{"id":"https://openalex.org/W7225640933","doi":"https://doi.org/10.32782/2415-8127.2026.74.22","title":"Modern Concepts of the Pathogenesis of Gastro-Oesophageal Reflux Disease","display_name":"Modern Concepts of the Pathogenesis of Gastro-Oesophageal Reflux Disease","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225640933","doi":"https://doi.org/10.32782/2415-8127.2026.74.22"},"language":"en","primary_location":{"id":"doi:10.32782/2415-8127.2026.74.22","doi":"https://doi.org/10.32782/2415-8127.2026.74.22","is_oa":true,"landing_page_url":"https://doi.org/10.32782/2415-8127.2026.74.22","pdf_url":"https://med-visnyk.uzhnu.uz.ua/index.php/med/article/download/407/511","source":{"id":"https://openalex.org/S4210241202","display_name":"\u041d\u0430\u0443\u043a\u043e\u0432\u0438\u0439 \u0432\u0456\u0441\u043d\u0438\u043a \u0423\u0436\u0433\u043e\u0440\u043e\u0434\u0441\u044c\u043a\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0421\u0435\u0440\u0456\u044f \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430","issn_l":"2415-8127","issn":["2415-8127"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77443782","host_organization_name":"Uzhhorod National University","host_organization_lineage":["https://openalex.org/I77443782"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u041d\u0430\u0443\u043a\u043e\u0432\u0438\u0439 \u0432\u0456\u0441\u043d\u0438\u043a \u0423\u0436\u0433\u043e\u0440\u043e\u0434\u0441\u044c\u043a\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0421\u0435\u0440\u0456\u044f \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://med-visnyk.uzhnu.uz.ua/index.php/med/article/download/407/511","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029434343","display_name":"T. Yu. Chernets","orcid":"https://orcid.org/0000-0001-7575-8391","observed_orcids":["https://orcid.org/0000-0001-7575-8391"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tetiana Yuriivna Chernets","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7575-8391","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033542039","display_name":"Svitlana V. Kucher","orcid":"https://orcid.org/0000-0003-1026-9567","observed_orcids":["https://orcid.org/0000-0003-1026-9567"]},"institutions":[{"id":"https://openalex.org/I4210156742","display_name":"I.Horbachevsky Ternopil National Medical University","ror":"https://ror.org/04gcpjy47","country_code":"UA","type":"education","lineage":["https://openalex.org/I4210156742"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Svitlana Viktorivna Kucher","raw_affiliation_strings":["Department of Internal Medicine Propedeutics and Phthisiology Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine"],"raw_orcid":"https://orcid.org/0000-0003-1026-9567","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Propedeutics and Phthisiology Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine","institution_ids":["https://openalex.org/I4210156742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023764206","display_name":"Melanie Ruda","orcid":"https://orcid.org/0000-0002-5407-3315","observed_orcids":["https://orcid.org/0000-0002-5407-3315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariia Myronivna Ruda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5407-3315","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093531315","display_name":"\u041a\u0430\u0432\u0435\u0446\u044c\u043a\u0430 \u041d\u0430\u0442\u0430\u043b\u0456\u044f \u0410\u043d\u0430\u0442\u043e\u043b\u0456\u0457\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-8365-6990","observed_orcids":["https://orcid.org/0000-0002-8365-6990"]},"institutions":[{"id":"https://openalex.org/I4210156742","display_name":"I.Horbachevsky Ternopil National Medical University","ror":"https://ror.org/04gcpjy47","country_code":"UA","type":"education","lineage":["https://openalex.org/I4210156742"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Nataliia Anatoliivna Kavetska","raw_affiliation_strings":["Department of Internal Medicine Propedeutics and Phthisiology Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine","Doctor of Philosophy , Associate Professor at the"],"raw_orcid":"https://orcid.org/0000-0002-8365-6990","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Propedeutics and Phthisiology Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine","institution_ids":["https://openalex.org/I4210156742"]},{"raw_affiliation_string":"Doctor of Philosophy , Associate Professor at the","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023710110","display_name":"Volodymyr G. Dzhyvak","orcid":"https://orcid.org/0000-0002-4885-7586","observed_orcids":["https://orcid.org/0000-0002-4885-7586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Volodymyr Heorhiyovych Dzhyvak","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4885-7586","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"2(74)","first_page":"137","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.8880000114440918},{"id":"https://openalex.org/keywords/esophagogastric-junction","display_name":"esophagogastric junction","score":0.8270000219345093},{"id":"https://openalex.org/keywords/lower-esophageal-sphincter","display_name":"lower esophageal sphincter","score":0.9229999780654907},{"id":"https://openalex.org/keywords/transient-lower-esophageal-sphincter-relaxations","display_name":"transient lower esophageal sphincter relaxations","score":0.925000011920929},{"id":"https://openalex.org/keywords/epithelial-barrier-function","display_name":"epithelial barrier function","score":0.7630000114440918},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/abdominal-obesity","display_name":"abdominal obesity","score":0.8920000195503235},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.8119999766349792},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.5410000085830688},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/visceral-sensitivity","display_name":"visceral sensitivity","score":0.8270000219345093},{"id":"https://openalex.org/keywords/erosive-reflux-disease","display_name":"erosive reflux disease","score":0.8220000267028809},{"id":"https://openalex.org/keywords/non-erosive-reflux-disease","display_name":"non-erosive reflux disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/reflux-hypersensitivity","display_name":"reflux hypersensitivity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/functional-heartburn","display_name":"functional heartburn","score":0.9940000176429749},{"id":"https://openalex.org/keywords/clinical-phenotype","display_name":"clinical phenotype","score":0.6869999766349792},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.8622999787330627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8073999881744385},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7088000178337097},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.6276999711990356},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.47870001196861267},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.43950000405311584},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4377000033855438},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.3962000012397766},{"id":"https://openalex.org/C124056412","wikidata":"https://www.wikidata.org/wiki/Q3320364","display_name":"Scientific evidence","level":2,"score":0.3700999915599823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36890000104904175},{"id":"https://openalex.org/C3020774429","wikidata":"https://www.wikidata.org/wiki/Q1201886","display_name":"Web of science","level":3,"score":0.35420000553131104},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.35260000824928284},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3319000005722046},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.32989999651908875},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3278000056743622},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.30219998955726624},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.2962999939918518},{"id":"https://openalex.org/C3018799001","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophageal sphincter","level":4,"score":0.29249998927116394},{"id":"https://openalex.org/C96526673","wikidata":"https://www.wikidata.org/wiki/Q4867047","display_name":"Basic science","level":2,"score":0.2921999990940094},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.29190000891685486},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.2879999876022339},{"id":"https://openalex.org/C2777683962","wikidata":"https://www.wikidata.org/wiki/Q650031","display_name":"Nerd","level":5,"score":0.28290000557899475},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.2599000036716461},{"id":"https://openalex.org/C2780323790","wikidata":"https://www.wikidata.org/wiki/Q2912193","display_name":"Esophageal disease","level":3,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.32782/2415-8127.2026.74.22","doi":"https://doi.org/10.32782/2415-8127.2026.74.22","is_oa":true,"landing_page_url":"https://doi.org/10.32782/2415-8127.2026.74.22","pdf_url":"https://med-visnyk.uzhnu.uz.ua/index.php/med/article/download/407/511","source":{"id":"https://openalex.org/S4210241202","display_name":"\u041d\u0430\u0443\u043a\u043e\u0432\u0438\u0439 \u0432\u0456\u0441\u043d\u0438\u043a \u0423\u0436\u0433\u043e\u0440\u043e\u0434\u0441\u044c\u043a\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0421\u0435\u0440\u0456\u044f \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430","issn_l":"2415-8127","issn":["2415-8127"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77443782","host_organization_name":"Uzhhorod National University","host_organization_lineage":["https://openalex.org/I77443782"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u041d\u0430\u0443\u043a\u043e\u0432\u0438\u0439 \u0432\u0456\u0441\u043d\u0438\u043a \u0423\u0436\u0433\u043e\u0440\u043e\u0434\u0441\u044c\u043a\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0421\u0435\u0440\u0456\u044f \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.32782/2415-8127.2026.74.22","doi":"https://doi.org/10.32782/2415-8127.2026.74.22","is_oa":true,"landing_page_url":"https://doi.org/10.32782/2415-8127.2026.74.22","pdf_url":"https://med-visnyk.uzhnu.uz.ua/index.php/med/article/download/407/511","source":{"id":"https://openalex.org/S4210241202","display_name":"\u041d\u0430\u0443\u043a\u043e\u0432\u0438\u0439 \u0432\u0456\u0441\u043d\u0438\u043a \u0423\u0436\u0433\u043e\u0440\u043e\u0434\u0441\u044c\u043a\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0421\u0435\u0440\u0456\u044f \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430","issn_l":"2415-8127","issn":["2415-8127"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77443782","host_organization_name":"Uzhhorod National University","host_organization_lineage":["https://openalex.org/I77443782"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u041d\u0430\u0443\u043a\u043e\u0432\u0438\u0439 \u0432\u0456\u0441\u043d\u0438\u043a \u0423\u0436\u0433\u043e\u0440\u043e\u0434\u0441\u044c\u043a\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0421\u0435\u0440\u0456\u044f \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225640933.pdf","grobid_xml":"https://content.openalex.org/works/W7225640933.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W2761358522","https://openalex.org/W2763032770","https://openalex.org/W2785608288","https://openalex.org/W2958445840","https://openalex.org/W3002280579","https://openalex.org/W3005347912","https://openalex.org/W3014840414","https://openalex.org/W3024309671","https://openalex.org/W3041055530","https://openalex.org/W3048384049","https://openalex.org/W3091113247","https://openalex.org/W3113403689","https://openalex.org/W3114191788","https://openalex.org/W3118329797","https://openalex.org/W3127604232","https://openalex.org/W3133892565","https://openalex.org/W3154428202","https://openalex.org/W3157293994","https://openalex.org/W3183515158","https://openalex.org/W3188288766","https://openalex.org/W3192919356","https://openalex.org/W3210272577","https://openalex.org/W3213175542","https://openalex.org/W3216394740","https://openalex.org/W4210471806","https://openalex.org/W4210756392","https://openalex.org/W4212914560","https://openalex.org/W4221003039","https://openalex.org/W4283657899","https://openalex.org/W4285153615","https://openalex.org/W4297902605","https://openalex.org/W4308956495","https://openalex.org/W4313424291","https://openalex.org/W4365517845","https://openalex.org/W4384665325","https://openalex.org/W4386922138","https://openalex.org/W4390589071","https://openalex.org/W4390858444","https://openalex.org/W4391568417","https://openalex.org/W4391777246","https://openalex.org/W4394848693","https://openalex.org/W4400431567","https://openalex.org/W4405108305","https://openalex.org/W4411628072","https://openalex.org/W4412957191","https://openalex.org/W4416210646","https://openalex.org/W7163664420"],"related_works":["https://openalex.org/W7128628686","https://openalex.org/W7217994669","https://openalex.org/W2357141337","https://openalex.org/W2040383750","https://openalex.org/W4390589071","https://openalex.org/W4290471423","https://openalex.org/W3028920190","https://openalex.org/W4408845363","https://openalex.org/W1701910674","https://openalex.org/W2370214118"],"abstract_inverted_index":{"Introduction.":[0],"Gastro-oesophageal":[1],"reflux":[2,241,244,246],"disease":[3],"is":[4,16,143,157,206,232,237,264],"one":[5],"of":[6,11,30,34,50,54,65,68,97,141,161,171,182,188,218,230,252,278],"the":[7,12,44,48,52,63,90,108,111,139,162,166,172,183,219],"most":[8],"common":[9],"disorders":[10],"gastrointestinal":[13],"tract;":[14],"it":[15],"characterised":[17],"by":[18,159,216],"considerable":[19],"clinical":[20,66,121],"variability":[21],"and":[22,57,71,101,128,133,151,179,199,212,224,248,259,267,273,297],"has":[23,202,254],"a":[24,144,207,265,283,286,290],"significant":[25],"impact":[26],"on":[27,234,294],"patients\u2019":[28],"quality":[29],"life.":[31],"The":[32,83,104,135,186,227],"aim":[33],"this":[35],"study":[36],"was":[37,76,86],"to":[38,78,115,120,289],"summarise":[39,79],"current":[40,80,228,279],"scientific":[41,81,130],"evidence":[42],"regarding":[43],"pathophysiological":[45,257,280],"mechanisms":[46],"underlying":[47],"development":[49,140],"GERD,":[51],"role":[53,156,187],"risk":[55,190],"factors":[56],"psycho-emotional":[58],"factors,":[59,191,197],"as":[60,62,193],"well":[61],"characteristics":[64],"phenotypes":[67],"GERD.":[69],"Materials":[70],"methods.":[72],"A":[73],"literature":[74,84],"review":[75],"conducted":[77],"data.":[82],"search":[85],"carried":[87],"out":[88],"in":[89,107],"international":[91],"electronic":[92],"databases":[93],"PubMed/MEDLINE,":[94],"Scopus,":[95],"Web":[96],"Science":[98],"Core":[99],"Collection":[100],"Google":[102],"Scholar.":[103],"publications":[105],"included":[106],"analysis":[109,136],"covered":[110],"period":[112],"from":[113,285],"2015":[114],"2026,":[116],"with":[117],"priority":[118],"given":[119],"guidelines,":[122],"consensus":[123],"documents,":[124],"systematic":[125],"reviews,":[126],"meta-analyses":[127],"original":[129],"studies.":[131],"Results":[132],"discussion.":[134],"showed":[137],"that":[138],"GERD":[142,211,231,263],"complex":[145],"process":[146],"involving":[147,270],"mechanical,":[148],"chemical,":[149],"sensory":[150],"neuroregulatory":[152],"factors.":[153],"An":[154,276],"important":[155],"played":[158],"dysfunction":[160,217],"anti-reflux":[163],"barrier":[164],"at":[165],"oesophagogastric":[167],"junction,":[168],"transient":[169],"relaxation":[170],"lower":[173],"oesophageal":[174,177,225],"sphincter,":[175],"impaired":[176],"clearance":[178],"reduced":[180],"resistance":[181],"epithelial":[184],"barrier.":[185],"modifiable":[189],"such":[192],"abdominal":[194],"obesity,":[195],"lifestyle":[196],"diet":[198],"sleep":[200],"disturbances,":[201],"been":[203],"established.":[204],"There":[205],"bidirectional":[208],"association":[209],"between":[210],"psychological":[213],"disorders,":[214],"mediated":[215],"\u2018brain-gut\u2019":[220],"axis,":[221],"visceral":[222],"sensitivity":[223],"hypersensitivity.":[226],"classification":[229],"based":[233,293],"phenotype,":[235],"which":[236,253],"divided":[238],"into":[239],"erosive":[240],"disease,":[242,245],"non-erosive":[243],"hypersensitivity":[247],"functional":[249,272,298],"heartburn,":[250],"each":[251],"its":[255],"own":[256],"mechanism":[258],"treatment":[260],"approach.":[261],"Conclusions.":[262],"multifactorial":[266],"heterogeneous":[268],"condition":[269],"structural,":[271],"psychosocial":[274],"mechanisms.":[275],"understanding":[277],"concepts":[281],"enables":[282],"shift":[284],"symptomatic":[287],"approach":[288,292],"personalised":[291],"clinical,":[295],"endoscopic":[296],"diagnostic":[299],"assessment.":[300]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}