{"id":"https://openalex.org/W7225645641","doi":"https://doi.org/10.3389/fcell.2026.1993089","title":"Ultrasound-responsive microbubble platforms in lung cancer: mechanisms, molecular targeting, and therapeutic applications","display_name":"Ultrasound-responsive microbubble platforms in lung cancer: mechanisms, molecular targeting, and therapeutic applications","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225645641","doi":"https://doi.org/10.3389/fcell.2026.1993089"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2026.1993089","doi":"https://doi.org/10.3389/fcell.2026.1993089","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1993089","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1993089/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1993089/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161342230","display_name":"Sanjesh Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101407740","display_name":"Chandigarh University","ror":"https://ror.org/05t4pvx35","country_code":"IN","type":"education","lineage":["https://openalex.org/I101407740"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjesh Kumar","raw_affiliation_strings":["School of Pharmacy, Chandigarh University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Chandigarh University","institution_ids":["https://openalex.org/I101407740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119390294","display_name":"Sambhavi Swarn","orcid":"https://orcid.org/0009-0006-6616-4560","observed_orcids":["https://orcid.org/0009-0006-6616-4560"]},"institutions":[{"id":"https://openalex.org/I110116418","display_name":"Maharaja Sayajirao University of Baroda","ror":"https://ror.org/01bx8ja67","country_code":"IN","type":"education","lineage":["https://openalex.org/I110116418"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sambhavi Swarn","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda","institution_ids":["https://openalex.org/I110116418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085019268","display_name":"Md Ali Mujtaba","orcid":"https://orcid.org/0000-0002-6372-890X","observed_orcids":["https://orcid.org/0000-0002-6372-890X"]},"institutions":[{"id":"https://openalex.org/I118590987","display_name":"Northern Border University","ror":"https://ror.org/03j9tzj20","country_code":"SA","type":"education","lineage":["https://openalex.org/I118590987"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Md Ali Mujtaba","raw_affiliation_strings":["Center for Health Research, Northern Border University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health Research, Northern Border University","institution_ids":["https://openalex.org/I118590987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140805078","display_name":"Mansi Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143247161","display_name":"Babasaheb Bhimrao Ambedkar University","ror":"https://ror.org/04x7ccp17","country_code":"IN","type":"education","lineage":["https://openalex.org/I143247161"]},{"id":"https://openalex.org/I147727580","display_name":"Dr. Bhimrao Ambedkar University","ror":"https://ror.org/00k4ab982","country_code":"IN","type":"education","lineage":["https://openalex.org/I147727580"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mansi Singh","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Baba Saheb Bhimrao Ambedkar University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Baba Saheb Bhimrao Ambedkar University","institution_ids":["https://openalex.org/I143247161","https://openalex.org/I147727580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161318004","display_name":"Manmohan Singhal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114149","display_name":"KR Mangalam University","ror":"https://ror.org/026b9sf88","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210114149"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manmohan Singhal","raw_affiliation_strings":["School of Medical & Allied Sciences, K.R. Mangalam University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical & Allied Sciences, K.R. Mangalam University","institution_ids":["https://openalex.org/I4210114149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031625375","display_name":"Devesh U. Kapoor","orcid":"https://orcid.org/0000-0003-4085-8936","observed_orcids":["https://orcid.org/0000-0003-4085-8936"]},"institutions":[{"id":"https://openalex.org/I4405255592","display_name":"Dr. Dayaram Patel Pharmacy College","ror":"https://ror.org/036dmex16","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405255592"]},{"id":"https://openalex.org/I74319210","display_name":"Chitkara University","ror":"https://ror.org/057d6z539","country_code":"IN","type":"education","lineage":["https://openalex.org/I74319210"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Devesh U. Kapoor","raw_affiliation_strings":["Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University","Dayaram Patel Pharmacy College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University","institution_ids":["https://openalex.org/I74319210"]},{"raw_affiliation_string":"Dayaram Patel Pharmacy College","institution_ids":["https://openalex.org/I4405255592"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5031625375","https://openalex.org/A5085019268"],"corresponding_institution_ids":["https://openalex.org/I118590987","https://openalex.org/I4405255592","https://openalex.org/I74319210"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/theranostics","display_name":"theranostics","score":0.8209999799728394},{"id":"https://openalex.org/keywords/inertial-cavitation","display_name":"inertial cavitation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/sonoporation","display_name":"sonoporation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/acoustic-microstreaming","display_name":"microstreaming","score":0.925000011920929},{"id":"https://openalex.org/keywords/contrast-enhanced-ultrasound","display_name":"contrast-enhanced ultrasound","score":0.6850000023841858},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"molecular imaging","score":0.7379999756813049},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.7279999852180481},{"id":"https://openalex.org/keywords/microrna-delivery","display_name":"microRNA delivery","score":0.6700000166893005},{"id":"https://openalex.org/keywords/oxygen-delivery","display_name":"oxygen delivery","score":0.9509999752044678},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/combined-radiotherapy","display_name":"combined radiotherapy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8149999976158142},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"artificial intelligence","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.6252999901771545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49630001187324524},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4837999939918518},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47189998626708984},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4620000123977661},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.44290000200271606},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.43160000443458557},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.412200003862381},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.392300009727478},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.3806000053882599},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.3750999867916107},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35409998893737793},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3529999852180481},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.34209999442100525},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.3034000098705292},{"id":"https://openalex.org/C2778807442","wikidata":"https://www.wikidata.org/wiki/Q6152005","display_name":"Treatment of lung cancer","level":3,"score":0.2953999936580658},{"id":"https://openalex.org/C2776165368","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Systemic circulation","level":2,"score":0.2913999855518341},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.28949999809265137},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2892000079154968},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.2865999937057495},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2858000099658966},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.26840001344680786},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2603999972343445},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.25679999589920044},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2565999925136566},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.2565000057220459},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.2558000087738037},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.25519999861717224}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fcell.2026.1993089","doi":"https://doi.org/10.3389/fcell.2026.1993089","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1993089","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1993089/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2026.1993089","doi":"https://doi.org/10.3389/fcell.2026.1993089","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1993089","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1993089/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225645641.pdf","grobid_xml":"https://content.openalex.org/works/W7225645641.grobid-xml"},"referenced_works_count":172,"referenced_works":["https://openalex.org/W1475717990","https://openalex.org/W2567449807","https://openalex.org/W2592909192","https://openalex.org/W2954954405","https://openalex.org/W2970819265","https://openalex.org/W2980518780","https://openalex.org/W2992226698","https://openalex.org/W2995584199","https://openalex.org/W3009201719","https://openalex.org/W3012319235","https://openalex.org/W3012485477","https://openalex.org/W3013052141","https://openalex.org/W3013582357","https://openalex.org/W3016907174","https://openalex.org/W3017206848","https://openalex.org/W3030834164","https://openalex.org/W3034471736","https://openalex.org/W3036716598","https://openalex.org/W3047618013","https://openalex.org/W3082417913","https://openalex.org/W3103758115","https://openalex.org/W3111468108","https://openalex.org/W3111904705","https://openalex.org/W3119081011","https://openalex.org/W3137619254","https://openalex.org/W3169031425","https://openalex.org/W3199465333","https://openalex.org/W3209036709","https://openalex.org/W3210793974","https://openalex.org/W3215575708","https://openalex.org/W3216256523","https://openalex.org/W4200441583","https://openalex.org/W4206566668","https://openalex.org/W4210411388","https://openalex.org/W4210781287","https://openalex.org/W4211133027","https://openalex.org/W4212766834","https://openalex.org/W4212827646","https://openalex.org/W4213350848","https://openalex.org/W4220733450","https://openalex.org/W4221018851","https://openalex.org/W4221040717","https://openalex.org/W4223637031","https://openalex.org/W4224122154","https://openalex.org/W4225565073","https://openalex.org/W4281289615","https://openalex.org/W4283025083","https://openalex.org/W4283779648","https://openalex.org/W4285288952","https://openalex.org/W4285493755","https://openalex.org/W4285503322","https://openalex.org/W4289253527","https://openalex.org/W4292181683","https://openalex.org/W4294946291","https://openalex.org/W4295136149","https://openalex.org/W4296467035","https://openalex.org/W4304687646","https://openalex.org/W4306662257","https://openalex.org/W4309245029","https://openalex.org/W4310036708","https://openalex.org/W4310785705","https://openalex.org/W4313648592","https://openalex.org/W4319655899","https://openalex.org/W4319769529","https://openalex.org/W4319925004","https://openalex.org/W4321371253","https://openalex.org/W4322769566","https://openalex.org/W4360798761","https://openalex.org/W4366263431","https://openalex.org/W4376644011","https://openalex.org/W4382138483","https://openalex.org/W4383346896","https://openalex.org/W4384339175","https://openalex.org/W4385494424","https://openalex.org/W4387043909","https://openalex.org/W4387345287","https://openalex.org/W4389795003","https://openalex.org/W4390661688","https://openalex.org/W4391219911","https://openalex.org/W4391322178","https://openalex.org/W4391960446","https://openalex.org/W4392292756","https://openalex.org/W4392380506","https://openalex.org/W4393251580","https://openalex.org/W4393973991","https://openalex.org/W4394606883","https://openalex.org/W4394837444","https://openalex.org/W4395958098","https://openalex.org/W4396871675","https://openalex.org/W4397024078","https://openalex.org/W4399128154","https://openalex.org/W4399149005","https://openalex.org/W4400775714","https://openalex.org/W4402804059","https://openalex.org/W4403040432","https://openalex.org/W4403309412","https://openalex.org/W4403585767","https://openalex.org/W4403626255","https://openalex.org/W4404079665","https://openalex.org/W4404249555","https://openalex.org/W4404330854","https://openalex.org/W4404337253","https://openalex.org/W4404601510","https://openalex.org/W4405246318","https://openalex.org/W4405525814","https://openalex.org/W4405931817","https://openalex.org/W4406860226","https://openalex.org/W4407081084","https://openalex.org/W4407250543","https://openalex.org/W4407582370","https://openalex.org/W4407870822","https://openalex.org/W4407898488","https://openalex.org/W4408198068","https://openalex.org/W4408447615","https://openalex.org/W4409137003","https://openalex.org/W4409162432","https://openalex.org/W4409265789","https://openalex.org/W4409326932","https://openalex.org/W4409381861","https://openalex.org/W4409898891","https://openalex.org/W4410301401","https://openalex.org/W4410304996","https://openalex.org/W4410430994","https://openalex.org/W4410506791","https://openalex.org/W4410743210","https://openalex.org/W4410820377","https://openalex.org/W4411302254","https://openalex.org/W4411457713","https://openalex.org/W4411626637","https://openalex.org/W4412483120","https://openalex.org/W4412587113","https://openalex.org/W4412830578","https://openalex.org/W4413037706","https://openalex.org/W4413105462","https://openalex.org/W4413250305","https://openalex.org/W4413401805","https://openalex.org/W4413875897","https://openalex.org/W4414136702","https://openalex.org/W4414575483","https://openalex.org/W4414838083","https://openalex.org/W4414960226","https://openalex.org/W4414979082","https://openalex.org/W4415094988","https://openalex.org/W4415560573","https://openalex.org/W4415928737","https://openalex.org/W4416734829","https://openalex.org/W4416939152","https://openalex.org/W4417195090","https://openalex.org/W7116738255","https://openalex.org/W7117248151","https://openalex.org/W7124898243","https://openalex.org/W7125955112","https://openalex.org/W7126099892","https://openalex.org/W7126231211","https://openalex.org/W7128927859","https://openalex.org/W7134240094","https://openalex.org/W7137339884","https://openalex.org/W7138063962","https://openalex.org/W7141759964","https://openalex.org/W7147352718","https://openalex.org/W7152024959","https://openalex.org/W7160942005","https://openalex.org/W7161554195","https://openalex.org/W7164849311","https://openalex.org/W7164986242","https://openalex.org/W7168284604","https://openalex.org/W7169713260","https://openalex.org/W7172411023","https://openalex.org/W7172537358","https://openalex.org/W7203719269","https://openalex.org/W7213463733","https://openalex.org/W7213583280"],"related_works":["https://openalex.org/W4403419591","https://openalex.org/W2583258708","https://openalex.org/W2037221334","https://openalex.org/W2265383182","https://openalex.org/W2891912903","https://openalex.org/W2995452531","https://openalex.org/W2393062819","https://openalex.org/W2048613059","https://openalex.org/W2219941652","https://openalex.org/W2006926663"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,72],"remains":[2],"a":[3],"major":[4],"cause":[5],"of":[6,29,43,46,67,92,101,114,149],"cancer-related":[7],"mortality,":[8],"while":[9],"the":[10,27,59,150],"heterogeneous":[11],"tumor":[12,96,115,151],"microenvironment,":[13],"abnormal":[14],"vasculature,":[15],"elevated":[16],"interstitial":[17],"fluid":[18],"pressure,":[19],"hypoxia,":[20],"and":[21,64,74,82,89,111,129,146,172,179,186],"dense":[22],"extracellular":[23],"matrix":[24],"substantially":[25],"limit":[26],"efficacy":[28],"conventional":[30],"systemic":[31],"therapies.":[32],"Ultrasound-responsive":[33],"microbubbles":[34],"(MBs)":[35],"have":[36],"emerged":[37],"as":[38],"versatile":[39],"theranostic":[40],"platforms":[41,182],"capable":[42],"overcoming":[44],"several":[45],"these":[47],"delivery":[48],"barriers":[49],"through":[50],"externally":[51],"controlled":[52],"acoustic":[53,161],"cavitation.":[54],"This":[55],"review":[56,138],"comprehensively":[57],"discusses":[58,140],"evolution,":[60],"physicochemical":[61],"characteristics,":[62],"composition,":[63],"functional":[65],"mechanisms":[66],"MB-based":[68],"systems":[69],"for":[70,104,192],"lung":[71,193],"diagnosis":[73],"therapy.":[75],"Particular":[76],"emphasis":[77],"is":[78,117],"placed":[79],"on":[80],"stable":[81],"inertial":[83],"cavitation,":[84],"sonoporation,":[85],"microstreaming,":[86],"vascular":[87],"permeabilization,":[88],"enhanced":[90],"transport":[91],"therapeutic":[93],"agents":[94],"into":[95],"tissue.":[97],"The":[98,137],"diagnostic":[99],"potential":[100],"targeted":[102,142],"MBs":[103],"contrast-enhanced":[105],"ultrasound,":[106],"molecular":[107],"imaging,":[108],"perfusion":[109],"assessment,":[110],"super-resolution":[112],"visualization":[113],"vasculature":[116],"highlighted.":[118],"Therapeutic":[119],"applications":[120],"encompassing":[121],"chemotherapeutics,":[122],"nucleic":[123],"acids,":[124],"microRNAs,":[125],"oxygen":[126],"delivery,":[127],"immunotherapy,":[128],"combination":[130],"strategies":[131],"with":[132],"radiotherapy":[133],"are":[134],"critically":[135],"examined.":[136],"also":[139],"molecularly":[141],"MBs,":[143],"nanoparticle\u2013MB":[144],"hybrids,":[145],"ultrasound-triggered":[147],"modulation":[148],"immune":[152],"microenvironment.":[153],"Despite":[154],"promising":[155],"preclinical":[156],"outcomes,":[157],"challenges":[158],"involving":[159],"pulmonary":[160],"attenuation,":[162],"short":[163],"circulation":[164],"time,":[165],"biodistribution,":[166],"treatment":[167],"parameter":[168],"standardization,":[169],"manufacturing,":[170],"safety,":[171],"regulatory":[173],"requirements":[174],"remain.":[175],"Emerging":[176],"theranostic,":[177],"hybrid,":[178],"artificial":[180],"intelligence-assisted":[181],"may":[183],"facilitate":[184],"personalized":[185],"clinically":[187],"translatable":[188],"microbubble-based":[189],"precision":[190],"therapy":[191],"cancer.":[194]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}