{"id":"https://openalex.org/W7225635701","doi":"https://doi.org/10.64898/2026.11.06.764855","title":"Identifying a neurochemical signature of the paraventricular nucleus of the thalamus that predicts individual variability in cue-reward learning","display_name":"Identifying a neurochemical signature of the paraventricular nucleus of the thalamus that predicts individual variability in cue-reward learning","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225635701","doi":"https://doi.org/10.64898/2026.11.06.764855"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.06.764855","doi":"https://doi.org/10.64898/2026.11.06.764855","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.06.764855","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.06.764855.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.06.764855.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078217268","display_name":"Shelly B. Flagel","orcid":"https://orcid.org/0000-0002-7309-9908","observed_orcids":["https://orcid.org/0000-0002-7309-9908"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shelly B Flagel","raw_affiliation_strings":["University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026600608","display_name":"Brianna Ramos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brianna A Ramos","raw_affiliation_strings":["University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161329238","display_name":"Sayan Chakrabarty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sayan Chakrabarty","raw_affiliation_strings":["University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024392733","display_name":"Caitlin N. Cain","orcid":"https://orcid.org/0000-0001-8367-5799","observed_orcids":["https://orcid.org/0000-0001-8367-5799"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin N Cain","raw_affiliation_strings":["University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033332525","display_name":"Elizaveta Levina","orcid":"https://orcid.org/0000-0002-0713-3450","observed_orcids":["https://orcid.org/0000-0002-0713-3450"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizaveta Levina","raw_affiliation_strings":["University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056086091","display_name":"Robert T. Kennedy","orcid":"https://orcid.org/0000-0003-2447-7471","observed_orcids":["https://orcid.org/0000-0003-2447-7471","https://orcid.org/0000-0001-9417-0534"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert T Kennedy","raw_affiliation_strings":["University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078217268"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paraventricular-thalamus","display_name":"paraventricular thalamus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sign-tracking","display_name":"sign-tracking","score":0.8479999899864197},{"id":"https://openalex.org/keywords/pavlovian-conditioned-approach","display_name":"Pavlovian conditioned approach","score":0.8730000257492065},{"id":"https://openalex.org/keywords/individual-differences","display_name":"individual differences","score":0.5899999737739563},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.8489999771118164},{"id":"https://openalex.org/keywords/endophenotypes","display_name":"endophenotypes","score":0.7870000004768372},{"id":"https://openalex.org/keywords/impulsivity","display_name":"impulsivity","score":0.6299999952316284},{"id":"https://openalex.org/keywords/attention-deficits","display_name":"attention deficits","score":0.5580000281333923},{"id":"https://openalex.org/keywords/drug-seeking-behavior","display_name":"drug-seeking behavior","score":0.6539999842643738},{"id":"https://openalex.org/keywords/mental-health-vulnerability","display_name":"psychiatric vulnerability","score":0.6389999985694885},{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/neurobehavioral-phenotype","display_name":"neurobehavioral phenotype","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.911899983882904},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7457000017166138},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.6144000291824341},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6054999828338623},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.36570000648498535},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.2996000051498413},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2971000075340271},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.2842000126838684},{"id":"https://openalex.org/C2780371621","wikidata":"https://www.wikidata.org/wiki/Q3709910","display_name":"Disconnection","level":2,"score":0.2833000123500824},{"id":"https://openalex.org/C139676723","wikidata":"https://www.wikidata.org/wiki/Q1193832","display_name":"Sign (mathematics)","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.27140000462532043},{"id":"https://openalex.org/C129564537","wikidata":"https://www.wikidata.org/wiki/Q1460873","display_name":"Neural correlates of consciousness","level":3,"score":0.26080000400543213},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2547999918460846},{"id":"https://openalex.org/C2778135649","wikidata":"https://www.wikidata.org/wiki/Q1432371","display_name":"Thalamic reticular nucleus","level":3,"score":0.2524000108242035}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.06.764855","doi":"https://doi.org/10.64898/2026.11.06.764855","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.06.764855","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.06.764855.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.06.764855","doi":"https://doi.org/10.64898/2026.11.06.764855","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.06.764855","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.06.764855.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225635701.pdf","grobid_xml":"https://content.openalex.org/works/W7225635701.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1964544283","https://openalex.org/W1922279051","https://openalex.org/W2780981889","https://openalex.org/W2595750997","https://openalex.org/W3001515090","https://openalex.org/W2973048655","https://openalex.org/W7172017073","https://openalex.org/W2202288124","https://openalex.org/W6888708460","https://openalex.org/W2733422043"],"abstract_inverted_index":{"To":[0],"investigate":[1],"neurochemical":[2,176,198],"factors":[3],"that":[4,16,200],"may":[5,205],"confer":[6],"vulnerability":[7,218],"to":[8,52,57,103,155,209,219],"psychiatric":[9,220],"disorders,":[10],"we":[11],"used":[12,154],"an":[13],"animal":[14],"model":[15],"captures":[17],"a":[18,24,35,83,195],"transdiagnostically":[19],"relevant":[20,107],"neurobehavioral":[21],"endophenotype.":[22],"During":[23],"Pavlovian":[25,118,150,188],"conditioned":[26,151,189],"approach":[27,152,190],"paradigm,":[28],"rats":[29,134],"learn":[30],"the":[31,53,80,111,125,129,149,157,165,179,183,207],"predictive":[32],"relationship":[33],"between":[34,170],"lever":[36,54],"cue":[37,225],"and":[38,68,114,145,164,204],"food":[39],"reward.":[40],"A":[41],"subset":[42],"of":[43,72,79,128,167,182],"rats,":[44],"sign":[45,59,138,143,210],"trackers,":[46,60],"also":[47],"attribute":[48],"incentive":[49],"motivational":[50],"value":[51],"cue.":[55],"Relative":[56],"non":[58,142],"STs":[61],"are":[62],"more":[63],"impulsive,":[64],"have":[65],"attentional":[66],"deficits,":[67],"show":[69],"greater":[70],"reinstatement":[71],"drug":[73],"seeking":[74],"behavior.":[75,191,227],"The":[76],"paraventricular":[77,126,180],"nucleus":[78,127,181],"thalamus":[81,130,184],"is":[82],"key":[84],"neural":[85],"node":[86],"implicated":[87],"in":[88,94,110,124,133,141,178],"these":[89],"individual":[90],"differences.":[91],"We":[92],"combined":[93],"vivo":[95],"microdialysis":[96],"with":[97,148,186],"liquid":[98],"chromatography":[99],"tandem":[100],"mass":[101],"spectrometry":[102],"quantify":[104],"22":[105],"neurobiologically":[106],"small":[108],"molecules":[109],"PVT":[112,197],"before":[113],"24":[115],"hours":[116],"after":[117,162],"training.":[119],"Before":[120],"training,":[121,163],"glucose":[122],"concentrations":[123,160],"were":[131,146],"higher":[132],"subsequently":[135],"classified":[136],"as":[137],"trackers":[139,144],"than":[140],"correlated":[147],"index":[153],"phenotype":[156],"rats.":[158],"Glucose":[159],"decreased":[161],"magnitude":[166],"change":[168],"differed":[169],"phenotypes.":[171],"Multivariate":[172],"regression":[173],"identified":[174],"baseline":[175],"profiles":[177],"associated":[185],"subsequent":[187],"These":[192],"findings":[193],"identify":[194],"candidate":[196],"signature":[199],"precedes":[201],"behavioral":[202],"phenotyping":[203],"mark":[206],"propensity":[208],"track,":[211],"providing":[212],"insight":[213],"into":[214],"potential":[215],"mechanisms":[216],"underlying":[217],"disorders":[221],"characterized":[222],"by":[223],"maladaptive":[224],"motivated":[226]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}