{"id":"https://openalex.org/W7225641371","doi":"https://doi.org/10.1038/s44161-026-00910-7","title":"A transient modified mRNA encoding Myc and cyclin T1 improves cardiac function after myocardial injury","display_name":"A transient modified mRNA encoding Myc and cyclin T1 improves cardiac function after myocardial injury","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225641371","doi":"https://doi.org/10.1038/s44161-026-00910-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/43003910"},"language":"en","primary_location":{"id":"doi:10.1038/s44161-026-00910-7","doi":"https://doi.org/10.1038/s44161-026-00910-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44161-026-00910-7","pdf_url":"https://www.nature.com/articles/s44161-026-00910-7.pdf","source":{"id":"https://openalex.org/S4210241135","display_name":"Nature Cardiovascular Research","issn_l":"2731-0590","issn":["2731-0590"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s44161-026-00910-7.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080546794","display_name":"Aleksandra Boikova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aleksandra Boikova","raw_affiliation_strings":["Department of Pharmacology, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061787466","display_name":"Gregory A. Quaife-Ryan","orcid":"https://orcid.org/0000-0002-0012-9934","observed_orcids":["https://orcid.org/0000-0002-0012-9934"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]},{"id":"https://openalex.org/I4210125554","display_name":"Prince Charles Hospital","ror":"https://ror.org/02cetwy62","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131","https://openalex.org/I4210125554"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gregory A. Quaife-Ryan","raw_affiliation_strings":["Prince Charles Hospital, Chermside, Queensland, Australia","QIMR Berghofer, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Charles Hospital, Chermside, Queensland, Australia","institution_ids":["https://openalex.org/I4210125554"]},{"raw_affiliation_string":"QIMR Berghofer, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059117680","display_name":"Christopher A. P. Batho","orcid":"https://orcid.org/0000-0002-4687-3101","observed_orcids":["https://orcid.org/0000-0002-4687-3101"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]},{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801782436","display_name":"The Gurdon Institute","ror":"https://ror.org/00fp3ce15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I2801782436","https://openalex.org/I87048295"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Christopher A. P. Batho","raw_affiliation_strings":["Department of Pharmacology, University of Cambridge, Cambridge, UK","Gurdon Institute, University of Cambridge, Cambridge, UK","QIMR Berghofer, Brisbane, Queensland, Australia","School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Gurdon Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801782436"]},{"raw_affiliation_string":"QIMR Berghofer, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I217937681"]},{"raw_affiliation_string":"School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093006458","display_name":"Rowda Dahir","orcid":"https://orcid.org/0009-0005-0030-1182","observed_orcids":["https://orcid.org/0009-0005-0030-1182"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801782436","display_name":"The Gurdon Institute","ror":"https://ror.org/00fp3ce15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I2801782436","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rowda Dahir","raw_affiliation_strings":["Department of Pharmacology, University of Cambridge, Cambridge, UK","Gurdon Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Gurdon Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801782436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032331281","display_name":"Henrietta Csern\u00e9 Szappanos","orcid":"https://orcid.org/0000-0003-0063-257X","observed_orcids":["https://orcid.org/0000-0003-0063-257X"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Henrietta Cserne Szappanos","raw_affiliation_strings":["QIMR Berghofer, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091561104","display_name":"Harley Robinson","orcid":"https://orcid.org/0000-0002-9374-5532","observed_orcids":["https://orcid.org/0000-0002-9374-5532"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Harley Robinson","raw_affiliation_strings":["QIMR Berghofer, Brisbane, Queensland, Australia"],"raw_orcid":"https://orcid.org/0000-0002-9374-5532","affiliations":[{"raw_affiliation_string":"QIMR Berghofer, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073011331","display_name":"Elsa Lawrence","orcid":"https://orcid.org/0000-0003-4280-0367","observed_orcids":["https://orcid.org/0000-0003-4280-0367"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801782436","display_name":"The Gurdon Institute","ror":"https://ror.org/00fp3ce15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I2801782436","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elsa Lawrence","raw_affiliation_strings":["Department of Pharmacology, University of Cambridge, Cambridge, UK","Gurdon Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Gurdon Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801782436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075781082","display_name":"Camilla Ascanelli","orcid":"https://orcid.org/0000-0002-6266-2822","observed_orcids":["https://orcid.org/0000-0002-6266-2822"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801782436","display_name":"The Gurdon Institute","ror":"https://ror.org/00fp3ce15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I2801782436","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Camilla Ascanelli","raw_affiliation_strings":["Department of Pharmacology, University of Cambridge, Cambridge, UK","Gurdon Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0002-6266-2822","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Gurdon Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801782436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161311154","display_name":"Jin Seok Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801782436","display_name":"The Gurdon Institute","ror":"https://ror.org/00fp3ce15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I2801782436","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jin Seok Lee","raw_affiliation_strings":["Department of Pharmacology, University of Cambridge, Cambridge, UK","Gurdon Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Gurdon Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801782436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161352974","display_name":"Kypros Kyprianou Kokonos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801782436","display_name":"The Gurdon Institute","ror":"https://ror.org/00fp3ce15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I2801782436","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kypros Kyprianou Kokonos","raw_affiliation_strings":["Department of Pharmacology, University of Cambridge, Cambridge, UK","Gurdon Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Gurdon Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801782436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034499493","display_name":"Karin Jennbacken","orcid":"https://orcid.org/0000-0003-1254-5158","observed_orcids":["https://orcid.org/0000-0003-1254-5158"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karin Jennbacken","raw_affiliation_strings":["Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism, R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-1254-5158","affiliations":[{"raw_affiliation_string":"Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism, R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045476539","display_name":"Christopher R. Hunter","orcid":"https://orcid.org/0009-0003-1362-5085","observed_orcids":["https://orcid.org/0009-0003-1362-5085"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Christopher R. Hunter","raw_affiliation_strings":["QIMR Berghofer, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055862522","display_name":"Patr\u00edcia Gon\u00e7alves\u2010Rodrigues","orcid":"https://orcid.org/0000-0003-3767-2559","observed_orcids":["https://orcid.org/0000-0003-3767-2559"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Patricia G. Rodrigues","raw_affiliation_strings":["Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism, R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-3767-2559","affiliations":[{"raw_affiliation_string":"Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism, R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074206369","display_name":"Gina Hyberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gina Hyberg","raw_affiliation_strings":["Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100369586","display_name":"Qing\u2010Dong Wang","orcid":"https://orcid.org/0000-0001-9570-4411","observed_orcids":["https://orcid.org/0000-0001-9570-4411"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Qing-Dong Wang","raw_affiliation_strings":["Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism, R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-9570-4411","affiliations":[{"raw_affiliation_string":"Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism, R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061698611","display_name":"Kenny M. Hansson","orcid":"https://orcid.org/0000-0003-0448-5140","observed_orcids":["https://orcid.org/0000-0003-0448-5140"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kenny M. Hansson","raw_affiliation_strings":["Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism, R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism, R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112973839","display_name":"Adam Seaton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801782436","display_name":"The Gurdon Institute","ror":"https://ror.org/00fp3ce15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I2801782436","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adam Seaton","raw_affiliation_strings":["Department of Pharmacology, University of Cambridge, Cambridge, UK","Gurdon Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Gurdon Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801782436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139826653","display_name":"Maria Victoria Rodriguez Noci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maria Victoria Rodriguez Noci","raw_affiliation_strings":["Department of Pharmacology, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161357764","display_name":"Alby Biju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alby Biju","raw_affiliation_strings":["Department of Pharmacology, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060826440","display_name":"Silvia Da Pra","orcid":"https://orcid.org/0000-0001-6906-2806","observed_orcids":["https://orcid.org/0000-0001-6906-2806"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Da Pra","raw_affiliation_strings":["Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063029870","display_name":"Gabriele D\u2019Uva","orcid":"https://orcid.org/0000-0001-9622-9288","observed_orcids":["https://orcid.org/0000-0001-9622-9288"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriele D\u2019Uva","raw_affiliation_strings":["Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy","IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9622-9288","affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053820317","display_name":"Megan J. Bywater","orcid":"https://orcid.org/0000-0002-7466-6927","observed_orcids":["https://orcid.org/0000-0002-7466-6927"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Megan Bywater","raw_affiliation_strings":["QIMR Berghofer, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002869469","display_name":"Jasmin Straube","orcid":"https://orcid.org/0000-0002-1748-0659","observed_orcids":["https://orcid.org/0000-0002-1748-0659"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jasmin Straube","raw_affiliation_strings":["QIMR Berghofer, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QIMR Berghofer, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083402180","display_name":"Kamil A. Sokolowski","orcid":"https://orcid.org/0000-0003-3679-2321","observed_orcids":["https://orcid.org/0000-0003-3679-2321"]},"institutions":[{"id":"https://openalex.org/I1308309334","display_name":"Translational Research Institute","ror":"https://ror.org/00v807439","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1308309334"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kamil A. Sokolowski","raw_affiliation_strings":["Preclinical imaging facility, Translational Research Institute, Woolloongabba, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical imaging facility, Translational Research Institute, Woolloongabba, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I1308309334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043703001","display_name":"Brian Wan-Chi Tse","orcid":"https://orcid.org/0000-0002-5982-8369","observed_orcids":["https://orcid.org/0000-0002-5982-8369"]},"institutions":[{"id":"https://openalex.org/I1308309334","display_name":"Translational Research Institute","ror":"https://ror.org/00v807439","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1308309334"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Brian W. C. Tse","raw_affiliation_strings":["Preclinical imaging facility, Translational Research Institute, Woolloongabba, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical imaging facility, Translational Research Institute, Woolloongabba, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I1308309334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115593204","display_name":"Thomas Krieg","orcid":"https://orcid.org/0000-0002-5192-580X","observed_orcids":["https://orcid.org/0000-0002-5192-580X","https://orcid.org/0000-0001-5616-8476"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Krieg","raw_affiliation_strings":["Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0002-5192-580X","affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048699892","display_name":"Ana Vuji\u0107","orcid":"https://orcid.org/0000-0002-0559-5299","observed_orcids":["https://orcid.org/0000-0002-0559-5299"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ana Vujic","raw_affiliation_strings":["Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038230299","display_name":"Mauro Giacca","orcid":"https://orcid.org/0000-0003-2927-7225","observed_orcids":["https://orcid.org/0000-0003-2927-7225"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I32003884","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I32003884"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Mauro Giacca","raw_affiliation_strings":["Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy","School of Cardiovascular and Metabolic Medicine & Sciences and British Heart Foundation Centre of Research Excellence, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]},{"raw_affiliation_string":"School of Cardiovascular and Metabolic Medicine & Sciences and British Heart Foundation Centre of Research Excellence, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I32003884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049941316","display_name":"Enzo R. Porrello","orcid":"https://orcid.org/0000-0001-6105-7463","observed_orcids":["https://orcid.org/0000-0001-6105-7463"]},"institutions":[{"id":"https://openalex.org/I1321649718","display_name":"Royal Children's Hospital","ror":"https://ror.org/02rktxt32","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1321649718"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Enzo R. Porrello","raw_affiliation_strings":["Department of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne, Parkville, Victoria, Australia","Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0001-6105-7463","affiliations":[{"raw_affiliation_string":"Department of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048692866","display_name":"Sanjay Sinha","orcid":"https://orcid.org/0000-0001-5900-1209","observed_orcids":["https://orcid.org/0000-0001-5900-1209"]},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sanjay Sinha","raw_affiliation_strings":["Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Puddicombe way, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0001-5900-1209","affiliations":[{"raw_affiliation_string":"Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Puddicombe way, Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048600861","display_name":"James E. Hudson","orcid":"https://orcid.org/0000-0003-0832-9356","observed_orcids":["https://orcid.org/0000-0003-0832-9356"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"James E. Hudson","raw_affiliation_strings":["Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. james.hudson@qimrb.edu.au","QIMR Berghofer, Brisbane, Queensland, Australia. james.hudson@qimrb.edu.au","School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia. james.hudson@qimrb.edu.au"],"raw_orcid":"https://orcid.org/0000-0003-0832-9356","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. james.hudson@qimrb.edu.au","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"QIMR Berghofer, Brisbane, Queensland, Australia. james.hudson@qimrb.edu.au","institution_ids":["https://openalex.org/I217937681"]},{"raw_affiliation_string":"School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia. james.hudson@qimrb.edu.au","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075385907","display_name":"Catherine H. Wilson","orcid":"https://orcid.org/0000-0002-5333-0295","observed_orcids":["https://orcid.org/0000-0002-5333-0295"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801782436","display_name":"The Gurdon Institute","ror":"https://ror.org/00fp3ce15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I2801782436","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Catherine H. Wilson","raw_affiliation_strings":["Department of Pharmacology, University of Cambridge, Cambridge, UK. chw39@cam.ac.uk","Gurdon Institute, University of Cambridge, Cambridge, UK. chw39@cam.ac.uk"],"raw_orcid":"https://orcid.org/0000-0002-5333-0295","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Cambridge, Cambridge, UK. chw39@cam.ac.uk","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Gurdon Institute, University of Cambridge, Cambridge, UK. chw39@cam.ac.uk","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801782436"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5048600861","https://openalex.org/A5075385907"],"corresponding_institution_ids":["https://openalex.org/I160993911","https://openalex.org/I165143802","https://openalex.org/I217937681","https://openalex.org/I241749","https://openalex.org/I2801782436"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":{"value":12690,"currency":"USD","value_usd":12690},"fwci":1.3452,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.72165518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cyclin-t1","display_name":"cyclin T1","score":1.0},{"id":"https://openalex.org/keywords/transient-expression","display_name":"transient expression","score":0.6169999837875366},{"id":"https://openalex.org/keywords/mrna-therapeutics","display_name":"mRNA therapeutics","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cardiomyocyte-proliferation","display_name":"cardiomyocyte proliferation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.9300000071525574},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cardiac-recovery","display_name":"cardiac function recovery","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.5803999900817871},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5605999827384949},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5583000183105469},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5444999933242798},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5338000059127808},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5327000021934509},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5027999877929688},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4643999934196472},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.44290000200271606},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.41690000891685486},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.41119998693466187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40849998593330383},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3937000036239624},{"id":"https://openalex.org/C28179978","wikidata":"https://www.wikidata.org/wiki/Q5198263","display_name":"Cyclin A2","level":5,"score":0.38519999384880066},{"id":"https://openalex.org/C2780799671","wikidata":"https://www.wikidata.org/wiki/Q17087362","display_name":"Transient (computer programming)","level":2,"score":0.3765000104904175},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3700999915599823},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.32910001277923584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3138999938964844},{"id":"https://openalex.org/C9743823","wikidata":"https://www.wikidata.org/wiki/Q5198264","display_name":"Cyclin B","level":5,"score":0.3116999864578247},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C2780360765","wikidata":"https://www.wikidata.org/wiki/Q5198275","display_name":"Cyclin E1","level":5,"score":0.3082999885082245},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.30230000615119934},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.2948000133037567},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2833999991416931},{"id":"https://openalex.org/C2778437423","wikidata":"https://www.wikidata.org/wiki/Q5198265","display_name":"Cyclin B1","level":5,"score":0.27720001339912415},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.27399998903274536}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s44161-026-00910-7","doi":"https://doi.org/10.1038/s44161-026-00910-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44161-026-00910-7","pdf_url":"https://www.nature.com/articles/s44161-026-00910-7.pdf","source":{"id":"https://openalex.org/S4210241135","display_name":"Nature Cardiovascular Research","issn_l":"2731-0590","issn":["2731-0590"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cardiovascular Research","raw_type":"journal-article"},{"id":"pmid:43003910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43003910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature cardiovascular research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s44161-026-00910-7","doi":"https://doi.org/10.1038/s44161-026-00910-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44161-026-00910-7","pdf_url":"https://www.nature.com/articles/s44161-026-00910-7.pdf","source":{"id":"https://openalex.org/S4210241135","display_name":"Nature Cardiovascular Research","issn_l":"2731-0590","issn":["2731-0590"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cardiovascular Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320314063","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30"},{"id":"https://openalex.org/F4320315122","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77"},{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320320273","display_name":"University of Cambridge","ror":"https://ror.org/013meh722"},{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"},{"id":"https://openalex.org/F4320320320","display_name":"Rosetrees Trust","ror":"https://ror.org/04e3zg361"},{"id":"https://openalex.org/F4320320974","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98"},{"id":"https://openalex.org/F4320320983","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752"},{"id":"https://openalex.org/F4320320984","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320323553","display_name":"Universit\u00e0 di Bologna","ror":"https://ror.org/01111rn36"},{"id":"https://openalex.org/F4320332119","display_name":"Snow Medical","ror":"https://ror.org/03ae6jr54"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337195","display_name":"Cancer Research UK Cambridge Institute, University of Cambridge","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225641371.pdf","grobid_xml":"https://content.openalex.org/works/W7225641371.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1966035570","https://openalex.org/W1969038150","https://openalex.org/W1972439979","https://openalex.org/W1977290507","https://openalex.org/W1998457769","https://openalex.org/W2012451954","https://openalex.org/W2016683877","https://openalex.org/W2030021123","https://openalex.org/W2044724807","https://openalex.org/W2047339163","https://openalex.org/W2054604628","https://openalex.org/W2070002301","https://openalex.org/W2070515279","https://openalex.org/W2091216861","https://openalex.org/W2092088164","https://openalex.org/W2094420876","https://openalex.org/W2098419906","https://openalex.org/W2134013131","https://openalex.org/W2146331332","https://openalex.org/W2146996213","https://openalex.org/W2152000585","https://openalex.org/W2160202656","https://openalex.org/W2161577298","https://openalex.org/W2167869412","https://openalex.org/W2526399253","https://openalex.org/W2602505141","https://openalex.org/W2767348608","https://openalex.org/W2781941964","https://openalex.org/W2797607167","https://openalex.org/W2900406456","https://openalex.org/W2909159088","https://openalex.org/W2914302538","https://openalex.org/W2916020270","https://openalex.org/W2943870140","https://openalex.org/W2992151131","https://openalex.org/W2997280954","https://openalex.org/W3004105709","https://openalex.org/W3005591321","https://openalex.org/W3007097494","https://openalex.org/W3007595289","https://openalex.org/W3013105716","https://openalex.org/W3014244669","https://openalex.org/W3015857002","https://openalex.org/W3022170850","https://openalex.org/W3023797901","https://openalex.org/W3033924035","https://openalex.org/W3088401235","https://openalex.org/W3111255098","https://openalex.org/W3113178943","https://openalex.org/W3113734454","https://openalex.org/W3132661792","https://openalex.org/W3134745470","https://openalex.org/W3174183571","https://openalex.org/W3183212625","https://openalex.org/W4281254240","https://openalex.org/W4306946790","https://openalex.org/W4321496535","https://openalex.org/W4378212544","https://openalex.org/W4385498145","https://openalex.org/W4385751599","https://openalex.org/W4387095456","https://openalex.org/W4393053160","https://openalex.org/W4404627084","https://openalex.org/W4408234728","https://openalex.org/W7098629088"],"related_works":["https://openalex.org/W4385551968","https://openalex.org/W7091598849","https://openalex.org/W7154279157","https://openalex.org/W1982942713","https://openalex.org/W4412522001","https://openalex.org/W2083636380","https://openalex.org/W2146935108","https://openalex.org/W2036917008","https://openalex.org/W3080204039","https://openalex.org/W4380793482"],"abstract_inverted_index":{"Myc":[0,37,63],"is":[1,8],"an":[2],"evolutionarily":[3],"conserved":[4],"transcription":[5],"factor":[6],"that":[7,62,73],"necessary":[9],"for":[10,70,96],"the":[11,105],"restoration":[12],"of":[13,36,107],"tissues":[14],"in":[15,84,104],"multiple":[16],"regenerative":[17,24],"species.":[18],"The":[19],"adult":[20,44],"mammalian":[21],"heart":[22],"lacks":[23],"capacity":[25],"and":[26,38,55,64,78],"cardiomyocytes":[27],"fail":[28],"to":[29,47,75,91,99],"divide":[30],"following":[31],"damage-induced":[32],"signaling.":[33],"Transgenic":[34],"expression":[35],"cyclin":[39,65],"T1":[40,66,94],"can":[41],"drive":[42],"substantial":[43],"cardiomyocyte":[45,71],"proliferation":[46,72],"replace":[48],"lost":[49],"cardiomyocytes.":[50],"Here,":[51],"using":[52],"transgenic":[53],"models":[54],"a":[56,89],"prototypical":[57],"mRNA":[58],"therapeutic,":[59],"we":[60],"show":[61],"require":[67],"transient":[68],"induction":[69],"leads":[74],"myocardial":[76,82],"repair":[77],"functional":[79],"recovery":[80],"after":[81],"infarction":[83],"mice.":[85],"This":[86],"research":[87],"provides":[88],"strategy":[90],"translate":[92],"Myc-cyclin":[93],"coexpression":[95],"cardiac":[97],"regeneration":[98],"address":[100],"serious":[101],"unmet":[102],"needs":[103],"treatment":[106],"cardiovascular":[108],"disease.":[109]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}