{"id":"https://openalex.org/W7225636622","doi":"https://doi.org/10.1016/j.ebiom.2026.106540","title":"Senescence-targeted engineered CAR-T immunotherapy: advances, challenges and perspectives for engineered senolytic immunotherapy","display_name":"Senescence-targeted engineered CAR-T immunotherapy: advances, challenges and perspectives for engineered senolytic immunotherapy","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225636622","doi":"https://doi.org/10.1016/j.ebiom.2026.106540"},"language":"en","primary_location":{"id":"doi:10.1016/j.ebiom.2026.106540","doi":"https://doi.org/10.1016/j.ebiom.2026.106540","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2026.106540","pdf_url":null,"source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ebiom.2026.106540","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137458597","display_name":"Jiayu Liu","orcid":"https://orcid.org/0009-0002-9544-6330","observed_orcids":["https://orcid.org/0009-0002-9544-6330"]},"institutions":[{"id":"https://openalex.org/I4210113495","display_name":"Children's Hospital of Zhejiang University","ror":"https://ror.org/025fyfd20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113495"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayu Liu","raw_affiliation_strings":["Department of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Children and Adolescents' Health and Diseases, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Children and Adolescents' Health and Diseases, Hangzhou, China","institution_ids":["https://openalex.org/I4210113495","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136926419","display_name":"Wenxia Shao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148790","display_name":"Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine","ror":"https://ror.org/05pwsw714","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148790"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenxia Shao","raw_affiliation_strings":["Department of Clinical Laboratory, Affiliated Hangzhou First People's Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Affiliated Hangzhou First People's Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210148790"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100347558","display_name":"Qing Ye","orcid":"https://orcid.org/0000-0001-6874-5146","observed_orcids":["https://orcid.org/0000-0001-6874-5146"]},"institutions":[{"id":"https://openalex.org/I4210113495","display_name":"Children's Hospital of Zhejiang University","ror":"https://ror.org/025fyfd20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113495"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing Ye","raw_affiliation_strings":["Department of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Children and Adolescents' Health and Diseases, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Children and Adolescents' Health and Diseases, Hangzhou, China","institution_ids":["https://openalex.org/I4210113495","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100347558"],"corresponding_institution_ids":["https://openalex.org/I4210113495","https://openalex.org/I76130692"],"apc_list":{"value":5780,"currency":"USD","value_usd":5780},"apc_paid":{"value":5780,"currency":"USD","value_usd":5780},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"134","issue":null,"first_page":"106540","last_page":"106540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.4997999966144562,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.4997999966144562,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.4867999851703644,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.7044000029563904},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6247000098228455},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5019000172615051},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4706000089645386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4528000056743622},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.4375999867916107},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.40070000290870667},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3700999915599823},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.3700999915599823},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3684000074863434},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3630000054836273},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.3521000146865845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33799999952316284},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.33230000734329224},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3190999925136566},{"id":"https://openalex.org/C2993043200","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical research","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C3019111730","wikidata":"https://www.wikidata.org/wiki/Q159236","display_name":"Genetically engineered","level":3,"score":0.2973000109195709},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2775999903678894},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2750999927520752},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.2621000111103058},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2538999915122986}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ebiom.2026.106540","doi":"https://doi.org/10.1016/j.ebiom.2026.106540","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2026.106540","pdf_url":null,"source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ebiom.2026.106540","doi":"https://doi.org/10.1016/j.ebiom.2026.106540","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2026.106540","pdf_url":null,"source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":132,"referenced_works":["https://openalex.org/W1570233039","https://openalex.org/W1598048539","https://openalex.org/W1926141441","https://openalex.org/W1973300568","https://openalex.org/W1973755084","https://openalex.org/W1974047233","https://openalex.org/W1976996489","https://openalex.org/W1977362098","https://openalex.org/W2010607826","https://openalex.org/W2012080977","https://openalex.org/W2047764904","https://openalex.org/W2054059225","https://openalex.org/W2056124145","https://openalex.org/W2057499380","https://openalex.org/W2063176993","https://openalex.org/W2069519394","https://openalex.org/W2074259682","https://openalex.org/W2094945699","https://openalex.org/W2104822687","https://openalex.org/W2162602733","https://openalex.org/W2264758825","https://openalex.org/W2266290735","https://openalex.org/W2337235966","https://openalex.org/W2422087212","https://openalex.org/W2466392202","https://openalex.org/W2504729294","https://openalex.org/W2544670169","https://openalex.org/W2750808153","https://openalex.org/W2762975995","https://openalex.org/W2788548733","https://openalex.org/W2795010312","https://openalex.org/W2860743873","https://openalex.org/W2884950178","https://openalex.org/W2885738092","https://openalex.org/W2893617001","https://openalex.org/W2904437342","https://openalex.org/W2909117878","https://openalex.org/W2912654909","https://openalex.org/W2913284769","https://openalex.org/W2959728234","https://openalex.org/W2972517993","https://openalex.org/W2974643180","https://openalex.org/W2990398036","https://openalex.org/W2990428470","https://openalex.org/W2995437528","https://openalex.org/W2999192494","https://openalex.org/W3012052929","https://openalex.org/W3018598304","https://openalex.org/W3036603151","https://openalex.org/W3037849083","https://openalex.org/W3048567615","https://openalex.org/W3084100386","https://openalex.org/W3089433670","https://openalex.org/W3104014715","https://openalex.org/W3107344158","https://openalex.org/W3111207111","https://openalex.org/W3124631812","https://openalex.org/W3128472348","https://openalex.org/W3153162508","https://openalex.org/W3157819146","https://openalex.org/W3158317353","https://openalex.org/W3159922673","https://openalex.org/W3161778279","https://openalex.org/W3188895967","https://openalex.org/W3200566697","https://openalex.org/W3208732515","https://openalex.org/W4206716689","https://openalex.org/W4210589143","https://openalex.org/W4213418289","https://openalex.org/W4226084107","https://openalex.org/W4282922995","https://openalex.org/W4291793058","https://openalex.org/W4292488030","https://openalex.org/W4295929648","https://openalex.org/W4297260156","https://openalex.org/W4309889967","https://openalex.org/W4310728750","https://openalex.org/W4311450808","https://openalex.org/W4311551454","https://openalex.org/W4313449211","https://openalex.org/W4323305783","https://openalex.org/W4360595418","https://openalex.org/W4365504554","https://openalex.org/W4365505095","https://openalex.org/W4367601956","https://openalex.org/W4376631082","https://openalex.org/W4377822117","https://openalex.org/W4385271103","https://openalex.org/W4385858278","https://openalex.org/W4386506045","https://openalex.org/W4387208670","https://openalex.org/W4388488716","https://openalex.org/W4389118946","https://openalex.org/W4391169172","https://openalex.org/W4391535834","https://openalex.org/W4392094024","https://openalex.org/W4392468342","https://openalex.org/W4392930808","https://openalex.org/W4396653330","https://openalex.org/W4396908434","https://openalex.org/W4399285708","https://openalex.org/W4400651835","https://openalex.org/W4402285822","https://openalex.org/W4404754574","https://openalex.org/W4405047695","https://openalex.org/W4405906879","https://openalex.org/W4406034879","https://openalex.org/W4406421213","https://openalex.org/W4407850217","https://openalex.org/W4407924220","https://openalex.org/W4409147382","https://openalex.org/W4409473760","https://openalex.org/W4409525148","https://openalex.org/W4409856605","https://openalex.org/W4410521465","https://openalex.org/W4410622127","https://openalex.org/W4411319615","https://openalex.org/W4413194714","https://openalex.org/W4413421849","https://openalex.org/W4413428153","https://openalex.org/W4413884100","https://openalex.org/W4414160625","https://openalex.org/W4415303601","https://openalex.org/W4416402949","https://openalex.org/W4416505881","https://openalex.org/W4416673660","https://openalex.org/W4417349584","https://openalex.org/W7126404191","https://openalex.org/W7128056052","https://openalex.org/W7135190934","https://openalex.org/W7160607760","https://openalex.org/W7162335142"],"related_works":[],"abstract_inverted_index":{"Cellular":[0],"senescence":[1],"acts":[2],"as":[3,84],"a":[4],"core":[5],"driver":[6],"of":[7,47,110],"chronic":[8],"diseases":[9],"and":[10,23,66,70,76,88,100,118],"tissue":[11],"degeneration.":[12],"Conventional":[13],"small-molecule":[14],"senolytics":[15],"face":[16],"critical":[17],"limitations":[18],"including":[19],"poor":[20],"target":[21],"specificity":[22,87],"off-target":[24],"toxicity":[25],"when":[26],"eliminating":[27],"heterogeneous":[28],"senescent":[29,49],"cell":[30],"populations.":[31],"This":[32],"review":[33],"systematically":[34],"discusses":[35],"senescence-targeted":[36],"engineered":[37],"chimeric":[38],"antigen":[39,86],"receptor":[40],"(CAR)-T":[41],"immunotherapy,":[42],"which":[43],"achieves":[44],"targeted":[45],"clearance":[46],"pathological":[48],"cells":[50],"by":[51],"recognising":[52],"specific":[53],"surface":[54],"markers.":[55],"It":[56],"summarises":[57],"target-antigen":[58],"evaluation":[59],"frameworks,":[60],"analyzes":[61],"aged":[62],"immunosuppressive":[63],"microenvironment":[64],"barriers":[65],"corresponding":[67],"engineering":[68],"strategies,":[69],"outlines":[71],"composite":[72],"efficacy":[73],"assessment":[74],"systems":[75],"tiered":[77],"biomarker-monitoring":[78],"workflows.":[79],"Key":[80],"translational":[81],"bottlenecks":[82],"such":[83],"imperfect":[85],"immune":[89],"escape":[90],"are":[91],"also":[92],"addressed.":[93],"Preclinical":[94],"studies":[95],"verify":[96],"organ":[97],"function":[98],"restoration":[99],"healthspan":[101],"extension,":[102],"while":[103],"clinical":[104,124],"evidence":[105],"remains":[106],"limited.":[107],"Future":[108],"integration":[109],"CAR-T":[111],"technology":[112],"with":[113],"smart":[114],"nanocarriers,":[115],"synthetic":[116],"biology":[117],"artificial":[119],"intelligence":[120],"will":[121],"promote":[122],"its":[123],"translation":[125],"for":[126],"senescence-associated":[127],"disorders.":[128]},"counts_by_year":[],"updated_date":"2026-11-10T13:44:29.811591","created_date":"2026-11-10T00:00:00"}