{"id":"https://openalex.org/W7225640904","doi":"https://doi.org/10.21203/rs.3.rs-11219830/v1","title":"Effect of Prophylactic Tranexamic Acid on Perioperative Blood Loss in High-Risk Cesarean Delivery: A Randomized Controlled Study","display_name":"Effect of Prophylactic Tranexamic Acid on Perioperative Blood Loss in High-Risk Cesarean Delivery: A Randomized Controlled Study","publication_year":2026,"publication_date":"2026-11-10","ids":{"openalex":"https://openalex.org/W7225640904","doi":"https://doi.org/10.21203/rs.3.rs-11219830/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11219830/v1","doi":"https://doi.org/10.21203/rs.3.rs-11219830/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11219830/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.21203/rs.3.rs-11219830/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091983839","display_name":"Burcin Onder","orcid":"https://orcid.org/0000-0001-8198-7238","observed_orcids":["https://orcid.org/0000-0001-8198-7238","https://orcid.org/0000-0002-1510-7930"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Bur\u00e7in \u00d6NDER","raw_affiliation_strings":["Pamukkale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pamukkale University","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119157110","display_name":"Mert Yetgin","orcid":"https://orcid.org/0009-0006-7838-558X","observed_orcids":["https://orcid.org/0009-0006-7838-558X"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mert YETG\u0130N","raw_affiliation_strings":["Pamukkale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pamukkale University","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102986486","display_name":"Asl\u0131 Mete","orcid":"https://orcid.org/0000-0002-5621-7407","observed_orcids":["https://orcid.org/0000-0002-5621-7407"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Asl\u0131 METE YILDIZ","raw_affiliation_strings":["Pamukkale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pamukkale University","institution_ids":["https://openalex.org/I48843708"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I48843708"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11389","display_name":"Maternal and fetal healthcare","score":0.17970000207424164,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9641000032424927},{"id":"https://openalex.org/C2780056395","wikidata":"https://www.wikidata.org/wiki/Q7902662","display_name":"Uterotonic","level":3,"score":0.8877999782562256},{"id":"https://openalex.org/C2779637338","wikidata":"https://www.wikidata.org/wiki/Q418666","display_name":"Tranexamic acid","level":3,"score":0.8206999897956848},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.798799991607666},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.753000020980835},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.5916000008583069},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5521000027656555},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.478300005197525},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.46050000190734863},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.44179999828338623},{"id":"https://openalex.org/C2991743468","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Blood loss","level":2,"score":0.43160000443458557},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4187000095844269},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.37119999527931213},{"id":"https://openalex.org/C2779526319","wikidata":"https://www.wikidata.org/wiki/Q615057","display_name":"Anesthesiology","level":2,"score":0.3578000068664551},{"id":"https://openalex.org/C2780659260","wikidata":"https://www.wikidata.org/wiki/Q1418513","display_name":"Uterine atony","level":3,"score":0.33149999380111694},{"id":"https://openalex.org/C2992886682","wikidata":"https://www.wikidata.org/wiki/Q282736","display_name":"Spinal anesthesia","level":2,"score":0.30979999899864197},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.30730000138282776},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.2768999934196472},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C2777312010","wikidata":"https://www.wikidata.org/wiki/Q4826775","display_name":"Autonomic dysreflexia","level":4,"score":0.2635999917984009},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.25450000166893005}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11219830/v1","doi":"https://doi.org/10.21203/rs.3.rs-11219830/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11219830/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11219830/v1","doi":"https://doi.org/10.21203/rs.3.rs-11219830/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11219830/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1973459687","https://openalex.org/W2036468563","https://openalex.org/W2120394603","https://openalex.org/W2529846601","https://openalex.org/W3104303810","https://openalex.org/W4237539137","https://openalex.org/W4285387766","https://openalex.org/W4380265946","https://openalex.org/W4391113018","https://openalex.org/W4392542856","https://openalex.org/W4401183436","https://openalex.org/W4405157296","https://openalex.org/W4415007678","https://openalex.org/W4415649250","https://openalex.org/W7167793748"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Postpartum":[2],"hemorrhage":[3],"(PPH)":[4],"remains":[5,44],"a":[6,115,295,332],"major":[7],"cause":[8],"of":[9,23,29,42,54,63,136,229,276,320,336],"maternal":[10],"morbidity":[11],"and":[12,59,93,141,151,158,170,205,328],"mortality.":[13],"Although":[14],"tranexamic":[15],"acid":[16],"(TXA)":[17],"is":[18],"recommended":[19],"for":[20,68],"the":[21,26,134,162,175,186,193,201,209,221,227,266,314,318],"treatment":[22],"established":[24],"PPH,":[25],"clinical":[27],"benefit":[28,335],"its":[30],"prophylactic":[31,334],"administration":[32],"during":[33,161,265],"cesarean":[34,70,280],"delivery,":[35,281],"particularly":[36],"in":[37,149,174,185,192,200,208,223,299],"women":[38,167,272],"at":[39,60,273],"increased":[40,61,274],"risk":[41,62,275],"hemorrhage,":[43],"uncertain.":[45],"Methods":[46],"Women":[47],"aged":[48],"18\u201345":[49],"years":[50],"with":[51,294],"American":[52],"Society":[53],"Anesthesiologists":[55],"physical":[56],"status":[57],"II":[58],"PPH":[64,277],"who":[65],"were":[66,77,87,168,172,218,255,263],"scheduled":[67],"elective":[69,279],"delivery":[71],"under":[72,307],"spinal":[73,187,194,309],"or":[74,109,234,242,245,303,310],"general":[75,202,210,311],"anesthesia":[76,80,91,195,211],"enrolled.":[78],"The":[79,119],"technique":[81],"was":[82,122,182,291],"selected":[83],"before":[84],"randomization.":[85],"Participants":[86],"subsequently":[88],"stratified":[89],"by":[90],"type":[92],"randomized":[94],"within":[95],"each":[96],"stratum":[97],"to":[98],"receive":[99],"either":[100,308],"1":[101,282],"g":[102,283],"intravenous":[103,284],"TXA":[104,285],"after":[105,287],"umbilical":[106,288],"cord":[107,289],"clamping":[108,290],"no":[110],"TXA.":[111,337],"All":[112],"patients":[113],"received":[114],"standardized":[116],"uterotonic":[117,154,247],"regimen.":[118],"primary":[120],"outcome":[121],"estimated":[123,224,300],"blood":[124,137,145,180,225,230,301],"loss":[125,138,181,231,302],"calculated":[126],"using":[127],"perioperative":[128,147,240],"hematocrit":[129,243],"values.":[130],"Secondary":[131],"outcomes":[132,306],"included":[133,173],"incidence":[135,228],">":[139,142,232,235,251],"500":[140,233],"1000":[143,236],"mL,":[144,237],"transfusion,":[146],"changes":[148],"hemoglobin":[150,241],"hematocrit,":[152],"additional":[153,246],"requirements,":[155,239],"adverse":[156],"events,":[157],"thromboembolic":[159,261],"events":[160,262],"three-month":[163,267],"follow-up":[164,268],"period.":[165,269],"Eighty-four":[166],"enrolled,":[169],"83":[171],"final":[176],"analysis.":[177],"Results":[178],"Estimated":[179],"511":[183],"mL":[184,191,199,207],"anesthesia\u2013TXA":[188,203],"group,":[189,197,204],"590":[190],"control":[196,212],"579":[198],"617":[206],"group.":[213],"No":[214,260],"statistically":[215,296,321],"significant":[216,297,322],"differences":[217,323],"observed":[219],"among":[220,258],"groups":[222],"loss,":[226],"transfusion":[238],"changes,":[244],"use":[248],"(all":[249],"P":[250],"0.05).":[252],"Adverse-event":[253],"rates":[254],"also":[256],"comparable":[257],"groups.":[259],"identified":[264],"Conclusions":[270],"In":[271],"undergoing":[278],"administered":[286],"not":[292,330],"associated":[293],"reduction":[298],"other":[304],"hemorrhage-related":[305],"anesthesia.":[312],"Given":[313],"limited":[315],"sample":[316],"size,":[317],"absence":[319],"should":[324],"be":[325],"interpreted":[326],"cautiously":[327],"does":[329],"exclude":[331],"potential":[333],"Trial":[338],"Registration":[339],"ClinicalTrials.gov,":[340],"NCT07870499.":[341],"Registered":[342],"on":[343],"October":[344],"6,":[345],"2026.":[346],"Retrospectively":[347],"registered.":[348]},"counts_by_year":[],"updated_date":"2026-11-10T13:44:29.811591","created_date":"2026-11-10T00:00:00"}