{"id":"https://openalex.org/W7225638468","doi":"https://doi.org/10.64898/2026.11.06.764618","title":"Regulation of sociality and neuronal development by the translation initiation factor eIF4H1 in Drosophila","display_name":"Regulation of sociality and neuronal development by the translation initiation factor eIF4H1 in Drosophila","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225638468","doi":"https://doi.org/10.64898/2026.11.06.764618"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.06.764618","doi":"https://doi.org/10.64898/2026.11.06.764618","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.06.764618","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.06.764618.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.06.764618.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137275863","display_name":"Erik Nolan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik Nolan","raw_affiliation_strings":["Washington University in St. Louis;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis;","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161357918","display_name":"Iris Chin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iris Chin","raw_affiliation_strings":["Gladstone Institute of Neurological Disease;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Neurological Disease;","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085673306","display_name":"Cassondra Vernier","orcid":"https://orcid.org/0000-0002-7381-3833","observed_orcids":["https://orcid.org/0000-0002-7381-3833"]},"institutions":[{"id":"https://openalex.org/I1921588","display_name":"University of Wisconsin\u2013Stout","ror":"https://ror.org/01gb8pc70","country_code":"US","type":"education","lineage":["https://openalex.org/I1921588"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassondra Vernier","raw_affiliation_strings":["University of Wisconsin - Stout Polytechnic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin - Stout Polytechnic","institution_ids":["https://openalex.org/I1921588"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013890263","display_name":"Yehuda Ben\u2010Shahar","orcid":"https://orcid.org/0000-0002-2956-2926","observed_orcids":["https://orcid.org/0000-0002-2956-2926"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yehuda Ben-Shahar","raw_affiliation_strings":["Washington University in St. Louis;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis;","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013890263"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13258","display_name":"Williams Syndrome Research","score":0.08879999816417694,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sociality","display_name":"sociality","score":0.6909999847412109},{"id":"https://openalex.org/keywords/williams-syndrome","display_name":"Williams syndrome","score":0.8259999752044678},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.7639999985694885},{"id":"https://openalex.org/keywords/neuronal-development","display_name":"neuronal development","score":0.722000002861023},{"id":"https://openalex.org/keywords/genetic-toolkit","display_name":"genetic toolkit","score":0.5239999890327454},{"id":"https://openalex.org/keywords/haploinsufficiency","display_name":"haploinsufficiency","score":0.7580000162124634},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.6800000071525574},{"id":"https://openalex.org/keywords/social-behavior","display_name":"social behavior","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8668000102043152},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6620000004768372},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6276000142097473},{"id":"https://openalex.org/C68838962","wikidata":"https://www.wikidata.org/wiki/Q852654","display_name":"Haploinsufficiency","level":4,"score":0.6101999878883362},{"id":"https://openalex.org/C207259873","wikidata":"https://www.wikidata.org/wiki/Q227241","display_name":"FOXP2","level":4,"score":0.5260999798774719},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.51419997215271},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.44429999589920044},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.42570000886917114},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.4050999879837036},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.39739999175071716},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.376800000667572},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.37380000948905945},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.37369999289512634},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.3634999990463257},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3614000082015991},{"id":"https://openalex.org/C461258","wikidata":"https://www.wikidata.org/wiki/Q1345738","display_name":"Neural development","level":3,"score":0.3472999930381775},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3472999930381775},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3416000008583069},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3138999938964844},{"id":"https://openalex.org/C152198750","wikidata":"https://www.wikidata.org/wiki/Q17165278","display_name":"Neurogenetics","level":3,"score":0.3010999858379364},{"id":"https://openalex.org/C176544851","wikidata":"https://www.wikidata.org/wiki/Q3307505","display_name":"Sociality","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.2888000011444092},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.28220000863075256},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.2732999920845032},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.26969999074935913},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.2678999900817871},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.260699987411499},{"id":"https://openalex.org/C105951970","wikidata":"https://www.wikidata.org/wiki/Q1036748","display_name":"Loss function","level":4,"score":0.2590000033378601},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.2563999891281128},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.2551000118255615},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.06.764618","doi":"https://doi.org/10.64898/2026.11.06.764618","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.06.764618","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.06.764618.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.06.764618","doi":"https://doi.org/10.64898/2026.11.06.764618","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.06.764618","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.06.764618.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225638468.pdf","grobid_xml":"https://content.openalex.org/works/W7225638468.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W1481867552","https://openalex.org/W1528632786","https://openalex.org/W1666195836","https://openalex.org/W1961449438","https://openalex.org/W1966282260","https://openalex.org/W1966901093","https://openalex.org/W1968448459","https://openalex.org/W1976125694","https://openalex.org/W1977044662","https://openalex.org/W1977514547","https://openalex.org/W1991484287","https://openalex.org/W1999181858","https://openalex.org/W1999194056","https://openalex.org/W2005604472","https://openalex.org/W2006327345","https://openalex.org/W2008004759","https://openalex.org/W2009757852","https://openalex.org/W2009851083","https://openalex.org/W2016667239","https://openalex.org/W2033949300","https://openalex.org/W2034143604","https://openalex.org/W2034278075","https://openalex.org/W2035358499","https://openalex.org/W2036950925","https://openalex.org/W2037313242","https://openalex.org/W2039730733","https://openalex.org/W2042892138","https://openalex.org/W2045192340","https://openalex.org/W2048862315","https://openalex.org/W2048909427","https://openalex.org/W2053894178","https://openalex.org/W2065943966","https://openalex.org/W2067975978","https://openalex.org/W2072946951","https://openalex.org/W2074609358","https://openalex.org/W2076843194","https://openalex.org/W2082600456","https://openalex.org/W2082932684","https://openalex.org/W2084923896","https://openalex.org/W2086079901","https://openalex.org/W2087744052","https://openalex.org/W2097658756","https://openalex.org/W2099607192","https://openalex.org/W2103451931","https://openalex.org/W2104775546","https://openalex.org/W2105039688","https://openalex.org/W2105686440","https://openalex.org/W2106417817","https://openalex.org/W2108366837","https://openalex.org/W2117794907","https://openalex.org/W2122772438","https://openalex.org/W2144713064","https://openalex.org/W2145502099","https://openalex.org/W2149524054","https://openalex.org/W2157497892","https://openalex.org/W2159832354","https://openalex.org/W2165492596","https://openalex.org/W2167279371","https://openalex.org/W2169222380","https://openalex.org/W2344833525","https://openalex.org/W2416983347","https://openalex.org/W2474079873","https://openalex.org/W2488060953","https://openalex.org/W2505035572","https://openalex.org/W2522175331","https://openalex.org/W2538121373","https://openalex.org/W2755722206","https://openalex.org/W2781902192","https://openalex.org/W2783309950","https://openalex.org/W2783499431","https://openalex.org/W2803256494","https://openalex.org/W2889326105","https://openalex.org/W2901551398","https://openalex.org/W2952891726","https://openalex.org/W2953683903","https://openalex.org/W2967205878","https://openalex.org/W2971103725","https://openalex.org/W2986502056","https://openalex.org/W3015005771","https://openalex.org/W3112375501","https://openalex.org/W3148916402","https://openalex.org/W3206844354","https://openalex.org/W4211265573","https://openalex.org/W4311686879","https://openalex.org/W4313334620","https://openalex.org/W4313543863","https://openalex.org/W4322495140","https://openalex.org/W4376122129","https://openalex.org/W4386332656","https://openalex.org/W4388141314","https://openalex.org/W4391316948","https://openalex.org/W4402170910","https://openalex.org/W4404375879","https://openalex.org/W4411291355","https://openalex.org/W4414159432","https://openalex.org/W4414616465","https://openalex.org/W7134168644","https://openalex.org/W7164122475","https://openalex.org/W7211934884"],"related_works":["https://openalex.org/W2141371381","https://openalex.org/W4401353859","https://openalex.org/W3094308362","https://openalex.org/W2123747365","https://openalex.org/W2979159260","https://openalex.org/W7167340299","https://openalex.org/W2731233744","https://openalex.org/W2039730733","https://openalex.org/W4396509045","https://openalex.org/W4405539233"],"abstract_inverted_index":{"Most":[0],"animal":[1],"species":[2],"exhibit":[3],"some":[4,164],"level":[5],"of":[6,33,74,111,126,138,150,152,165,175,200,205,219,248,275,287],"sociality.":[7],"However,":[8],"whether":[9],"sociality-related":[10],"traits":[11,77,177],"evolved":[12],"independently,":[13],"or":[14],"are":[15,254],"instead":[16],"derived":[17],"from":[18],"common":[19],"core":[20,75],"mechanisms,":[21],"remains":[22],"controversial.":[23],"Nevertheless,":[24],"an":[25,130,198],"emerging":[26],"theoretical":[27],"framework":[28],"stipulates":[29],"that":[30,53,55,67,120,161,226,238,253,264,279],"key":[31],"aspects":[32],"how":[34],"animals":[35],"interact":[36],"with":[37,87,256],"their":[38],"social":[39,58,76,139,176,281],"environments":[40],"may":[41,64,167,266],"be":[42],"regulated":[43],"by":[44,99,106,184],"a":[45,91,107,169,190,201,213,242,268,288],"phylogenetically":[46],"conserved":[47,69,170,203,269,289],"genetic":[48,186,291],"toolkit.":[49,292],"Therefore,":[50],"we":[51,82,159,195],"hypothesized":[52,119],"mutations":[54],"lead":[56],"to":[57],"deficits":[59],"in":[60,71,97,122,133,142,157,172,221,232,245,271],"specific":[61,249],"human":[62,93],"disorders":[63],"implicate":[65],"genes":[66,85,128,155],"play":[68],"roles":[70],"the":[72,134,145,153,173,185,206,222,233,246,273,276,285],"regulation":[73,174,218],"across":[78,178],"Animalia.":[79],"Specifically,":[80],"here":[81],"focus":[83],"on":[84],"associated":[86,255],"Williams":[88],"syndrome":[89],"(WS),":[90],"rare":[92],"multi-system":[94],"disorder":[95],"characterized":[96],"part":[98],"hypersocial":[100],"cognitive":[101,259],"traits.":[102],"WS":[103],"is":[104,229],"caused":[105],"hemizygous":[108],"chromosomal":[109],"microdeletion":[110],"25-28":[112],"protein-coding":[113],"genes.":[114],"Consequently,":[115],"it":[116],"has":[117],"been":[118],"haploinsufficiency":[121],"at":[123,162],"least":[124,163],"one":[125],"these":[127],"plays":[129,241],"important":[131],"role":[132,171,244],"development":[135,274],"and/or":[136],"function":[137,270],"neural":[140],"circuits":[141,278],"humans.":[143],"Because":[144],"Drosophila":[146],"genome":[147],"encodes":[148],"orthologs":[149],"17":[151],"28":[154],"deleted":[156],"WS,":[158],"reasoned":[160],"them":[166],"serve":[168,267],"flies":[179],"and":[180,237,258],"humans,":[181],"as":[182,212],"predicted":[183],"toolkit":[187],"framework.":[188],"Using":[189],"neuron-specific":[191],"RNAi":[192],"knockdown":[193],"screen,":[194],"identified":[196],"eIF4H1,":[197],"ortholog":[199],"highly":[202],"subunit":[204],"eukaryotic":[207],"translation":[208],"initiation":[209],"complex":[210],"eIF4F,":[211],"candidate":[214],"gene":[215],"for":[216],"neuronal":[217,231,277],"sociality":[220,257,290],"fly.":[223],"We":[224],"show":[225],"eIF4H1":[227,265],"expression":[228],"predominantly":[230],"adult":[234],"fly":[235],"brain,":[236],"its":[239],"action":[240],"differential":[243],"organization":[247],"dopaminergic":[250],"neuron":[251],"subtypes":[252],"functions.":[260],"These":[261],"results":[262],"indicate":[263],"regulating":[272],"regulate":[280],"behaviors,":[282],"thus":[283],"supporting":[284],"idea":[286]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
