Pressure in Patients Treated for Hypertension and Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Trial","display_name":"Effects of Omega-3 Supplementation on Inflammatory Biomarkers and Ambulatory and Central Blood Pressure in Patients Treated for Hypertension and Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Trial","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225647337","doi":"https://doi.org/10.3390/nu18213717"},"language":"en","primary_location":{"id":"doi:10.3390/nu18213717","doi":"https://doi.org/10.3390/nu18213717","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18213717","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/nu18213717","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061920833","display_name":"Carol Kotliar","orcid":"https://orcid.org/0009-0006-9871-3886","observed_orcids":["https://orcid.org/0009-0006-9871-3886"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I29406707","display_name":"Pontificia Universidad Cat\u00f3lica Argentina","ror":"https://ror.org/0422kzb24","country_code":"AR","type":"education","lineage":["https://openalex.org/I29406707"]},{"id":"https://openalex.org/I4210099959","display_name":"Hospital Universitario Austral","ror":"https://ror.org/014nx0w70","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210099959"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Carol Kotliar","raw_affiliation_strings":["Center of Hypertension, Institute of Cardiology, Hospital Universitario Austral, Av.Per\u00f3n 1500, Pilar 1629, Buenos Aires, Argentina","Institute for Biomedical Research, School of Medical Sciences, Pontifical Catholic University of Argentina, National Scientific and Technical Research Council, Alicia Moreau de Justo 1600, Capital Federal, Buenos Aires 1107, Argentina","Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0009-0006-9871-3886","affiliations":[{"raw_affiliation_string":"Center of Hypertension, Institute of Cardiology, Hospital Universitario Austral, Av.Per\u00f3n 1500, Pilar 1629, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210099959"]},{"raw_affiliation_string":"Institute for Biomedical Research, School of Medical Sciences, Pontifical Catholic University of Argentina, National Scientific and Technical Research Council, Alicia Moreau de Justo 1600, Capital Federal, Buenos Aires 1107, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I29406707"]},{"raw_affiliation_string":"Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008253473","display_name":"Roc\u00edo Mart\u00ednez Vivot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I29406707","display_name":"Pontificia Universidad Cat\u00f3lica Argentina","ror":"https://ror.org/0422kzb24","country_code":"AR","type":"education","lineage":["https://openalex.org/I29406707"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Roc\u00edo Mart\u00ednez Vivot","raw_affiliation_strings":["Institute for Biomedical Research, School of Medical Sciences, Pontifical Catholic University of Argentina, National Scientific and Technical Research Council, Alicia Moreau de Justo 1600, Capital Federal, Buenos Aires 1107, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Research, School of Medical Sciences, Pontifical Catholic University of Argentina, National Scientific and Technical Research Council, Alicia Moreau de Justo 1600, Capital Federal, Buenos Aires 1107, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I29406707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089305432","display_name":"C. Beltramo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristian Beltramo","raw_affiliation_strings":["Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048199514","display_name":"Ezequiel Huguet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ezequiel Huguet","raw_affiliation_strings":["Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021313957","display_name":"Alfredo Lozada","orcid":"https://orcid.org/0000-0002-4151-3350","observed_orcids":["https://orcid.org/0000-0002-4151-3350"]},"institutions":[{"id":"https://openalex.org/I4210099959","display_name":"Hospital Universitario Austral","ror":"https://ror.org/014nx0w70","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210099959"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Alfredo Lozada","raw_affiliation_strings":["Cholesterol Clinic, Hospital Universitario Austral, Av.Per\u00f3n 1500, Pilar 1629, Buenos Aires, Argentina","Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-4151-3350","affiliations":[{"raw_affiliation_string":"Cholesterol Clinic, Hospital Universitario Austral, Av.Per\u00f3n 1500, Pilar 1629, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210099959"]},{"raw_affiliation_string":"Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161306199","display_name":"Laura Montecchiesi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Montecchiesi","raw_affiliation_strings":["Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006999673","display_name":"Leopoldo Marc\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leopoldo Marcon","raw_affiliation_strings":["Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026416710","display_name":"Sebasti\u00e1n Obregon","orcid":"https://orcid.org/0000-0002-6918-9759","observed_orcids":["https://orcid.org/0000-0002-6918-9759"]},"institutions":[{"id":"https://openalex.org/I4210099959","display_name":"Hospital Universitario Austral","ror":"https://ror.org/014nx0w70","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210099959"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Sebasti\u00e1n Eduardo Obreg\u00f3n","raw_affiliation_strings":["Center of Hypertension, Institute of Cardiology, Hospital Universitario Austral, Av.Per\u00f3n 1500, Pilar 1629, Buenos Aires, Argentina","Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-6918-9759","affiliations":[{"raw_affiliation_string":"Center of Hypertension, Institute of Cardiology, Hospital Universitario Austral, Av.Per\u00f3n 1500, Pilar 1629, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210099959"]},{"raw_affiliation_string":"Santa Mar\u00eda de la Salud Medical Center, Av. del Libertador 16131, San Isidro 1643, Buenos Aires, Argentina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061920833"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I29406707","https://openalex.org/I4210099959"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"21","first_page":"3717","last_page":"3717"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9589999914169312},{"id":"https://openalex.org/keywords/omega-3-supplementation","display_name":"omega-3 supplementation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":1.0},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.9660000205039978},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ambulatory-blood-pressure","display_name":"ambulatory blood pressure","score":0.9769999980926514},{"id":"https://openalex.org/keywords/central-blood-pressure","display_name":"central blood pressure","score":0.984000027179718},{"id":"https://openalex.org/keywords/pulse-wave-velocity","display_name":"pulse wave velocity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/vascular-function","display_name":"vascular function","score":0.8939999938011169},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.640999972820282},{"id":"https://openalex.org/keywords/cardiovascular-risk-reduction","display_name":"cardiovascular risk reduction","score":0.43799999356269836},{"id":"https://openalex.org/keywords/nocturnal-blood-pressure","display_name":"nocturnal blood pressure","score":0.3959999978542328},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8583999872207642},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7724000215530396},{"id":"https://openalex.org/C149323552","wikidata":"https://www.wikidata.org/wiki/Q3090739","display_name":"Ambulatory blood pressure","level":3,"score":0.7253000140190125},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.6184999942779541},{"id":"https://openalex.org/C118190526","wikidata":"https://www.wikidata.org/wiki/Q7239981","display_name":"Prehypertension","level":3,"score":0.5598000288009644},{"id":"https://openalex.org/C2778319312","wikidata":"https://www.wikidata.org/wiki/Q2118022","display_name":"Pulse wave velocity","level":3,"score":0.5498999953269958},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5401999950408936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5331000089645386},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.47620001435279846},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4724999964237213},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.44909998774528503},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4359000027179718},{"id":"https://openalex.org/C17140001","wikidata":"https://www.wikidata.org/wiki/Q1759415","display_name":"Pulse pressure","level":3,"score":0.4345000088214874},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.3743000030517578},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.37130001187324524},{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.3598000109195709},{"id":"https://openalex.org/C169554166","wikidata":"https://www.wikidata.org/wiki/Q496359","display_name":"Systole","level":4,"score":0.3440000116825104},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.311599999666214},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.30469998717308044},{"id":"https://openalex.org/C2775965419","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter trial","level":4,"score":0.28459998965263367},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.27230000495910645},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.2720000147819519},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.2676999866962433},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26409998536109924},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2632000148296356},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.259799987077713}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/nu18213717","doi":"https://doi.org/10.3390/nu18213717","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18213717","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/nu18213717","doi":"https://doi.org/10.3390/nu18213717","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18213717","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410603994","https://openalex.org/W7128041264","https://openalex.org/W2193666498","https://openalex.org/W1969425489","https://openalex.org/W2027101557","https://openalex.org/W2591043823","https://openalex.org/W1600072104","https://openalex.org/W2113066574","https://openalex.org/W4248501265","https://openalex.org/W3045217176"],"abstract_inverted_index":{"Background:":[0],"Omega-3":[1],"fatty":[2,37],"acids":[3,38],"exert":[4],"anti-inflammatory":[5],"and":[6,19,43,49,54,107,194,226,233,251],"hemodynamic":[7],"effects;":[8],"however,":[9],"their":[10],"concurrent":[11],"effects":[12,28,97],"in":[13,57,89,127,242],"patients":[14],"receiving":[15],"treatment":[16],"for":[17,86,114],"hypertension":[18],"dyslipidemia":[20],"remain":[21],"incompletely":[22],"characterized.":[23],"Objective:":[24],"To":[25],"evaluate":[26],"the":[27,128],"of":[29,32,79],"12":[30,87],"weeks":[31],"supplementation":[33,121],"with":[34,118,124,247],"pharmaceutical-grade":[35],"omega-3":[36,72,120],"on":[39],"inflammatory":[40],"biomarkers,":[41],"central":[42,180,222],"brachial":[44],"blood":[45,154,168,182,224],"pressure":[46,155,169,183],"including":[47],"office":[48],"24":[50],"h":[51],"ambulatory":[52,219],"measurements,":[53],"vascular":[55],"function":[56],"this":[58,62],"population.":[59],"Methods:":[60],"In":[61],"exploratory,":[63],"randomized,":[64],"double-blind,":[65],"placebo-controlled":[66],"pilot":[67],"trial,":[68],"100":[69],"adults":[70],"received":[71],"ethyl":[73],"esters":[74],"at":[75],"a":[76,83],"capsule":[77],"dose":[78],"2":[80],"g/day":[81],"or":[82],"matching":[84],"placebo":[85],"weeks,":[88],"addition":[90],"to":[91,136,147,161,175,189,204],"stable":[92],"usual":[93],"pharmacological":[94],"treatment.":[95],"Treatment":[96],"were":[98,105,111],"estimated":[99,195],"using":[100],"linear":[101],"mixed-effects":[102],"models.":[103],"p-values":[104],"nominal,":[106],"95%":[108,133,144,158,172,186,201],"confidence":[109],"intervals":[110],"not":[112],"adjusted":[113],"multiplicity.":[115],"Results:":[116],"Compared":[117],"placebo,":[119],"was":[122],"associated":[123],"greater":[125],"reductions":[126],"neutrophil-to-lymphocyte":[129],"ratio":[130],"(NLR;":[131],"\u22120.43;":[132],"CI,":[134,145,159,173,187,202],"\u22120.73":[135],"\u22120.13;":[137],"p":[138,149,163,177,191,206],"=":[139,150,164,178,192],"0.005),":[140],"ferritin":[141],"(\u221247.32":[142],"ng/mL;":[143],"\u221277.55":[146],"\u221217.08;":[148],"0.003),":[151],"daytime":[152],"systolic":[153,181,223],"(\u22126.52":[156],"mmHg;":[157,171,185],"\u221210.66":[160],"\u22122.39;":[162],"0.002),":[165],"nighttime":[166],"diastolic":[167],"(\u22125.55":[170],"\u22129.87":[174],"\u22121.22;":[176],"0.013),":[179],"(\u22126.71":[184],"\u221212.22":[188],"\u22121.20;":[190],"0.019),":[193],"pulse":[196],"wave":[197],"velocity":[198],"(\u22120.77":[199],"m/s;":[200],"\u22121.19":[203],"\u22120.36;":[205],"<":[207],"0.001).":[208],"Conclusions:":[209],"The":[210],"trial":[211],"identified":[212],"exploratory":[213],"signals":[214],"involving":[215],"NLR,":[216],"ferritin,":[217],"selected":[218],"blood-pressure":[220],"measures,":[221],"pressure,":[225],"algorithm-derived":[227],"ePWV.":[228],"Multiplicity,":[229],"limited":[230],"sample":[231],"size,":[232],"incomplete":[234],"outcome":[235],"availability":[236],"preclude":[237],"confirmatory":[238],"interpretation.":[239],"Independent":[240],"replication":[241],"larger,":[243],"prospectively":[244],"registered":[245],"trials":[246],"clearly":[248],"specified":[249],"endpoints":[250],"reproducible":[252],"sample-size":[253],"calculations":[254],"is":[255],"required.":[256]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
