{"id":"https://openalex.org/W7225638880","doi":"https://doi.org/10.1021/acs.jcim.6c02386","title":"Structural Insights into the Coaggregation Mechanism of TTR and TDP","display_name":"Structural Insights into the Coaggregation Mechanism of TTR and TDP","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225638880","doi":"https://doi.org/10.1021/acs.jcim.6c02386"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jcim.6c02386","doi":"https://doi.org/10.1021/acs.jcim.6c02386","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.6c02386","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161335218","display_name":"Xiaoyu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23632641","display_name":"Shanghai University of Electric Power","ror":"https://ror.org/02w4tny03","country_code":"CN","type":"education","lineage":["https://openalex.org/I23632641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Li","raw_affiliation_strings":["Shanghai University of Electric Power , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University of Electric Power , , ,","institution_ids":["https://openalex.org/I23632641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109763126","display_name":"Yuanming Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23632641","display_name":"Shanghai University of Electric Power","ror":"https://ror.org/02w4tny03","country_code":"CN","type":"education","lineage":["https://openalex.org/I23632641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanming Cao","raw_affiliation_strings":["Shanghai University of Electric Power , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University of Electric Power , , ,","institution_ids":["https://openalex.org/I23632641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161343878","display_name":"Keqing Zhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23632641","display_name":"Shanghai University of Electric Power","ror":"https://ror.org/02w4tny03","country_code":"CN","type":"education","lineage":["https://openalex.org/I23632641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keqing Zhan","raw_affiliation_strings":["Shanghai University of Electric Power , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University of Electric Power , , ,","institution_ids":["https://openalex.org/I23632641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100758334","display_name":"Yanyan Zhu","orcid":"https://orcid.org/0000-0003-4602-676X","observed_orcids":["https://orcid.org/0000-0003-4602-676X","https://orcid.org/0009-0001-9355-1535","https://orcid.org/0009-0005-3315-182X"]},"institutions":[{"id":"https://openalex.org/I23632641","display_name":"Shanghai University of Electric Power","ror":"https://ror.org/02w4tny03","country_code":"CN","type":"education","lineage":["https://openalex.org/I23632641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyan Zhu","raw_affiliation_strings":["Shanghai University of Electric Power , , ,"],"raw_orcid":"https://orcid.org/0000-0003-4602-676X","affiliations":[{"raw_affiliation_string":"Shanghai University of Electric Power , , ,","institution_ids":["https://openalex.org/I23632641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063085710","display_name":"\u8d75\u5e86\u6770","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qingjie Zhao","raw_affiliation_strings":["Shanghai University of Traditional Chinese Medicine , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University of Traditional Chinese Medicine , , ,","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161360649","display_name":"Yujie Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23632641","display_name":"Shanghai University of Electric Power","ror":"https://ror.org/02w4tny03","country_code":"CN","type":"education","lineage":["https://openalex.org/I23632641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yujie Chen","raw_affiliation_strings":["Shanghai University of Electric Power , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University of Electric Power , , ,","institution_ids":["https://openalex.org/I23632641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065859286","display_name":"Hui Li","orcid":"https://orcid.org/0000-0001-9198-3951","observed_orcids":["https://orcid.org/0000-0001-9198-3951","https://orcid.org/0000-0002-7577-1366","https://orcid.org/0000-0001-9346-6982","https://orcid.org/0000-0002-2459-9068","https://orcid.org/0000-0001-6310-8965","https://orcid.org/0000-0001-5592-7004","https://orcid.org/0000-0002-4293-4763","https://orcid.org/0009-0006-4455-2562","https://orcid.org/0000-0001-5211-8324","https://orcid.org/0000-0001-6946-4362","https://orcid.org/0000-0001-9275-4739","https://orcid.org/0000-0002-1961-7946","https://orcid.org/0000-0003-1979-4763","https://orcid.org/0000-0001-8082-4218","https://orcid.org/0000-0002-1457-8650","https://orcid.org/0000-0002-6294-6761","https://orcid.org/0000-0003-3483-1307","https://orcid.org/0000-0001-8310-7169","https://orcid.org/0000-0001-9158-9401","https://orcid.org/0000-0002-0707-5940","https://orcid.org/0000-0002-3841-5557","https://orcid.org/0000-0002-6890-2583","https://orcid.org/0000-0002-7030-8065","https://orcid.org/0000-0002-7481-095X","https://orcid.org/0000-0002-8533-2084","https://orcid.org/0000-0002-8749-0385","https://orcid.org/0000-0002-8968-3076","https://orcid.org/0000-0003-1048-4670","https://orcid.org/0009-0004-9396-0568","https://orcid.org/0000-0001-5441-2818","https://orcid.org/0000-0001-5568-9026","https://orcid.org/0000-0002-1761-6907","https://orcid.org/0000-0002-1804-1412","https://orcid.org/0000-0002-5841-6805","https://orcid.org/0000-0002-9116-8196","https://orcid.org/0000-0003-0268-1180","https://orcid.org/0000-0003-0463-8178","https://orcid.org/0000-0003-1152-5817","https://orcid.org/0000-0003-1744-1526","https://orcid.org/0000-0003-2288-791X","https://orcid.org/0000-0003-2988-368X","https://orcid.org/0000-0003-3604-9271","https://orcid.org/0000-0003-4623-2125","https://orcid.org/0000-0003-4852-8042","https://orcid.org/0009-0000-5604-8247","https://orcid.org/0009-0001-7191-0998","https://orcid.org/0009-0003-6823-7776","https://orcid.org/0009-0004-0699-6053","https://orcid.org/0009-0007-5083-6016","https://orcid.org/0000-0001-5294-8731","https://orcid.org/0000-0001-5437-7063","https://orcid.org/0000-0001-7006-4542","https://orcid.org/0000-0001-7754-7141","https://orcid.org/0000-0001-8106-6340","https://orcid.org/0000-0001-8356-6154","https://orcid.org/0000-0001-8776-6911","https://orcid.org/0000-0001-8904-4859","https://orcid.org/0000-0001-9051-6489","https://orcid.org/0000-0001-9139-3855","https://orcid.org/0000-0001-9251-9106","https://orcid.org/0000-0001-9377-6681","https://orcid.org/0000-0001-9418-3976","https://orcid.org/0000-0002-0358-8298","https://orcid.org/0000-0002-0749-7107","https://orcid.org/0000-0002-1191-2203","https://orcid.org/0000-0002-1257-6483","https://orcid.org/0000-0002-1752-5167","https://orcid.org/0000-0002-2262-0564","https://orcid.org/0000-0002-2515-3076","https://orcid.org/0000-0002-2721-0337","https://orcid.org/0000-0002-3312-8532","https://orcid.org/0000-0002-3435-8698","https://orcid.org/0000-0002-3705-3654","https://orcid.org/0000-0002-4469-2606","https://orcid.org/0000-0002-4496-5846","https://orcid.org/0000-0002-6084-2707","https://orcid.org/0000-0002-6557-3251","https://orcid.org/0000-0002-6959-3233","https://orcid.org/0000-0002-7382-6546","https://orcid.org/0000-0002-7457-4192","https://orcid.org/0000-0002-8574-4468","https://orcid.org/0000-0002-9179-3741","https://orcid.org/0000-0002-9476-0830","https://orcid.org/0000-0002-9546-6836","https://orcid.org/0000-0003-0142-7500","https://orcid.org/0000-0003-0348-7910","https://orcid.org/0000-0003-0513-6321","https://orcid.org/0000-0003-0824-6518","https://orcid.org/0000-0003-2876-1525","https://orcid.org/0000-0003-3583-3988","https://orcid.org/0000-0003-3737-0833","https://orcid.org/0000-0003-4097-6836","https://orcid.org/0000-0003-4304-6378","https://orcid.org/0000-0003-4681-8791","https://orcid.org/0009-0000-4252-7941","https://orcid.org/0009-0001-1235-2818","https://orcid.org/0009-0001-7466-9757","https://orcid.org/0009-0001-8913-0762","https://orcid.org/0009-0002-6073-5837","https://orcid.org/0009-0002-7336-4959","https://orcid.org/0009-0002-9071-0358","https://orcid.org/0009-0003-5826-6805","https://orcid.org/0009-0004-5439-0398","https://orcid.org/0009-0005-8789-6288","https://orcid.org/0009-0006-7034-6498","https://orcid.org/0009-0006-7611-9544","https://orcid.org/0009-0007-1649-9159","https://orcid.org/0009-0007-5907-2104","https://orcid.org/0009-0009-0912-2315","https://orcid.org/0009-0009-3700-6258","https://orcid.org/0009-0009-3827-385X","https://orcid.org/0009-0009-5275-6700","https://orcid.org/0009-0009-5438-0778","https://orcid.org/0009-0009-6069-4263","https://orcid.org/0009-0009-8524-5608","https://orcid.org/0000-0001-5324-746X","https://orcid.org/0000-0001-5363-6676","https://orcid.org/0000-0001-5537-1886","https://orcid.org/0000-0001-5914-8833","https://orcid.org/0000-0001-6457-6496","https://orcid.org/0000-0001-7223-1754","https://orcid.org/0000-0001-7583-6003","https://orcid.org/0000-0001-7671-0613","https://orcid.org/0000-0001-7693-9733","https://orcid.org/0000-0001-7849-9735","https://orcid.org/0000-0001-7915-582X","https://orcid.org/0000-0001-8710-5558","https://orcid.org/0000-0001-9209-9906","https://orcid.org/0000-0001-9368-826X","https://orcid.org/0000-0001-9472-7785","https://orcid.org/0000-0001-9547-648X","https://orcid.org/0000-0001-9673-9544","https://orcid.org/0000-0001-9825-054X","https://orcid.org/0000-0002-0033-7944","https://orcid.org/0000-0002-0080-6800","https://orcid.org/0000-0002-0137-2717","https://orcid.org/0000-0002-0409-2227","https://orcid.org/0000-0002-0583-3314","https://orcid.org/0000-0002-0685-3309","https://orcid.org/0000-0002-1002-6357","https://orcid.org/0000-0002-1010-1281","https://orcid.org/0000-0002-1137-5487","https://orcid.org/0000-0002-1348-6973","https://orcid.org/0000-0002-1877-9599","https://orcid.org/0000-0002-2419-2700","https://orcid.org/0000-0002-2659-923X","https://orcid.org/0000-0002-2689-2241","https://orcid.org/0000-0002-2987-8373","https://orcid.org/0000-0002-3174-1376","https://orcid.org/0000-0002-3286-1409","https://orcid.org/0000-0002-3336-3946","https://orcid.org/0000-0002-3388-0740","https://orcid.org/0000-0002-3533-8170","https://orcid.org/0000-0002-3776-2151","https://orcid.org/0000-0002-3964-4554","https://orcid.org/0000-0002-4750-1457","https://orcid.org/0000-0002-4762-9442","https://orcid.org/0000-0002-5140-6030","https://orcid.org/0000-0002-5312-2832","https://orcid.org/0000-0002-5705-2835","https://orcid.org/0000-0002-5720-8078","https://orcid.org/0000-0002-6634-9593","https://orcid.org/0000-0002-6636-9842","https://orcid.org/0000-0002-6737-8118","https://orcid.org/0000-0002-6800-1101","https://orcid.org/0000-0002-7514-5656","https://orcid.org/0000-0002-7530-3343","https://orcid.org/0000-0002-7685-282X","https://orcid.org/0000-0002-7895-2859","https://orcid.org/0000-0002-7919-8093","https://orcid.org/0000-0002-8102-5917","https://orcid.org/0000-0002-8117-8980","https://orcid.org/0000-0002-8445-4776","https://orcid.org/0000-0002-8560-0472","https://orcid.org/0000-0002-8659-086X","https://orcid.org/0000-0002-8723-8112","https://orcid.org/0000-0002-8762-8129","https://orcid.org/0000-0002-8866-5941","https://orcid.org/0000-0002-9190-0500","https://orcid.org/0000-0002-9296-5074","https://orcid.org/0000-0002-9456-1874","https://orcid.org/0000-0002-9485-3041","https://orcid.org/0000-0002-9892-8370","https://orcid.org/0000-0003-1132-3238","https://orcid.org/0000-0003-1160-4515","https://orcid.org/0000-0003-1322-2684","https://orcid.org/0000-0003-1383-8972","https://orcid.org/0000-0003-1765-9322","https://orcid.org/0000-0003-1805-8430","https://orcid.org/0000-0003-2291-7840","https://orcid.org/0000-0003-2462-6174","https://orcid.org/0000-0003-2821-3465","https://orcid.org/0000-0003-2916-9208","https://orcid.org/0000-0003-3178-0997","https://orcid.org/0000-0003-3834-2682","https://orcid.org/0000-0003-3983-9287","https://orcid.org/0000-0003-4377-0550","https://orcid.org/0000-0003-4380-6277","https://orcid.org/0000-0003-4542-4686","https://orcid.org/0000-0003-4626-7416","https://orcid.org/0000-0003-4632-7490","https://orcid.org/0000-0003-4646-0515","https://orcid.org/0000-0003-4783-4945","https://orcid.org/0000-0003-4813-3227","https://orcid.org/0000-0003-4990-0109","https://orcid.org/0009-0000-0044-1939","https://orcid.org/0009-0000-0178-9056","https://orcid.org/0009-0000-2084-927X","https://orcid.org/0009-0000-2366-7287","https://orcid.org/0009-0000-3214-8374","https://orcid.org/0009-0000-3462-5699","https://orcid.org/0009-0000-3475-6410","https://orcid.org/0009-0000-4397-7979","https://orcid.org/0009-0000-4796-784X","https://orcid.org/0009-0000-7262-382X","https://orcid.org/0009-0000-7438-894X","https://orcid.org/0009-0000-9190-7350","https://orcid.org/0009-0001-1048-0330","https://orcid.org/0009-0001-1584-2652","https://orcid.org/0009-0001-2405-5570","https://orcid.org/0009-0001-2667-8843","https://orcid.org/0009-0001-4515-7808","https://orcid.org/0009-0001-6192-0519","https://orcid.org/0009-0001-6372-0705","https://orcid.org/0009-0001-6445-5413","https://orcid.org/0009-0001-8048-1072","https://orcid.org/0009-0002-0146-1418","https://orcid.org/0009-0002-0386-5627","https://orcid.org/0009-0002-0448-9918","https://orcid.org/0009-0002-1129-5994","https://orcid.org/0009-0002-3103-2497","https://orcid.org/0009-0002-3675-0420","https://orcid.org/0009-0002-3712-3066","https://orcid.org/0009-0002-3812-8950","https://orcid.org/0009-0002-3991-9965","https://orcid.org/0009-0002-4051-5319","https://orcid.org/0009-0002-4257-8276","https://orcid.org/0009-0002-6138-0580","https://orcid.org/0009-0002-7806-4883","https://orcid.org/0009-0002-8110-8429","https://orcid.org/0009-0003-0650-3346","https://orcid.org/0009-0003-1741-1930","https://orcid.org/0009-0003-2165-9760","https://orcid.org/0009-0003-3703-0799","https://orcid.org/0009-0003-3727-3336","https://orcid.org/0009-0003-3971-6380","https://orcid.org/0009-0003-4909-0318","https://orcid.org/0009-0003-5289-8449","https://orcid.org/0009-0003-5521-9069","https://orcid.org/0009-0003-6728-6138","https://orcid.org/0009-0003-7403-0958","https://orcid.org/0009-0003-7701-6430","https://orcid.org/0009-0003-7728-2704","https://orcid.org/0009-0003-8154-6573","https://orcid.org/0009-0003-8636-8665","https://orcid.org/0009-0003-8950-2428","https://orcid.org/0009-0003-9245-7023","https://orcid.org/0009-0004-0782-6400","https://orcid.org/0009-0004-0938-4650","https://orcid.org/0009-0004-1780-9508","https://orcid.org/0009-0004-1982-8710","https://orcid.org/0009-0004-3665-9744","https://orcid.org/0009-0004-4216-8087","https://orcid.org/0009-0004-5230-3449","https://orcid.org/0009-0004-5978-3246","https://orcid.org/0009-0004-6504-508X","https://orcid.org/0009-0004-6901-4467","https://orcid.org/0009-0004-6945-8092","https://orcid.org/0009-0004-7562-9062","https://orcid.org/0009-0004-8151-1132","https://orcid.org/0009-0004-8658-535X","https://orcid.org/0009-0004-9035-5338","https://orcid.org/0009-0005-0274-3996","https://orcid.org/0009-0005-0911-2310","https://orcid.org/0009-0005-2385-082X","https://orcid.org/0009-0005-2597-376X","https://orcid.org/0009-0005-3521-1304","https://orcid.org/0009-0005-3584-2376","https://orcid.org/0009-0005-4055-4520","https://orcid.org/0009-0005-4326-4369","https://orcid.org/0009-0005-5805-3695","https://orcid.org/0009-0005-6014-2881","https://orcid.org/0009-0005-6670-3766","https://orcid.org/0009-0005-6912-7514","https://orcid.org/0009-0005-7033-8415","https://orcid.org/0009-0005-7264-4168","https://orcid.org/0009-0005-9193-323X","https://orcid.org/0009-0005-9701-5704","https://orcid.org/0009-0006-0618-7859","https://orcid.org/0009-0006-0897-9454","https://orcid.org/0009-0006-1173-7675","https://orcid.org/0009-0006-1381-3133","https://orcid.org/0009-0006-3804-4860","https://orcid.org/0009-0006-4150-7889","https://orcid.org/0009-0006-4182-1915","https://orcid.org/0009-0006-6601-2639","https://orcid.org/0009-0006-7288-5882","https://orcid.org/0009-0006-7325-7044","https://orcid.org/0009-0006-8699-6508","https://orcid.org/0009-0006-9201-104X","https://orcid.org/0009-0006-9747-8474","https://orcid.org/0009-0007-0044-7282","https://orcid.org/0009-0007-0200-1989","https://orcid.org/0009-0007-0567-7458","https://orcid.org/0009-0007-1194-1403","https://orcid.org/0009-0007-1798-9934","https://orcid.org/0009-0007-2081-2531","https://orcid.org/0009-0007-3450-4652","https://orcid.org/0009-0007-6243-3863","https://orcid.org/0009-0007-6489-273X","https://orcid.org/0009-0007-6906-4909","https://orcid.org/0009-0007-7810-604X","https://orcid.org/0009-0007-8455-456X","https://orcid.org/0009-0007-8482-550X","https://orcid.org/0009-0007-8585-5356","https://orcid.org/0009-0007-8868-1558","https://orcid.org/0009-0007-8873-1156","https://orcid.org/0009-0007-9485-0952","https://orcid.org/0009-0007-9828-0192","https://orcid.org/0009-0008-0428-5900","https://orcid.org/0009-0008-0743-6444","https://orcid.org/0009-0008-1180-5062","https://orcid.org/0009-0008-1633-8029","https://orcid.org/0009-0008-3253-6391","https://orcid.org/0009-0008-4456-8163","https://orcid.org/0009-0008-5056-5524","https://orcid.org/0009-0008-6524-7641","https://orcid.org/0009-0008-7380-9122","https://orcid.org/0009-0008-8314-6078","https://orcid.org/0009-0008-8429-8110","https://orcid.org/0009-0008-9480-0856","https://orcid.org/0009-0009-0329-5370","https://orcid.org/0009-0009-0685-3489","https://orcid.org/0009-0009-0772-6588","https://orcid.org/0009-0009-2335-9474","https://orcid.org/0009-0009-2405-7451","https://orcid.org/0009-0009-3380-8069","https://orcid.org/0009-0009-4344-5820","https://orcid.org/0009-0009-4898-0304","https://orcid.org/0009-0009-6783-6113","https://orcid.org/0009-0009-8280-7249","https://orcid.org/0009-0008-4264-9998"]},"institutions":[{"id":"https://openalex.org/I23632641","display_name":"Shanghai University of Electric Power","ror":"https://ror.org/02w4tny03","country_code":"CN","type":"education","lineage":["https://openalex.org/I23632641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huiyu Li","raw_affiliation_strings":["Shanghai University of Electric Power , , ,"],"raw_orcid":"https://orcid.org/0000-0002-0749-7107","affiliations":[{"raw_affiliation_string":"Shanghai University of Electric Power , , ,","institution_ids":["https://openalex.org/I23632641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063085710","https://openalex.org/A5065859286","https://openalex.org/A5161360649"],"corresponding_institution_ids":["https://openalex.org/I23632641","https://openalex.org/I4210098460"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.07930000126361847,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prealbumin","display_name":"prealbumin","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tdp-43","display_name":"TDP-43","score":0.9580000042915344},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tdp-43-proteinopathy","display_name":"TDP-43 proteinopathy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/protein-self-aggregation","display_name":"protein self-aggregation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/heterohexamer","display_name":"heterohexamer","score":0.718999981880188},{"id":"https://openalex.org/keywords/homohexamer","display_name":"homohexamer","score":0.8600000143051147},{"id":"https://openalex.org/keywords/beta-barrel","display_name":"beta-barrel","score":0.8429999947547913},{"id":"https://openalex.org/keywords/bilayer-structure","display_name":"bilayer structure","score":0.7310000061988831},{"id":"https://openalex.org/keywords/beta-sheet-content","display_name":"\u03b2-sheet content","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.9950000047683716},{"id":"https://openalex.org/keywords/amyloidosis","display_name":"amyloidosis","score":0.6299999952316284},{"id":"https://openalex.org/keywords/protein-conformational-ensembles","display_name":"protein conformational ensembles","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C121157162","wikidata":"https://www.wikidata.org/wiki/Q419999","display_name":"Transthyretin","level":2,"score":0.6100999712944031},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5673999786376953},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5625},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5566999912261963},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5436999797821045},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5163000226020813},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4426000118255615},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.38019999861717224},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.37950000166893005},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.3546000123023987},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.33649998903274536},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.3131999969482422},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.29820001125335693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2962000072002411},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.27730000019073486},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2687999904155731},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2678999900817871},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2547999918460846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.jcim.6c02386","doi":"https://doi.org/10.1021/acs.jcim.6c02386","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.6c02386","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemical Information and Modeling","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1491824558","https://openalex.org/W1965650805","https://openalex.org/W1975860260","https://openalex.org/W1990145006","https://openalex.org/W1995276702","https://openalex.org/W1997581921","https://openalex.org/W2001399725","https://openalex.org/W2008708467","https://openalex.org/W2027177575","https://openalex.org/W2029667189","https://openalex.org/W2029880255","https://openalex.org/W2032719480","https://openalex.org/W2044707242","https://openalex.org/W2056286291","https://openalex.org/W2057477511","https://openalex.org/W2059980851","https://openalex.org/W2065140753","https://openalex.org/W2067174909","https://openalex.org/W2073073462","https://openalex.org/W2081693079","https://openalex.org/W2094186244","https://openalex.org/W2103945336","https://openalex.org/W2112343021","https://openalex.org/W2116660354","https://openalex.org/W2136305293","https://openalex.org/W2163485494","https://openalex.org/W2170087857","https://openalex.org/W2171268876","https://openalex.org/W2239119992","https://openalex.org/W2316054449","https://openalex.org/W2330416673","https://openalex.org/W2495970857","https://openalex.org/W2803667870","https://openalex.org/W2935622333","https://openalex.org/W2949934835","https://openalex.org/W3111773861","https://openalex.org/W3130337837","https://openalex.org/W3160485263","https://openalex.org/W3171817762","https://openalex.org/W4229456350","https://openalex.org/W4285162674","https://openalex.org/W4308685961","https://openalex.org/W4388209805","https://openalex.org/W4388904022","https://openalex.org/W4392805325","https://openalex.org/W4404184367","https://openalex.org/W4410012207","https://openalex.org/W4411341661"],"related_works":["https://openalex.org/W3194043672","https://openalex.org/W4387694003","https://openalex.org/W3130337837","https://openalex.org/W3135770824","https://openalex.org/W4404468613","https://openalex.org/W4200195001","https://openalex.org/W4408175820","https://openalex.org/W4391657355","https://openalex.org/W2029880255","https://openalex.org/W7026537008"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"self-aggregation":[2],"of":[3,14,30,52,99,125,144,155,158,166],"TTR":[4,22,145],"and":[5,23,36,55,69,117,146,162],"TDP":[6],"proteins":[7],"is":[8],"closely":[9],"associated":[10],"with":[11],"the":[12,28,49,95,100,107,121,126,133,137,142,156,164],"treatment":[13],"TDP-43":[15,24],"proteinopathies.":[16],"Recent":[17],"experimental":[18],"evidence":[19],"suggests":[20],"that":[21,78,132],"can":[25,81,90],"coaggregate":[26],"in":[27,140],"cytoplasm":[29],"Amyotrophic":[31],"lateral":[32],"sclerosis":[33],"(ALS)":[34],"patients":[35],"disease":[37],"models.":[38],"However,":[39],"their":[40],"coaggregation":[41,97,123,143],"molecular":[42,63,66],"mechanisms":[43],"are":[44],"unknown.":[45],"Herein,":[46],"we":[47],"investigated":[48],"conformational":[50],"ensembles":[51],"TTR,":[53],"TDP,":[54],"TTR-TDP":[56,79,101,108,127],"systems,":[57,106],"respectively,":[58],"employing":[59],"all-atom":[60],"replica":[61],"exchange":[62],"dynamics":[64,67],"(REMD),":[65],"(MD),":[68],"coarse":[70],"grain":[71],"(CG)":[72],"MD":[73],"simulation":[74],"methods.":[75],"Analyses":[76],"reveal":[77,131],"heterohexamer":[80],"assemble":[82],"into":[83],"closed/open":[84],"\u03b2-barrel":[85],"structures,":[86,93],"but":[87],"TTR/TDP":[88,105],"homohexamer":[89],"form":[91],"bilayer":[92],"implying":[94],"distinct":[96],"property":[98],"heterohexamer.":[102,128],"Compared":[103],"to":[104],"system":[109],"has":[110],"a":[111,152],"higher":[112],"\u03b2-sheet":[113],"content,":[114],"longer":[115],"\u03b2-strands":[116],"larger":[118],"\u03b2-sheets,":[119],"suggesting":[120],"stronger":[122],"ability":[124],"Further":[129],"analyses":[130],"hydrophobic":[134],"interactions":[135],"play":[136],"pivotal":[138],"role":[139],"driving":[141],"TDP.":[147],"These":[148],"findings":[149],"may":[150],"provide":[151],"deeper":[153],"understanding":[154],"pathogenesis":[157],"related":[159],"amyloid":[160],"diseases":[161],"prove":[163],"development":[165],"novel":[167],"therapeutic":[168],"strategies.":[169]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}