{"id":"https://openalex.org/W7225638112","doi":"https://doi.org/10.3892/br.2026.2225","title":"Soluble CD109 released from lung adenocarcinoma cells activates the STAT3 signaling pathway to promote lymphatic endothelial cell migration","display_name":"Soluble CD109 released from lung adenocarcinoma cells activates the STAT3 signaling pathway to promote lymphatic endothelial cell migration","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225638112","doi":"https://doi.org/10.3892/br.2026.2225"},"language":"en","primary_location":{"id":"doi:10.3892/br.2026.2225","doi":"https://doi.org/10.3892/br.2026.2225","is_oa":true,"landing_page_url":"https://doi.org/10.3892/br.2026.2225","pdf_url":"http://www.spandidos-publications.com/10.3892/br.2026.2225/download","source":{"id":"https://openalex.org/S2754599785","display_name":"Biomedical Reports","issn_l":"2049-9434","issn":["2049-9434","2049-9442"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/br.2026.2225/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045648603","display_name":"Tongyao Shang","orcid":"https://orcid.org/0000-0002-9821-7085","observed_orcids":["https://orcid.org/0000-0002-9821-7085"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tongyao Shang","raw_affiliation_strings":["Department of Laboratory Medicine, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250014, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250014, P.R.\u00a0China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161320659","display_name":"Yiran Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiran Sun","raw_affiliation_strings":["Laboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R.\u00a0China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161338767","display_name":"Yanelys Diaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Yanelys Diaz","raw_affiliation_strings":["Clinical Investigation and Biomedical Research Directions, Center for Genetic Engineering and Biotechnology, Havana 11600, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Investigation and Biomedical Research Directions, Center for Genetic Engineering and Biotechnology, Havana 11600, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134428591","display_name":"Jiahe Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahe Shen","raw_affiliation_strings":["Department of Laboratory Medicine, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250014, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250014, P.R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161338417","display_name":"Jing Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Liu","raw_affiliation_strings":["Laboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China","Medical Research Center, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250014, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Medical Research Center, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250014, P.R.\u00a0China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161357292","display_name":"Carolina Callejas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Carolina Callejas","raw_affiliation_strings":["Clinical Investigation and Biomedical Research Directions, Center for Genetic Engineering and Biotechnology, Havana 11600, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Investigation and Biomedical Research Directions, Center for Genetic Engineering and Biotechnology, Havana 11600, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161356032","display_name":"Mariana Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Mariana Torres","raw_affiliation_strings":["Clinical Investigation and Biomedical Research Directions, Center for Genetic Engineering and Biotechnology, Havana 11600, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Investigation and Biomedical Research Directions, Center for Genetic Engineering and Biotechnology, Havana 11600, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161342504","display_name":"Xidi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xidi Wang","raw_affiliation_strings":["Laboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059366244","display_name":"Mar\u00eda del Carmen Luzardo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2656126","display_name":"University of Havana","ror":"https://ror.org/04204gr61","country_code":"CU","type":"education","lineage":["https://openalex.org/I2656126"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Maria D Luzardo","raw_affiliation_strings":["Laboratory of Toxins and Liposomes, Center for Protein Studies, Faculty of Biology, University of Havana (UH), Lab UH\u2011CIM, Havana 10400, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Toxins and Liposomes, Center for Protein Studies, Faculty of Biology, University of Havana (UH), Lab UH\u2011CIM, Havana 10400, Cuba","institution_ids":["https://openalex.org/I2656126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148391019","display_name":"Xiaohong Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohong Shi","raw_affiliation_strings":["Department of Laboratory Medicine, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250014, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250014, P.R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5134449621","display_name":"Ju Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ju Liu","raw_affiliation_strings":["Laboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China","Medical Research Center, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250014, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Medical Research Center, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250014, P.R.\u00a0China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210153274"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12426","display_name":"Lymphatic Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd109","display_name":"CD109","score":0.8629999756813049},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9509999752044678},{"id":"https://openalex.org/keywords/lymphatic-endothelial-cells","display_name":"lymphatic endothelial cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.6169999837875366},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.7730000019073486},{"id":"https://openalex.org/keywords/jak2-stat3-signaling-pathway","display_name":"JAK2/STAT3 signaling","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.765999972820282},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.546999990940094},{"id":"https://openalex.org/keywords/stattic","display_name":"Stattic","score":0.7789999842643738},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2910366181","wikidata":"https://www.wikidata.org/wiki/Q6708239","display_name":"Lymphatic Endothelium","level":3,"score":0.8339999914169312},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.6509000062942505},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6491000056266785},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.6061999797821045},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5378000140190125},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5052000284194946},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.46309998631477356},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45969998836517334},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.43880000710487366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4374000132083893},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4180000126361847},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4106000065803528},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4077000021934509},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3783000111579895},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3781999945640564},{"id":"https://openalex.org/C125864771","wikidata":"https://www.wikidata.org/wiki/Q13360240","display_name":"Lymph node stromal cell","level":3,"score":0.34860000014305115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3472999930381775},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.3314000070095062},{"id":"https://openalex.org/C157333092","wikidata":"https://www.wikidata.org/wiki/Q902835","display_name":"JAK-STAT signaling pathway","level":4,"score":0.30889999866485596},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.30820000171661377},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.29660001397132874},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.296099990606308},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2939999997615814},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.28929999470710754},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27970001101493835},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.27649998664855957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.266400009393692},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.26589998602867126},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.25769999623298645},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25440001487731934},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3892/br.2026.2225","doi":"https://doi.org/10.3892/br.2026.2225","is_oa":true,"landing_page_url":"https://doi.org/10.3892/br.2026.2225","pdf_url":"http://www.spandidos-publications.com/10.3892/br.2026.2225/download","source":{"id":"https://openalex.org/S2754599785","display_name":"Biomedical Reports","issn_l":"2049-9434","issn":["2049-9434","2049-9442"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3892/br.2026.2225","doi":"https://doi.org/10.3892/br.2026.2225","is_oa":true,"landing_page_url":"https://doi.org/10.3892/br.2026.2225","pdf_url":"http://www.spandidos-publications.com/10.3892/br.2026.2225/download","source":{"id":"https://openalex.org/S2754599785","display_name":"Biomedical Reports","issn_l":"2049-9434","issn":["2049-9434","2049-9442"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225638112.pdf","grobid_xml":"https://content.openalex.org/works/W7225638112.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4213059758","https://openalex.org/W2588755013","https://openalex.org/W3114250084","https://openalex.org/W2989736007","https://openalex.org/W7214028099","https://openalex.org/W4389225338","https://openalex.org/W3090934714","https://openalex.org/W4293582240","https://openalex.org/W2620162514","https://openalex.org/W3009956843"],"abstract_inverted_index":{"Lung":[0],"adenocarcinoma":[1],"(LUAD),":[2],"the":[3,18,58,110,179,211],"predominant":[4],"subtype":[5],"of":[6,79,92,109,165,169,203,233],"non-small":[7],"cell":[8,54,199,225],"lung":[9],"cancer,":[10],"frequently":[11],"metastasizes":[12],"to":[13],"regional":[14],"lymph":[15],"nodes":[16],"through":[17,201,218],"lymphatic":[19,35,52,98,197,223],"system.CD109":[20],"is":[21,26],"upregulated":[22],"in":[23,64,131,160,182,207,230,240],"LUAD":[24,49,66,193,220],"and":[25,56,82,88,106,122,138,157,177],"associated":[27],"with":[28,163,172],"poor":[29],"prognosis;":[30],"however,":[31],"its":[32],"effects":[33,91],"on":[34,95],"endothelial":[36,53,99,198,224],"cells":[37,50,68,100,133,194,221],"remain":[38],"poorly":[39],"characterized.The":[40],"present":[41,206],"study":[42],"investigated":[43],"whether":[44],"soluble":[45,93,189],"CD109":[46,80,94,140,190,234],"released":[47,191],"from":[48,192],"influences":[51],"function":[55],"explored":[57],"underlying":[59],"molecular":[60],"mechanisms.CD109":[61],"was":[62,75,117],"overexpressed":[63],"human":[65,96],"A549":[67,132],"using":[69,84,104,119,125],"an":[70],"adenoviral":[71],"vector.Conditioned":[72],"medium":[73],"(CD109-CM)":[74],"collected":[76],"following":[77],"demonstration":[78],"expression":[81],"secretion":[83],"reverse":[85],"transcription-quantitative":[86],"PCR":[87],"western":[89,120],"blotting.The":[90],"dermal":[97],"(HDLECs)":[101],"were":[102],"evaluated":[103,124],"proliferation":[105],"migration":[107,200],"assays.Involvement":[108],"Janus":[111],"kinase":[112],"2":[113],"(JAK2)/STAT3":[114],"signaling":[115,171],"pathway":[116],"examined":[118],"blotting":[121],"further":[123,229],"Stattic,":[126],"a":[127,215,236],"STAT3":[128,158,166,170,175],"inhibitor.CD109":[129],"overexpression":[130],"significantly":[134,145],"increased":[135,155],"both":[136],"cellular":[137],"secreted":[139],"levels.Despite":[141],"CD109-CM":[142,154],"having":[143],"not":[144],"affected":[146],"HDLEC":[147,152,183],"proliferation,":[148],"it":[149],"markedly":[150],"enhanced":[151],"migration.Mechanistically,":[153],"JAK2":[156],"phosphorylation":[159,176],"HDLECs,":[161],"consistent":[162],"activation":[164,202],"signaling.Pharmacological":[167],"inhibition":[168],"Stattic":[173],"attenuated":[174],"abolished":[178],"CD109-CM-induced":[180],"increase":[181],"migration.Collectively,":[184],"these":[185],"findings":[186,209],"demonstrated":[187],"that":[188],"may":[195],"promote":[196],"JAK2/STAT3":[204],"signaling.The":[205],"vitro":[208],"identified":[210],"CD109-JAK2/STAT3":[212],"axis":[213],"as":[214,235],"potential":[216,237],"mechanism":[217],"which":[219],"modulate":[222],"behavior,":[226],"thus":[227],"supporting":[228],"vivo":[231],"investigation":[232],"therapeutic":[238],"target":[239],"LUAD.":[241]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
