{"id":"https://openalex.org/W7225646605","doi":"https://doi.org/10.3390/biomedicines14112571","title":"The Gut Microbiome in Gastrointestinal Cancer: Unravelling the Hidden Drivers of Tumorigenesis and Therapeutic Response","display_name":"The Gut Microbiome in Gastrointestinal Cancer: Unravelling the Hidden Drivers of Tumorigenesis and Therapeutic Response","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225646605","doi":"https://doi.org/10.3390/biomedicines14112571"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines14112571","doi":"https://doi.org/10.3390/biomedicines14112571","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14112571","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biomedicines14112571","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146660551","display_name":"Vivaan Dudeja","orcid":"https://orcid.org/0009-0009-1837-9411","observed_orcids":["https://orcid.org/0009-0009-1837-9411"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivaan Dudeja","raw_affiliation_strings":["Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA"],"raw_orcid":"https://orcid.org/0009-0009-1837-9411","affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085266209","display_name":"Suresh Sulekha Dhanisha","orcid":"https://orcid.org/0000-0003-3485-5499","observed_orcids":["https://orcid.org/0000-0003-3485-5499"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhanisha Sulekha Suresh","raw_affiliation_strings":["Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA"],"raw_orcid":"https://orcid.org/0000-0003-3485-5499","affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021462424","display_name":"Suryansh Suryansh","orcid":"https://orcid.org/0009-0003-7804-8696","observed_orcids":["https://orcid.org/0009-0003-7804-8696"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suryansh Suryansh","raw_affiliation_strings":["Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161331451","display_name":"Maria Fernanda Salcedo-Noriega","orcid":"https://orcid.org/0000-0002-3557-8537","observed_orcids":["https://orcid.org/0000-0002-3557-8537"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Fernanda Salcedo-Noriega","raw_affiliation_strings":["Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA"],"raw_orcid":"https://orcid.org/0000-0002-3557-8537","affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065871484","display_name":"Utpreksha Vaish","orcid":"https://orcid.org/0000-0002-8370-442X","observed_orcids":["https://orcid.org/0000-0002-8370-442X"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Utpreksha Vaish","raw_affiliation_strings":["Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124502043","display_name":"Andy Tran","orcid":"https://orcid.org/0000-0002-8370-9749","observed_orcids":["https://orcid.org/0000-0002-8370-9749"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andy Tran","raw_affiliation_strings":["Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA"],"raw_orcid":"https://orcid.org/0000-0002-8370-9749","affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124970966","display_name":"Sweta Bhandari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sweta Bhandari","raw_affiliation_strings":["Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128895277","display_name":"Abhiram Beena Kannan","orcid":"https://orcid.org/0009-0003-7834-5500","observed_orcids":["https://orcid.org/0009-0003-7834-5500"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhiram Beena Kannan","raw_affiliation_strings":["Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA"],"raw_orcid":"https://orcid.org/0009-0003-7834-5500","affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161347527","display_name":"Nandita Raikwar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nandita Raikwar","raw_affiliation_strings":["Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129842881","display_name":"Abdur Rehman Asrarul Haque","orcid":"https://orcid.org/0009-0009-3716-1303","observed_orcids":["https://orcid.org/0009-0009-3716-1303"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdur Rehman Asrarul Haque","raw_affiliation_strings":["Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA"],"raw_orcid":"https://orcid.org/0009-0009-3716-1303","affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124960074","display_name":"Saikiran Chatre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saikiran Chatre","raw_affiliation_strings":["Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084289518","display_name":"Srikanth Iyer","orcid":"https://orcid.org/0009-0005-8920-8725","observed_orcids":["https://orcid.org/0009-0005-8920-8725","https://orcid.org/0000-0002-2030-4867"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Srikanth Iyer","raw_affiliation_strings":["Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Iowa Health Care, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084289518"],"corresponding_institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"11","first_page":"2571","last_page":"2571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gastrointestinal-cancer","display_name":"gastrointestinal cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/fusobacterium-nucleatum","display_name":"Fusobacterium nucleatum","score":0.9549999833106995},{"id":"https://openalex.org/keywords/porphyromonas-gingivalis","display_name":"Porphyromonas gingivalis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gastric-carcinogenesis","display_name":"gastric carcinogenesis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/streptococcus-anginosus","display_name":"Streptococcus anginosus","score":0.8889999985694885},{"id":"https://openalex.org/keywords/bile-acid-metabolism","display_name":"bile acid metabolism","score":0.5830000042915344},{"id":"https://openalex.org/keywords/colibactin","display_name":"colibactin","score":0.8510000109672546},{"id":"https://openalex.org/keywords/lipopolysaccharide-translocation","display_name":"lipopolysaccharide translocation","score":0.890999972820282},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6629999876022339},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.5170000195503235},{"id":"https://openalex.org/keywords/radiotherapy-toxicity","display_name":"radiotherapy toxicity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8790000081062317},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":0.8019999861717224},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":1.0},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.7134000062942505},{"id":"https://openalex.org/C2777349128","wikidata":"https://www.wikidata.org/wiki/Q5510311","display_name":"Fusobacterium nucleatum","level":4,"score":0.7125999927520752},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6926000118255615},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6154000163078308},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6150000095367432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6075999736785889},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.592199981212616},{"id":"https://openalex.org/C189506811","wikidata":"https://www.wikidata.org/wiki/Q5148442","display_name":"Colonisation resistance","level":3,"score":0.5767999887466431},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5303999781608582},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5202000141143799},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5058000087738037},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4237000048160553},{"id":"https://openalex.org/C120667501","wikidata":"https://www.wikidata.org/wiki/Q6839493","display_name":"Microecology","level":2,"score":0.4189000129699707},{"id":"https://openalex.org/C2780960513","wikidata":"https://www.wikidata.org/wiki/Q2720082","display_name":"Fusobacterium","level":4,"score":0.33709999918937683},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3352000117301941},{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.29649999737739563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29429998993873596},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.28450000286102295},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28139999508857727},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.27309998869895935},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.2709999978542328},{"id":"https://openalex.org/C137923570","wikidata":"https://www.wikidata.org/wiki/Q2121103","display_name":"Fecal bacteriotherapy","level":4,"score":0.2703000009059906},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.2639999985694885},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.2540999948978424},{"id":"https://openalex.org/C2780832600","wikidata":"https://www.wikidata.org/wiki/Q134684","display_name":"Helicobacter","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/biomedicines14112571","doi":"https://doi.org/10.3390/biomedicines14112571","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14112571","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines14112571","doi":"https://doi.org/10.3390/biomedicines14112571","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14112571","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":312,"referenced_works":["https://openalex.org/W92371174","https://openalex.org/W1420654867","https://openalex.org/W1529695053","https://openalex.org/W1882428435","https://openalex.org/W1976130670","https://openalex.org/W1987375206","https://openalex.org/W1988877663","https://openalex.org/W1990515033","https://openalex.org/W1997608252","https://openalex.org/W2006292369","https://openalex.org/W2012065014","https://openalex.org/W2030407395","https://openalex.org/W2031686588","https://openalex.org/W2033386838","https://openalex.org/W2041989558","https://openalex.org/W2045320588","https://openalex.org/W2049964362","https://openalex.org/W2058849414","https://openalex.org/W2059128083","https://openalex.org/W2077492307","https://openalex.org/W2086697405","https://openalex.org/W2096139589","https://openalex.org/W2101945476","https://openalex.org/W2106136875","https://openalex.org/W2107097628","https://openalex.org/W2111895881","https://openalex.org/W2116652997","https://openalex.org/W2124632458","https://openalex.org/W2131186249","https://openalex.org/W2133267962","https://openalex.org/W2136466723","https://openalex.org/W2140145798","https://openalex.org/W2140679462","https://openalex.org/W2154888801","https://openalex.org/W2165456770","https://openalex.org/W2167430231","https://openalex.org/W2185075416","https://openalex.org/W2219584773","https://openalex.org/W2263583031","https://openalex.org/W2273454643","https://openalex.org/W2283554601","https://openalex.org/W2331953994","https://openalex.org/W2342609081","https://openalex.org/W2359714630","https://openalex.org/W2400898657","https://openalex.org/W2409636417","https://openalex.org/W2528306813","https://openalex.org/W2537571631","https://openalex.org/W2552283579","https://openalex.org/W2553024592","https://openalex.org/W2580335599","https://openalex.org/W2593296604","https://openalex.org/W2594663793","https://openalex.org/W2609601056","https://openalex.org/W2616825195","https://openalex.org/W2621056634","https://openalex.org/W2625048728","https://openalex.org/W2625207619","https://openalex.org/W2658508676","https://openalex.org/W2694487218","https://openalex.org/W2732947281","https://openalex.org/W2739778494","https://openalex.org/W2742147437","https://openalex.org/W2743073899","https://openalex.org/W2744179277","https://openalex.org/W2748737443","https://openalex.org/W2749700969","https://openalex.org/W2756403351","https://openalex.org/W2765314233","https://openalex.org/W2766903152","https://openalex.org/W2768799378","https://openalex.org/W2769206492","https://openalex.org/W2769517706","https://openalex.org/W2771173285","https://openalex.org/W2778253332","https://openalex.org/W2782333299","https://openalex.org/W2786541232","https://openalex.org/W2789769540","https://openalex.org/W2791926234","https://openalex.org/W2792256546","https://openalex.org/W2795824476","https://openalex.org/W2800992604","https://openalex.org/W2803285013","https://openalex.org/W2804448077","https://openalex.org/W2883291178","https://openalex.org/W2887627155","https://openalex.org/W2906946400","https://openalex.org/W2907216794","https://openalex.org/W2911143260","https://openalex.org/W2917155356","https://openalex.org/W2920009718","https://openalex.org/W2927453907","https://openalex.org/W2932049125","https://openalex.org/W2940482094","https://openalex.org/W2950917437","https://openalex.org/W2953449085","https://openalex.org/W2956016709","https://openalex.org/W2957401314","https://openalex.org/W2963107239","https://openalex.org/W2963245811","https://openalex.org/W2964688507","https://openalex.org/W2965379763","https://openalex.org/W2967450000","https://openalex.org/W2979146632","https://openalex.org/W2986028382","https://openalex.org/W2989587737","https://openalex.org/W2990182987","https://openalex.org/W2995280816","https://openalex.org/W2996185021","https://openalex.org/W3000378948","https://openalex.org/W3004464570","https://openalex.org/W3008359597","https://openalex.org/W3014573611","https://openalex.org/W3015963259","https://openalex.org/W3016607029","https://openalex.org/W3020935727","https://openalex.org/W3023057053","https://openalex.org/W3026587634","https://openalex.org/W3033741160","https://openalex.org/W3039360174","https://openalex.org/W3042553188","https://openalex.org/W3081548621","https://openalex.org/W3083241614","https://openalex.org/W3088203083","https://openalex.org/W3089396603","https://openalex.org/W3095661830","https://openalex.org/W3096433371","https://openalex.org/W3096573278","https://openalex.org/W3097156613","https://openalex.org/W3110065237","https://openalex.org/W3110963740","https://openalex.org/W3111836013","https://openalex.org/W3112001494","https://openalex.org/W3117817208","https://openalex.org/W3120427380","https://openalex.org/W3126208996","https://openalex.org/W3138068311","https://openalex.org/W3151021440","https://openalex.org/W3154507045","https://openalex.org/W3175895832","https://openalex.org/W3177384123","https://openalex.org/W3177869587","https://openalex.org/W3179327521","https://openalex.org/W3184541229","https://openalex.org/W3190759759","https://openalex.org/W3193797930","https://openalex.org/W3194223767","https://openalex.org/W3194909284","https://openalex.org/W3207256610","https://openalex.org/W3208100646","https://openalex.org/W3210468733","https://openalex.org/W4200001874","https://openalex.org/W4200153380","https://openalex.org/W4200191667","https://openalex.org/W4200260883","https://openalex.org/W4205859368","https://openalex.org/W4206272664","https://openalex.org/W4207025204","https://openalex.org/W4210569788","https://openalex.org/W4210773546","https://openalex.org/W4210896785","https://openalex.org/W4211110828","https://openalex.org/W4212814623","https://openalex.org/W4212954224","https://openalex.org/W4214673864","https://openalex.org/W4214706689","https://openalex.org/W4220731595","https://openalex.org/W4220869078","https://openalex.org/W4220897697","https://openalex.org/W4223955556","https://openalex.org/W4224260803","https://openalex.org/W4225279814","https://openalex.org/W4280582668","https://openalex.org/W4280588910","https://openalex.org/W4281288917","https://openalex.org/W4282974371","https://openalex.org/W4283075856","https://openalex.org/W4283314687","https://openalex.org/W4291819147","https://openalex.org/W4295106190","https://openalex.org/W4296354115","https://openalex.org/W4296681502","https://openalex.org/W4297964611","https://openalex.org/W4303614593","https://openalex.org/W4303621924","https://openalex.org/W4306410908","https://openalex.org/W4308026780","https://openalex.org/W4310217075","https://openalex.org/W4312130094","https://openalex.org/W4313312155","https://openalex.org/W4313399255","https://openalex.org/W4313598922","https://openalex.org/W4319039693","https://openalex.org/W4321493192","https://openalex.org/W4353016372","https://openalex.org/W4360955699","https://openalex.org/W4361026330","https://openalex.org/W4361202504","https://openalex.org/W4361214802","https://openalex.org/W4362519989","https://openalex.org/W4366822705","https://openalex.org/W4367297493","https://openalex.org/W4367548616","https://openalex.org/W4376957641","https://openalex.org/W4377286889","https://openalex.org/W4379645870","https://openalex.org/W4382502654","https://openalex.org/W4383896314","https://openalex.org/W4384037985","https://openalex.org/W4384563606","https://openalex.org/W4384626749","https://openalex.org/W4384663666","https://openalex.org/W4384701478","https://openalex.org/W4384938362","https://openalex.org/W4385730731","https://openalex.org/W4386324971","https://openalex.org/W4386929477","https://openalex.org/W4388292884","https://openalex.org/W4388656357","https://openalex.org/W4388658182","https://openalex.org/W4389509892","https://openalex.org/W4389683775","https://openalex.org/W4390110967","https://openalex.org/W4391365063","https://openalex.org/W4391396993","https://openalex.org/W4391993678","https://openalex.org/W4392638507","https://openalex.org/W4392699774","https://openalex.org/W4392984046","https://openalex.org/W4393976444","https://openalex.org/W4394755386","https://openalex.org/W4394858496","https://openalex.org/W4395068267","https://openalex.org/W4396546668","https://openalex.org/W4396664002","https://openalex.org/W4399881440","https://openalex.org/W4400036793","https://openalex.org/W4400769951","https://openalex.org/W4400774344","https://openalex.org/W4400977720","https://openalex.org/W4401504362","https://openalex.org/W4401691424","https://openalex.org/W4402622976","https://openalex.org/W4403079701","https://openalex.org/W4403417900","https://openalex.org/W4404125038","https://openalex.org/W4404519976","https://openalex.org/W4404685073","https://openalex.org/W4405076813","https://openalex.org/W4405181268","https://openalex.org/W4405290006","https://openalex.org/W4405996053","https://openalex.org/W4406328332","https://openalex.org/W4406875678","https://openalex.org/W4407897760","https://openalex.org/W4407988672","https://openalex.org/W4409177560","https://openalex.org/W4409323418","https://openalex.org/W4409729414","https://openalex.org/W4409926531","https://openalex.org/W4410040735","https://openalex.org/W4410301569","https://openalex.org/W4410974032","https://openalex.org/W4411042384","https://openalex.org/W4411091609","https://openalex.org/W4411127845","https://openalex.org/W4411354223","https://openalex.org/W4411469044","https://openalex.org/W4411791578","https://openalex.org/W4412080667","https://openalex.org/W4412157110","https://openalex.org/W4412159285","https://openalex.org/W4413138958","https://openalex.org/W4413318599","https://openalex.org/W4413741245","https://openalex.org/W4414169284","https://openalex.org/W4414262284","https://openalex.org/W4414299226","https://openalex.org/W4415027528","https://openalex.org/W4415131904","https://openalex.org/W4415537350","https://openalex.org/W4415684485","https://openalex.org/W4415827875","https://openalex.org/W4416535090","https://openalex.org/W4417024267","https://openalex.org/W7113897565","https://openalex.org/W7117979541","https://openalex.org/W7119508673","https://openalex.org/W7125926693","https://openalex.org/W7131423554","https://openalex.org/W7134908487","https://openalex.org/W7135052078","https://openalex.org/W7136085583","https://openalex.org/W7138915579","https://openalex.org/W7139923726","https://openalex.org/W7140119093","https://openalex.org/W7140304633","https://openalex.org/W7143857240","https://openalex.org/W7149013872","https://openalex.org/W7154101671","https://openalex.org/W7154490891","https://openalex.org/W7160546915","https://openalex.org/W7161420718","https://openalex.org/W7162306140","https://openalex.org/W7162500368","https://openalex.org/W7162751951","https://openalex.org/W7162864934","https://openalex.org/W7165787202","https://openalex.org/W7166468822","https://openalex.org/W7167608393","https://openalex.org/W7168405474","https://openalex.org/W7203627559"],"related_works":["https://openalex.org/W7144218552","https://openalex.org/W4415684485","https://openalex.org/W3198493551","https://openalex.org/W7204933218","https://openalex.org/W4391447157","https://openalex.org/W4285180320","https://openalex.org/W7162079031","https://openalex.org/W7196936830","https://openalex.org/W4400849710","https://openalex.org/W4412922978"],"abstract_inverted_index":{"Gastrointestinal":[0],"(GI)":[1],"cancers":[2,172],"represent":[3],"26%":[4],"of":[5,15,20,163,200,211,253],"all":[6],"cancer":[7,16,21,76,188,255],"cases":[8],"worldwide":[9],"and":[10,30,39,48,51,64,68,80,96,121,128,136,158,173,197,203,214,221,233,247],"are":[11,145,239],"responsible":[12],"for":[13,43],"35%":[14],"deaths.":[17],"These":[18,144,237],"types":[19],"have":[22],"significant":[23],"clinical":[24],"challenges":[25],"due":[26],"to":[27,75,130,160,196,229,243],"late":[28],"detection":[29],"treatment":[31,189],"resistance.":[32,236],"The":[33,191],"gut":[34,166],"microbiome":[35,192],"is":[36],"a":[37,53,147,156],"complex":[38],"adaptable":[40],"ecosystem":[41],"crucial":[42],"metabolism,":[44,135,209],"intestinal":[45],"barrier":[46,124],"maintenance,":[47],"immune":[49,78,204,215],"function,":[50],"establishes":[52],"strong":[54],"two-way":[55],"interaction":[56],"within":[57],"the":[58,164,179,251],"host.":[59],"Tumors":[60],"affect":[61],"both":[62],"local":[63],"systemic":[65],"microbial":[66,90,167,181],"environments,":[67],"dysbiosis,":[69],"an":[70,184],"imbalance":[71],"in":[72,151,176,187],"microbiota,":[73],"contributes":[74],"development,":[77],"evasion,":[79],"progression":[81],"across":[82],"different":[83],"GI":[84,88,171],"regions.":[85],"In":[86,119],"upper":[87],"malignancies,":[89],"species":[91],"such":[92,115],"as":[93,116],"Fusobacterium":[94],"nucleatum":[95],"Porphyromonas":[97],"gingivalis":[98],"promote":[99],"chronic":[100],"inflammation,":[101],"while":[102],"gastric":[103],"carcinogenesis":[104],"develops":[105],"from":[106],"Helicobacter":[107],"pylori-induced":[108],"atrophy":[109],"through":[110,140,207],"secondary":[111],"colonization":[112],"by":[113],"bacteria":[114,127],"Streptococcus":[117],"anginosus.":[118],"hepatopancreatobiliary":[120],"colorectal":[122],"cancers,":[123],"disruption":[125],"allows":[126],"lipopolysaccharides":[129],"translocate,":[131],"disrupts":[132],"bile":[133],"acid":[134],"causes":[137],"genotoxic":[138],"damage":[139],"agents":[141],"like":[142,218],"colibactin.":[143],"just":[146],"few":[148],"examples":[149],"covered":[150,155],"this":[152],"review.":[153],"We":[154],"comprehensive":[157],"up":[159],"date":[161],"overview":[162],"major":[165],"communities":[168,182],"associated":[169],"with":[170],"their":[174],"role":[175,186],"oncogenesis.":[177],"Additionally,":[178],"gut-derived":[180],"play":[183],"active":[185,241],"outcomes.":[190],"influences":[193],"patient":[194],"responses":[195],"side":[198],"effects":[199],"chemotherapy,":[201],"radiotherapy,":[202],"checkpoint":[205],"blockades":[206],"drug":[208],"modulation":[210],"mucosal":[212],"injury,":[213],"remodeling.":[216],"Strategies":[217],"prebiotics,":[219],"probiotics,":[220],"fecal":[222],"microbiota":[223],"transplantation":[224],"(FMT)":[225],"offer":[226],"promising":[227],"approaches":[228],"reduce":[230,248],"treatment-related":[231],"toxicities":[232],"overcome":[234],"therapeutic":[235,245],"strategies":[238],"under":[240],"evaluation":[242],"address":[244],"resistance":[246],"toxicity,":[249],"highlighting":[250],"potential":[252],"microbiome-directed":[254],"medicine.":[256]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
