{"id":"https://openalex.org/W7225637823","doi":"https://doi.org/10.21203/rs.3.rs-11639554/v1","title":"Endopolyphosphatase activity of RNase A from bovine pancreas","display_name":"Endopolyphosphatase activity of RNase A from bovine pancreas","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225637823","doi":"https://doi.org/10.21203/rs.3.rs-11639554/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11639554/v1","doi":"https://doi.org/10.21203/rs.3.rs-11639554/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11639554/v1","pdf_url":"https://www.researchsquare.com/article/rs-11639554/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11639554/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161346338","display_name":"Alexandr Tomashevsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158654","display_name":"G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms","ror":"https://ror.org/048zssa22","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210158654"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexandr Tomashevsky","raw_affiliation_strings":["Skryabin Institute of Biochemistry and Physiology of Microorganisms"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skryabin Institute of Biochemistry and Physiology of Microorganisms","institution_ids":["https://openalex.org/I4210158654"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085035170","display_name":"Tatiana V Kulakovskaya","orcid":"https://orcid.org/0000-0001-8556-809X","observed_orcids":["https://orcid.org/0000-0001-8556-809X"]},"institutions":[{"id":"https://openalex.org/I4210158654","display_name":"G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms","ror":"https://ror.org/048zssa22","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210158654"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Tatiana Kulakovskaya","raw_affiliation_strings":["Skryabin Institute of Biochemistry and Physiology of Microorganisms"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skryabin Institute of Biochemistry and Physiology of Microorganisms","institution_ids":["https://openalex.org/I4210158654"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210158654"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rnase-a","display_name":"ribonuclease A","score":0.9470000267028809},{"id":"https://openalex.org/keywords/inorganic-polyphosphate","display_name":"inorganic polyphosphate","score":0.9100000262260437},{"id":"https://openalex.org/keywords/rna-contamination","display_name":"RNA contamination","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ribonuclease-inhibitor","display_name":"ribonuclease inhibitor","score":0.9670000076293945},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.824999988079071},{"id":"https://openalex.org/keywords/divalent-metal-cations","display_name":"divalent metal cations","score":0.9169999957084656},{"id":"https://openalex.org/keywords/bovine-pancreas","display_name":"bovine pancreas","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.8234999775886536},{"id":"https://openalex.org/C2778976237","wikidata":"https://www.wikidata.org/wiki/Q422523","display_name":"Ribonuclease","level":4,"score":0.8082000017166138},{"id":"https://openalex.org/C2778038992","wikidata":"https://www.wikidata.org/wiki/Q420783","display_name":"Polyphosphate","level":3,"score":0.805400013923645},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6819000244140625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6782000064849854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5961999893188477},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.48010000586509705},{"id":"https://openalex.org/C2780704907","wikidata":"https://www.wikidata.org/wiki/Q87195451","display_name":"Pancreatic ribonuclease","level":5,"score":0.4447000026702881},{"id":"https://openalex.org/C2992404650","wikidata":"https://www.wikidata.org/wiki/Q5272330","display_name":"Divalent metal","level":3,"score":0.4262999892234802},{"id":"https://openalex.org/C2776813977","wikidata":"https://www.wikidata.org/wiki/Q2711884","display_name":"Bovine pancreatic ribonuclease","level":5,"score":0.4074999988079071},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.37049999833106995},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36800000071525574},{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.36730000376701355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33640000224113464},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.328000009059906},{"id":"https://openalex.org/C10419127","wikidata":"https://www.wikidata.org/wiki/Q1989580","display_name":"Cell-free system","level":3,"score":0.31369999051094055},{"id":"https://openalex.org/C69766542","wikidata":"https://www.wikidata.org/wiki/Q3430179","display_name":"RNase H","level":5,"score":0.29899999499320984},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.2687999904155731},{"id":"https://openalex.org/C188528350","wikidata":"https://www.wikidata.org/wiki/Q3415271","display_name":"RNase PH","level":5,"score":0.2680000066757202},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2671999931335449}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11639554/v1","doi":"https://doi.org/10.21203/rs.3.rs-11639554/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11639554/v1","pdf_url":"https://www.researchsquare.com/article/rs-11639554/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11639554/v1","doi":"https://doi.org/10.21203/rs.3.rs-11639554/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11639554/v1","pdf_url":"https://www.researchsquare.com/article/rs-11639554/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225637823.pdf","grobid_xml":"https://content.openalex.org/works/W7225637823.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1974855874","https://openalex.org/W1981979006","https://openalex.org/W2095082817","https://openalex.org/W2098852054","https://openalex.org/W2112356204","https://openalex.org/W2499278905","https://openalex.org/W2509112979","https://openalex.org/W2564768425","https://openalex.org/W2943811997","https://openalex.org/W2996150229","https://openalex.org/W3005740451","https://openalex.org/W3022595427","https://openalex.org/W3121006590","https://openalex.org/W3165288103","https://openalex.org/W4211216439","https://openalex.org/W4224108450","https://openalex.org/W4402734114","https://openalex.org/W4407757380","https://openalex.org/W4411461014","https://openalex.org/W4416723416","https://openalex.org/W7122365971","https://openalex.org/W7165919765"],"related_works":["https://openalex.org/W2012102520","https://openalex.org/W2039068941","https://openalex.org/W2392131592","https://openalex.org/W2087494190","https://openalex.org/W2049170375","https://openalex.org/W12359615","https://openalex.org/W2033344288","https://openalex.org/W120073566","https://openalex.org/W2044516812","https://openalex.org/W2025176816"],"abstract_inverted_index":{"Abstract":[0],"Inorganic":[1],"polyphosphate":[2,47],"preparations":[3,22,48],"from":[4,23,49],"various":[5],"biological":[6],"samples":[7],"often":[8],"contain":[9],"significant":[10],"RNA":[11,24],"contamination,":[12],"complicating":[13],"their":[14],"analysis.":[15],"The":[16],"standard":[17],"method":[18],"for":[19],"purifying":[20],"such":[21],"is":[25,75],"the":[26,82],"treatment":[27],"with":[28,56],"RNases,":[29],"particularly":[30],"RNase":[31],"A.":[32],"This":[33,73],"study":[34],"demonstrated":[35],"that":[36],"commercial":[37],"preparation":[38],"of":[39,61],"RNAse":[40],"A,":[41],"at":[42],"concentrations":[43],"used":[44],"to":[45,63,81],"purify":[46],"RNA,":[50],"exhibits":[51],"endopolyphosphatase":[52],"activity":[53,74],"against":[54],"polyphosphates":[55],"an":[57],"average":[58],"chain":[59],"length":[60],"65":[62],"208":[64],"phosphate":[65],"residues,":[66],"but":[67],"does":[68,87],"not":[69,88],"exhibit":[70],"exopolyphosphatase":[71],"activity.":[72],"inhibited":[76],"by":[77],"ribonuclease":[78],"inhibitor,":[79],"insensitive":[80],"polyphosphatase":[83],"inhibitor":[84],"heparin":[85],"and":[86],"require":[89],"divalent":[90],"metal":[91],"cations.":[92]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
