{"id":"https://openalex.org/W7225636259","doi":"https://doi.org/10.21203/rs.3.rs-11373244/v1","title":"Feasibility of a Low Injection Rate Protocol for Bronchial Artery Imaging Using Spectral CT Angiography","display_name":"Feasibility of a Low Injection Rate Protocol for Bronchial Artery Imaging Using Spectral CT Angiography","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225636259","doi":"https://doi.org/10.21203/rs.3.rs-11373244/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11373244/v1","doi":"https://doi.org/10.21203/rs.3.rs-11373244/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11373244/v1","pdf_url":"https://www.researchsquare.com/article/rs-11373244/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11373244/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093246691","display_name":"FU Langzhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Langzhou Fu","raw_affiliation_strings":["Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Medical University","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161314026","display_name":"Xiaoying Ni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoying Ni","raw_affiliation_strings":["Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Medical University","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136730515","display_name":"Longyu Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longyu Duan","raw_affiliation_strings":["Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Medical University","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5150704015","display_name":"Shanshan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Zhang","raw_affiliation_strings":["Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Medical University","institution_ids":["https://openalex.org/I87780372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I87780372"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.061799999326467514,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bronchial-artery","display_name":"bronchial artery","score":0.8930000066757202},{"id":"https://openalex.org/keywords/iodinated-contrast-media","display_name":"iodinated contrast media","score":0.503000020980835},{"id":"https://openalex.org/keywords/monochromatic-imaging","display_name":"monochromatic imaging","score":0.8360000252723694},{"id":"https://openalex.org/keywords/contrast-to-noise-ratio","display_name":"contrast-to-noise ratio","score":0.9139999747276306},{"id":"https://openalex.org/keywords/signal-to-noise-ratio","display_name":"signal-to-noise ratio","score":0.8820000290870667},{"id":"https://openalex.org/keywords/iohexol","display_name":"iohexol","score":0.8569999933242798},{"id":"https://openalex.org/keywords/bronchial-artery-stenosis","display_name":"bronchial artery stenosis","score":0.6470000147819519},{"id":"https://openalex.org/keywords/image-quality","display_name":"image quality","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7847999930381775},{"id":"https://openalex.org/C40833965","wikidata":"https://www.wikidata.org/wiki/Q6901438","display_name":"Monochromatic color","level":2,"score":0.7226999998092651},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6258999705314636},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.6039000153541565},{"id":"https://openalex.org/C55020928","wikidata":"https://www.wikidata.org/wiki/Q3813865","display_name":"Image quality","level":3,"score":0.5813999772071838},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5703999996185303},{"id":"https://openalex.org/C3232514","wikidata":"https://www.wikidata.org/wiki/Q7575196","display_name":"Spectral imaging","level":2,"score":0.4767000079154968},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.4004000127315521},{"id":"https://openalex.org/C2779786684","wikidata":"https://www.wikidata.org/wiki/Q906156","display_name":"Contrast medium","level":2,"score":0.34439998865127563},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.3294999897480011},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.2948000133037567},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C2776982972","wikidata":"https://www.wikidata.org/wiki/Q424788","display_name":"Iopamidol","level":3,"score":0.2856999933719635},{"id":"https://openalex.org/C2780977465","wikidata":"https://www.wikidata.org/wiki/Q927103","display_name":"Bronchial artery","level":3,"score":0.2750000059604645},{"id":"https://openalex.org/C2779222893","wikidata":"https://www.wikidata.org/wiki/Q3275337","display_name":"Iodinated contrast","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C2781347138","wikidata":"https://www.wikidata.org/wiki/Q1024492","display_name":"Computed tomography angiography","level":3,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11373244/v1","doi":"https://doi.org/10.21203/rs.3.rs-11373244/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11373244/v1","pdf_url":"https://www.researchsquare.com/article/rs-11373244/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11373244/v1","doi":"https://doi.org/10.21203/rs.3.rs-11373244/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11373244/v1","pdf_url":"https://www.researchsquare.com/article/rs-11373244/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225636259.pdf","grobid_xml":"https://content.openalex.org/works/W7225636259.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W184259052","https://openalex.org/W2022835549","https://openalex.org/W2107070840","https://openalex.org/W2293187262","https://openalex.org/W2582314333","https://openalex.org/W2606101117","https://openalex.org/W2745722184","https://openalex.org/W2758991702","https://openalex.org/W2799951688","https://openalex.org/W2801473945","https://openalex.org/W2802678129","https://openalex.org/W2892664725","https://openalex.org/W3139206069","https://openalex.org/W3171159255","https://openalex.org/W4221099077","https://openalex.org/W4311679842","https://openalex.org/W4391482029","https://openalex.org/W4402077495","https://openalex.org/W4403460467","https://openalex.org/W4408031844","https://openalex.org/W4410453002","https://openalex.org/W6945894429","https://openalex.org/W6964946639"],"related_works":["https://openalex.org/W2187845948","https://openalex.org/W2367317270","https://openalex.org/W2351961500","https://openalex.org/W2293187262","https://openalex.org/W2534806021","https://openalex.org/W2392032017","https://openalex.org/W277474372","https://openalex.org/W2355112159","https://openalex.org/W2512673996","https://openalex.org/W3028861736"],"abstract_inverted_index":{"Abstract":[0],"Rationale":[1],"and":[2,19,35,80,131,141,195,219,229,247],"Objectives:":[3],"Computed":[4],"tomography":[5],"(CT)":[6],"angiography":[7,95,239],"of":[8,32,58,67,108,148,166],"the":[9,30,55,65,118,123,149,154,201,216],"bronchial":[10],"artery":[11],"(BA)":[12],"typically":[13],"requires":[14],"high-concentration":[15],"iodine":[16],"contrast":[17,33,46,70],"agents":[18],"high":[20],"injection":[21,102],"rates":[22],"to":[23,63,184],"achieve":[24],"adequate":[25],"vessel":[26],"enhancement,":[27],"which":[28],"increases":[29],"risks":[31],"extravasation":[34],"renal":[36],"burden.":[37],"Spectral":[38],"CT":[39,75,94,238],"with":[40,73,99,160],"monochromatic":[41,177],"imaging":[42,256],"can":[43],"improve":[44],"vascular":[45],"at":[47,117,240],"lower":[48],"energy":[49,178],"levels":[50],"(<70":[51],"keV)":[52,214],"by":[53,122],"enhancing":[54],"photoelectric":[56],"effect":[57],"iodine.":[59],"This":[60],"study":[61],"aimed":[62],"evaluate":[64],"feasibility":[66],"a":[68,100,234,254],"low-injection-rate":[69],"protocol":[71],"combined":[72],"spectral":[74,93,237],"for":[76,179,258],"BA":[77,150,180,250,259],"imaging.":[78],"Materials":[79],"Methods:":[81],"One":[82],"hundred":[83],"nine":[84],"patients":[85],"(72":[86],"males,":[87],"61.05\u00b112.72":[88],"years)":[89],"who":[90],"underwent":[91],"chest":[92],"(GE":[96],"Revolution":[97],"256)":[98],"low":[101],"rate":[103],"(\u22643.0":[104],"mL/s,":[105],"60\u201370":[106],"mL":[107],"350":[109],"mgI/mL":[110],"iohexol)":[111],"were":[112,134,151,173,198],"retrospectively":[113],"enrolled.":[114],"Monochromatic":[115],"images":[116],"optimal":[119,124,176,209,245],"keV":[120,133,186,210,243],"(determined":[121],"contrast-to-noise":[125],"ratio":[126,138],"[CNR]":[127],"curve),":[128],"60":[129],"keV,":[130],"70":[132],"reconstructed.":[135],"The":[136,175,208],"signal-to-noise":[137],"(SNR),":[139],"CNR,":[140,194],"subjective":[142,196],"image":[143,221,251],"quality":[144,222],"scores":[145,197],"(5-point":[146],"scale)":[147],"compared":[152],"among":[153,200],"three":[155,202],"groups":[156,203],"using":[157],"non-parametric":[158],"tests":[159],"Bonferroni":[161],"correction.":[162],"Results:":[163],"A":[164],"total":[165],"253":[167],"BAs":[168],"(125":[169],"left,":[170],"128":[171],"right)":[172],"displayed.":[174],"ranged":[181],"from":[182],"40":[183],"50":[185],"(mean:":[187],"43.62\u00b12.19":[188],"keV).":[189],"Significant":[190],"differences":[191],"in":[192],"SNR,":[193],"observed":[199],"(all":[204],"P":[205],"<":[206],"0.05).":[207],"group":[211],"(approximately":[212],"44":[213,242],"yielded":[215],"highest":[217],"CNR":[218,246],"best":[220],"on":[223],"maximum":[224],"intensity":[225],"projection,":[226],"volume":[227],"rendering,":[228],"fused":[230],"images.":[231],"Conclusion:":[232],"Under":[233],"low-contrast-injection-rate":[235],"protocol,":[236],"approximately":[241],"provides":[244],"significantly":[248],"improves":[249],"quality,":[252],"offering":[253],"reliable":[255],"method":[257],"evaluation.":[260]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}