{"id":"https://openalex.org/W7225638732","doi":"https://doi.org/10.1007/s43032-026-02240-2","title":"Vaginal Progesterone Administration Subtly Influences Biomechanics and Composition of Mouse Cervix in Pregnancy","display_name":"Vaginal Progesterone Administration Subtly Influences Biomechanics and Composition of Mouse Cervix in Pregnancy","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225638732","doi":"https://doi.org/10.1007/s43032-026-02240-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/43002375"},"language":"en","primary_location":{"id":"doi:10.1007/s43032-026-02240-2","doi":"https://doi.org/10.1007/s43032-026-02240-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s43032-026-02240-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s43032-026-02240-2.pdf","source":{"id":"https://openalex.org/S68157034","display_name":"Reproductive Sciences","issn_l":"1933-7191","issn":["1933-7191","1933-7205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s43032-026-02240-2.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008308869","display_name":"M. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengcun Chen","raw_affiliation_strings":["McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078497858","display_name":"Stephanie N. Weiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie N. Weiss","raw_affiliation_strings":["McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053937825","display_name":"Jonathon L. Blank","orcid":"https://orcid.org/0000-0002-4155-8049","observed_orcids":["https://orcid.org/0000-0002-4155-8049"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathon L. Blank","raw_affiliation_strings":["McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083353796","display_name":"Jeremy D. Eekhoff","orcid":"https://orcid.org/0000-0002-0494-2439","observed_orcids":["https://orcid.org/0000-0002-0494-2439"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy D. Eekhoff","raw_affiliation_strings":["McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048189307","display_name":"Michal A. Elovitz","orcid":"https://orcid.org/0000-0001-7554-7180","observed_orcids":["https://orcid.org/0000-0001-7554-7180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michal A. Elovitz","raw_affiliation_strings":["Nuttall Women's Health, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuttall Women's Health, New York, NY, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014456616","display_name":"Louis J. Soslowsky","orcid":"https://orcid.org/0000-0001-9325-7662","observed_orcids":["https://orcid.org/0000-0001-9325-7662"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Louis J. Soslowsky","raw_affiliation_strings":["McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA. soslowsk@upenn.edu"],"raw_orcid":"https://orcid.org/0000-0001-9325-7662","affiliations":[{"raw_affiliation_string":"McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA. soslowsk@upenn.edu","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014456616"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vaginal-progesterone","display_name":"vaginal progesterone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cervical-spine-biomechanics","display_name":"cervical spine biomechanics","score":0.9120000004768372},{"id":"https://openalex.org/keywords/preterm-birth-prevention","display_name":"preterm birth prevention","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cervical-ripening","display_name":"cervical ripening","score":0.6980000138282776},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.47099998593330383},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tissue-hydration","display_name":"tissue hydration","score":0.8790000081062317},{"id":"https://openalex.org/keywords/fatigue-life","display_name":"fatigue life","score":0.49900001287460327},{"id":"https://openalex.org/keywords/late-pregnancy","display_name":"late pregnancy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.3540000021457672},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8359000086784363},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.763700008392334},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.6407999992370605},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5694000124931335},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4821000099182129},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4812999963760376},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.47429999709129333},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4399999976158142},{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.41130000352859497},{"id":"https://openalex.org/C2777744392","wikidata":"https://www.wikidata.org/wiki/Q5880","display_name":"Vagina","level":2,"score":0.38339999318122864},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.3587000072002411},{"id":"https://openalex.org/C2778723060","wikidata":"https://www.wikidata.org/wiki/Q6058566","display_name":"Intravaginal administration","level":3,"score":0.35510000586509705},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3310999870300293},{"id":"https://openalex.org/C2909151182","wikidata":"https://www.wikidata.org/wiki/Q625506","display_name":"Preterm labour","level":4,"score":0.32600000500679016},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.3246000111103058},{"id":"https://openalex.org/C2776344615","wikidata":"https://www.wikidata.org/wiki/Q625506","display_name":"Premature birth","level":4,"score":0.3073999881744385},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.28949999809265137},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.2766000032424927},{"id":"https://openalex.org/C2779508502","wikidata":"https://www.wikidata.org/wiki/Q5065334","display_name":"Cervical cerclage","level":4,"score":0.2612000107765198},{"id":"https://openalex.org/C2910530332","wikidata":"https://www.wikidata.org/wiki/Q2563414","display_name":"Cervical insufficiency","level":4,"score":0.2556000053882599}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s43032-026-02240-2","doi":"https://doi.org/10.1007/s43032-026-02240-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s43032-026-02240-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s43032-026-02240-2.pdf","source":{"id":"https://openalex.org/S68157034","display_name":"Reproductive Sciences","issn_l":"1933-7191","issn":["1933-7191","1933-7205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Sciences","raw_type":"journal-article"},{"id":"pmid:43002375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43002375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive sciences (Thousand Oaks, Calif.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s43032-026-02240-2","doi":"https://doi.org/10.1007/s43032-026-02240-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s43032-026-02240-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s43032-026-02240-2.pdf","source":{"id":"https://openalex.org/S68157034","display_name":"Reproductive Sciences","issn_l":"1933-7191","issn":["1933-7191","1933-7205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337897","display_name":"Penn Center for Musculoskeletal Disorders","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225638732.pdf","grobid_xml":"https://content.openalex.org/works/W7225638732.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1504526870","https://openalex.org/W1963928942","https://openalex.org/W1971532261","https://openalex.org/W1972414087","https://openalex.org/W1976277705","https://openalex.org/W1992634340","https://openalex.org/W1994778356","https://openalex.org/W2003105309","https://openalex.org/W2011764393","https://openalex.org/W2023080332","https://openalex.org/W2027820828","https://openalex.org/W2036555739","https://openalex.org/W2057724677","https://openalex.org/W2063947947","https://openalex.org/W2065614074","https://openalex.org/W2084398582","https://openalex.org/W2098963564","https://openalex.org/W2104885173","https://openalex.org/W2124007700","https://openalex.org/W2127573615","https://openalex.org/W2142895045","https://openalex.org/W2152244013","https://openalex.org/W2170400471","https://openalex.org/W2276408674","https://openalex.org/W2292546422","https://openalex.org/W2604851146","https://openalex.org/W2607273661","https://openalex.org/W2757059187","https://openalex.org/W2759659974","https://openalex.org/W2767818213","https://openalex.org/W2806685304","https://openalex.org/W2809908436","https://openalex.org/W2883465300","https://openalex.org/W2907497194","https://openalex.org/W2934301299","https://openalex.org/W2981584661","https://openalex.org/W3080275311","https://openalex.org/W3097918626","https://openalex.org/W3118352897","https://openalex.org/W3138680213","https://openalex.org/W3149242295","https://openalex.org/W4210493444","https://openalex.org/W4280535184","https://openalex.org/W4282921332","https://openalex.org/W4297215945","https://openalex.org/W4307919290","https://openalex.org/W4309683215","https://openalex.org/W4322772956","https://openalex.org/W4387381283","https://openalex.org/W4399683275","https://openalex.org/W4401580174","https://openalex.org/W4409929823","https://openalex.org/W7117105295"],"related_works":["https://openalex.org/W2007980186","https://openalex.org/W4391068520","https://openalex.org/W2023080332","https://openalex.org/W2806685304","https://openalex.org/W2564058576","https://openalex.org/W2968025091","https://openalex.org/W2400504924","https://openalex.org/W2790902308","https://openalex.org/W2060067944","https://openalex.org/W2883465300"],"abstract_inverted_index":{"During":[0],"pregnancy,":[1],"the":[2,8,25,59,69,114,192],"cervix":[3,26,60],"provides":[4],"mechanical":[5,133,205],"support":[6],"for":[7,47,117,191],"developing":[9],"fetus":[10],"and":[11,20,39,71,76,101,120,160,207],"then":[12],"dynamically":[13],"remodels":[14],"during":[15,86],"late":[16,87],"gestation":[17],"to":[18,30,67,104,168],"soften":[19],"enable":[21],"parturition.":[22],"Dysfunction":[23],"of":[24,36,74,150,181,195],"can":[27],"therefore":[28],"lead":[29],"preterm":[31,48,200],"birth,":[32],"a":[33,187],"leading":[34],"cause":[35],"neonatal":[37],"morbidity":[38],"mortality.":[40],"Progestational":[41],"agents":[42],"have":[43],"been":[44],"extensively":[45],"studied":[46],"birth":[49,201],"prevention,":[50],"yet":[51],"data":[52],"on":[53,58,80],"their":[54],"direct":[55],"biomechanical":[56,70,174,189],"impact":[57],"are":[61],"limited.":[62],"Therefore,":[63],"this":[64],"study":[65],"aimed":[66],"investigate":[68],"compositional":[72,121],"effects":[73,175],"systemic":[75,93],"vaginal":[77,95,141,196],"progesterone":[78,96,124,142,154,197],"administration":[79],"cervical":[81,131,144,157,204],"tissue":[82,182],"integrity":[83],"in":[84,130,198],"mice":[85,90],"gestation.":[88],"Pregnant":[89],"received":[91],"daily":[92],"or":[94,135],"from":[97],"gestational":[98],"days":[99],"14-17":[100],"were":[102,109],"compared":[103],"vehicle":[105],"controls.":[106],"Cervical":[107],"tissues":[108],"harvested":[110],"six":[111],"hours":[112],"after":[113],"final":[115],"treatment":[116,125],"structural,":[118],"mechanical,":[119],"assessment.":[122],"Systemic":[123],"did":[126],"not":[127],"produce":[128],"changes":[129],"structure,":[132],"properties,":[134],"extracellular":[136],"matrix":[137],"composition.":[138],"In":[139],"contrast,":[140],"increased":[143],"tangent":[145],"modulus":[146],"at":[147],"different":[148],"stages":[149],"fatigue":[151],"life.":[152],"Vaginal":[153],"also":[155],"reduced":[156],"cross-sectional":[158],"area":[159],"water":[161],"content,":[162],"while":[163],"increasing":[164],"collagen":[165],"concentration":[166],"relative":[167],"wet":[169],"weight,":[170],"suggesting":[171],"that":[172],"its":[173],"may":[176],"be":[177],"mediated":[178],"through":[179],"modulation":[180],"hydration.":[183],"These":[184],"findings":[185],"provide":[186],"plausible":[188],"basis":[190],"clinical":[193],"efficacy":[194],"preventing":[199],"by":[202],"preserving":[203],"stability":[206],"attenuating":[208],"premature":[209],"softening.":[210]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
