{"id":"https://openalex.org/W7225637710","doi":"https://doi.org/10.1021/acs.jafc.6c09524","title":"Peptidomics Reveals That Goat Milk Is Closer to Human Milk Than Cow Milk in Proline-Rich Oligopeptide Release during In Vitro Dynamic Infant Digestion","display_name":"Peptidomics Reveals That Goat Milk Is Closer to Human Milk Than Cow Milk in Proline-Rich Oligopeptide Release during In Vitro Dynamic Infant Digestion","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225637710","doi":"https://doi.org/10.1021/acs.jafc.6c09524"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jafc.6c09524","doi":"https://doi.org/10.1021/acs.jafc.6c09524","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.6c09524","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079159072","display_name":"Hailing Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hailing Song","raw_affiliation_strings":["Nanchang University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanchang University , , , ,","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104103637","display_name":"Yifei Li","orcid":"https://orcid.org/0009-0008-6093-3546","observed_orcids":["https://orcid.org/0009-0008-6093-3546"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifei Li","raw_affiliation_strings":["Nanchang University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanchang University , , , ,","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042027831","display_name":"Caidong Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caidong Zhao","raw_affiliation_strings":["Nanchang University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanchang University , , , ,","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083945494","display_name":"Zeyuan Deng","orcid":"https://orcid.org/0000-0001-5650-1507","observed_orcids":["https://orcid.org/0000-0001-5650-1507"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeyuan Deng","raw_affiliation_strings":["Nanchang University , , , ,"],"raw_orcid":"https://orcid.org/0000-0001-5650-1507","affiliations":[{"raw_affiliation_string":"Nanchang University , , , ,","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129854123","display_name":"Xiaoyu Peng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoyu Peng","raw_affiliation_strings":["Ausnutria Dairy (China) Co., Ltd , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ausnutria Dairy (China) Co., Ltd , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161318341","display_name":"Wei Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Ausnutria Dairy (China) Co., Ltd , ,","Hunan Center of Technology Innovation for Maternal, Infant, and Children Food , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ausnutria Dairy (China) Co., Ltd , ,","institution_ids":[]},{"raw_affiliation_string":"Hunan Center of Technology Innovation for Maternal, Infant, and Children Food , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056827057","display_name":"Yu Gao","orcid":"https://orcid.org/0000-0002-3375-1666","observed_orcids":["https://orcid.org/0000-0002-3375-1666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Gao","raw_affiliation_strings":["Ausnutria Dairy (China) Co., Ltd , ,"],"raw_orcid":"https://orcid.org/0000-0002-3375-1666","affiliations":[{"raw_affiliation_string":"Ausnutria Dairy (China) Co., Ltd , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121063908","display_name":"Yalun Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yalun Zou","raw_affiliation_strings":["Nanchang University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanchang University , , , ,","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057847938","display_name":"Liufeng Zheng","orcid":"https://orcid.org/0000-0003-2648-2653","observed_orcids":["https://orcid.org/0000-0003-2648-2653"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liufeng Zheng","raw_affiliation_strings":["Nanchang University , , , ,"],"raw_orcid":"https://orcid.org/0000-0003-2648-2653","affiliations":[{"raw_affiliation_string":"Nanchang University , , , ,","institution_ids":["https://openalex.org/I141649914"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057847938"],"corresponding_institution_ids":["https://openalex.org/I141649914"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.06589999794960022,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13540","display_name":"Animal Diversity and Health Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/goat-milk","display_name":"goat milk","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cow-s-milk","display_name":"cow's milk","score":0.9729999899864197},{"id":"https://openalex.org/keywords/breast-milk","display_name":"breast milk","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oligopeptides","display_name":"oligopeptides","score":0.8330000042915344},{"id":"https://openalex.org/keywords/proline-rich-peptides","display_name":"proline-rich peptides","score":0.9520000219345093},{"id":"https://openalex.org/keywords/peptidomics","display_name":"peptidomics","score":0.6679999828338623},{"id":"https://openalex.org/keywords/casein-peptides","display_name":"casein peptides","score":0.7749999761581421},{"id":"https://openalex.org/keywords/bioactive-peptides","display_name":"bioactive peptides","score":0.949999988079071},{"id":"https://openalex.org/keywords/infant-nutrition","display_name":"infant nutrition","score":0.8320000171661377},{"id":"https://openalex.org/keywords/milk-protein-digestion","display_name":"milk protein digestion","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C13935069","wikidata":"https://www.wikidata.org/wiki/Q2157266","display_name":"Oligopeptide","level":3,"score":0.8960000276565552},{"id":"https://openalex.org/C2781357212","wikidata":"https://www.wikidata.org/wiki/Q5275608","display_name":"Digestion (alchemy)","level":2,"score":0.6141999959945679},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6014999747276306},{"id":"https://openalex.org/C2992972311","wikidata":"https://www.wikidata.org/wiki/Q8495","display_name":"Cow milk","level":2,"score":0.5974000096321106},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5860999822616577},{"id":"https://openalex.org/C2779150110","wikidata":"https://www.wikidata.org/wiki/Q2287198","display_name":"Infant formula","level":2,"score":0.5361999869346619},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.5059999823570251},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4896000027656555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4406000077724457},{"id":"https://openalex.org/C2778498626","wikidata":"https://www.wikidata.org/wiki/Q2736146","display_name":"Sheep milk","level":2,"score":0.4275999963283539},{"id":"https://openalex.org/C2776965311","wikidata":"https://www.wikidata.org/wiki/Q623636","display_name":"Camel milk","level":2,"score":0.3716999888420105},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.35179999470710754},{"id":"https://openalex.org/C2993643364","wikidata":"https://www.wikidata.org/wiki/Q8495","display_name":"Milk protein","level":2,"score":0.3084999918937683},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.299699991941452},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.27160000801086426},{"id":"https://openalex.org/C2992940123","wikidata":"https://www.wikidata.org/wiki/Q8495","display_name":"Bovine milk","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C2994368867","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal system","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C2779815552","wikidata":"https://www.wikidata.org/wiki/Q484583","display_name":"Proline","level":3,"score":0.2556999921798706}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.jafc.6c09524","doi":"https://doi.org/10.1021/acs.jafc.6c09524","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.6c09524","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.9208999872207642,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322665","display_name":"Natural Science Foundation of Jiangxi Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W974254039","https://openalex.org/W2017553619","https://openalex.org/W2041530621","https://openalex.org/W2085075574","https://openalex.org/W2087169338","https://openalex.org/W2107308648","https://openalex.org/W2161129645","https://openalex.org/W2162061338","https://openalex.org/W2192102928","https://openalex.org/W2734777740","https://openalex.org/W2762825110","https://openalex.org/W2792978186","https://openalex.org/W2896728388","https://openalex.org/W2918929658","https://openalex.org/W2950465084","https://openalex.org/W3007596865","https://openalex.org/W3081722339","https://openalex.org/W3103064051","https://openalex.org/W3111236756","https://openalex.org/W3159295432","https://openalex.org/W3217152956","https://openalex.org/W4284975979","https://openalex.org/W4295737061","https://openalex.org/W4362657509","https://openalex.org/W4365458008","https://openalex.org/W4377024364","https://openalex.org/W4383721964","https://openalex.org/W4384700794","https://openalex.org/W4387409152","https://openalex.org/W4394819180","https://openalex.org/W4400519815","https://openalex.org/W4400674325","https://openalex.org/W4400949503","https://openalex.org/W4403083495","https://openalex.org/W4404341990","https://openalex.org/W4405437234","https://openalex.org/W4408200047","https://openalex.org/W4410278221","https://openalex.org/W4411869793","https://openalex.org/W4412979860","https://openalex.org/W4413138802","https://openalex.org/W4414001690","https://openalex.org/W4414824889","https://openalex.org/W7163348281"],"related_works":["https://openalex.org/W7214188176","https://openalex.org/W7203759072","https://openalex.org/W2896728388","https://openalex.org/W4408200047","https://openalex.org/W4280515349","https://openalex.org/W7124541740","https://openalex.org/W4387949006","https://openalex.org/W7160704094","https://openalex.org/W2563910983","https://openalex.org/W4414001690"],"abstract_inverted_index":{"Abstract":[0],"Human":[1],"milk":[2,49,53,65,85,122,131],"is":[3,123],"the":[4,74],"gold":[5],"standard":[6],"for":[7,132],"infant":[8,17,135],"nutrition.":[9],"This":[10],"study":[11],"employed":[12],"an":[13],"in":[14,54],"vitro":[15],"dynamic":[16],"gastrointestinal":[18],"digestion":[19],"model":[20],"coupled":[21],"with":[22,57,113],"peptidomics":[23],"to":[24,125,141],"profile":[25],"oligopeptide":[26],"release":[27],"from":[28,41],"human,":[29,42],"goat,":[30,43],"and":[31,38,44,83,106],"cow":[32,45,64,96,130],"milk.":[33,97],"Peptidomics":[34],"identified":[35],"717,":[36],"658,":[37],"514":[39],"oligopeptides":[40,92,100],"milk,":[46,108],"respectively.":[47],"Goat":[48],"closely":[50],"mirrored":[51],"human":[52,105,133],"length":[55],"distribution,":[56],"both":[58],"peaking":[59],"at":[60,69],"4\u20135":[61],"residues,":[62],"whereas":[63],"exhibited":[66],"a":[67],"peak":[68],"6\u20137":[70],"residues.":[71],"Proline":[72],"was":[73],"most":[75],"abundant":[76],"amino":[77],"acid":[78],"residue":[79],"across":[80],"all":[81],"sources,":[82],"goat":[84,107,121],"generated":[86],"significantly":[87],"higher":[88],"numbers":[89],"of":[90],"short":[91],"(\u226410":[93],"residues)":[94],"than":[95],"Notably,":[98],"38":[99],"were":[101],"exclusively":[102],"shared":[103],"between":[104],"predominantly":[109],"proline-rich,":[110],"casein-derived":[111],"sequences":[112],"multiple":[114],"predicted":[115,124],"bioactivities.":[116],"These":[117],"findings":[118],"indicate":[119],"that":[120],"offer":[126],"functional":[127],"advantages":[128],"over":[129],"milk-oriented":[134],"nutrition,":[136],"primarily":[137],"through":[138],"its":[139],"capacity":[140],"generate":[142],"proline-rich":[143],"bioactive":[144],"oligopeptides.":[145]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}