{"id":"https://openalex.org/W7225645785","doi":"https://doi.org/10.21203/rs.3.rs-11179153/v1","title":"Dynapenia in Patients with Diabetic Nephropathy: A Cross-Sectional Comparative Study","display_name":"Dynapenia in Patients with Diabetic Nephropathy: A Cross-Sectional Comparative Study","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225645785","doi":"https://doi.org/10.21203/rs.3.rs-11179153/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11179153/v1","doi":"https://doi.org/10.21203/rs.3.rs-11179153/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11179153/v1","pdf_url":"https://www.researchsquare.com/article/rs-11179153/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11179153/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161316997","display_name":"Hasan K\u0131rmaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154959","display_name":"Gaziosmanpa\u015fa E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/03hda5c25","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4387154959"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hasan K\u0131rmaz","raw_affiliation_strings":["Gaziosmanpa\u015fa E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gaziosmanpa\u015fa E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi","institution_ids":["https://openalex.org/I4387154959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112069506","display_name":"Emel Tatl\u0131","orcid":"https://orcid.org/0000-0002-7582-5520","observed_orcids":["https://orcid.org/0000-0002-7582-5520"]},"institutions":[{"id":"https://openalex.org/I4387154959","display_name":"Gaziosmanpa\u015fa E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/03hda5c25","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4387154959"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Emel Tatli","raw_affiliation_strings":["Gaziosmanpa\u015fa E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gaziosmanpa\u015fa E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi","institution_ids":["https://openalex.org/I4387154959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069125098","display_name":"Okcan Basat","orcid":"https://orcid.org/0000-0002-5222-9136","observed_orcids":["https://orcid.org/0000-0002-5222-9136"]},"institutions":[{"id":"https://openalex.org/I4387154959","display_name":"Gaziosmanpa\u015fa E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/03hda5c25","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4387154959"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Okcan Basat","raw_affiliation_strings":["Gaziosmanpa\u015fa E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gaziosmanpa\u015fa E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi","institution_ids":["https://openalex.org/I4387154959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084324080","display_name":"Abdullah Ozan Polat","orcid":"https://orcid.org/0000-0002-4398-0817","observed_orcids":["https://orcid.org/0000-0002-4398-0817"]},"institutions":[{"id":"https://openalex.org/I4387154959","display_name":"Gaziosmanpa\u015fa E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/03hda5c25","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4387154959"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Abdullah Ozan Polat","raw_affiliation_strings":["Gaziosmanpa\u015fa E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gaziosmanpa\u015fa E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi","institution_ids":["https://openalex.org/I4387154959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4387154959"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.17749999463558197,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynapenia","display_name":"dynapenia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.996999979019165},{"id":"https://openalex.org/keywords/handgrip-strength","display_name":"grip strength","score":0.9350000023841858},{"id":"https://openalex.org/keywords/functional-mobility","display_name":"functional mobility","score":0.8240000009536743},{"id":"https://openalex.org/keywords/timed-up-and-go-test","display_name":"Timed Up and Go test","score":0.9559999704360962},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.9549999833106995},{"id":"https://openalex.org/keywords/muscle-strength","display_name":"muscle strength","score":0.6679999828338623},{"id":"https://openalex.org/keywords/microvascular-complications","display_name":"microvascular complications","score":0.5789999961853027},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.6110000014305115},{"id":"https://openalex.org/keywords/waist-and-hip-circumference","display_name":"waist and hip circumference","score":0.6019999980926514},{"id":"https://openalex.org/keywords/body-fat-percentage","display_name":"body fat percentage","score":0.5960000157356262},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.6769999861717224},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9480000138282776},{"id":"https://openalex.org/keywords/albumin-creatinine-ratio","display_name":"albumin-creatinine ratio","score":0.7289999723434448},{"id":"https://openalex.org/keywords/skeletal-muscle-mass","display_name":"skeletal muscle mass","score":0.6700000166893005},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9399999976158142},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.761900007724762},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7203999757766724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5669999718666077},{"id":"https://openalex.org/C33872192","wikidata":"https://www.wikidata.org/wiki/Q864287","display_name":"Bioelectrical impedance analysis","level":3,"score":0.5238000154495239},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.4936000108718872},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.47099998593330383},{"id":"https://openalex.org/C2776255841","wikidata":"https://www.wikidata.org/wiki/Q5647202","display_name":"Hand strength","level":3,"score":0.46299999952316284},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.44999998807907104},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.40560001134872437},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4032000005245209},{"id":"https://openalex.org/C3020110884","wikidata":"https://www.wikidata.org/wiki/Q695416","display_name":"Outpatient clinic","level":2,"score":0.3937000036239624},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.38839998841285706},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.32420000433921814},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3192000091075897},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.31049999594688416},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30709999799728394},{"id":"https://openalex.org/C2988918651","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Muscle strength","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C2992343062","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Muscle mass","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.25609999895095825},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.25279998779296875}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11179153/v1","doi":"https://doi.org/10.21203/rs.3.rs-11179153/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11179153/v1","pdf_url":"https://www.researchsquare.com/article/rs-11179153/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11179153/v1","doi":"https://doi.org/10.21203/rs.3.rs-11179153/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11179153/v1","pdf_url":"https://www.researchsquare.com/article/rs-11179153/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225645785.pdf","grobid_xml":"https://content.openalex.org/works/W7225645785.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1630194903","https://openalex.org/W1982152979","https://openalex.org/W2027839256","https://openalex.org/W2039177386","https://openalex.org/W2059614742","https://openalex.org/W2124482078","https://openalex.org/W2127873216","https://openalex.org/W2529935764","https://openalex.org/W2606561303","https://openalex.org/W2790284551","https://openalex.org/W2912769729","https://openalex.org/W2999164781","https://openalex.org/W3023731634","https://openalex.org/W3092692788","https://openalex.org/W3135408183","https://openalex.org/W3153479957"],"related_works":["https://openalex.org/W4407364772","https://openalex.org/W2769247146","https://openalex.org/W2096204066","https://openalex.org/W4406091110","https://openalex.org/W4213169800","https://openalex.org/W2787034811","https://openalex.org/W2507012646","https://openalex.org/W3091882873","https://openalex.org/W2052732133","https://openalex.org/W4385957047"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,17,52,62,99,107,126,150,154,169,189,206,240,281,304,313,315,321,356],"objective:":[3],"Diabetic":[4],"nephropathy":[5,33,130,268,339,347,371],"is":[6],"a":[7,72,133,351,357,364],"frequent":[8],"microvascular":[9],"complication":[10],"of":[11,25,32,85,117,198,201,208,338,345,354,360,385],"type":[12],"2":[13],"diabetes":[14,42,239,283],"mellitus":[15,330],"(T2DM),":[16],"both":[18,220],"conditions":[19],"have":[20],"been":[21],"linked":[22],"to":[23,35,69,113],"loss":[24,80],"muscle":[26,75,86,319],"strength":[27,79,163,215,296,336],"(dynapenia).":[28],"Whether":[29],"the":[30,36,151,177,256,266,292,342],"presence":[31,344],"adds":[34],"muscle-strength":[37],"deficit":[38],"already":[39],"associated":[40,332,349],"with":[41,59,64,71,122,128,180,203,210,251,299,317,333,350],"remains":[43],"incompletely":[44],"defined.":[45],"We":[46],"compared":[47],"handgrip":[48,148,162,214,295,335],"strength,":[49],"functional":[50,368,375,386],"mobility":[51,369],"body":[53,300],"composition":[54],"among":[55],"healthy":[56,119],"controls,":[57,120,199],"patients":[58,63,121,127,202,209,381],"isolated":[60,204,238,282],"T2DM,":[61,205],"diabetic":[65,129,211,221,246,258,267,346,380],"nephropathy,":[66,125],"restricting":[67],"enrollment":[68],"individuals":[70],"preserved":[73],"skeletal":[74,318],"mass":[76,87,301],"so":[77],"that":[78],"could":[81],"be":[82],"evaluated":[83],"independently":[84],"loss.":[88],"Methods":[89],"In":[90],"this":[91],"single-center,":[92],"cross-sectional,":[93],"descriptive-analytical":[94],"study":[95],"conducted":[96],"between":[97,255],"February":[98],"April":[100],"2024,":[101],"117":[102],"adults":[103],"attending":[104],"family":[105],"medicine":[106],"nephrology":[108],"outpatient":[109],"clinics":[110],"were":[111],"allocated":[112],"three":[114],"equal":[115],"groups":[116,222],"39:":[118],"T2DM":[123],"without":[124],"(defined":[131],"by":[132],"urine":[134],"albumin-to-creatinine":[135],"ratio":[136],">":[137],"300":[138],"mg/g).":[139],"All":[140],"participants":[141],"underwent":[142],"laboratory":[143],"testing,":[144],"bioelectrical":[145],"impedance":[146],"analysis,":[147],"dynamometry":[149],"Timed":[152],"Up":[153],"Go":[155],"(TUG)":[156],"test.":[157],"Dynapenia":[158,193],"was":[159,194,216,262,331,348],"defined":[160],"as":[161],"below":[164],"28.5":[165],"kg":[166,171,229,236,244],"in":[167,172,196,219,224,230,237,245,265,275],"men":[168],"18.5":[170],"women.":[173],"Group":[174],"comparisons":[175],"used":[176],"Kruskal-Wallis":[178],"test":[179],"Bonferroni":[181],"post-hoc":[182],"correction,":[183],"chi-square":[184],"or":[185],"Fisher's":[186],"exact":[187],"tests,":[188],"Spearman":[190],"correlation.":[191],"Results":[192],"present":[195],"0%":[197],"28.2%":[200],"38.5%":[207],"nephropathy.":[212],"Mean":[213],"significantly":[217,263],"lower":[218],"than":[223,274],"controls":[225,231,276],"(31.85":[226],"\u00b1":[227,234,242,271,278,285],"8.58":[228],"vs":[232],"26.25":[233],"8.97":[235],"24.95":[241],"7.17":[243],"nephropathy;":[247],"p":[248,288,325],"=":[249],"0.001),":[250],"no":[252],"significant":[253],"difference":[254],"two":[257],"groups.":[259],"TUG":[260,307,361],"duration":[261],"longer":[264],"group":[269],"(13.73":[270],"1.49":[272],"s)":[273,280],"(10.48":[277],"1.4":[279],"(11.31":[284],"1.61":[286],"s;":[287],"<":[289,326],"0.001).":[290],"Across":[291],"whole":[293],"cohort,":[294],"correlated":[297],"inversely":[298],"index,":[302],"waist":[303],"hip":[305],"circumference,":[306],"duration,":[308],"body-fat":[309],"percentage,":[310],"fasting":[311],"glucose":[312],"HbA1c,":[314],"positively":[316],"percentage":[320],"total":[322],"protein":[323],"(all":[324],"0.05).":[327],"Conclusions":[328],"Diabetes":[329],"reduced":[334],"irrespective":[337],"status,":[340],"but":[341],"additional":[343],"higher":[352],"prevalence":[353],"dynapenia":[355],"marked":[358],"prolongation":[359],"performance,":[362],"indicating":[363],"greater":[365],"impact":[366],"on":[367],"once":[370],"develops.":[372],"Simple,":[373],"low-cost":[374],"assessments":[376],"may":[377],"help":[378],"identify":[379],"at":[382],"greatest":[383],"risk":[384],"decline.":[387]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}