{"id":"https://openalex.org/W7225644174","doi":"https://doi.org/10.21203/rs.3.rs-11346624/v1","title":"Glabranin counteracts MAFLD by stimulating liver lipid catabolism via the PKA-AMPK axis","display_name":"Glabranin counteracts MAFLD by stimulating liver lipid catabolism via the PKA-AMPK axis","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225644174","doi":"https://doi.org/10.21203/rs.3.rs-11346624/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11346624/v1","doi":"https://doi.org/10.21203/rs.3.rs-11346624/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11346624/v1","pdf_url":"https://www.researchsquare.com/article/rs-11346624/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11346624/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080147546","display_name":"Hind Moukham","orcid":"https://orcid.org/0000-0002-1122-921X","observed_orcids":["https://orcid.org/0000-0002-1122-921X"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Hind Moukham","raw_affiliation_strings":["University of Milano-Bicocca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milano-Bicocca","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114389592","display_name":"Giorgia Spandri","orcid":"https://orcid.org/0009-0009-9251-110X","observed_orcids":["https://orcid.org/0009-0009-9251-110X"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgia Spandri","raw_affiliation_strings":["University of Milano-Bicocca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milano-Bicocca","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077029773","display_name":"Daniela Beghelli","orcid":"https://orcid.org/0000-0002-4935-7874","observed_orcids":["https://orcid.org/0000-0002-4935-7874"]},"institutions":[{"id":"https://openalex.org/I112859197","display_name":"Universit\u00e0 di Camerino","ror":"https://ror.org/0005w8d69","country_code":"IT","type":"education","lineage":["https://openalex.org/I112859197"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Beghelli","raw_affiliation_strings":["Universit\u00e0 di Camerino"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e0 di Camerino","institution_ids":["https://openalex.org/I112859197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043587003","display_name":"Valentina Santoro","orcid":"https://orcid.org/0000-0003-0859-8230","observed_orcids":["https://orcid.org/0000-0003-0859-8230"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Santoro","raw_affiliation_strings":["University of Salerno"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Salerno","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034881174","display_name":"Simona Serio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Serio","raw_affiliation_strings":["University of Salerno"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Salerno","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019999127","display_name":"Anna Lisa Piccinelli","orcid":"https://orcid.org/0000-0001-6102-2762","observed_orcids":["https://orcid.org/0000-0001-6102-2762"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Lisa Piccinelli","raw_affiliation_strings":["University of Salerno"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Salerno","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078641625","display_name":"Elisa Maffioli","orcid":"https://orcid.org/0000-0002-5539-1825","observed_orcids":["https://orcid.org/0000-0002-5539-1825"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Maffioli","raw_affiliation_strings":["University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071561699","display_name":"Gabriella Tedeschi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriella Tedeschi","raw_affiliation_strings":["University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034281716","display_name":"Massimo Labra","orcid":"https://orcid.org/0000-0003-1065-5804","observed_orcids":["https://orcid.org/0000-0003-1065-5804"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Labra","raw_affiliation_strings":["University of Milano-Bicocca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milano-Bicocca","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017165246","display_name":"Bianca Schrul","orcid":"https://orcid.org/0009-0000-4823-2570","observed_orcids":["https://orcid.org/0009-0000-4823-2570"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bianca Schrul","raw_affiliation_strings":["Saarland University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saarland University","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025769567","display_name":"Farida Tripodi","orcid":"https://orcid.org/0000-0003-1246-979X","observed_orcids":["https://orcid.org/0000-0003-1246-979X"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Farida Tripodi","raw_affiliation_strings":["University of Milano-Bicocca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milano-Bicocca","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037747320","display_name":"Paola Coccetti","orcid":"https://orcid.org/0000-0001-5898-5883","observed_orcids":["https://orcid.org/0000-0001-5898-5883"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Coccetti","raw_affiliation_strings":["University of Milano-Bicocca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milano-Bicocca","institution_ids":["https://openalex.org/I66752286"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lipophagy","display_name":"lipophagy","score":0.906000018119812},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mitochondrial-fatty-acid-beta-oxidation","display_name":"mitochondrial beta-oxidation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nrf2-antioxidant-response","display_name":"Nrf2 antioxidant response","score":0.9670000076293945},{"id":"https://openalex.org/keywords/prenylated-flavanones","display_name":"prenylated flavanones","score":0.8429999947547913},{"id":"https://openalex.org/keywords/licorice","display_name":"licorice","score":0.9879999756813049},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7710000276565552},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8299999833106995},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6378999948501587},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.5485000014305115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4837999939918518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4661000072956085},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4648999869823456},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4641000032424927},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.45179998874664307},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.43059998750686646},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4269999861717224},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4004000127315521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39980000257492065},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.3716000020503998},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.36309999227523804},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.35580000281333923},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.35010001063346863},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.3474000096321106},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.34630000591278076},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.3346000015735626},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.32910001277923584},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.32100000977516174},{"id":"https://openalex.org/C54174078","wikidata":"https://www.wikidata.org/wiki/Q3197188","display_name":"Kinome","level":3,"score":0.31869998574256897},{"id":"https://openalex.org/C2994476132","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid oxidation","level":3,"score":0.31189998984336853},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.3052999973297119},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.30379998683929443},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C2778435403","wikidata":"https://www.wikidata.org/wiki/Q243309","display_name":"Carnitine","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.26440000534057617}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11346624/v1","doi":"https://doi.org/10.21203/rs.3.rs-11346624/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11346624/v1","pdf_url":"https://www.researchsquare.com/article/rs-11346624/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11346624/v1","doi":"https://doi.org/10.21203/rs.3.rs-11346624/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11346624/v1","pdf_url":"https://www.researchsquare.com/article/rs-11346624/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320323322","display_name":"Universit\u00e4t des Saarlandes","ror":"https://ror.org/01jdpyv68"},{"id":"https://openalex.org/F7311471023","display_name":"NextGenerationEU","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225644174.pdf","grobid_xml":"https://content.openalex.org/works/W7225644174.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W593333272","https://openalex.org/W1942089699","https://openalex.org/W1966339676","https://openalex.org/W1970637701","https://openalex.org/W1974560613","https://openalex.org/W1984658969","https://openalex.org/W1997901667","https://openalex.org/W2007867750","https://openalex.org/W2040200224","https://openalex.org/W2062812115","https://openalex.org/W2070021310","https://openalex.org/W2091049385","https://openalex.org/W2124420768","https://openalex.org/W2128051015","https://openalex.org/W2144600435","https://openalex.org/W2154587590","https://openalex.org/W2215535790","https://openalex.org/W2345648062","https://openalex.org/W2551107256","https://openalex.org/W2616648530","https://openalex.org/W2623250002","https://openalex.org/W2729569907","https://openalex.org/W2734724639","https://openalex.org/W2737660124","https://openalex.org/W2741201317","https://openalex.org/W2748137738","https://openalex.org/W2783075722","https://openalex.org/W2802837323","https://openalex.org/W2889932786","https://openalex.org/W2891417207","https://openalex.org/W2911512568","https://openalex.org/W2917101543","https://openalex.org/W2918862857","https://openalex.org/W2939895909","https://openalex.org/W2942695470","https://openalex.org/W2947765622","https://openalex.org/W2950526259","https://openalex.org/W2983332157","https://openalex.org/W2984524859","https://openalex.org/W3002312315","https://openalex.org/W3081463887","https://openalex.org/W3097333890","https://openalex.org/W3108936441","https://openalex.org/W3116080770","https://openalex.org/W3122988712","https://openalex.org/W3126288346","https://openalex.org/W3145969289","https://openalex.org/W3157134902","https://openalex.org/W3167938297","https://openalex.org/W3196740623","https://openalex.org/W3202962880","https://openalex.org/W4214491113","https://openalex.org/W4225708294","https://openalex.org/W4308834893","https://openalex.org/W4311089428","https://openalex.org/W4317569193","https://openalex.org/W4376615921","https://openalex.org/W4385278824","https://openalex.org/W4385613148","https://openalex.org/W4387009529","https://openalex.org/W4390821965","https://openalex.org/W4391176028","https://openalex.org/W4395665870","https://openalex.org/W4396608370","https://openalex.org/W4400812073","https://openalex.org/W4400917750","https://openalex.org/W4402700500","https://openalex.org/W4408554653","https://openalex.org/W4412631326","https://openalex.org/W4413117974","https://openalex.org/W4416729263","https://openalex.org/W7118874986","https://openalex.org/W7129279770","https://openalex.org/W7154586058","https://openalex.org/W7155000768","https://openalex.org/W7164498023","https://openalex.org/W7168298438","https://openalex.org/W7203453115"],"related_works":["https://openalex.org/W4412599628","https://openalex.org/W7134889116","https://openalex.org/W7169072274","https://openalex.org/W7204619244","https://openalex.org/W4407743723","https://openalex.org/W7223781758","https://openalex.org/W4410089408","https://openalex.org/W7225612521","https://openalex.org/W2160730167","https://openalex.org/W4409525464"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Metabolic":[2],"dysfunction-associated":[3],"fatty":[4,227],"liver":[5,13],"disease":[6],"(MAFLD)":[7],"is":[8],"the":[9,25,32,130,217,255],"most":[10],"prevalent":[11],"chronic":[12],"disorder":[14],"worldwide":[15],"and":[16,35,54,71,74,90,99,123,145,150,159,188,230,242,257,262],"remains":[17],"without":[18],"effective":[19],"pharmacological":[20],"interventions":[21],"capable":[22],"of":[23,38,40,58,84,129,138,166,216,259],"targeting":[24],"underlying":[26],"metabolic":[27,91,157,164,196,207],"dysfunction.":[28],"Here,":[29],"we":[30],"investigated":[31],"therapeutic":[33],"potential":[34],"molecular":[36],"mechanisms":[37],"action":[39],"glabranin,":[41],"a":[42,173,204,251,264],"prenylated":[43],"flavanone":[44],"isolated":[45],"from":[46],"Glycyrrhiza":[47],"glabra":[48],"leaves,":[49],"in":[50,52,55,64,75,110,118,170,238,240,243],"complementary":[51],"vitro":[53,241],"vivo":[56,171,244],"models":[57],"steatosis.":[59],"Methods:":[60],"Steatosis":[61],"was":[62],"induced":[63],"HepG2":[65,113],"cells":[66],"by":[67,135],"exposure":[68],"to":[69],"oleic":[70],"palmitic":[72],"acids,":[73],"Drosophila":[76],"melanogaster":[77,177],"through":[78,214],"high-fat":[79,174],"diet":[80],"feeding.":[81],"The":[82,163],"effects":[83],"glabranin":[85,142,167,202,233,249],"on":[86],"lipid":[87,107,183,212,223],"droplets":[88,108,224],"accumulation":[89,109],"homeostasis":[92],"were":[93,168],"evaluated":[94],"using":[95,172],"integrated":[96],"phenotypic,":[97],"proteomic,":[98],"kinome":[100,124],"analyses.":[101],"Results:":[102],"Glabranin":[103,179],"markedly":[104],"reduced":[105],"intracellular":[106],"oleic/palmitic":[111],"acid-overloaded":[112],"cells,":[114],"as":[115,117,203,250],"well":[116],"Huh7":[119],"cells.":[120],"Integrated":[121],"proteomic":[122],"profiling":[125],"revealed":[126],"robust":[127],"activation":[128,215],"cAMP-PKA-AMPK":[131,218],"signaling":[132],"axis,":[133],"accompanied":[134],"coordinated":[136],"induction":[137],"lipid-catabolic":[139],"pathways.":[140,197],"Mechanistically,":[141],"enhanced":[143],"lipolysis":[144],"lipophagy,":[146],"promoted":[147],"mitochondrial":[148,226],"\u03b2-oxidation,":[149],"stimulated":[151],"NRF2-dependent":[152],"antioxidant":[153,231],"responses,":[154],"thereby":[155],"restoring":[156],"flexibility":[158],"reducing":[160],"lipotoxic":[161],"stress.":[162],"benefits":[165],"confirmed":[169],"diet-induced":[175],"D.":[176],"model.":[178],"supplementation":[180],"significantly":[181],"decreased":[182],"accumulation,":[184],"restored":[185],"locomotor":[186],"performance,":[187],"improved":[189],"survival,":[190],"demonstrating":[191],"efficacy":[192],"across":[193],"evolutionarily":[194],"conserved":[195],"Conclusions:":[198],"Our":[199],"findings":[200],"identify":[201],"previously":[205],"unrecognized":[206],"modulator":[208],"that":[209],"reprograms":[210],"hepatic":[211],"metabolism":[213],"network.":[219],"By":[220],"simultaneously":[221],"enhancing":[222],"clearance,":[225],"acid":[228],"utilization,":[229],"defense,":[232],"effectively":[234],"counteracts":[235],"steatotic":[236],"state":[237],"both":[239],"models.":[245],"These":[246],"results":[247],"position":[248],"promising":[252],"candidate":[253],"for":[254,267],"prevention":[256],"treatment":[258],"early-stage":[260],"MAFLD":[261],"provide":[263],"strong":[265],"rationale":[266],"its":[268],"further":[269],"preclinical":[270],"development.":[271]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}