{"id":"https://openalex.org/W7225644251","doi":"https://doi.org/10.21203/rs.3.rs-11244820/v1","title":"Pharmacological enhancement of 20S proteasome-mediated degradation exposes a vulnerability in human papillomavirus (HPV)-driven cervical cancer","display_name":"Pharmacological enhancement of 20S proteasome-mediated degradation exposes a vulnerability in human papillomavirus (HPV)-driven cervical cancer","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225644251","doi":"https://doi.org/10.21203/rs.3.rs-11244820/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11244820/v1","doi":"https://doi.org/10.21203/rs.3.rs-11244820/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11244820/v1","pdf_url":"https://www.researchsquare.com/article/rs-11244820/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11244820/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059724481","display_name":"Jetze J. Tepe","orcid":"https://orcid.org/0000-0001-5467-5589","observed_orcids":["https://orcid.org/0000-0001-5467-5589"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jetze Tepe","raw_affiliation_strings":["University of Virginia"],"raw_orcid":"https://orcid.org/0000-0001-5467-5589","affiliations":[{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105845956","display_name":"Shannon Cartwright","orcid":"https://orcid.org/0009-0009-5946-6351","observed_orcids":["https://orcid.org/0009-0009-5946-6351"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Cartwright","raw_affiliation_strings":["University of Virginia"],"raw_orcid":"https://orcid.org/0009-0009-5946-6351","affiliations":[{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161360842","display_name":"Linh Le","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linh Le","raw_affiliation_strings":["University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119547094","display_name":"Allison Carranza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Carranza","raw_affiliation_strings":["University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161350916","display_name":"Kate Hartnett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate Hartnett","raw_affiliation_strings":["University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088230911","display_name":"Bahareh Ghaffari","orcid":"https://orcid.org/0000-0003-0126-334X","observed_orcids":["https://orcid.org/0000-0003-0126-334X"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bahareh Ghaffari","raw_affiliation_strings":["Michigan State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan State University","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102672087","display_name":"Yue Dou","orcid":"https://orcid.org/0009-0003-5557-0852","observed_orcids":["https://orcid.org/0009-0003-5557-0852"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Dou","raw_affiliation_strings":["University of Virginia"],"raw_orcid":"https://orcid.org/0009-0003-5557-0852","affiliations":[{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117735065","display_name":"Guruprasad Varma Konduru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guruprasad Konduru","raw_affiliation_strings":["University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068687737","display_name":"Pankaj Kumar","orcid":"https://orcid.org/0000-0002-8702-8879","observed_orcids":["https://orcid.org/0000-0002-8702-8879"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pankaj Kumar","raw_affiliation_strings":["University of Virginia"],"raw_orcid":"https://orcid.org/0000-0002-8702-8879","affiliations":[{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161317010","display_name":"Tian Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tian Zhang","raw_affiliation_strings":["University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.1324000060558319,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8880000114440918},{"id":"https://openalex.org/keywords/20s-proteasome","display_name":"20S proteasome","score":0.9779999852180481},{"id":"https://openalex.org/keywords/proteasome-activation","display_name":"proteasome activation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/hpv-e6","display_name":"E6 oncoprotein","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hpv-e7","display_name":"E7 oncoprotein","score":1.0},{"id":"https://openalex.org/keywords/ubiquitin-independent-degradation","display_name":"ubiquitin-independent degradation","score":0.875},{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.9100000262260437},{"id":"https://openalex.org/keywords/p53-degradation","display_name":"p53 degradation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.6050000190734863},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.5680000185966492},{"id":"https://openalex.org/keywords/therapeutic-vulnerabilities","display_name":"therapeutic vulnerabilities","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.8295000195503235},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.5817000269889832},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.5806000232696533},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5737000107765198},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.49630001187324524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4772000014781952},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.45329999923706055},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4499000012874603},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.44519999623298645},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43230000138282776},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.42010000348091125},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40630000829696655},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.4009999930858612},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.38940000534057617},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.38420000672340393},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.37139999866485596},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.34929999709129333},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.34459999203681946},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3359000086784363},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3257000148296356},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3206000030040741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3043000102043152},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.296099990606308},{"id":"https://openalex.org/C2909762590","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene Proteins","level":4,"score":0.2824000120162964},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.28060001134872437},{"id":"https://openalex.org/C2780009117","wikidata":"https://www.wikidata.org/wiki/Q900189","display_name":"HPV vaccines","level":5,"score":0.2768999934196472},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.27320000529289246},{"id":"https://openalex.org/C2780879997","wikidata":"https://www.wikidata.org/wiki/Q952587","display_name":"Viral protein","level":3,"score":0.26010000705718994}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11244820/v1","doi":"https://doi.org/10.21203/rs.3.rs-11244820/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11244820/v1","pdf_url":"https://www.researchsquare.com/article/rs-11244820/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11244820/v1","doi":"https://doi.org/10.21203/rs.3.rs-11244820/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11244820/v1","pdf_url":"https://www.researchsquare.com/article/rs-11244820/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225644251.pdf","grobid_xml":"https://content.openalex.org/works/W7225644251.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1967880683","https://openalex.org/W1972651021","https://openalex.org/W1983110751","https://openalex.org/W1992976870","https://openalex.org/W1993253909","https://openalex.org/W2001381770","https://openalex.org/W2010457001","https://openalex.org/W2012599889","https://openalex.org/W2013339424","https://openalex.org/W2023329572","https://openalex.org/W2024627774","https://openalex.org/W2044307399","https://openalex.org/W2053542738","https://openalex.org/W2062234623","https://openalex.org/W2076984061","https://openalex.org/W2078679356","https://openalex.org/W2092710982","https://openalex.org/W2103583298","https://openalex.org/W2116356926","https://openalex.org/W2124420768","https://openalex.org/W2133927986","https://openalex.org/W2136707718","https://openalex.org/W2138216581","https://openalex.org/W2169787292","https://openalex.org/W2214074259","https://openalex.org/W2325329016","https://openalex.org/W2402362653","https://openalex.org/W2412832033","https://openalex.org/W2587676626","https://openalex.org/W2592937673","https://openalex.org/W2614497882","https://openalex.org/W2761249894","https://openalex.org/W2806339429","https://openalex.org/W2807767253","https://openalex.org/W2890394402","https://openalex.org/W2893323080","https://openalex.org/W2922513613","https://openalex.org/W2938352153","https://openalex.org/W2944917021","https://openalex.org/W2949713887","https://openalex.org/W2962823170","https://openalex.org/W3001262658","https://openalex.org/W3002503982","https://openalex.org/W3012843216","https://openalex.org/W3111188267","https://openalex.org/W3167370391","https://openalex.org/W3175752499","https://openalex.org/W3194801911","https://openalex.org/W3200328701","https://openalex.org/W3217462642","https://openalex.org/W4220699429","https://openalex.org/W4224231151","https://openalex.org/W4306156038","https://openalex.org/W4362594610","https://openalex.org/W4366609202","https://openalex.org/W4389787847","https://openalex.org/W4391897124","https://openalex.org/W4398193136","https://openalex.org/W4399327884","https://openalex.org/W4399566482","https://openalex.org/W4406780607","https://openalex.org/W7120115855"],"related_works":["https://openalex.org/W4408930715","https://openalex.org/W4409631344","https://openalex.org/W2002115764","https://openalex.org/W2321751614","https://openalex.org/W2981437601","https://openalex.org/W2075543278","https://openalex.org/W2275319121","https://openalex.org/W2257710780","https://openalex.org/W4414299887","https://openalex.org/W3035116989"],"abstract_inverted_index":{"Abstract":[0],"Abstract:":[1],"Despite":[2],"the":[3,43,66,84,102,110,127],"availability":[4],"of":[5,35,42,68,113,126,146,156,177],"prophylactic":[6],"vaccines":[7],"against":[8],"human":[9],"papillomavirus":[10],"(HPV),":[11],"infection":[12],"and":[13,27,47,119,132,144,165,180],"subsequent":[14],"cervical":[15],"cancer":[16],"remain":[17],"a":[18,79,98,130,173,186],"significant":[19],"global":[20],"health":[21],"problem.":[22],"HPV":[23,91,117,178],"viral":[24,92],"oncoproteins":[25,179],"E6":[26,118],"E7":[28,120],"drive":[29],"oncogenesis,":[30],"in":[31,97,129],"part":[32],"through":[33,83,101],"disruption":[34],"cell":[36,151],"growth":[37],"control":[38],"pathways":[39,158],"via":[40],"degradation":[41],"tumor":[44],"suppressors":[45],"p53":[46],"pRB,":[48],"respectively.":[49],"These":[50],"proteins":[51,73,93],"contain":[52],"intrinsically":[53],"disordered":[54],"regions":[55],"that":[56,89,109],"enable":[57],"interactions":[58],"with":[59,78,162],"multiple":[60],"cellular":[61],"targets":[62],"but":[63],"also":[64,107],"complicate":[65],"development":[67],"conventional":[69],"therapeutics.":[70],"While":[71],"these":[72,90,170],"have":[74],"previously":[75,174],"been":[76],"associated":[77],"ubiquitin-dependent":[80],"clearance":[81],"mechanism":[82],"26S":[85],"proteasome,":[86],"we":[87],"show":[88,108],"can":[94],"be":[95],"degraded":[96],"ubiquitin-independent":[99],"method":[100],"20S":[103,135,182],"proteasome":[104,136,183],"alone.":[105],"We":[106],"small":[111],"molecule-enhancement":[112],"this":[114],"protease":[115],"reduces":[116],"protein":[121],"levels":[122],"across":[123],"high-risk":[124],"strains":[125],"virus":[128],"proteasome-dependent":[131],"transcription-independent":[133],"manner.":[134],"activation":[137,184],"suppressed":[138],"HPV-driven":[139],"phenotypes,":[140],"including":[141,159],"reduced":[142,163],"proliferation":[143],"restoration":[145],"cell-cycle":[147],"regulatory":[148],"signaling.":[149,168],"Whole":[150],"proteomic":[152],"analysis":[153],"revealed":[154],"remodeling":[155],"cancer-associated":[157],"shifts":[160],"consistent":[161],"proliferative":[164],"oncogenic":[166],"metabolic":[167],"Collectively,":[169],"findings":[171],"identify":[172],"unrecognized":[175],"vulnerability":[176],"establish":[181],"as":[185],"potential":[187],"therapeutic":[188],"strategy":[189],"for":[190],"HPV-associated":[191],"cancers.":[192]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
