{"id":"https://openalex.org/W7225626466","doi":"https://doi.org/10.1186/s40035-026-00596-8","title":"Rab GTPases and the Rabopathy framework: from synaptic trafficking to neurodegeneration via LRRK2-driven pathology","display_name":"Rab GTPases and the Rabopathy framework: from synaptic trafficking to neurodegeneration via LRRK2-driven pathology","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225626466","doi":"https://doi.org/10.1186/s40035-026-00596-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/43004376"},"language":"en","primary_location":{"id":"doi:10.1186/s40035-026-00596-8","doi":"https://doi.org/10.1186/s40035-026-00596-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40035-026-00596-8","pdf_url":"https://link.springer.com/content/pdf/10.1186/s40035-026-00596-8.pdf","source":{"id":"https://openalex.org/S2764798395","display_name":"Translational Neurodegeneration","issn_l":"2047-9158","issn":["2047-9158","2096-6466"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Neurodegeneration","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s40035-026-00596-8.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119013901","display_name":"Linan Zha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linan Zha","raw_affiliation_strings":["Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161348094","display_name":"Jing Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Xu","raw_affiliation_strings":["Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161323827","display_name":"Xiaoling Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoling Zhu","raw_affiliation_strings":["Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161357533","display_name":"Qikun Tu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qikun Tu","raw_affiliation_strings":["Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161359483","display_name":"Chunwei Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunwei Zhong","raw_affiliation_strings":["Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161313390","display_name":"Linshi Zhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linshi Zhan","raw_affiliation_strings":["Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144716353","display_name":"\u5f20\u9ed8\u5ce4","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mojiao Zhang","raw_affiliation_strings":["Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161342192","display_name":"Dongshan Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongshan Zhou","raw_affiliation_strings":["Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107196374","display_name":"Xifeng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210093739","display_name":"First Affiliated Hospital of Jiangxi Medical College","ror":"https://ror.org/00g3pqv36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093739"]},{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xifeng Wang","raw_affiliation_strings":["Department of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China","Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210093739","https://openalex.org/I4210164024"]},{"raw_affiliation_string":"Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161339010","display_name":"Jianhang Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhang Wu","raw_affiliation_strings":["Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074779275","display_name":"\u534e\u798f\u6d32","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fuzhou Hua","raw_affiliation_strings":["Department of Anesthesiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. huafuzhou@126.com","Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China. huafuzhou@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. huafuzhou@126.com","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210108480"]},{"raw_affiliation_string":"Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China. huafuzhou@126.com","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161331529","display_name":"Xilong Guan","orcid":"https://orcid.org/0009-0006-0184-8750","observed_orcids":["https://orcid.org/0009-0006-0184-8750"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xilong Guan","raw_affiliation_strings":["Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China. xilongguan24@163.com","Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China. xilongguan24@163.com"],"raw_orcid":"https://orcid.org/0009-0006-0184-8750","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Nanchang University Affiliated Yingtan Hospital, Yingtan, 335099, China. xilongguan24@163.com","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, 330006, China. xilongguan24@163.com","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074779275","https://openalex.org/A5161331529"],"corresponding_institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210108480"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rab-gtpases","display_name":"Rab GTPases","score":1.0},{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.9120000004768372},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7979999780654907},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8370000123977661},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":1.0},{"id":"https://openalex.org/keywords/synaptic-vesicle-trafficking","display_name":"synaptic vesicle trafficking","score":0.8790000081062317},{"id":"https://openalex.org/keywords/synaptic-maturation","display_name":"synapse maturation","score":0.6380000114440918},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.9916999936103821},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7301999926567078},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.7294999957084656},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6389999985694885},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.619700014591217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5296000242233276},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5037999749183655},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.4359999895095825},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.41280001401901245},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4052000045776367},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.3880000114440918},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.37380000948905945},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37220001220703125},{"id":"https://openalex.org/C167019083","wikidata":"https://www.wikidata.org/wiki/Q4082043","display_name":"Vesicular transport protein","level":4,"score":0.3628999888896942},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.3562000095844269},{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.3433000147342682},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.3287999927997589},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.3260999917984009},{"id":"https://openalex.org/C2780427247","wikidata":"https://www.wikidata.org/wiki/Q409961","display_name":"LRRK2","level":4,"score":0.31769999861717224},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.2777000069618225},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C2908668639","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle recycling","level":5,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1186/s40035-026-00596-8","doi":"https://doi.org/10.1186/s40035-026-00596-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40035-026-00596-8","pdf_url":"https://link.springer.com/content/pdf/10.1186/s40035-026-00596-8.pdf","source":{"id":"https://openalex.org/S2764798395","display_name":"Translational Neurodegeneration","issn_l":"2047-9158","issn":["2047-9158","2096-6466"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Neurodegeneration","raw_type":"journal-article"},{"id":"pmid:43004376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43004376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational neurodegeneration","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s40035-026-00596-8","doi":"https://doi.org/10.1186/s40035-026-00596-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40035-026-00596-8","pdf_url":"https://link.springer.com/content/pdf/10.1186/s40035-026-00596-8.pdf","source":{"id":"https://openalex.org/S2764798395","display_name":"Translational Neurodegeneration","issn_l":"2047-9158","issn":["2047-9158","2096-6466"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Neurodegeneration","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225626466.pdf","grobid_xml":"https://content.openalex.org/works/W7225626466.grobid-xml"},"referenced_works_count":107,"referenced_works":["https://openalex.org/W1483422351","https://openalex.org/W1527091318","https://openalex.org/W1595083713","https://openalex.org/W1910661134","https://openalex.org/W1951215936","https://openalex.org/W1955514224","https://openalex.org/W1964189494","https://openalex.org/W1965630710","https://openalex.org/W1967900265","https://openalex.org/W1972943699","https://openalex.org/W1976458700","https://openalex.org/W1986897578","https://openalex.org/W1988178943","https://openalex.org/W1990914976","https://openalex.org/W1994668150","https://openalex.org/W2000546875","https://openalex.org/W2001219494","https://openalex.org/W2001721522","https://openalex.org/W2014413787","https://openalex.org/W2014923822","https://openalex.org/W2015957622","https://openalex.org/W2024469079","https://openalex.org/W2030241259","https://openalex.org/W2031999218","https://openalex.org/W2035521611","https://openalex.org/W2036631182","https://openalex.org/W2038924652","https://openalex.org/W2047137800","https://openalex.org/W2060351135","https://openalex.org/W2060592627","https://openalex.org/W2067470102","https://openalex.org/W2088983693","https://openalex.org/W2103464937","https://openalex.org/W2110157421","https://openalex.org/W2113263629","https://openalex.org/W2114442092","https://openalex.org/W2120460631","https://openalex.org/W2120689665","https://openalex.org/W2122296109","https://openalex.org/W2124363259","https://openalex.org/W2130444809","https://openalex.org/W2133623572","https://openalex.org/W2136622247","https://openalex.org/W2137710360","https://openalex.org/W2150557642","https://openalex.org/W2163915292","https://openalex.org/W2164646446","https://openalex.org/W2164660797","https://openalex.org/W2164899453","https://openalex.org/W2166595775","https://openalex.org/W2167069331","https://openalex.org/W2167721936","https://openalex.org/W2170402695","https://openalex.org/W2191269904","https://openalex.org/W2233837568","https://openalex.org/W2253950023","https://openalex.org/W2294297066","https://openalex.org/W2406510679","https://openalex.org/W2418039970","https://openalex.org/W2460612985","https://openalex.org/W2491708393","https://openalex.org/W2592962880","https://openalex.org/W2768016303","https://openalex.org/W2770997070","https://openalex.org/W2781684601","https://openalex.org/W2803787904","https://openalex.org/W2806366257","https://openalex.org/W2807315174","https://openalex.org/W2883053634","https://openalex.org/W2888203729","https://openalex.org/W2891994821","https://openalex.org/W2893774852","https://openalex.org/W2943260565","https://openalex.org/W2971453795","https://openalex.org/W2986932567","https://openalex.org/W3003080326","https://openalex.org/W3004823952","https://openalex.org/W3007154337","https://openalex.org/W3007962915","https://openalex.org/W3012061414","https://openalex.org/W3019998570","https://openalex.org/W3023580811","https://openalex.org/W3034798869","https://openalex.org/W3111365582","https://openalex.org/W3116817930","https://openalex.org/W3135116035","https://openalex.org/W3136908976","https://openalex.org/W3165378963","https://openalex.org/W3169685488","https://openalex.org/W4224945149","https://openalex.org/W4237892712","https://openalex.org/W4280596427","https://openalex.org/W4309661695","https://openalex.org/W4376273173","https://openalex.org/W4389425807","https://openalex.org/W4390656812","https://openalex.org/W4392017112","https://openalex.org/W4392460250","https://openalex.org/W4396786171","https://openalex.org/W4401206580","https://openalex.org/W4402955834","https://openalex.org/W4410152720","https://openalex.org/W4410216353","https://openalex.org/W4410571395","https://openalex.org/W4415473780","https://openalex.org/W7140216134","https://openalex.org/W7160897265"],"related_works":["https://openalex.org/W3122371224","https://openalex.org/W4318192165","https://openalex.org/W2802487502","https://openalex.org/W3159792869","https://openalex.org/W3158237497","https://openalex.org/W3159802643","https://openalex.org/W2788206659","https://openalex.org/W7214110797","https://openalex.org/W4292506183","https://openalex.org/W4393040800"],"abstract_inverted_index":{"Neurodegenerative":[0],"diseases":[1],"such":[2],"as":[3,65],"Alzheimer's":[4],"disease":[5,8,12],"(AD),":[6],"Parkinson's":[7],"(PD),":[9],"and":[10,81,86,114,120,148,180],"Huntington's":[11],"(HD)":[13],"show":[14],"significant":[15],"differences":[16],"in":[17,32,79,84,141,146,152],"their":[18],"clinical":[19],"manifestations,":[20],"but":[21],"they":[22],"all":[23],"seem":[24],"to":[25,104],"share":[26],"a":[27,47,66,160],"common":[28,68],"upstream":[29],"problem:":[30],"malfunction":[31],"the":[33,43,75,108,115,124,183,187],"membrane":[34],"transport":[35,98],"controlled":[36],"by":[37],"Rab":[38,89,131,156,178],"GTPases.":[39],"This":[40],"review":[41],"introduces":[42],"concept":[44],"of":[45,107,111,118,123,129,155,172,176,182],"Rabopathy,":[46],"framework":[48],"that":[49],"connects":[50],"developmental":[51],"synaptic":[52,112],"maturation":[53],"defects":[54],"with":[55,74],"late-onset":[56],"protein":[57],"aggregation.":[58],"The":[59,127],"LRRK2-Rab":[60],"phosphorylation":[61],"axis":[62],"is":[63,99],"emerging":[64],"potential":[67],"amplifying":[69],"mechanism":[70],"across":[71],"these":[72],"disorders,":[73],"strongest":[76],"mechanistic":[77],"support":[78],"PD":[80],"growing":[82],"implications":[83],"AD":[85],"HD.":[87,153],"When":[88],"substrates":[90],"are":[91],"excessively":[92],"phosphorylated":[93],"at":[94,186],"specific":[95],"sites,":[96],"vesicular":[97],"impaired":[100],"or":[101],"arrested,":[102],"leading":[103],"progressive":[105],"depletion":[106],"reserve":[109],"pool":[110,117],"vesicles":[113],"surface":[116],"receptors,":[119],"severe":[121],"compromise":[122],"autophagy-lysosome":[125],"flux.":[126],"failure":[128],"distinct":[130],"sub-networks":[132],"also":[133],"produces":[134],"disease-specific":[135],"signatures,":[136],"including":[137],"Rab5-driven":[138],"endosomal":[139],"congestion":[140],"AD,":[142],"Rab35-mediated":[143],"\u03b1-synuclein":[144],"secretion":[145],"PD,":[147],"Rab11/Rab7":[149],"trafficking":[150,184],"collapse":[151],"Restoration":[154],"flux":[157],"may":[158],"be":[159,168],"therapeutic":[161],"strategy":[162],"for":[163],"neurodegenerative":[164],"diseases,":[165],"which":[166],"can":[167],"achieved":[169],"through":[170],"calibration":[171],"LRRK2":[173],"activity,":[174],"modulation":[175],"selective":[177],"subtypes,":[179],"rescue":[181],"network":[185],"systems":[188],"level.":[189]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
