{"id":"https://openalex.org/W7225636920","doi":"https://doi.org/10.64898/2026.11.03.764138","title":"Polyphyletic origins and lineage-specific expansion of chemosensory systems in phylum Actinomycetota","display_name":"Polyphyletic origins and lineage-specific expansion of chemosensory systems in phylum Actinomycetota","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225636920","doi":"https://doi.org/10.64898/2026.11.03.764138"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.03.764138","doi":"https://doi.org/10.64898/2026.11.03.764138","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.03.764138","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.03.764138","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161340126","display_name":"Sri Nithya S","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65181880","display_name":"Indian Institute of Technology Hyderabad","ror":"https://ror.org/01j4v3x97","country_code":"IN","type":"education","lineage":["https://openalex.org/I65181880"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sri Nithya S","raw_affiliation_strings":["Indian Institute of Technology Hyderabad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Technology Hyderabad","institution_ids":["https://openalex.org/I65181880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135632553","display_name":"Sherin Brighty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65181880","display_name":"Indian Institute of Technology Hyderabad","ror":"https://ror.org/01j4v3x97","country_code":"IN","type":"education","lineage":["https://openalex.org/I65181880"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sherin Brighty","raw_affiliation_strings":["Indian Institute of Technology Hyderabad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Technology Hyderabad","institution_ids":["https://openalex.org/I65181880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038270768","display_name":"Gaurav Sharma","orcid":"https://orcid.org/0000-0002-2861-7446","observed_orcids":["https://orcid.org/0000-0002-2861-7446"]},"institutions":[{"id":"https://openalex.org/I65181880","display_name":"Indian Institute of Technology Hyderabad","ror":"https://ror.org/01j4v3x97","country_code":"IN","type":"education","lineage":["https://openalex.org/I65181880"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Gaurav Sharma","raw_affiliation_strings":["Indian Institute of Technology Hyderabad"],"raw_orcid":"https://orcid.org/0000-0002-2861-7446","affiliations":[{"raw_affiliation_string":"Indian Institute of Technology Hyderabad","institution_ids":["https://openalex.org/I65181880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038270768"],"corresponding_institution_ids":["https://openalex.org/I65181880"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemosensory-system","display_name":"chemosensory system","score":0.9850000143051147},{"id":"https://openalex.org/keywords/actinobacteria","display_name":"actinobacteria","score":0.9800000190734863},{"id":"https://openalex.org/keywords/two-component-systems","display_name":"two-component systems","score":0.8550000190734863},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.6449999809265137},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6499999761581421},{"id":"https://openalex.org/keywords/polyphyletic-origin","display_name":"polyphyletic origin","score":0.6549999713897705},{"id":"https://openalex.org/keywords/gene-loss","display_name":"gene loss","score":0.8029999732971191},{"id":"https://openalex.org/keywords/non-motile-bacteria","display_name":"non-motile bacteria","score":0.8939999938011169},{"id":"https://openalex.org/keywords/bacterial-evolution","display_name":"bacterial evolution","score":0.5699999928474426},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C162100973","wikidata":"https://www.wikidata.org/wiki/Q217743","display_name":"Polyphyly","level":5,"score":0.9232000112533569},{"id":"https://openalex.org/C91066513","wikidata":"https://www.wikidata.org/wiki/Q38348","display_name":"Phylum","level":3,"score":0.892799973487854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8446000218391418},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.6796000003814697},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.6323000192642212},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5680999755859375},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.4693000018596649},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.36550000309944153},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35690000653266907},{"id":"https://openalex.org/C62142553","wikidata":"https://www.wikidata.org/wiki/Q200312","display_name":"Convergent evolution","level":4,"score":0.34540000557899475},{"id":"https://openalex.org/C68775705","wikidata":"https://www.wikidata.org/wiki/Q903761","display_name":"Parallel evolution","level":4,"score":0.33809998631477356},{"id":"https://openalex.org/C33009525","wikidata":"https://www.wikidata.org/wiki/Q208841","display_name":"Coevolution","level":2,"score":0.322299987077713},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.298799991607666},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.29589998722076416},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2937999963760376},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.272599995136261},{"id":"https://openalex.org/C2778330419","wikidata":"https://www.wikidata.org/wiki/Q10892","display_name":"Protist","level":3,"score":0.26570001244544983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.03.764138","doi":"https://doi.org/10.64898/2026.11.03.764138","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.03.764138","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.03.764138","doi":"https://doi.org/10.64898/2026.11.03.764138","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.03.764138","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3135896380","https://openalex.org/W2769988184","https://openalex.org/W7160955139","https://openalex.org/W2177612699","https://openalex.org/W7161044593","https://openalex.org/W1678017316","https://openalex.org/W2055745581","https://openalex.org/W2105783449","https://openalex.org/W2088191697","https://openalex.org/W2274972366"],"abstract_inverted_index":{"Phylum":[0],"Actinomycetota":[1,184],"(syn.":[2],"Actinobacteriota":[3],"or":[4,96,129],"Actinobacteria),":[5],"one":[6],"of":[7,52,66,77,87,119,147,153,183,219],"the":[8,30,57,60,117,213],"largest":[9],"well-studied":[10],"bacterial":[11],"phyla,":[12],"is":[13],"renowned":[14],"for":[15,116,212],"complex":[16],"morphology,":[17],"non-motility,":[18],"ecological":[19,73,199],"versatility,":[20,74],"and":[21,63,72,142,171,216],"secondary":[22],"metabolite":[23],"production.":[24],"Chemosensory":[25],"systems":[26,101],"(CSS)":[27],"are":[28,103],"among":[29],"most":[31],"sophisticated":[32],"prokaryotic":[33],"signal":[34],"transduction":[35],"architectures,":[36],"yet":[37],"their":[38],"evolutionary":[39,64,163,210],"distribution":[40],"in":[41,110,195,221],"this":[42],"phylum":[43,58],"remains":[44],"poorly":[45],"understood.":[46],"Here,":[47],"a":[48,85,90,157,161,208],"comparative":[49],"genomic":[50,70],"analysis":[51],"693":[53],"high-quality":[54],"genomes":[55,78],"spanning":[56],"resolves":[59],"diversity,":[61],"distribution,":[62,159],"trajectories":[65],"CSS.":[67],"Despite":[68],"extensive":[69],"complexity":[71],"only":[75,194],"6.9%":[76],"encode":[79],"complete":[80],"CSS":[81,127,192,220],"clusters,":[82],"confined":[83],"to":[84],"subset":[86],"lineages":[88,124,197],"within":[89],"few":[91],"classes,":[92,112],"indicating":[93],"lineage-specific":[94,134],"retention":[95],"loss.":[97,173],"In":[98],"contrast,":[99],"two-component":[100],"(TCS)":[102],"ubiquitously":[104],"abundant,":[105],"with":[106,191],"hybrid":[107],"kinases":[108],"enriched":[109],"CSS-deficient":[111],"suggesting":[113],"functional":[114,217],"compensation":[115],"absence":[118],"dedicated":[120],"chemosensory":[121],"pathways.":[122],"Basal":[123],"retain":[125],"simplified":[126],"(F1":[128],"F5),":[130],"whereas":[131],"Actinomycetes":[132],"show":[133,177],"expansion":[135],"into":[136],"multiple":[137,167],"classes":[138],"(F5,":[139],"F8,":[140],"F9,":[141],"ACF),":[143],"often":[144],"co-occurring,":[145],"indicative":[146],"enhanced":[148,202],"sensory":[149],"complexity.":[150],"The":[151],"phylogeny":[152],"CheA":[154],"homologs":[155],"shows":[156],"polyphyletic":[158],"supporting":[160],"mosaic":[162],"history":[164],"shaped":[165],"by":[166],"independent":[168],"acquisitions,":[169],"diversification,":[170,215],"gene":[172],"Collectively,":[174],"our":[175],"findings":[176],"that,":[178],"unlike":[179],"motile":[180],"bacteria,":[181],"members":[182],"rely":[185],"predominantly":[186],"on":[187],"TCS-driven":[188],"regulatory":[189],"networks,":[190],"retained":[193],"select":[196],"where":[198],"demands":[200],"require":[201],"environmental":[203],"sensing.":[204],"This":[205],"work":[206],"provides":[207],"phylum-wide":[209],"framework":[211],"emergence,":[214],"specialization":[218],"non-motile":[222],"bacteria.":[223]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}