{"id":"https://openalex.org/W7225624506","doi":"https://doi.org/10.64898/2026.11.05.764569","title":"Age-dependent mechanical stress underlies unexpected vestibular differentiation and regeneration patterns","display_name":"Age-dependent mechanical stress underlies unexpected vestibular differentiation and regeneration patterns","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225624506","doi":"https://doi.org/10.64898/2026.11.05.764569"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.05.764569","doi":"https://doi.org/10.64898/2026.11.05.764569","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764569","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.05.764569.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.05.764569.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026866755","display_name":"Shahar Kasirer","orcid":"https://orcid.org/0000-0002-4103-881X","observed_orcids":["https://orcid.org/0000-0002-4103-881X"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shahar Inbar Kasirer","raw_affiliation_strings":["Tel Aviv University;"],"raw_orcid":"https://orcid.org/0000-0002-4103-881X","affiliations":[{"raw_affiliation_string":"Tel Aviv University;","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161331087","display_name":"Michal Shraga","orcid":"https://orcid.org/0009-0007-6576-5783","observed_orcids":["https://orcid.org/0009-0007-6576-5783"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Michal Shraga","raw_affiliation_strings":["Tel Aviv University;"],"raw_orcid":"https://orcid.org/0009-0007-6576-5783","affiliations":[{"raw_affiliation_string":"Tel Aviv University;","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003394843","display_name":"Tim Dullweber","orcid":"https://orcid.org/0000-0001-5563-4949","observed_orcids":["https://orcid.org/0000-0001-5563-4949"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tim Dullweber","raw_affiliation_strings":["University of Basel;"],"raw_orcid":"https://orcid.org/0000-0001-5563-4949","affiliations":[{"raw_affiliation_string":"University of Basel;","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058662123","display_name":"Olga Loza","orcid":"https://orcid.org/0000-0002-2002-9770","observed_orcids":["https://orcid.org/0000-0002-2002-9770"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Olga Loza","raw_affiliation_strings":["Tel Aviv University;"],"raw_orcid":"https://orcid.org/0000-0002-2002-9770","affiliations":[{"raw_affiliation_string":"Tel Aviv University;","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066658152","display_name":"Anna Erzberger","orcid":"https://orcid.org/0000-0002-2200-4665","observed_orcids":["https://orcid.org/0000-0002-2200-4665"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna Erzberger","raw_affiliation_strings":["EMBL Heidelberg"],"raw_orcid":"https://orcid.org/0000-0002-2200-4665","affiliations":[{"raw_affiliation_string":"EMBL Heidelberg","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071779550","display_name":"David Sprinzak","orcid":"https://orcid.org/0000-0001-6776-6957","observed_orcids":["https://orcid.org/0000-0001-6776-6957"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"David Sprinzak","raw_affiliation_strings":["Tel Aviv University;"],"raw_orcid":"https://orcid.org/0000-0001-6776-6957","affiliations":[{"raw_affiliation_string":"Tel Aviv University;","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071779550"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hair-cell-differentiation","display_name":"hair cell differentiation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/mechanical-stress","display_name":"mechanical stress","score":0.8090000152587891},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8370000123977661},{"id":"https://openalex.org/keywords/lateral-inhibition","display_name":"lateral inhibition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/supporting-cells","display_name":"supporting cells","score":0.6340000033378601},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.7889999747276306},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"mathematical model","score":0.5130000114440918},{"id":"https://openalex.org/keywords/inner-ear","display_name":"inner ear","score":0.5199999809265137},{"id":"https://openalex.org/keywords/mechanobiology","display_name":"mechanobiology","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.8205000162124634},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6916000247001648},{"id":"https://openalex.org/C190041318","wikidata":"https://www.wikidata.org/wiki/Q596832","display_name":"Vestibular system","level":2,"score":0.659500002861023},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6425999999046326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5645999908447266},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4620000123977661},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.4309999942779541},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.3837999999523163},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.3675999939441681},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.36390000581741333},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3580999970436096},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.3434999883174896},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.33390000462532043},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.3273000121116638},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.32519999146461487},{"id":"https://openalex.org/C2778421575","wikidata":"https://www.wikidata.org/wiki/Q2004165","display_name":"Vestibular nuclei","level":3,"score":0.3212999999523163},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32100000977516174},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.3140000104904175},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30160000920295715},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3003000020980835},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.27000001072883606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.05.764569","doi":"https://doi.org/10.64898/2026.11.05.764569","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764569","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.05.764569.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.05.764569","doi":"https://doi.org/10.64898/2026.11.05.764569","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764569","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/09/2026.11.05.764569.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225624506.pdf","grobid_xml":"https://content.openalex.org/works/W7225624506.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W609353"],"related_works":["https://openalex.org/W4313550005","https://openalex.org/W4409703469","https://openalex.org/W2046045845","https://openalex.org/W2055871124","https://openalex.org/W1971181044","https://openalex.org/W2274170291","https://openalex.org/W2124096393","https://openalex.org/W3186631740","https://openalex.org/W3149385916","https://openalex.org/W1997352132"],"abstract_inverted_index":{"Loss":[0],"of":[1,11,46,87,136,158,195],"inner-ear":[2],"sensory":[3],"hair":[4],"cells":[5,49],"(HCs)":[6],"is":[7,27],"a":[8,20,51,155,182,199],"major":[9],"cause":[10],"hearing":[12],"and":[13,32,90,120,143,161,173,192],"balance":[14],"disorders.":[15],"Promoting":[16],"HC":[17,88,141,159,190],"regeneration":[18,66,144,191],"offers":[19,181],"potential":[21,200],"therapeutic":[22,201],"strategy,":[23],"but":[24],"regenerative":[25,177],"capacity":[26,67],"limited":[28],"in":[29,39,50,65,79,103,166,189],"adult":[30],"mammals":[31],"declines":[33],"rapidly":[34],"during":[35],"early":[36],"postnatal":[37],"development":[38,89],"mice.":[40],"HCs":[41,106],"can":[42],"regenerate":[43],"through":[44],"trans-differentiation":[45],"neighboring":[47],"supporting":[48],"process":[52],"controlled":[53],"by":[54],"Notch":[55,137,174],"mediated":[56],"lateral":[57,100],"inhibition.":[58],"However,":[59],"the":[60,63,85,98,125,168,186],"factors":[61],"underlying":[62,164],"decrease":[64],"are":[68],"poorly":[69],"understood.":[70],"Here,":[71],"we":[72],"combine":[73],"live":[74],"imaging":[75],"with":[76,118],"single-HC":[77],"ablation":[78],"mouse":[80],"vestibular":[81],"explants":[82],"to":[83,109],"track":[84],"dynamics":[86],"regeneration.":[91],"We":[92,112],"reveal":[93],"unexpected":[94],"age-dependent":[95,187],"deviations":[96],"from":[97],"classical":[99],"inhibition":[101],"model,":[102],"which":[104,167],"new":[105],"differentiate":[107],"adjacent":[108],"existing":[110],"HCs.":[111],"find":[113],"that":[114,121],"mechanical":[115,134,152,196],"stress":[116,153],"changes":[117],"age":[119],"perturbing":[122],"it":[123],"alters":[124],"observed":[126],"differentiation":[127,142,160],"patterns.":[128],"A":[129],"mathematical":[130],"model":[131],"incorporating":[132],"local":[133,171],"regulation":[135,197],"signaling":[138,175],"captures":[139],"both":[140],"patterns":[145],"across":[146],"ages.":[147],"Together,":[148],"these":[149],"findings":[150],"identify":[151],"as":[154,198],"crucial":[156],"regulator":[157],"support":[162],"an":[163],"mechanism":[165],"interplay":[169],"between":[170],"mechanics":[172],"shapes":[176],"responses.":[178],"This":[179],"coupling":[180],"framework":[183],"for":[184],"understanding":[185],"decline":[188],"motivates":[193],"investigation":[194],"target.":[202]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
