{"id":"https://openalex.org/W7225626951","doi":"https://doi.org/10.64898/2026.11.06.26367201","title":"Donepezil, galantamine and rivastigmine and progression to memantine add-on therapy in Alzheimer's disease: a nationwide cohort study emulating a target trial in the Brazilian Unified Health System","display_name":"Donepezil, galantamine and rivastigmine and progression to memantine add-on therapy in Alzheimer's disease: a nationwide cohort study emulating a target trial in the Brazilian Unified Health System","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225626951","doi":"https://doi.org/10.64898/2026.11.06.26367201"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.06.26367201","doi":"https://doi.org/10.64898/2026.11.06.26367201","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.06.26367201","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/09/2026.11.06.26367201.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/09/2026.11.06.26367201.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158777702","display_name":"Gabriela Imbuzeiro Cardoso","orcid":"https://orcid.org/0009-0004-3001-9519","observed_orcids":["https://orcid.org/0009-0004-3001-9519"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabriela Imbuzeiro Cardoso","raw_affiliation_strings":["Health Informatics Laboratory (LabInfoS), Departamento de Ciencias Medicas Integradas, Faculdade de Ciencias Medicas, Centro Biomedico, Universidade do Estado do Rio de Janeiro, Cabo Frio 28905-320, RJ, Brazil.;"],"raw_orcid":"https://orcid.org/0009-0004-3001-9519","affiliations":[{"raw_affiliation_string":"Health Informatics Laboratory (LabInfoS), Departamento de Ciencias Medicas Integradas, Faculdade de Ciencias Medicas, Centro Biomedico, Universidade do Estado do Rio de Janeiro, Cabo Frio 28905-320, RJ, Brazil.;","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140837926","display_name":"Priscilla Vogt Fernandes de Souza","orcid":"https://orcid.org/0009-0009-1301-4202","observed_orcids":["https://orcid.org/0009-0009-1301-4202"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Priscilla Vogt Fernandes de Souza","raw_affiliation_strings":["Health Informatics Laboratory (LabInfoS), Departamento de Ciencias Medicas Integradas, Faculdade de Ciencias Medicas, Centro Biomedico, Universidade do Estado do Rio de Janeiro, Cabo Frio 28905-320, RJ, Brazil.;"],"raw_orcid":"https://orcid.org/0009-0009-1301-4202","affiliations":[{"raw_affiliation_string":"Health Informatics Laboratory (LabInfoS), Departamento de Ciencias Medicas Integradas, Faculdade de Ciencias Medicas, Centro Biomedico, Universidade do Estado do Rio de Janeiro, Cabo Frio 28905-320, RJ, Brazil.;","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027948999","display_name":"Jhenifer Paiva Quadros","orcid":"https://orcid.org/0000-0002-0039-7285","observed_orcids":["https://orcid.org/0000-0002-0039-7285"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jhenifer de Paiva Quadros","raw_affiliation_strings":["Health Informatics Laboratory (LabInfoS), Departamento de Ciencias Medicas Integradas, Faculdade de Ciencias Medicas, Centro Biomedico, Universidade do Estado do Rio de Janeiro, Cabo Frio 28905-320, RJ, Brazil;"],"raw_orcid":"https://orcid.org/0000-0002-0039-7285","affiliations":[{"raw_affiliation_string":"Health Informatics Laboratory (LabInfoS), Departamento de Ciencias Medicas Integradas, Faculdade de Ciencias Medicas, Centro Biomedico, Universidade do Estado do Rio de Janeiro, Cabo Frio 28905-320, RJ, Brazil;","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150337812","display_name":"Mardia Brito De Souza Alcantara","orcid":"https://orcid.org/0009-0007-9393-2534","observed_orcids":["https://orcid.org/0009-0007-9393-2534"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mardia Brito de Souza Alcantara","raw_affiliation_strings":["Faculdade de Ciencias Medicas, Centro Biomedico, Universidade do Estado do Rio de Janeiro, Cabo Frio 28905-320, RJ, Brazil"],"raw_orcid":"https://orcid.org/0009-0007-9393-2534","affiliations":[{"raw_affiliation_string":"Faculdade de Ciencias Medicas, Centro Biomedico, Universidade do Estado do Rio de Janeiro, Cabo Frio 28905-320, RJ, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009519051","display_name":"H\u00e9rcules Rezende Freitas","orcid":"https://orcid.org/0000-0003-1584-9157","observed_orcids":["https://orcid.org/0000-0003-1584-9157"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Hercules Rezende Freitas","raw_affiliation_strings":["Health Informatics Laboratory (LabInfoS), Departamento de Ciencias Medicas Integradas, Faculdade de Ciencias Medicas, Centro Biomedico, Universidade do Estado do Rio de Janeiro, Cabo Frio 28905-320, RJ, Brazil;"],"raw_orcid":"https://orcid.org/0000-0003-1584-9157","affiliations":[{"raw_affiliation_string":"Health Informatics Laboratory (LabInfoS), Departamento de Ciencias Medicas Integradas, Faculdade de Ciencias Medicas, Centro Biomedico, Universidade do Estado do Rio de Janeiro, Cabo Frio 28905-320, RJ, Brazil;","institution_ids":["https://openalex.org/I40034438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009519051"],"corresponding_institution_ids":["https://openalex.org/I40034438"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.04600000008940697,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.871999979019165},{"id":"https://openalex.org/keywords/galantamine","display_name":"galantamine","score":1.0},{"id":"https://openalex.org/keywords/rivastigmine","display_name":"rivastigmine","score":1.0},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7630000114440918},{"id":"https://openalex.org/keywords/target-trial-emulation","display_name":"target trial emulation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/unified-health-system-sus","display_name":"Unified Health System (SUS)","score":0.7879999876022339},{"id":"https://openalex.org/keywords/inverse-probability-of-treatment-weighting","display_name":"inverse probability of treatment weighting","score":0.6460000276565552},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.5429999828338623},{"id":"https://openalex.org/keywords/health-policy-evaluation","display_name":"health policy evaluation","score":0.36899998784065247},{"id":"https://openalex.org/keywords/south-america","display_name":"South America","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C2779056891","wikidata":"https://www.wikidata.org/wiki/Q412690","display_name":"Galantamine","level":5,"score":0.9290000200271606},{"id":"https://openalex.org/C2776332859","wikidata":"https://www.wikidata.org/wiki/Q411887","display_name":"Rivastigmine","level":5,"score":0.9277999997138977},{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.8845000267028809},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8352000117301941},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4903999865055084},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.47279998660087585},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4498000144958496},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42829999327659607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41920000314712524},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.3944000005722046},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3695000112056732},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.36550000309944153},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.33869999647140503},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3131999969482422},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.31049999594688416},{"id":"https://openalex.org/C3020110884","wikidata":"https://www.wikidata.org/wiki/Q695416","display_name":"Outpatient clinic","level":2,"score":0.3003000020980835},{"id":"https://openalex.org/C124306116","wikidata":"https://www.wikidata.org/wiki/Q2512965","display_name":"Ambulatory care","level":3,"score":0.29840001463890076},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.2824000120162964},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2800000011920929},{"id":"https://openalex.org/C140206745","wikidata":"https://www.wikidata.org/wiki/Q5308895","display_name":"Drug holiday","level":3,"score":0.26899999380111694},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.2540999948978424},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.06.26367201","doi":"https://doi.org/10.64898/2026.11.06.26367201","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.06.26367201","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/09/2026.11.06.26367201.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.06.26367201","doi":"https://doi.org/10.64898/2026.11.06.26367201","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.06.26367201","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/09/2026.11.06.26367201.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225626951.pdf","grobid_xml":"https://content.openalex.org/works/W7225626951.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1849521086","https://openalex.org/W1895538680","https://openalex.org/W1973885323","https://openalex.org/W1995945562","https://openalex.org/W2048470090","https://openalex.org/W2071066672","https://openalex.org/W2110818436","https://openalex.org/W2116810060","https://openalex.org/W2126049444","https://openalex.org/W2142495742","https://openalex.org/W2143879671","https://openalex.org/W2164595809","https://openalex.org/W2298338128","https://openalex.org/W2599076725","https://openalex.org/W2900742318","https://openalex.org/W2972544193","https://openalex.org/W3011217235","https://openalex.org/W3041047318","https://openalex.org/W3122843734","https://openalex.org/W3138811377","https://openalex.org/W4413943356","https://openalex.org/W7168349186"],"related_works":["https://openalex.org/W7222388304","https://openalex.org/W7160524815","https://openalex.org/W2945624955","https://openalex.org/W1994829604","https://openalex.org/W2093326148","https://openalex.org/W2014644831","https://openalex.org/W2116664498","https://openalex.org/W1558886884","https://openalex.org/W2133842711","https://openalex.org/W2034856442"],"abstract_inverted_index":{"Background.":[0],"Donepezil,":[1],"galantamine":[2,92,275,327,349],"and":[3,95,141,187,203,229,239,328,350,376,388,447,487],"rivastigmine":[4,94,278,357],"are":[5,449],"dispensed":[6],"free":[7],"of":[8,63,108,181,216,237,291,314,411,435],"charge":[9],"to":[10,14,43,89,121,170,220,346,354,386],"people":[11],"with":[12,78,242,322,326,331,334,422,431,440,484],"mild":[13],"moderate":[15,53],"Alzheimer's":[16,79],"disease":[17,50,80,445],"in":[18,30,75,207,404,452],"the":[19,36,49,52,109,155,160,208,214,261,336,405,453],"Brazilian":[20],"Unified":[21],"Health":[22],"System":[23],"(SUS),":[24],"but":[25],"their":[26],"comparative":[27],"long-term":[28],"effectiveness":[29],"routine":[31,418],"care":[32],"is":[33,41],"unknown.":[34],"Under":[35],"national":[37],"clinical":[38,64,486],"protocol,":[39],"memantine":[40,56,98,136,157,296,315,436],"added":[42],"a":[44,61,72,83,129,289,369,426,432,476],"cholinesterase":[45],"inhibitor":[46],"(ChEI)":[47],"when":[48],"reaches":[51],"stage,":[54],"so":[55],"add-on":[57,217,297,316,437],"can":[58],"serve":[59],"as":[60,190,378,425],"marker":[62],"progression.":[65],"Methods.":[66],"Nationwide":[67],"new-user":[68],"cohort":[69,266],"study":[70],"emulating":[71],"target":[73],"trial":[74],"which":[76],"adults":[77],"eligible":[81],"for":[82,97,288,348,356],"ChEI":[84,131],"would":[85],"be":[86,482],"randomly":[87],"assigned":[88],"start":[90],"donepezil,":[91,323,335],"or":[93,179,257,442,462],"followed":[96,287],"add-on.":[99],"We":[100,124,212],"used":[101],"outpatient":[102],"medication":[103],"dispensing":[104,158,406,454],"authorizations":[105],"(APAC":[106],"records":[107],"Outpatient":[110],"Information":[111],"System,":[112],"SIA/SUS)":[113],"from":[114,247],"all":[115,224,302],"27":[116],"federative":[117],"units,":[118],"January":[119],"2018":[120],"December":[122,142],"2025.":[123],"included":[125,267],"patients":[126,200,225,413],"who":[127],"started":[128,226],"single":[130],"between":[132],"October":[133],"2019,":[134],"after":[135,144,159],"was":[137,154,201,317,340,429],"first":[138,156],"recorded":[139,167,186,403,451],"nationally,":[140],"2025,":[143],"at":[145,165,218],"least":[146],"12":[147,219],"months":[148,176,222],"without":[149,177],"anti-dementia":[150],"dispensing.":[151],"The":[152,251,265,309],"outcome":[153,371],"index":[161],"month.":[162],"Follow-up":[163],"ended":[164,205],"add-on,":[166],"death,":[168],"loss":[169],"follow-up":[171,204],"(more":[172],"than":[173,438,468],"3":[174],"observed":[175],"dispensing)":[178],"end":[180],"data.":[182,489],"Deaths":[183,399],"were":[184,188,306,363,400],"rarely":[185],"treated":[189,412],"censoring.":[191],"One":[192],"pseudonymized":[193],"health":[194],"card":[195],"number":[196],"shared":[197],"by":[198,465],"many":[199],"excluded,":[202],"earlier":[206],"two":[209],"affected":[210],"states.":[211],"estimated":[213],"risk":[215,338,381,434],"48":[221],"had":[223],"each":[227],"drug":[228],"remained":[230],"under":[231],"observation,":[232],"using":[233],"stabilized":[234],"inverse":[235],"probability":[236],"treatment":[238],"censoring":[240,259],"weights,":[241],"95%":[243],"confidence":[244],"intervals":[245],"(CI)":[246],"200":[248],"bootstrap":[249],"replicates.":[250],"analysis":[252],"assumed":[253],"no":[254],"unmeasured":[255],"confounding":[256,464],"informative":[258],"given":[260],"measured":[262],"covariates.":[263],"Results.":[264],"142":[268],"758":[269],"new":[270],"users":[271],"(donepezil":[272],"74":[273],"165;":[274],"30":[276],"691;":[277],"37":[279],"902;":[280],"mean":[281,304],"age":[282,391],"77.3":[283],"years;":[284],"63.0%":[285],"women),":[286],"median":[290],"14":[292],"months;":[293],"9":[294],"812":[295],"events":[298,379],"occurred.":[299],"After":[300],"weighting,":[301],"standardized":[303],"differences":[305],"below":[307,396],"0.05.":[308],"24-month":[310,337],"weighted":[311],"cumulative":[312],"incidence":[313],"9.7%":[318],"(95%":[319],"CI":[320],"9.4-10.0)":[321],"9.0%":[324],"(8.6-9.4)":[325],"5.6%":[329],"(5.3-5.9)":[330],"rivastigmine.":[332],"Compared":[333],"difference":[339,382,457],"-0.7":[341],"percentage":[342],"points":[343],"(pp)":[344],"(-1.1":[345],"-0.3)":[347],"-4.1":[351,383],"pp":[352],"(-4.5":[353],"-3.7)":[355],"(risk":[358,393],"ratio":[359,394],"0.58,":[360],"0.55-0.61).":[361],"Estimates":[362],"stable":[364],"across":[365],"sensitivity":[366],"analyses,":[367],"including":[368],"composite":[370],"that":[372],"counted":[373],"unrecorded":[374],"deaths":[375],"dropouts":[377],"(24-month":[380],"pp,":[384],"-4.8":[385],"-3.3)":[387],"analyses":[389,472],"within":[390],"groups":[392],"0.64":[395],"75":[397],"years).":[398],"almost":[401],"never":[402],"data":[407],"(at":[408],"most":[409],"0.47%":[410],"per":[414],"year).":[415],"Conclusions.":[416],"In":[417],"SUS":[419],"care,":[420],"initiation":[421,439],"rivastigmine,":[423],"mostly":[424],"transdermal":[427],"patch,":[428],"associated":[430],"lower":[433],"donepezil":[441],"galantamine.":[443],"Because":[444],"severity":[446,466],"death":[448],"not":[450],"data,":[455],"this":[456],"may":[458],"reflect":[459],"prescribing":[460],"patterns":[461],"residual":[463],"rather":[467],"slower":[469],"progression;":[470],"additional":[471],"made":[473],"differential":[474],"mortality":[475,488],"less":[477],"likely":[478],"explanation.":[479],"It":[480],"should":[481],"confirmed":[483],"linked":[485]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
