{"id":"https://openalex.org/W7225637307","doi":"https://doi.org/10.56919/usci.2655.009","title":"Spectroscopic and Computational Insights into the Effects of Physicochemical Parameters on Antimalarial Drug-Albumin Interactions: A Comprehensive Review","display_name":"Spectroscopic and Computational Insights into the Effects of Physicochemical Parameters on Antimalarial Drug-Albumin Interactions: A Comprehensive Review","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225637307","doi":"https://doi.org/10.56919/usci.2655.009"},"language":"en","primary_location":{"id":"doi:10.56919/usci.2655.009","doi":"https://doi.org/10.56919/usci.2655.009","is_oa":true,"landing_page_url":"https://doi.org/10.56919/usci.2655.009","pdf_url":null,"source":{"id":"https://openalex.org/S4394736051","display_name":"UMYU Scientifica","issn_l":"2955-1145","issn":["2955-1145","2955-1153"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-2"],"host_organization":"https://openalex.org/I327500432","host_organization_name":"Umaru Musa Yar'adua University","host_organization_lineage":["https://openalex.org/I327500432"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"UMYU Scientifica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.56919/usci.2655.009","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050307824","display_name":"Kabiru Abubakar Musa","orcid":"https://orcid.org/0009-0009-4044-4486","observed_orcids":["https://orcid.org/0009-0009-4044-4486"]},"institutions":[{"id":"https://openalex.org/I919958821","display_name":"Bayero University Kano","ror":"https://ror.org/049pzty39","country_code":"NG","type":"education","lineage":["https://openalex.org/I919958821"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Kabiru Abubakar Musa","raw_affiliation_strings":["Department of Biochemistry, Faculty of Basic Medical Sciences, Bayero University, Kano, Nigeria","Green Genes Research, Dundee United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Basic Medical Sciences, Bayero University, Kano, Nigeria","institution_ids":["https://openalex.org/I919958821"]},{"raw_affiliation_string":"Green Genes Research, Dundee United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133757417","display_name":"Zainab Aliyu Muhammad","orcid":"https://orcid.org/0009-0003-4115-7426","observed_orcids":["https://orcid.org/0009-0003-4115-7426"]},"institutions":[{"id":"https://openalex.org/I4405273700","display_name":"Baba Ahmed University","ror":"https://ror.org/00ac4gz35","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405273700"]},{"id":"https://openalex.org/I54459138","display_name":"University of Salford","ror":"https://ror.org/01tmqtf75","country_code":"GB","type":"education","lineage":["https://openalex.org/I54459138"]}],"countries":["GB","NG"],"is_corresponding":false,"raw_author_name":"Zainab Aliyu Muhammad","raw_affiliation_strings":["Biomedical Research Center, Faculty of Science, Engineering and Environment, University of Salford, Manchester, United Kingdom","Department of Biochemistry, Faculty of Science and Computing, Baba-Ahmed University, Kano, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Center, Faculty of Science, Engineering and Environment, University of Salford, Manchester, United Kingdom","institution_ids":["https://openalex.org/I54459138"]},{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science and Computing, Baba-Ahmed University, Kano, Nigeria","institution_ids":["https://openalex.org/I4405273700"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061175201","display_name":"Fatima Ibrahim Aliyu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919958821","display_name":"Bayero University Kano","ror":"https://ror.org/049pzty39","country_code":"NG","type":"education","lineage":["https://openalex.org/I919958821"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Fatima Ibrahim Aliyu","raw_affiliation_strings":["Department of Biochemistry, Faculty of Basic Medical Sciences, Bayero University, Kano, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Basic Medical Sciences, Bayero University, Kano, Nigeria","institution_ids":["https://openalex.org/I919958821"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"5","first_page":"100","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-albumin-interaction","display_name":"drug-albumin interaction","score":0.8080000281333923},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.8920000195503235},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sulfadoxine","display_name":"sulfadoxine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pyrimethamine","display_name":"pyrimethamine","score":1.0},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.6710000038146973},{"id":"https://openalex.org/keywords/fluorescence-quenching","display_name":"fluorescence quenching","score":0.8730000257492065},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.7680000066757202},{"id":"https://openalex.org/keywords/temperature-effects","display_name":"temperature effects","score":0.6039999723434448},{"id":"https://openalex.org/keywords/ph-effect","display_name":"pH effect","score":0.9169999957084656},{"id":"https://openalex.org/keywords/ionic-strength","display_name":"ionic strength","score":0.8410000205039978},{"id":"https://openalex.org/keywords/drug-ionization","display_name":"drug ionization","score":0.7049999833106995},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.9779999852180481},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7419999837875366},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7879999876022339},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5515999794006348},{"id":"https://openalex.org/C121745418","wikidata":"https://www.wikidata.org/wiki/Q585536","display_name":"Quenching (fluorescence)","level":3,"score":0.47609999775886536},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.4408999979496002},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.4259999990463257},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4180000126361847},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.39250001311302185},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.37470000982284546},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3725999891757965},{"id":"https://openalex.org/C192071366","wikidata":"https://www.wikidata.org/wiki/Q2991682","display_name":"Drug design","level":2,"score":0.34450000524520874},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.3393999934196472},{"id":"https://openalex.org/C187428577","wikidata":"https://www.wikidata.org/wiki/Q898396","display_name":"Ionic strength","level":3,"score":0.33739998936653137},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3319000005722046},{"id":"https://openalex.org/C2182769","wikidata":"https://www.wikidata.org/wiki/Q62500","display_name":"Ionic bonding","level":3,"score":0.320499986410141},{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.3183000087738037},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.31119999289512634},{"id":"https://openalex.org/C90260826","wikidata":"https://www.wikidata.org/wiki/Q899157","display_name":"Hydrophobic effect","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2971999943256378},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.29319998621940613},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.2913999855518341},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.287200003862381},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26080000400543213}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.56919/usci.2655.009","doi":"https://doi.org/10.56919/usci.2655.009","is_oa":true,"landing_page_url":"https://doi.org/10.56919/usci.2655.009","pdf_url":null,"source":{"id":"https://openalex.org/S4394736051","display_name":"UMYU Scientifica","issn_l":"2955-1145","issn":["2955-1145","2955-1153"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-2"],"host_organization":"https://openalex.org/I327500432","host_organization_name":"Umaru Musa Yar'adua University","host_organization_lineage":["https://openalex.org/I327500432"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"UMYU Scientifica","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.56919/usci.2655.009","doi":"https://doi.org/10.56919/usci.2655.009","is_oa":true,"landing_page_url":"https://doi.org/10.56919/usci.2655.009","pdf_url":null,"source":{"id":"https://openalex.org/S4394736051","display_name":"UMYU Scientifica","issn_l":"2955-1145","issn":["2955-1145","2955-1153"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-2"],"host_organization":"https://openalex.org/I327500432","host_organization_name":"Umaru Musa Yar'adua University","host_organization_lineage":["https://openalex.org/I327500432"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"UMYU Scientifica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W2088164623","https://openalex.org/W2430221050","https://openalex.org/W2767848703","https://openalex.org/W2783855936","https://openalex.org/W2958048258","https://openalex.org/W2990669411","https://openalex.org/W2999705722","https://openalex.org/W3007960320","https://openalex.org/W3022547731","https://openalex.org/W3027647493","https://openalex.org/W3055656341","https://openalex.org/W3154943946","https://openalex.org/W3205910340","https://openalex.org/W3215881367","https://openalex.org/W4200149769","https://openalex.org/W4200594939","https://openalex.org/W4205444308","https://openalex.org/W4214710444","https://openalex.org/W4220698983","https://openalex.org/W4220706000","https://openalex.org/W4281640531","https://openalex.org/W4289766809","https://openalex.org/W4291281608","https://openalex.org/W4295992366","https://openalex.org/W4296015373","https://openalex.org/W4309269754","https://openalex.org/W4309737076","https://openalex.org/W4309924944","https://openalex.org/W4323353512","https://openalex.org/W4389674317","https://openalex.org/W4392049369","https://openalex.org/W4392425679","https://openalex.org/W4396752252","https://openalex.org/W4400380920","https://openalex.org/W4403791192","https://openalex.org/W4407799466","https://openalex.org/W4409247985","https://openalex.org/W4413612757","https://openalex.org/W7153506017","https://openalex.org/W7223549312"],"related_works":["https://openalex.org/W7171638933","https://openalex.org/W7153506017","https://openalex.org/W4376141191","https://openalex.org/W7223549312","https://openalex.org/W3027647493","https://openalex.org/W7010630751","https://openalex.org/W4414123418","https://openalex.org/W2768021261","https://openalex.org/W2060374545","https://openalex.org/W2331405994"],"abstract_inverted_index":{"Serum":[0],"albumin":[1,31,129],"is":[2,26,50,78,146],"a":[3,51,198],"key":[4,171],"factor":[5],"in":[6,57,137],"the":[7,54,58,80,128,159,185],"transport,":[8],"bioavailability,":[9],"and":[10,23,40,46,68,85,95,121,150,167,184,191,209],"overall":[11],"pharmacokinetics":[12],"of":[13,53,82,127],"many":[14],"therapeutic":[15],"agents.":[16],"For":[17],"antimalarial":[18],"drugs":[19,104],"such":[20],"as":[21],"sulfadoxine":[22],"pyrimethamine,":[24],"it":[25],"crucial":[27],"to":[28,38,107,116,181,216],"study":[29],"how":[30],"affects":[32],"them":[33],"under":[34,205],"different":[35],"physicochemical":[36],"conditions":[37,190,208],"predict":[39],"determine":[41],"drug":[42,144],"distribution,":[43],"resistance":[44],"development,":[45],"efficacy.":[47],"The":[48,76,174],"review":[49,175],"synthesis":[52,196],"results":[55,161],"reported":[56],"literature":[59],"on":[60,79,88],"fluorescence":[61],"spectroscopy,":[62],"UV-Vis":[63],"absorption,":[64],"FTIR,":[65],"circular":[66],"dichroism,":[67],"molecular":[69],"docking":[70],"research":[71],"that":[72,164,212],"characterize":[73],"drug-albumin":[74],"interaction.":[75],"focus":[77],"effects":[81],"temperature,":[83],"pH,":[84],"ionic":[86,154],"strength":[87],"binding":[89,122,138],"affinity,":[90],"quenching":[91,126],"mechanisms,":[92],"structural":[93],"perturbation,":[94],"interactions":[96,169,204],"with":[97,131],"protein":[98],"residues.":[99],"In":[100],"most":[101],"studies,":[102],"some":[103],"consistently":[105],"bind":[106,115],"Sudlow":[108],"site":[109,117],"I":[110],"(subdomain":[111,119],"IIA),":[112],"while":[113],"others":[114],"II":[118],"IIIA),":[120],"mostly":[123],"causes":[124],"stationary":[125],"structure":[130],"slight":[132],"conformational":[133],"changes.":[134],"Temperature-dependent":[135],"decreases":[136],"affinity":[139],"confirm":[140],"exothermic":[141],"complexation,":[142],"whereas":[143],"ionization":[145],"influenced":[147],"by":[148,153,162],"pH":[149],"electrostatic":[151],"complementarity":[152],"strength.":[155],"Docking":[156],"experiments":[157],"complement":[158],"spectroscopic":[160],"showing":[163],"hydrogen":[165],"bonding":[166],"hydrophobic":[168],"are":[170],"stabilizing":[172],"forces.":[173],"highlights":[176,210],"discrepancies":[177],"across":[178],"studies":[179,214],"due":[180],"methodological":[182],"differences":[183],"need":[186,215],"for":[187,201],"standardized":[188],"experimental":[189],"complementary":[192],"computational":[193],"validation.":[194],"This":[195],"provides":[197],"mechanistic":[199],"basis":[200],"predicting":[202],"drug-protein":[203],"physiologically":[206],"relevant":[207],"gaps":[211],"future":[213],"address.":[217]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}