{"id":"https://openalex.org/W7225635542","doi":"https://doi.org/10.3390/medsci14070763","title":"Tissue and Plasma NGS Are Complementary for Molecular Profiling in Advanced Non-Small Cell Lung Cancer: Real-World Concordance and Clinical Impact","display_name":"Tissue and Plasma NGS Are Complementary for Molecular Profiling in Advanced Non-Small Cell Lung Cancer: Real-World Concordance and Clinical Impact","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225635542","doi":"https://doi.org/10.3390/medsci14070763"},"language":"en","primary_location":{"id":"doi:10.3390/medsci14070763","doi":"https://doi.org/10.3390/medsci14070763","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medsci14070763","pdf_url":null,"source":{"id":"https://openalex.org/S2739445098","display_name":"Medical Sciences","issn_l":"2076-3271","issn":["2076-3271"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/medsci14070763","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048600301","display_name":"Ana G\u00f3mez\u2010Rueda","orcid":"https://orcid.org/0000-0003-4215-8474","observed_orcids":["https://orcid.org/0000-0003-4215-8474"]},"institutions":[{"id":"https://openalex.org/I4210106572","display_name":"Hospital Universitario Pr\u00edncipe de Asturias","ror":"https://ror.org/01az6dv73","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210106572","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana G\u00f3mez-Rueda","raw_affiliation_strings":["Oncology Service, University Hospital of Pr\u00edncipe de Asturias, Alcal\u00e1-Meco Road, s/n, Alcal\u00e1 de Henares, 28805 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Service, University Hospital of Pr\u00edncipe de Asturias, Alcal\u00e1-Meco Road, s/n, Alcal\u00e1 de Henares, 28805 Madrid, Spain","institution_ids":["https://openalex.org/I4210106572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161328932","display_name":"Pilar Garrido-Lopez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]},{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Garrido-Lopez","raw_affiliation_strings":["Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, University Campus, 19th Street, Madrid-Barcelona Road, Km 33.600, Alcal\u00e1 de Henares, 28805 Madrid, Spain","Oncology Service, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain","Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, University Campus, 19th Street, Madrid-Barcelona Road, Km 33.600, Alcal\u00e1 de Henares, 28805 Madrid, Spain","institution_ids":["https://openalex.org/I189268942"]},{"raw_affiliation_string":"Oncology Service, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain","institution_ids":["https://openalex.org/I4210127475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080477547","display_name":"Leonel Pekarek","orcid":"https://orcid.org/0000-0002-5966-9003","observed_orcids":["https://orcid.org/0000-0002-5966-9003"]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]},{"id":"https://openalex.org/I4210093872","display_name":"Hospital Universitario de Guadalajara","ror":"https://ror.org/00jkz9152","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210093872","https://openalex.org/I4210141158"]},{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Leonel Pekarek","raw_affiliation_strings":["Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, University Campus, 19th Street, Madrid-Barcelona Road, Km 33.600, Alcal\u00e1 de Henares, 28805 Madrid, Spain","Oncology Service, University Hospital of Guadalajara, Donante de Sangre Street, s/n, 19002 Guadalajara, Spain","Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-5966-9003","affiliations":[{"raw_affiliation_string":"Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, University Campus, 19th Street, Madrid-Barcelona Road, Km 33.600, Alcal\u00e1 de Henares, 28805 Madrid, Spain","institution_ids":["https://openalex.org/I189268942"]},{"raw_affiliation_string":"Oncology Service, University Hospital of Guadalajara, Donante de Sangre Street, s/n, 19002 Guadalajara, Spain","institution_ids":["https://openalex.org/I4210093872"]},{"raw_affiliation_string":"Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain","institution_ids":["https://openalex.org/I4210127475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023696165","display_name":"Miguel Angel Ortega","orcid":"https://orcid.org/0000-0003-2588-1708","observed_orcids":["https://orcid.org/0000-0003-2588-1708"]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]},{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Miguel A Ortega","raw_affiliation_strings":["Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, University Campus, 19th Street, Madrid-Barcelona Road, Km 33.600, Alcal\u00e1 de Henares, 28805 Madrid, Spain","Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0003-2588-1708","affiliations":[{"raw_affiliation_string":"Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, University Campus, 19th Street, Madrid-Barcelona Road, Km 33.600, Alcal\u00e1 de Henares, 28805 Madrid, Spain","institution_ids":["https://openalex.org/I189268942"]},{"raw_affiliation_string":"Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain","institution_ids":["https://openalex.org/I4210127475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161360751","display_name":"Eduardo David Roberts-Cervantes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093872","display_name":"Hospital Universitario de Guadalajara","ror":"https://ror.org/00jkz9152","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210093872","https://openalex.org/I4210141158"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo David Roberts-Cervantes","raw_affiliation_strings":["Oncology Service, University Hospital of Guadalajara, Donante de Sangre Street, s/n, 19002 Guadalajara, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Service, University Hospital of Guadalajara, Donante de Sangre Street, s/n, 19002 Guadalajara, Spain","institution_ids":["https://openalex.org/I4210093872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059815421","display_name":"Mar\u00eda Eugenia Olmedo-Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Eugenia Olmedo-Garc\u00eda","raw_affiliation_strings":["Oncology Service, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Service, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024047759","display_name":"Yolanda Lage","orcid":"https://orcid.org/0000-0002-9351-3184","observed_orcids":["https://orcid.org/0000-0002-9351-3184"]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Yolanda Lage-Alfranca","raw_affiliation_strings":["Oncology Service, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-9351-3184","affiliations":[{"raw_affiliation_string":"Oncology Service, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161079312","display_name":"Miguel Garc\u00eda Pardo de Santayana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Garc\u00eda Pardo De Santayana","raw_affiliation_strings":["Oncology Service, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Service, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078093203","display_name":"Jes\u00fas Chamorro-P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jesus Chamorro-Perez","raw_affiliation_strings":["Oncology Service, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Service, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161360061","display_name":"Lario Martinez-Margaret","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lario Martinez-Margaret","raw_affiliation_strings":["Oncology Service, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Service, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103016045","display_name":"Amparo Benito","orcid":"https://orcid.org/0000-0002-1312-4892","observed_orcids":["https://orcid.org/0000-0002-1312-4892"]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Amparo Benito-Berlinches","raw_affiliation_strings":["Pathology Department, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1312-4892","affiliations":[{"raw_affiliation_string":"Pathology Department, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161330928","display_name":"Almudena Santos","orcid":"https://orcid.org/0000-0002-4145-0580","observed_orcids":["https://orcid.org/0000-0002-4145-0580"]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Almudena Sant\u00f3n","raw_affiliation_strings":["Pathology Department, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-4145-0580","affiliations":[{"raw_affiliation_string":"Pathology Department, Hospital Universitario Ram\u00f3n y Cajal, Ram\u00f3n y Cajal Institute for Health Research (IRYCIS), Colmenar Viejo Road, Km 9.100, 28034 Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023696165"],"corresponding_institution_ids":["https://openalex.org/I189268942","https://openalex.org/I4210127475"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1689},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1689},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"7","first_page":"763","last_page":"763"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-non-small-cell-lung-cancer","display_name":"advanced non-small cell lung cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.8240000009536743},{"id":"https://openalex.org/keywords/molecular-profiling","display_name":"molecular profiling","score":0.6919999718666077},{"id":"https://openalex.org/keywords/actionable-genomic-alterations","display_name":"actionable genomic alterations","score":0.800000011920929},{"id":"https://openalex.org/keywords/concordance","display_name":"concordance","score":0.7960000038146973},{"id":"https://openalex.org/keywords/treatment-modification","display_name":"treatment modification","score":0.5799999833106995},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8040000200271606},{"id":"https://openalex.org/keywords/clinical-trial-enrollment","display_name":"clinical trial recruitment","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.9434999823570251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8878999948501587},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5443999767303467},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.54339998960495},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5115000009536743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49410000443458557},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4887000024318695},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.4611999988555908},{"id":"https://openalex.org/C179786068","wikidata":"https://www.wikidata.org/wiki/Q16257937","display_name":"Molecular diagnostics","level":2,"score":0.44530001282691956},{"id":"https://openalex.org/C2994067223","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"Genomic sequencing","level":4,"score":0.39239999651908875},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3855000138282776},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.38530001044273376},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.366100013256073},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.36559998989105225},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3596000075340271},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.35440000891685486},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2671000063419342},{"id":"https://openalex.org/C3020077223","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomic information","level":4,"score":0.26350000500679016}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/medsci14070763","doi":"https://doi.org/10.3390/medsci14070763","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medsci14070763","pdf_url":null,"source":{"id":"https://openalex.org/S2739445098","display_name":"Medical Sciences","issn_l":"2076-3271","issn":["2076-3271"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/medsci14070763","doi":"https://doi.org/10.3390/medsci14070763","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medsci14070763","pdf_url":null,"source":{"id":"https://openalex.org/S2739445098","display_name":"Medical Sciences","issn_l":"2076-3271","issn":["2076-3271"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320313831","display_name":"Comunidad de Madrid","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1953677527","https://openalex.org/W2082424649","https://openalex.org/W2105022277","https://openalex.org/W2126816979","https://openalex.org/W2131760216","https://openalex.org/W2144430639","https://openalex.org/W2146448515","https://openalex.org/W2160981405","https://openalex.org/W2164777277","https://openalex.org/W2258130809","https://openalex.org/W2289678372","https://openalex.org/W2302158695","https://openalex.org/W2410217600","https://openalex.org/W2419318462","https://openalex.org/W2513731937","https://openalex.org/W2514722200","https://openalex.org/W2550710477","https://openalex.org/W2566478217","https://openalex.org/W2739175998","https://openalex.org/W2742802588","https://openalex.org/W2745259295","https://openalex.org/W2767162493","https://openalex.org/W2771888931","https://openalex.org/W2774620365","https://openalex.org/W2785515282","https://openalex.org/W2787118659","https://openalex.org/W2792694005","https://openalex.org/W2795397600","https://openalex.org/W2804318759","https://openalex.org/W2886238008","https://openalex.org/W2903677975","https://openalex.org/W2929104600","https://openalex.org/W2980253478","https://openalex.org/W3080458669","https://openalex.org/W3082496783","https://openalex.org/W3136351248","https://openalex.org/W4213085451","https://openalex.org/W4226065969","https://openalex.org/W4312195879","https://openalex.org/W4317761498","https://openalex.org/W4322756172","https://openalex.org/W4382933583","https://openalex.org/W4399830882","https://openalex.org/W4405920997"],"related_works":["https://openalex.org/W4381486260","https://openalex.org/W7162532732","https://openalex.org/W3035793819","https://openalex.org/W7165666686","https://openalex.org/W4294939402","https://openalex.org/W3199343388","https://openalex.org/W4416630989","https://openalex.org/W4410795939","https://openalex.org/W4388776523","https://openalex.org/W4399283030"],"abstract_inverted_index":{"Background:":[0],"Comprehensive":[1],"molecular":[2,54,113],"profiling":[3,194],"is":[4],"increasingly":[5],"important":[6],"in":[7,94,98,143,195],"advanced":[8,42,196],"non-small":[9],"cell":[10],"lung":[11],"cancer":[12],"(NSCLC),":[13],"but":[14],"the":[15,70,179],"integration":[16],"of":[17,38,72,82,181,185],"tissue-":[18,57,121],"and":[19,24,48,56,69,122,159,174,187],"plasma-based":[20,59,123,160],"next-generation":[21],"sequencing":[22],"(NGS)":[23],"its":[25],"real-world":[26],"therapeutic":[27,176],"impact":[28,71,177],"remain":[29],"uncertain.":[30],"Methods:":[31],"We":[32],"conducted":[33],"a":[34,139],"retrospective":[35],"single-center":[36],"study":[37],"205":[39],"patients":[40,96,100,117,145],"with":[41,129],"NSCLC":[43],"treated":[44],"between":[45,171],"January":[46,49],"2016":[47],"2019":[50],"who":[51,118],"underwent":[52,119],"routine":[53],"testing":[55],"and/or":[58],"NGS.":[60],"Concordance":[61],"was":[62,77,127],"assessed":[63],"for":[64],"clinically":[65],"relevant":[66],"genomic":[67,92,104,167,193],"alterations,":[68],"NGS":[73,84,88,109,135,161],"on":[74],"treatment":[75,141,188],"decisions":[76],"evaluated.":[78],"Results:":[79],"A":[80],"total":[81],"280":[83],"assays":[85],"were":[86,106],"performed.":[87],"identified":[89,107],"potentially":[90,102],"actionable":[91,103],"alterations":[93,105],"88":[95],"(42.9%);":[97],"50":[99],"(24.4%),":[101],"by":[108],"relative":[110],"to":[111,138],"conventional":[112],"testing.":[114],"Among":[115],"64":[116],"both":[120],"NGS,":[124],"overall":[125],"agreement":[126],"78.1%,":[128],"moderate":[130],"concordance":[131],"(\u03ba":[132],"=":[133],"0.533).":[134],"results":[136],"led":[137],"direct":[140],"modification":[142],"23":[144],"(11.2%),":[146],"including":[147],"clinical":[148,182],"trial":[149],"enrollment,":[150],"standard":[151],"targeted":[152],"therapy,":[153],"or":[154],"compassionate-use":[155],"treatment.":[156],"Conclusions:":[157],"Tissue-":[158],"provided":[162],"complementary":[163],"rather":[164],"than":[165],"interchangeable":[166],"information.":[168],"The":[169],"difference":[170],"theoretical":[172],"actionability":[173],"actual":[175],"highlights":[178],"importance":[180],"context,":[183],"timing":[184],"testing,":[186],"availability":[189],"when":[190],"interpreting":[191],"comprehensive":[192],"NSCLC.":[197]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}