{"id":"https://openalex.org/W7225639366","doi":"https://doi.org/10.1186/s12888-026-08620-x","title":"DTI-ALPS evidence of glymphatic function enhancement following dexmedetomidine-controlled sleep in patients with insomnia and depression","display_name":"DTI-ALPS evidence of glymphatic function enhancement following dexmedetomidine-controlled sleep in patients with insomnia and depression","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225639366","doi":"https://doi.org/10.1186/s12888-026-08620-x"},"language":"en","primary_location":{"id":"doi:10.1186/s12888-026-08620-x","doi":"https://doi.org/10.1186/s12888-026-08620-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12888-026-08620-x","pdf_url":null,"source":{"id":"https://openalex.org/S94610253","display_name":"BMC Psychiatry","issn_l":"1471-244X","issn":["1471-244X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12888-026-08620-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126769513","display_name":"Yongqiong Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099941","display_name":"Jinshan Hospital of Fudan University","ror":"https://ror.org/013a5fa56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099941"]},{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongqiong Tao","raw_affiliation_strings":["Department of Radiology, Changzhou Second People\u2019s Hospital, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000, China","Department of Radiology, Jinshan Hospital of Fudan University, Shanghai, 201508, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Changzhou Second People\u2019s Hospital, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Radiology, Jinshan Hospital of Fudan University, Shanghai, 201508, China","institution_ids":["https://openalex.org/I4210099941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101108157","display_name":"Yonghong Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonghong Zhou","raw_affiliation_strings":["Department of Anesthesiology, Changzhou Second People\u2019s Hospital, Changzhou Medical Center, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Changzhou, 213000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Changzhou Second People\u2019s Hospital, Changzhou Medical Center, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Changzhou, 213000, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159857138","display_name":"Yongtao Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongtao Tang","raw_affiliation_strings":["Department of Radiology, Changzhou Second People\u2019s Hospital, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Changzhou Second People\u2019s Hospital, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161323800","display_name":"Peng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086647","display_name":"Philips (China)","ror":"https://ror.org/001tk4253","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210086647","https://openalex.org/I4210122849"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Wu","raw_affiliation_strings":["Philips Healthcare, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philips Healthcare, Shanghai, China","institution_ids":["https://openalex.org/I4210086647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161348655","display_name":"Zhouquan Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhouquan Wu","raw_affiliation_strings":["Department of Anesthesiology, Changzhou Second People\u2019s Hospital, Changzhou Medical Center, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Changzhou, 213000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Changzhou Second People\u2019s Hospital, Changzhou Medical Center, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Changzhou, 213000, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101739322","display_name":"Ying Li","orcid":"https://orcid.org/0000-0002-7595-2212","observed_orcids":["https://orcid.org/0000-0002-7595-2212"]},"institutions":[{"id":"https://openalex.org/I4210099941","display_name":"Jinshan Hospital of Fudan University","ror":"https://ror.org/013a5fa56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099941"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Li","raw_affiliation_strings":["Department of Radiology, Jinshan Hospital of Fudan University, Shanghai, 201508, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Jinshan Hospital of Fudan University, Shanghai, 201508, China","institution_ids":["https://openalex.org/I4210099941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101711316","display_name":"Haifeng Shi","orcid":"https://orcid.org/0000-0002-5825-1959","observed_orcids":["https://orcid.org/0000-0002-5825-1959"]},"institutions":[{"id":"https://openalex.org/I4210099941","display_name":"Jinshan Hospital of Fudan University","ror":"https://ror.org/013a5fa56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099941"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haifeng Shi","raw_affiliation_strings":["Department of Radiology, Jinshan Hospital of Fudan University, Shanghai, 201508, China"],"raw_orcid":"https://orcid.org/0000-0002-5825-1959","affiliations":[{"raw_affiliation_string":"Department of Radiology, Jinshan Hospital of Fudan University, Shanghai, 201508, China","institution_ids":["https://openalex.org/I4210099941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101711316","https://openalex.org/A5101739322","https://openalex.org/A5161348655"],"corresponding_institution_ids":["https://openalex.org/I4210099941","https://openalex.org/I4210151861","https://openalex.org/I83519826"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.6967999935150146},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.6811000108718872},{"id":"https://openalex.org/C101054994","wikidata":"https://www.wikidata.org/wiki/Q15474254","display_name":"Glymphatic system","level":3,"score":0.6491000056266785},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.630299985408783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5473999977111816},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5195000171661377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5145999789237976},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.45239999890327454},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4212999939918518},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.4189000129699707},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.3610999882221222},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.35429999232292175},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.3224000036716461},{"id":"https://openalex.org/C3018449479","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressed mood","level":3,"score":0.3034000098705292},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2922999858856201},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.2921000123023987},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.28349998593330383},{"id":"https://openalex.org/C2776245837","wikidata":"https://www.wikidata.org/wiki/Q25053505","display_name":"Pittsburgh Sleep Quality Index","level":4,"score":0.26649999618530273},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2624000012874603},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.25929999351501465},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2565000057220459}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12888-026-08620-x","doi":"https://doi.org/10.1186/s12888-026-08620-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12888-026-08620-x","pdf_url":null,"source":{"id":"https://openalex.org/S94610253","display_name":"BMC Psychiatry","issn_l":"1471-244X","issn":["1471-244X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Psychiatry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12888-026-08620-x","doi":"https://doi.org/10.1186/s12888-026-08620-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12888-026-08620-x","pdf_url":null,"source":{"id":"https://openalex.org/S94610253","display_name":"BMC Psychiatry","issn_l":"1471-244X","issn":["1471-244X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"To":[0],"investigate":[1],"glymphatic":[2,106],"system":[3],"alterations":[4,107],"in":[5,32,122,127,161,168,219],"chronic":[6],"insomnia":[7],"disorder":[8,15],"(CID)":[9],"patients":[10,34,45,55,170],"comorbid":[11],"with":[12,21,35,152,180,200,214,233],"major":[13],"depressive":[14],"(MDD)":[16],"following":[17],"patient-controlled":[18],"sleep":[19,91],"therapy":[20],"dexmedetomidine":[22],"(Dex-PCSL),":[23],"and":[24,46,59,79,92,99,108,115,185,224],"to":[25,104],"evaluate":[26,105],"the":[27,85,123,128,132,140,153,192],"utility":[28],"of":[29,203],"DTI-ALPS":[30,86,226],"parameters":[31],"distinguishing":[33],"high":[36],"versus":[37],"low":[38],"treatment":[39,198,235],"sensitivity.":[40],"Seventy":[41],"CID":[42,220],"+":[43,221],"MDD":[44,222],"36":[47],"matched":[48],"good":[49],"sleepers":[50],"(GSs)":[51],"were":[52,60,88,102,119],"enrolled.":[53],"All":[54],"received":[56],"sub-anesthetic":[57],"Dex-PCSL":[58,211],"categorized":[61],"as":[62],"high-sensitivity":[63],"(HS-case,":[64],">":[65],"25%":[66],"PSQI":[67,174],"reduction)":[68],"or":[69],"low-sensitivity":[70],"(LS-case,":[71],"\u2264":[72],"25%).":[73],"MRI":[74],"scanning":[75],"was":[76,177,212],"performed":[77],"before":[78],"after":[80],"treatment.":[81],"Diffusion-related":[82],"metrics,":[83],"including":[84],"index,":[87],"quantified":[89],"alongside":[90],"mood":[93],"assessments.":[94],"Group":[95],"comparisons,":[96],"correlation":[97],"analyses,":[98],"ROC":[100,188],"analysis":[101,189],"used":[103],"predictive":[109],"performance.":[110],"At":[111],"baseline,":[112],"both":[113,162],"hemispheric":[114],"total":[116,186],"ALPS":[117,150,158,167,194],"indices":[118,159],"significantly":[120],"lower":[121],"LS-case":[124,144,169],"group":[125,134,145],"than":[126],"GS":[129,141],"group,":[130],"whereas":[131],"HS-case":[133,154],"showed":[135,190],"no":[136],"significant":[137],"differences":[138],"from":[139],"group.":[142,155],"The":[143,173],"also":[146],"demonstrated":[147],"reduced":[148],"right-hemisphere":[149,166,182,193,225],"compared":[151],"Following":[156],"treatment,":[157],"increased":[160,215],"patient":[163],"groups;":[164],"yet,":[165],"remained":[171],"lower.":[172],"reduction":[175],"rate":[176],"positively":[178],"correlated":[179],"baseline":[181],"ALPS,":[183],"x_proj_R,":[184],"ALPS.":[187],"that":[191],"index":[195],"effectively":[196],"predicted":[197],"sensitivity,":[199],"an":[201],"AUC":[202],"0.821":[204],"(95%":[205],"CI:":[206],"0.735\u20130.907,":[207],"P":[208],"<":[209],"0.001).":[210],"associated":[213,232],"glymphatic-related":[216],"imaging":[217],"markers":[218],"patients,":[223],"may":[227],"represent":[228],"a":[229],"potential":[230],"biomarker":[231],"individual":[234],"responsiveness,":[236],"providing":[237],"insights":[238],"for":[239],"personalized":[240],"therapy.":[241]},"counts_by_year":[],"updated_date":"2026-11-10T13:44:29.811591","created_date":"2026-11-10T00:00:00"}