{"id":"https://openalex.org/W7225625273","doi":"https://doi.org/10.21203/rs.3.rs-11418778/v1","title":"Predicting the need for adjuvant radiation therapy according to EAU guidelines among patients with unfavorable intermediate-risk prostate after radical prostatectomy","display_name":"Predicting the need for adjuvant radiation therapy according to EAU guidelines among patients with unfavorable intermediate-risk prostate after radical prostatectomy","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225625273","doi":"https://doi.org/10.21203/rs.3.rs-11418778/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11418778/v1","doi":"https://doi.org/10.21203/rs.3.rs-11418778/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11418778/v1","pdf_url":"https://www.researchsquare.com/article/rs-11418778/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11418778/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022247623","display_name":"Carolin Siech","orcid":"https://orcid.org/0000-0002-5460-4171","observed_orcids":["https://orcid.org/0000-0002-5460-4171"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carolin Siech","raw_affiliation_strings":["Goethe University Frankfurt, University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe University Frankfurt, University Hospital","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078016116","display_name":"Tonio Br\u00fcggemann","orcid":"https://orcid.org/0009-0002-7992-6334","observed_orcids":["https://orcid.org/0009-0002-7992-6334"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tonio Br\u00fcggemann","raw_affiliation_strings":["Goethe University Frankfurt, University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe University Frankfurt, University Hospital","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114203373","display_name":"Quynh Chi Le","orcid":"https://orcid.org/0009-0008-9209-8776","observed_orcids":["https://orcid.org/0009-0008-9209-8776"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Quynh Chi Le","raw_affiliation_strings":["Goethe University Frankfurt, University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe University Frankfurt, University Hospital","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014469422","display_name":"Maximilian Filzmayer","orcid":"https://orcid.org/0009-0005-5715-9965","observed_orcids":["https://orcid.org/0009-0005-5715-9965"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Filzmayer","raw_affiliation_strings":["Goethe University Frankfurt, University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe University Frankfurt, University Hospital","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033309904","display_name":"Felix Prei\u00dfer","orcid":"https://orcid.org/0000-0002-7382-9632","observed_orcids":["https://orcid.org/0000-0002-7382-9632"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Felix Preisser","raw_affiliation_strings":["University Hospital Hamburg-Eppendorf"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hamburg-Eppendorf","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108930457","display_name":"Neele Heckmann","orcid":"https://orcid.org/0009-0006-7612-3535","observed_orcids":["https://orcid.org/0009-0006-7612-3535"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Neele Heckmann","raw_affiliation_strings":["University Hospital Hamburg-Eppendorf"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hamburg-Eppendorf","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030908792","display_name":"Tobias Maurer","orcid":"https://orcid.org/0000-0002-5660-7691","observed_orcids":["https://orcid.org/0000-0002-5660-7691"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Maurer","raw_affiliation_strings":["University Hospital Hamburg-Eppendorf"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hamburg-Eppendorf","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021068063","display_name":"Maximilian Kriegmair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Kriegmair","raw_affiliation_strings":["University of Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Heidelberg","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030545703","display_name":"Derya Tilki","orcid":"https://orcid.org/0000-0001-7033-1380","observed_orcids":["https://orcid.org/0000-0001-7033-1380"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Derya Tilki","raw_affiliation_strings":["University Hospital Hamburg-Eppendorf"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hamburg-Eppendorf","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013463417","display_name":"Felix K.\u2010H. Chun","orcid":"https://orcid.org/0000-0001-8486-9536","observed_orcids":["https://orcid.org/0000-0001-8486-9536","https://orcid.org/0000-0002-1644-2677"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Felix K. H. Chun","raw_affiliation_strings":["Goethe University Frankfurt, University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe University Frankfurt, University Hospital","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014573705","display_name":"Markus Graefen","orcid":"https://orcid.org/0000-0003-3609-3512","observed_orcids":["https://orcid.org/0000-0003-3609-3512"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Graefen","raw_affiliation_strings":["University Hospital Hamburg-Eppendorf"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hamburg-Eppendorf","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024518815","display_name":"Thomas P Steuber","orcid":"https://orcid.org/0000-0001-6963-6611","observed_orcids":["https://orcid.org/0000-0001-6963-6611"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Steuber","raw_affiliation_strings":["University Hospital Hamburg-Eppendorf"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hamburg-Eppendorf","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069068387","display_name":"Pierre Tennstedt","orcid":"https://orcid.org/0000-0001-9237-3442","observed_orcids":["https://orcid.org/0000-0001-9237-3442"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pierre Tennstedt","raw_affiliation_strings":["University Hospital Hamburg-Eppendorf"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Hamburg-Eppendorf","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058513513","display_name":"Mike Wenzel","orcid":"https://orcid.org/0000-0002-4338-0889","observed_orcids":["https://orcid.org/0000-0002-4338-0889"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mike Wenzel","raw_affiliation_strings":["Goethe University Frankfurt, University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe University Frankfurt, University Hospital","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112048021","display_name":"Philipp Mandel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Mandel","raw_affiliation_strings":["Goethe University Frankfurt, University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe University Frankfurt, University Hospital","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adjuvant-radiotherapy","display_name":"adjuvant radiotherapy","score":0.8429999947547913},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7250000238418579},{"id":"https://openalex.org/keywords/unfavorable-intermediate-risk-prostate-cancer","display_name":"unfavorable intermediate-risk prostate cancer","score":0.8330000042915344},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/preoperative-prediction-model","display_name":"preoperative prediction model","score":0.7879999876022339},{"id":"https://openalex.org/keywords/eau-guidelines","display_name":"EAU guidelines","score":0.7210000157356262},{"id":"https://openalex.org/keywords/nccn-guidelines","display_name":"NCCN guidelines","score":0.9100000262260437},{"id":"https://openalex.org/keywords/prostate-volume","display_name":"prostate volume","score":0.8100000023841858},{"id":"https://openalex.org/keywords/preoperative-psa","display_name":"preoperative PSA","score":0.9079999923706055},{"id":"https://openalex.org/keywords/gleason-grade","display_name":"Gleason grade","score":0.7509999871253967},{"id":"https://openalex.org/keywords/clinical-tumor-stage","display_name":"clinical tumor stage","score":0.7160000205039978},{"id":"https://openalex.org/keywords/internal-validation","display_name":"internal validation","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.923799991607666},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.9054999947547913},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7458999752998352},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.6478000283241272},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5831000208854675},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.5641999840736389},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5440999865531921},{"id":"https://openalex.org/C3018454096","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant radiotherapy","level":3,"score":0.5044999718666077},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4754999876022339},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4650000035762787},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.46059998869895935},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.40799999237060547},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.3993000090122223},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38999998569488525},{"id":"https://openalex.org/C2781217009","wikidata":"https://www.wikidata.org/wiki/Q4086927","display_name":"Prostate biopsy","level":4,"score":0.3856000006198883},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.37860000133514404},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3763999938964844},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36730000376701355},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.3634999990463257},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3124000132083893},{"id":"https://openalex.org/C2780091936","wikidata":"https://www.wikidata.org/wiki/Q17103890","display_name":"T-stage","level":3,"score":0.31029999256134033},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2985999882221222},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.28049999475479126},{"id":"https://openalex.org/C2777008409","wikidata":"https://www.wikidata.org/wiki/Q4914714","display_name":"Biochemical recurrence","level":5,"score":0.2752000093460083},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.25870001316070557}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11418778/v1","doi":"https://doi.org/10.21203/rs.3.rs-11418778/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11418778/v1","pdf_url":"https://www.researchsquare.com/article/rs-11418778/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11418778/v1","doi":"https://doi.org/10.21203/rs.3.rs-11418778/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11418778/v1","pdf_url":"https://www.researchsquare.com/article/rs-11418778/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225625273.pdf","grobid_xml":"https://content.openalex.org/works/W7225625273.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W2004625759","https://openalex.org/W2512371764","https://openalex.org/W2586176133","https://openalex.org/W2793680743","https://openalex.org/W2913005048","https://openalex.org/W3014387161","https://openalex.org/W3128646645","https://openalex.org/W3162348349","https://openalex.org/W3165451958","https://openalex.org/W3170537322","https://openalex.org/W4220655697","https://openalex.org/W4220812334","https://openalex.org/W4226280117","https://openalex.org/W4363678013","https://openalex.org/W4401063809","https://openalex.org/W4402965282","https://openalex.org/W4407113226","https://openalex.org/W4413936757","https://openalex.org/W7126071465"],"related_works":["https://openalex.org/W4413936757","https://openalex.org/W7126071465","https://openalex.org/W2144970805","https://openalex.org/W2529193835","https://openalex.org/W2972650405","https://openalex.org/W2566233058","https://openalex.org/W2001901993","https://openalex.org/W4251650965","https://openalex.org/W3092486180","https://openalex.org/W2789338923"],"abstract_inverted_index":{"Abstract":[0],"Objective:":[1],"To":[2],"develop":[3],"and":[4,131,153,171,176,206],"internally":[5],"validate":[6],"a":[7,47],"multivariable":[8,238],"model":[9,179,239],"for":[10,15,66,98,114,119,181,187,218],"preoperatively":[11],"predicting":[12],"the":[13,28,76,84,182,185,216,236],"indication":[14,65,113,186,217],"adjuvant":[16,67,115,120,188,219],"radiation":[17,68,116,121,189,220],"therapy":[18,69,122,190,221],"after":[19,94,222],"radical":[20,223],"prostatectomy":[21,224],"according":[22,70,225],"to":[23,71,214,226,233],"current":[24,72,227],"guideline":[25,73,229],"recommendations":[26,74,230],"of":[27,31,75,149,157,184],"European":[29],"Association":[30],"Urology":[32],"(EAU)":[33],"in":[34],"National":[35],"Comprehensive":[36],"Cancer":[37],"Network":[38],"(NCCN)":[39],"unfavorable":[40,55,199],"intermediate-risk":[41,56,173,200],"prostate":[42,57,127,201],"cancer":[43,58,202],"patients.":[44,59],"Methods:":[45],"Within":[46],"high-volume":[48],"center":[49],"database":[50],"(01/2010-08/2024),":[51],"we":[52],"identified":[53],"NCCN":[54,198],"Univariable":[60],"logistic":[61,80],"regression":[62,81],"models":[63,82],"addressed":[64],"EAU":[77,228],"(2026).":[78,231],"Multivariable":[79,178],"included":[83],"most":[85],"informative,":[86],"statistically":[87],"significant":[88],"preoperative":[89,137,204],"predictors.":[90],"Accuracy":[91],"was":[92,123,191],"quantified":[93],"2000":[95],"bootstrap":[96],"resamples":[97],"internal":[99],"validation":[100],"with":[101,125],"Harrell\u2019s":[102],"concordance":[103],"index":[104],"(c-index).":[105],"Results:":[106],"Of":[107],"9652":[108],"patients,":[109,203],"1154":[110],"(12%)":[111],"had":[112],"therapy.":[117],"Indication":[118],"associated":[124],"higher":[126,136,146,154,163],"volume":[128],"(>":[129],"45":[130],"25\u201345":[132],"cm":[133],"3":[134],"),":[135],"PSA":[138],"value":[139],"(continuous),":[140],"suspicious":[141],"clinical":[142,207,234],"tumor":[143,208],"stage":[144],"(cT2),":[145],"absolute":[147],"number":[148],"positive":[150,158],"biopsy":[151,159,168],"cores":[152,160],"relative":[155],"proportion":[156],"(both":[161],"continuous),":[162],"Gleason":[164],"Grade":[165],"Group":[166],"on":[167],"(GGG":[169],"3)":[170],"multiple":[172],"factors":[174],"(3":[175],"2).":[177],"c-index":[180],"prediction":[183],"0.709":[192],"(95%":[193],"CI":[194],"0.689\u20130.722).":[195],"Conclusions:":[196],"In":[197],"patient":[205],"characteristics":[209],"can":[210],"be":[211,241],"reliably":[212],"used":[213],"predict":[215],"Prior":[232],"application,":[235],"present":[237],"should":[240],"externally":[242],"validated.":[243]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}