{"id":"https://openalex.org/W7225628621","doi":"https://doi.org/10.1177/22313354261493704","title":"Bioactive Prenylated Flavonoids from Macaranga tanarius (L.) M\u00fcll.-Arg.: A Systematic Scoping Review of Phytochemistry, Antioxidant Activity, and Antidiabetic Mechanisms","display_name":"Bioactive Prenylated Flavonoids from Macaranga tanarius (L.) M\u00fcll.-Arg.: A Systematic Scoping Review of Phytochemistry, Antioxidant Activity, and Antidiabetic Mechanisms","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225628621","doi":"https://doi.org/10.1177/22313354261493704"},"language":"en","primary_location":{"id":"doi:10.1177/22313354261493704","doi":"https://doi.org/10.1177/22313354261493704","is_oa":true,"landing_page_url":"https://doi.org/10.1177/22313354261493704","pdf_url":null,"source":{"id":"https://openalex.org/S2764844132","display_name":"Journal of Applied Pharmaceutical Science","issn_l":"2231-3354","issn":["2231-3354"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4327876862","host_organization_name":"Open Science Publishers LLP","host_organization_lineage":["https://openalex.org/P4327876862"],"host_organization_lineage_names":["Open Science Publishers LLP"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1177/22313354261493704","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013753075","display_name":"Amalia Eka Putri","orcid":"https://orcid.org/0009-0005-7882-0361","observed_orcids":["https://orcid.org/0009-0005-7882-0361"]},"institutions":[{"id":"https://openalex.org/I134635517","display_name":"Bandung Institute of Technology","ror":"https://ror.org/00apj8t60","country_code":"ID","type":"education","lineage":["https://openalex.org/I134635517"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Amalia Eka Putri","raw_affiliation_strings":["Department of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, West Java, Indonesia","Pharmacy Study Program, STIKes Karya Putra Bangsa Tulungagung, Tulungagung, East Java, Indonesia"],"raw_orcid":"https://orcid.org/0009-0005-7882-0361","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, West Java, Indonesia","institution_ids":["https://openalex.org/I134635517"]},{"raw_affiliation_string":"Pharmacy Study Program, STIKes Karya Putra Bangsa Tulungagung, Tulungagung, East Java, Indonesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045402982","display_name":"Muhamad \u0130nsanu","orcid":"https://orcid.org/0000-0002-1326-4414","observed_orcids":["https://orcid.org/0000-0002-1326-4414"]},"institutions":[{"id":"https://openalex.org/I134635517","display_name":"Bandung Institute of Technology","ror":"https://ror.org/00apj8t60","country_code":"ID","type":"education","lineage":["https://openalex.org/I134635517"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Muhamad Insanu","raw_affiliation_strings":["Department of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, West Java, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-1326-4414","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, West Java, Indonesia","institution_ids":["https://openalex.org/I134635517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076726445","display_name":"Irda Fidrianny","orcid":"https://orcid.org/0000-0002-2654-0318","observed_orcids":["https://orcid.org/0000-0002-2654-0318"]},"institutions":[{"id":"https://openalex.org/I134635517","display_name":"Bandung Institute of Technology","ror":"https://ror.org/00apj8t60","country_code":"ID","type":"education","lineage":["https://openalex.org/I134635517"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Irda Fidrianny","raw_affiliation_strings":["Department of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, West Java, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-2654-0318","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, West Java, Indonesia","institution_ids":["https://openalex.org/I134635517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I134635517"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.5889000296592712,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.5889000296592712,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.34790000319480896,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macaranga-tanarius","display_name":"Macaranga tanarius","score":1.0},{"id":"https://openalex.org/keywords/prenylated-flavonoids","display_name":"prenylated flavonoids","score":0.9879999756813049},{"id":"https://openalex.org/keywords/green-propolis","display_name":"green propolis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/antidiabetic-mechanism","display_name":"antidiabetic mechanism","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9470000267028809},{"id":"https://openalex.org/keywords/glucose-transporter-1","display_name":"glucose transporter 1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.8709999918937683},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/phytochemistry","display_name":"phytochemistry","score":0.652999997138977},{"id":"https://openalex.org/keywords/safety-assessment","display_name":"safety assessment","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6467999815940857},{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.6452000141143799},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49230000376701355},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.48669999837875366},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.46470001339912415},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4560000002384186},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4065000116825104},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.38609999418258667},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37770000100135803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3776000142097473},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35280001163482666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34369999170303345},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.3346000015735626},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.3100000023841858},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3000999987125397},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.25529998540878296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1177/22313354261493704","doi":"https://doi.org/10.1177/22313354261493704","is_oa":true,"landing_page_url":"https://doi.org/10.1177/22313354261493704","pdf_url":null,"source":{"id":"https://openalex.org/S2764844132","display_name":"Journal of Applied Pharmaceutical Science","issn_l":"2231-3354","issn":["2231-3354"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4327876862","host_organization_name":"Open Science Publishers LLP","host_organization_lineage":["https://openalex.org/P4327876862"],"host_organization_lineage_names":["Open Science Publishers LLP"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1177/22313354261493704","doi":"https://doi.org/10.1177/22313354261493704","is_oa":true,"landing_page_url":"https://doi.org/10.1177/22313354261493704","pdf_url":null,"source":{"id":"https://openalex.org/S2764844132","display_name":"Journal of Applied Pharmaceutical Science","issn_l":"2231-3354","issn":["2231-3354"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4327876862","host_organization_name":"Open Science Publishers LLP","host_organization_lineage":["https://openalex.org/P4327876862"],"host_organization_lineage_names":["Open Science Publishers LLP"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1985282446","https://openalex.org/W1988573995","https://openalex.org/W2050732772","https://openalex.org/W2065325305","https://openalex.org/W2083344137","https://openalex.org/W2104137282","https://openalex.org/W2763380116","https://openalex.org/W2891378911","https://openalex.org/W2955328698","https://openalex.org/W2962010987","https://openalex.org/W2967186233","https://openalex.org/W3004563230","https://openalex.org/W3047866922","https://openalex.org/W3119952098","https://openalex.org/W3135720644","https://openalex.org/W3136878673","https://openalex.org/W3162447269","https://openalex.org/W3193781848","https://openalex.org/W4200026682","https://openalex.org/W4200280400","https://openalex.org/W4200533463","https://openalex.org/W4206644696","https://openalex.org/W4210964508","https://openalex.org/W4211073818","https://openalex.org/W4214915484","https://openalex.org/W4224275107","https://openalex.org/W4281801724","https://openalex.org/W4283457102","https://openalex.org/W4285393103","https://openalex.org/W4310782457","https://openalex.org/W4312210127","https://openalex.org/W4319005286","https://openalex.org/W4322096508","https://openalex.org/W4388633818","https://openalex.org/W4396790916","https://openalex.org/W4400150291","https://openalex.org/W4402581852","https://openalex.org/W4403231108","https://openalex.org/W4407703160","https://openalex.org/W4408164710","https://openalex.org/W4410827547","https://openalex.org/W4410929201","https://openalex.org/W4413330990"],"related_works":["https://openalex.org/W1988573995","https://openalex.org/W1985282446","https://openalex.org/W2967186233","https://openalex.org/W1128653504","https://openalex.org/W4408164710","https://openalex.org/W7067165648","https://openalex.org/W2065325305","https://openalex.org/W3043698199","https://openalex.org/W1514146137","https://openalex.org/W2073200609"],"abstract_inverted_index":{"Macaranga":[0,50],"tanarius":[1,46,154],"(L.)":[2],"M\u00fcll.-Arg.":[3],"(Euphorbiaceae),":[4],"a":[5,76,137,157],"botanical":[6],"source":[7],"of":[8,89,122],"green-propolis,":[9],"contains":[10],"diverse":[11],"secondary":[12],"metabolites,":[13],"including":[14],"characteristic":[15],"prenylated":[16,57],"flavonoids.":[17],"This":[18],"systematic":[19],"scoping":[20],"review":[21],"mapped":[22],"phytochemical,":[23],"antioxidant,":[24],"preclinical":[25,158],"antidiabetic,":[26],"safety,":[27],"and":[28,34,52,62,82,91,107,125,133,148,169],"translational":[29],"evidence":[30,36,66,95,150],"using":[31],"direct,":[32],"comparative,":[33],"contextual":[35,54],"roles.":[37],"Source":[38],"verification":[39],"yielded":[40],"49":[41],"records:":[42],"25":[43],"direct":[44],"M.":[45,153],"studies,":[47,51,165],"18":[48],"comparative":[49],"six":[53],"studies.":[55],"Recurring":[56],"flavonoids":[58],"included":[59],"macaflavanones":[60],"A-G":[61],"nymphaeol/propolin-type":[63],"compounds.":[64],"Antioxidant":[65],"was":[67,100,146],"most":[68],"frequently":[69],"reported":[70],"but":[71],"remained":[72,96],"mainly":[73],"chemical/in":[74],"vitro;":[75],"methanolic":[77],"leaf":[78],"extract":[79],"showed":[80],"2,2-diphenyl-1-picrylhydrazyl":[81],"2,2\u02b9-azino-bis(3-ethylbenzothiazoline-6-sulfonic":[83],"acid)":[84],"half-maximal":[85],"inhibitory":[86],"concentration":[87],"values":[88],"0.87":[90],"4.36":[92],"\u00b5g/mL.":[93],"Antidiabetic":[94],"preclinical:":[97],"Glucose":[98],"uptake":[99],"associated":[101],"with":[102,116],"AMP-activated":[103],"protein":[104],"kinase":[105],"phosphorylation":[106],"glucose":[108],"transporter":[109],"1":[110],"(GLUT1)":[111],"expression":[112],"in":[113],"L6":[114],"myotubes,":[115],"additional":[117],"findings":[118,128],"from":[119,130],"animal":[120],"models":[121,132],"diabetic":[123],"nephropathy":[124],"retinopathy.":[126],"These":[127],"arise":[129],"different":[131],"do":[134],"not":[135],"establish":[136],"single":[138],"confirmed":[139],"therapeutic":[140],"mechanism.":[141],"No":[142],"human":[143],"clinical":[144,174],"study":[145],"identified,":[147],"safety":[149,167],"remains":[151,156],"preliminary.":[152],"therefore":[155],"natural-product":[159],"candidate":[160],"requiring":[161],"botanical/chemical":[162],"standardization,":[163],"pharmacokinetic/exposure":[164],"repeated-dose":[166],"assessment,":[168],"further":[170],"animal-model":[171],"validation":[172],"before":[173],"investigation.":[175]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
