{"id":"https://openalex.org/W7225627889","doi":"https://doi.org/10.1038/s41598-026-76991-y","title":"Redox, lipid, and metabolic changes associated with early tolerance to combination chemotherapy in two pancreatic cancer cell models","display_name":"Redox, lipid, and metabolic changes associated with early tolerance to combination chemotherapy in two pancreatic cancer cell models","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225627889","doi":"https://doi.org/10.1038/s41598-026-76991-y"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-76991-y","doi":"https://doi.org/10.1038/s41598-026-76991-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-76991-y","pdf_url":"https://www.nature.com/articles/s41598-026-76991-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-76991-y_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111318420","display_name":"Rossella Mosca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossella Mosca","raw_affiliation_strings":["Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118987913","display_name":"Martina Avanatti","orcid":"https://orcid.org/0009-0005-6326-2897","observed_orcids":["https://orcid.org/0009-0005-6326-2897"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Avanatti","raw_affiliation_strings":["Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161350683","display_name":"Monica Infantino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Infantino","raw_affiliation_strings":["Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161311618","display_name":"Rosa Ricciulli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosa Ricciulli","raw_affiliation_strings":["Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031164933","display_name":"Gemma Sardelli","orcid":"https://orcid.org/0000-0002-3617-0496","observed_orcids":["https://orcid.org/0000-0002-3617-0496"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gemma Sardelli","raw_affiliation_strings":["Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109783136","display_name":"Adrian Florentin Suman","orcid":"https://orcid.org/0009-0000-7318-7361","observed_orcids":["https://orcid.org/0009-0000-7318-7361"]},"institutions":[{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Adrian Florentin Suman","raw_affiliation_strings":["Institute of Clinical Physiology, CNR, via Moruzzi 1, 56124, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Physiology, CNR, via Moruzzi 1, 56124, Pisa, Italy","institution_ids":["https://openalex.org/I4210106076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008246765","display_name":"Roberta Moschini","orcid":"https://orcid.org/0000-0001-5227-2348","observed_orcids":["https://orcid.org/0000-0001-5227-2348"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Moschini","raw_affiliation_strings":["Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002616891","display_name":"Mario Cappiello","orcid":"https://orcid.org/0000-0002-8864-5043","observed_orcids":["https://orcid.org/0000-0002-8864-5043"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Cappiello","raw_affiliation_strings":["Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161328101","display_name":"Antonella Del-Corso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella Del-Corso","raw_affiliation_strings":["Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006433955","display_name":"Francesco Balestri","orcid":"https://orcid.org/0000-0003-3758-8517","observed_orcids":["https://orcid.org/0000-0003-3758-8517"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco Balestri","raw_affiliation_strings":["Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033342633","display_name":"Giovanni Signore","orcid":"https://orcid.org/0000-0002-0067-2240","observed_orcids":["https://orcid.org/0000-0002-0067-2240"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Signore","raw_affiliation_strings":["Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy","Institute of Clinical Physiology, CNR, via Moruzzi 1, 56124, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Biochemistry Unit, University of Pisa, via S. Zeno 51, 56127, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Institute of Clinical Physiology, CNR, via Moruzzi 1, 56124, Pisa, Italy","institution_ids":["https://openalex.org/I4210106076"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006433955"],"corresponding_institution_ids":["https://openalex.org/I108290504"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.524399995803833,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.524399995803833,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.4221000075340271,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chemotherapy-tolerance","display_name":"chemotherapy tolerance","score":0.6940000057220459},{"id":"https://openalex.org/keywords/folfirinox","display_name":"FOLFIRINOX","score":0.7900000214576721},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6159999966621399},{"id":"https://openalex.org/keywords/mia-paca-2-cells","display_name":"MIA PaCa-2 cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/panc-1-cells","display_name":"PANC-1 cells","score":1.0},{"id":"https://openalex.org/keywords/lipid-remodeling","display_name":"lipid remodeling","score":0.7900000214576721},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.7350000143051147},{"id":"https://openalex.org/keywords/phosphatidylethanolamine","display_name":"phosphatidylethanolamine","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.6129999756813049},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9089999794960022},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glutathione-reductase","display_name":"glutathione reductase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mitochondrial-oxidation","display_name":"mitochondrial oxidation","score":0.6420000195503235},{"id":"https://openalex.org/keywords/redox-state","display_name":"redox state","score":0.5410000085830688},{"id":"https://openalex.org/keywords/lactic-acid-production","display_name":"lactic acid production","score":0.8550000190734863},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5149999856948853},{"id":"https://openalex.org/keywords/adaptive-tolerance","display_name":"adaptive tolerance","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6243000030517578},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5504999756813049},{"id":"https://openalex.org/C2781170229","wikidata":"https://www.wikidata.org/wiki/Q426095","display_name":"Phosphatidylethanolamine","level":5,"score":0.5331000089645386},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.475600004196167},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.4426000118255615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4275999963283539},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42080000042915344},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.4140999913215637},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.40619999170303345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4058000147342682},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.37869998812675476},{"id":"https://openalex.org/C165069038","wikidata":"https://www.wikidata.org/wiki/Q420930","display_name":"Glutathione reductase","level":5,"score":0.3725000023841858},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3709999918937683},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36899998784065247},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.35249999165534973},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3352000117301941},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33329999446868896},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3296999931335449},{"id":"https://openalex.org/C2777148230","wikidata":"https://www.wikidata.org/wiki/Q17144959","display_name":"FOLFIRINOX","level":5,"score":0.3246999979019165},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32199999690055847},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3163999915122986},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.3147999942302704},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.302700012922287},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3021000027656555},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.29580000042915344},{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C3019864225","wikidata":"https://www.wikidata.org/wiki/Q5867482","display_name":"Combination chemotherapy","level":3,"score":0.27889999747276306},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.2786000072956085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2702000141143799},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.26750001311302185},{"id":"https://openalex.org/C158086472","wikidata":"https://www.wikidata.org/wiki/Q21103287","display_name":"GPX4","level":5,"score":0.26649999618530273},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.26649999618530273},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.2630999982357025},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.25459998846054077}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-76991-y","doi":"https://doi.org/10.1038/s41598-026-76991-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-76991-y","pdf_url":"https://www.nature.com/articles/s41598-026-76991-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-76991-y","doi":"https://doi.org/10.1038/s41598-026-76991-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-76991-y","pdf_url":"https://www.nature.com/articles/s41598-026-76991-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225627889.pdf","grobid_xml":"https://content.openalex.org/works/W7225627889.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7223816305","https://openalex.org/W7021004165","https://openalex.org/W4417149725","https://openalex.org/W4285733052","https://openalex.org/W7148806729","https://openalex.org/W4414585658","https://openalex.org/W7158429353","https://openalex.org/W3153725593","https://openalex.org/W4310522586","https://openalex.org/W3013545381"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1],"ductal":[2],"adenocarcinoma":[3],"(PDAC)":[4],"shows":[5,124],"limited":[6],"responsiveness":[7],"to":[8,22,37,44,204,226],"chemotherapy":[9,39],"and":[10,49,61,75,87,112,114,119,137,162,170,211],"rapidly":[11],"develops":[12],"resistance,":[13],"which":[14],"can":[15,199],"be":[16,200,205],"facilitated":[17],"by":[18,68,159],"early":[19,35],"adaptive":[20],"tolerance":[21,36,225],"sub-lethal":[23],"drug":[24,78],"exposure.":[25],"Here,":[26],"we":[27],"investigated":[28],"changes":[29,156],"associated":[30],"with":[31,149],"the":[32,64,81,222],"development":[33],"of":[34,58,97,110,117],"a":[38,53],"combination":[40],"analogous":[41],"in":[42,46,102,166,175,193],"composition":[43],"FOLFIRINOX":[45],"MIA":[47,127,167,178],"PaCa-2":[48,128,168,179],"PANC-1":[50,105,142,176],"cells":[51,106,129,143,169,180],"using":[52],"stepwise":[54],"adaptation":[55],"approach.":[56],"Comparison":[57],"metabolic":[59],"similarities":[60],"divergences":[62],"between":[63],"two":[65],"cell":[66,91],"lines":[67],"dose-response":[69],"analysis":[70],"revealed":[71,90],"limited,":[72],"yet":[73],"progressive":[74],"cell-specific,":[76],"shiftsin":[77],"sensitivity.":[79],"At":[80],"consolidated":[82],"stage,":[83],"Nile":[84],"Red":[85],"imaging":[86],"targeted":[88],"lipidomics":[89],"line-specific":[92],"lipid":[93],"remodeling,":[94],"including":[95],"elongation":[96],"membrane":[98],"phospholipid":[99],"acyl":[100],"chains":[101],"both":[103,194],"lines.":[104],"show":[107,144],"increased":[108,131,150,160],"saturation":[109],"phosphatidylcholine":[111],"triacylglycerols":[113],"reduced":[115,145,171,183],"polyunsaturation":[116],"phosphatidylethanolamine":[118],"phosphatidylcholine.":[120],"Antioxidant":[121],"profiling":[122],"also":[123,181],"model-dependent":[125],"patterns:":[126],"exhibit":[130],"total":[132,134,151],"catalase,":[133],"glutathione":[135,138,152],"S-transferase,":[136],"reductase":[139],"activities,":[140],"whereas":[141],"catalase":[146],"activity":[147],"together":[148],"S-transferase":[153],"activity.":[154],"These":[155],"are":[157],"accompanied":[158],"cytosolic":[161],"mitochondrial":[163,172],"oxidation-dependent":[164,173],"fluorescence":[165,174],"cells.":[177],"showed":[182],"extracellular":[184],"lactate":[185],"production,":[186],"while":[187],"cellular":[188],"energy":[189],"charge":[190],"remained":[191],"unchanged":[192],"models.":[195],"Whether":[196],"these":[197],"adaptations":[198],"exploited":[201],"therapeutically":[202],"remains":[203],"tested;":[206],"they":[207],"nevertheless":[208],"identify":[209],"redox-":[210],"lipid-related":[212],"pathways":[213],"as":[214],"candidates":[215],"for":[216],"functional":[217],"studies":[218],"aimed":[219],"at":[220],"preventing":[221],"transition":[223],"from":[224],"stable":[227],"resistance.":[228]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
