{"id":"https://openalex.org/W7225630299","doi":"https://doi.org/10.1038/s41598-026-78101-4","title":"Prevalence of autoimmune disease and associated 5-hydroxymethylcytosine cell-free DNA patterns in appendiceal neoplasms","display_name":"Prevalence of autoimmune disease and associated 5-hydroxymethylcytosine cell-free DNA patterns in appendiceal neoplasms","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225630299","doi":"https://doi.org/10.1038/s41598-026-78101-4"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-78101-4","doi":"https://doi.org/10.1038/s41598-026-78101-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-78101-4","pdf_url":"https://www.nature.com/articles/s41598-026-78101-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-78101-4_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068192543","display_name":"Biren Reddy","orcid":"https://orcid.org/0000-0001-8891-3610","observed_orcids":["https://orcid.org/0000-0001-8891-3610"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Biren Reddy","raw_affiliation_strings":["Division of Surgical Oncology, Yale School of Medicine, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Yale School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043289945","display_name":"Yuri Malina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuri Malina","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA","Department of Chemistry, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Chemistry, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025973468","display_name":"Celyn Bregio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celyn Bregio","raw_affiliation_strings":["Pritzker School of Medicine, The University of Chicago Medical Center, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pritzker School of Medicine, The University of Chicago Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068713545","display_name":"Ankit Dhiman","orcid":"https://orcid.org/0000-0003-3086-2587","observed_orcids":["https://orcid.org/0000-0003-3086-2587"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ankit Dhiman","raw_affiliation_strings":["Department of Surgery, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020783059","display_name":"Rushabh Gujarathi","orcid":"https://orcid.org/0000-0002-1748-6508","observed_orcids":["https://orcid.org/0000-0002-1748-6508"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rushabh Gujarathi","raw_affiliation_strings":["Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082380048","display_name":"David G. Su","orcid":"https://orcid.org/0000-0002-8693-612X","observed_orcids":["https://orcid.org/0000-0002-8693-612X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Su","raw_affiliation_strings":["Division of Surgical Oncology, Yale School of Medicine, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Yale School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023302132","display_name":"Varun Vivek Bansal","orcid":"https://orcid.org/0000-0002-9973-0884","observed_orcids":["https://orcid.org/0000-0002-9973-0884"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Varun V. Bansal","raw_affiliation_strings":["Division of Surgical Oncology, Yale School of Medicine, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Yale School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092718822","display_name":"Ryan C. Owyang","orcid":"https://orcid.org/0000-0003-0532-5915","observed_orcids":["https://orcid.org/0000-0003-0532-5915"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan C. Owyang","raw_affiliation_strings":["Department of Chemistry, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002913392","display_name":"Sofia Fertuzinhos","orcid":"https://orcid.org/0000-0002-3045-4201","observed_orcids":["https://orcid.org/0000-0002-3045-4201"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sofia Fertuzinhos","raw_affiliation_strings":["Bioinformatics Support Hub, Cushing/Whitney Library, Yale School of Medicine, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Support Hub, Cushing/Whitney Library, Yale School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019527884","display_name":"Roshni Roy Chowdhury","orcid":"https://orcid.org/0000-0002-1561-1133","observed_orcids":["https://orcid.org/0000-0002-1561-1133"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roshni Roy Chowdhury","raw_affiliation_strings":["Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070440578","display_name":"Lindsay Alpert","orcid":"https://orcid.org/0000-0002-3599-8830","observed_orcids":["https://orcid.org/0000-0002-3599-8830"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay Alpert","raw_affiliation_strings":["Department of Pathology, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021303180","display_name":"Kelly L. Olino","orcid":"https://orcid.org/0000-0001-6209-5218","observed_orcids":["https://orcid.org/0000-0001-6209-5218"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly Olino","raw_affiliation_strings":["Division of Surgical Oncology, Yale School of Medicine, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Yale School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100750451","display_name":"Lu Gao","orcid":"https://orcid.org/0000-0002-9264-6655","observed_orcids":["https://orcid.org/0000-0002-9264-6655"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Gao","raw_affiliation_strings":["Department of Chemistry, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005112247","display_name":"Marc Bissonnette","orcid":"https://orcid.org/0000-0001-8420-4294","observed_orcids":["https://orcid.org/0000-0001-8420-4294"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Bissonnette","raw_affiliation_strings":["Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091114864","display_name":"Chuan He","orcid":"https://orcid.org/0000-0003-4319-7424","observed_orcids":["https://orcid.org/0000-0003-4319-7424","https://orcid.org/0000-0002-9983-7526","https://orcid.org/0000-0002-6171-810X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuan He","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA","Department of Chemistry, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Chemistry, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053712180","display_name":"Kiran Kalyan Turaga","orcid":"https://orcid.org/0000-0001-8541-586X","observed_orcids":["https://orcid.org/0000-0001-8541-586X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kiran K. Turaga","raw_affiliation_strings":["Department of Surgery, Division of Surgical Oncology, Yale School of Medicine, New Haven, CT, USA","Division of Surgical Oncology, Yale School of Medicine, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Surgical Oncology, Yale School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Division of Surgical Oncology, Yale School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5053712180"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.2612000107765198,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11473","display_name":"Appendicitis Diagnosis and Management","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.8569999933242798},{"id":"https://openalex.org/keywords/appendiceal-neoplasms","display_name":"appendiceal neoplasms","score":0.9940000176429749},{"id":"https://openalex.org/keywords/5-hydroxymethylcytosine","display_name":"5-hydroxymethylcytosine","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.8410000205039978},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hashimoto-s-thyroiditis","display_name":"Hashimoto's thyroiditis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.5360000133514404},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7429999709129333},{"id":"https://openalex.org/keywords/erbb-signaling-pathway","display_name":"ErbB signaling","score":0.9330000281333923},{"id":"https://openalex.org/keywords/fcepsilonri","display_name":"Fc\u03b5RI","score":0.7960000038146973},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7519999742507935},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.645799994468689},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.604200005531311},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5358999967575073},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5274999737739563},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5238000154495239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46799999475479126},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44769999384880066},{"id":"https://openalex.org/C2776362883","wikidata":"https://www.wikidata.org/wiki/Q187842","display_name":"Autoimmune thyroiditis","level":4,"score":0.4408999979496002},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.3813999891281128},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.36910000443458557},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.36809998750686646},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.36059999465942383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33629998564720154},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.3255999982357025},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3188999891281128},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31690001487731934},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.29789999127388},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.2976999878883362},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.2976999878883362},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.29339998960494995},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.2888999879360199},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2831999957561493},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2831999957561493},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2800000011920929},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.2797999978065491},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.27570000290870667},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2574999928474426},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-78101-4","doi":"https://doi.org/10.1038/s41598-026-78101-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-78101-4","pdf_url":"https://www.nature.com/articles/s41598-026-78101-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-78101-4","doi":"https://doi.org/10.1038/s41598-026-78101-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-78101-4","pdf_url":"https://www.nature.com/articles/s41598-026-78101-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225630299.pdf","grobid_xml":"https://content.openalex.org/works/W7225630299.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4403320630"],"related_works":["https://openalex.org/W7162629315","https://openalex.org/W4410815109","https://openalex.org/W4318904302","https://openalex.org/W3031748144","https://openalex.org/W7205427197","https://openalex.org/W7171088401","https://openalex.org/W4391091309","https://openalex.org/W4404339490","https://openalex.org/W4286297600","https://openalex.org/W2604770477"],"abstract_inverted_index":{"Autoimmune":[0],"diseases":[1],"(AID)":[2],"are":[3],"associated":[4],"with":[5,15,34,146,157],"increased":[6],"risk":[7],"of":[8,27,37,139,191],"developing":[9],"gastrointestinal":[10],"cancers,":[11,184],"but":[12],"their":[13],"relationship":[14],"appendiceal":[16,183],"neoplasms":[17],"(AENs)":[18],"remains":[19],"unexplored.":[20],"We":[21],"performed":[22],"a":[23,35,58,178],"multi-institutional":[24],"retrospective":[25],"review":[26],"179":[28],"AEN":[29],"patients,":[30],"identifying":[31],"44":[32],"(24.6%)":[33],"history":[36],"AID,":[38],"most":[39],"commonly":[40],"suspected":[41],"Hashimoto\u2019s":[42],"thyroiditis":[43],"(14.0%).":[44],"5-hydroxymethylcytosine":[45],"(5hmC),":[46],"an":[47],"epigenetic":[48,180],"marker":[49],"involved":[50],"in":[51,144,182],"gene":[52],"regulation":[53],"and":[54,92,101,108,116,125,141,163,165],"immune":[55,151],"function,":[56],"offers":[57],"promising":[59],"tool":[60],"for":[61,153],"studying":[62],"tumor":[63,117],"biology.":[64],"Plasma":[65],"samples":[66],"from":[67,81],"68":[68],"patients":[69,103,145],"were":[70],"analyzed":[71],"using":[72],"Nano-hmC-Seal":[73],"(5hmC-Seal)":[74],"technology":[75],"to":[76,177],"generate":[77],"genome-wide":[78],"5hmC":[79,83],"profiles":[80],"cfDNA.":[82],"profiling":[84],"identified":[85],"58":[86],"candidate":[87,94],"differentially":[88,95,131],"hydroxymethylated":[89,96,132],"regions":[90,133],"(DhMRs)":[91],"80":[93],"genes":[97,119,135],"(DhMGs)":[98],"between":[99],"AID":[100],"non-AID":[102],"based":[104],"on":[105],"nominal":[106],"p-value":[107],"effect-size":[109],"thresholds.":[110],"These":[111,169],"included.":[112],"several":[113],"oncogenes,":[114],"proto-oncogenes,":[115],"suppressor":[118],"such":[120],"as":[121],"MNT,":[122],"FYN,":[123],"ERG,":[124],"KAT6B.":[126],"Functional":[127],"pathway":[128],"analysis":[129],"involving":[130],"or":[134],"revealed":[136],"significant":[137],"hydroxymethylation":[138],"immune-related":[140],"oncogenic":[142],"pathways":[143],"autoimmune":[147,173],"disease,":[148],"including":[149],"intestinal":[150],"network":[152],"IgA":[154],"production,":[155],"along":[156],"the":[158],"IgE":[159],"high-affinity":[160],"receptor,":[161],"Fc\u03b5RI,":[162],"MAPK":[164],"ErbB":[166],"signaling":[167],"pathways.":[168],"findings":[170],"suggest":[171],"that":[172],"conditions":[174],"might":[175],"contribute":[176],"distinct":[179],"landscape":[181],"supporting":[185],"further":[186],"investigation":[187],"into":[188],"immune-mediated":[189],"mechanisms":[190],"tumorigenesis.":[192]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
