{"id":"https://openalex.org/W7225640803","doi":"https://doi.org/10.1002/npr2.70186","title":"When SOREMPs Meet Episodic Hypersomnia: REM Dysregulation as a Trait or State in Kleine\u2013Levin Syndrome","display_name":"When SOREMPs Meet Episodic Hypersomnia: REM Dysregulation as a Trait or State in Kleine\u2013Levin Syndrome","publication_year":2026,"publication_date":"2026-11-08","ids":{"openalex":"https://openalex.org/W7225640803","doi":"https://doi.org/10.1002/npr2.70186","pmid":"https://pubmed.ncbi.nlm.nih.gov/43000941"},"language":"en","primary_location":{"id":"doi:10.1002/npr2.70186","doi":"https://doi.org/10.1002/npr2.70186","is_oa":true,"landing_page_url":"https://doi.org/10.1002/npr2.70186","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/npr2.70186","source":{"id":"https://openalex.org/S4210189692","display_name":"Neuropsychopharmacology Reports","issn_l":"2574-173X","issn":["2574-173X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/npr2.70186","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136260093","display_name":"Shinichiro M. Koga","orcid":"https://orcid.org/0000-0002-6632-8987","observed_orcids":["https://orcid.org/0000-0002-6632-8987"]},"institutions":[{"id":"https://openalex.org/I110617504","display_name":"Tokyo University of Foreign Studies","ror":"https://ror.org/027tyzk91","country_code":"JP","type":"education","lineage":["https://openalex.org/I110617504"]},{"id":"https://openalex.org/I29457043","display_name":"Japan Women's University","ror":"https://ror.org/04gpcyk21","country_code":"JP","type":"education","lineage":["https://openalex.org/I29457043"]},{"id":"https://openalex.org/I3020605285","display_name":"Tokyo Metropolitan Komagome Hospital","ror":"https://ror.org/04eqd2f30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3020605285"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shinichiro M. Koga","raw_affiliation_strings":["Department of Medicine, Tokyo Metropolitan Center for Cancer and Infectious Diseases Komagome Hospital  Tokyo Japan","Section for General Internal Medicine and Primary Care Tokyo University of Foreign Studies  Tokyo Japan","Section for Pediatrics and Adolescent Medicine Japan Women's University  Tokyo Japan"],"raw_orcid":"https://orcid.org/0000-0002-6632-8987","affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Metropolitan Center for Cancer and Infectious Diseases Komagome Hospital  Tokyo Japan","institution_ids":["https://openalex.org/I3020605285"]},{"raw_affiliation_string":"Section for General Internal Medicine and Primary Care Tokyo University of Foreign Studies  Tokyo Japan","institution_ids":["https://openalex.org/I110617504"]},{"raw_affiliation_string":"Section for Pediatrics and Adolescent Medicine Japan Women's University  Tokyo Japan","institution_ids":["https://openalex.org/I29457043"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5136260093"],"corresponding_institution_ids":["https://openalex.org/I110617504","https://openalex.org/I29457043","https://openalex.org/I3020605285"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12569","display_name":"Restless Legs Syndrome Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kleine-levin-syndrome","display_name":"Kleine-Levin syndrome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/rem-sleep-behavior-disorder","display_name":"REM sleep behavior disorder","score":0.6140000224113464},{"id":"https://openalex.org/keywords/rem-sleep-regulation","display_name":"REM sleep regulation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/state-versus-trait","display_name":"trait versus state","score":0.6060000061988831},{"id":"https://openalex.org/keywords/hypersomnolence","display_name":"hypersomnolence","score":0.7369999885559082},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6151000261306763},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.600600004196167},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.5145999789237976},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3538999855518341},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3319999873638153},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.3095000088214874},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.29840001463890076},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2800000011920929},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2515000104904175},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.24969999492168427}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006970","descriptor_name":"Disorders of Excessive Somnolence","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006970","descriptor_name":"Disorders of Excessive Somnolence","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012895","descriptor_name":"Sleep, REM","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017593","descriptor_name":"Kleine-Levin Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D017593","descriptor_name":"Kleine-Levin Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/npr2.70186","doi":"https://doi.org/10.1002/npr2.70186","is_oa":true,"landing_page_url":"https://doi.org/10.1002/npr2.70186","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/npr2.70186","source":{"id":"https://openalex.org/S4210189692","display_name":"Neuropsychopharmacology Reports","issn_l":"2574-173X","issn":["2574-173X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology Reports","raw_type":"journal-article"},{"id":"pmid:43000941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43000941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology reports","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1002/npr2.70186","doi":"https://doi.org/10.1002/npr2.70186","is_oa":true,"landing_page_url":"https://doi.org/10.1002/npr2.70186","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/npr2.70186","source":{"id":"https://openalex.org/S4210189692","display_name":"Neuropsychopharmacology Reports","issn_l":"2574-173X","issn":["2574-173X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225640803.pdf","grobid_xml":"https://content.openalex.org/works/W7225640803.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2077067094","https://openalex.org/W3011526828","https://openalex.org/W3012845600","https://openalex.org/W4413139718","https://openalex.org/W4416793657","https://openalex.org/W7118901450"],"related_works":["https://openalex.org/W7133841319","https://openalex.org/W4410989914","https://openalex.org/W2044810684","https://openalex.org/W7152738273","https://openalex.org/W2071261443","https://openalex.org/W758282109","https://openalex.org/W2436658026","https://openalex.org/W2192397309","https://openalex.org/W2039574847","https://openalex.org/W4220867768"],"abstract_inverted_index":{"REM":[0],"dysregulation":[1],"in":[2,20],"Kleine-Levin":[3],"syndrome":[4],"may":[5],"reflect":[6],"a":[7],"trait,":[8],"an":[9],"episode-dependent":[10],"state,":[11],"or":[12],"profound":[13],"hypersomnolence;":[14],"SOREMPs":[15],"should":[16],"therefore":[17],"be":[18],"interpreted":[19],"the":[21,24],"context":[22],"of":[23],"longitudinal":[25],"clinical":[26],"phenotype.":[27]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
