{"id":"https://openalex.org/W7225622638","doi":"https://doi.org/10.1021/acs.jafc.6c14320","title":"ERRFI1 Deficiency Facilitates ErbB1 Hyperphosphorylation to Trigger NLRP3 Inflammasome-Mediated Pyroptosis in Arsenic-Induced Thyroid Injury: In Vivo and In Vitro Evidence","display_name":"ERRFI1 Deficiency Facilitates ErbB1 Hyperphosphorylation to Trigger NLRP3 Inflammasome-Mediated Pyroptosis in Arsenic-Induced Thyroid Injury: In Vivo and In Vitro Evidence","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225622638","doi":"https://doi.org/10.1021/acs.jafc.6c14320"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jafc.6c14320","doi":"https://doi.org/10.1021/acs.jafc.6c14320","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jafc.6c14320","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.jafc.6c14320","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161310365","display_name":"Lili Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lili Fan","raw_affiliation_strings":["Guizhou Medical University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guizhou Medical University , , , ,","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035930967","display_name":"Jie Xiang","orcid":"https://orcid.org/0000-0001-8937-3564","observed_orcids":["https://orcid.org/0000-0001-8937-3564","https://orcid.org/0000-0003-1170-4946"]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Xiang","raw_affiliation_strings":["Guizhou Medical University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guizhou Medical University , , , ,","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039439375","display_name":"Qian Song","orcid":"https://orcid.org/0000-0001-6545-8926","observed_orcids":["https://orcid.org/0000-0001-6545-8926"]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Song","raw_affiliation_strings":["Guizhou Medical University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guizhou Medical University , , , ,","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161319404","display_name":"Huifen Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huifen Xu","raw_affiliation_strings":["Guizhou Medical University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guizhou Medical University , , , ,","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100416770","display_name":"Dapeng Wang","orcid":"https://orcid.org/0000-0001-5810-1806","observed_orcids":["https://orcid.org/0000-0001-5810-1806"]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]},{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dapeng Wang","raw_affiliation_strings":["(Harbin Medical University, Guizhou Medical University, Xi\u2019an Jiaotong University) , , , ,","Guizhou Medical University , , , ,"],"raw_orcid":"https://orcid.org/0000-0001-5810-1806","affiliations":[{"raw_affiliation_string":"(Harbin Medical University, Guizhou Medical University, Xi\u2019an Jiaotong University) , , , ,","institution_ids":["https://openalex.org/I149137203","https://openalex.org/I156144747","https://openalex.org/I87445476"]},{"raw_affiliation_string":"Guizhou Medical University , , , ,","institution_ids":["https://openalex.org/I149137203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100416770"],"corresponding_institution_ids":["https://openalex.org/I149137203","https://openalex.org/I156144747","https://openalex.org/I87445476"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.334199994802475,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.026499999687075615,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/errfi1","display_name":"ERRFI1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":1.0},{"id":"https://openalex.org/keywords/sodium-arsenite","display_name":"sodium arsenite","score":0.8450000286102295},{"id":"https://openalex.org/keywords/endocrine-disruption","display_name":"endocrine disruption","score":0.7369999885559082},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nthy-ori-3-1-cells","display_name":"Nthy-ori 3-1 cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/endocrine-dysfunction","display_name":"endocrine dysfunction","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.7422999739646912},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7063000202178955},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.7010999917984009},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5212000012397766},{"id":"https://openalex.org/C2779495234","wikidata":"https://www.wikidata.org/wiki/Q419586","display_name":"Sodium arsenite","level":3,"score":0.4893999993801117},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4821000099182129},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.47200000286102295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40790000557899475},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39809998869895935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36309999227523804},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3467000126838684},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3391999900341034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3183000087738037},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3172999918460846},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3061000108718872},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30140000581741333},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2809000015258789},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C2993711000","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell injury","level":3,"score":0.2662999927997589}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.jafc.6c14320","doi":"https://doi.org/10.1021/acs.jafc.6c14320","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jafc.6c14320","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/acs.jafc.6c14320","doi":"https://doi.org/10.1021/acs.jafc.6c14320","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jafc.6c14320","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W578997013","https://openalex.org/W1516796322","https://openalex.org/W1988607961","https://openalex.org/W2001561772","https://openalex.org/W2007649418","https://openalex.org/W2019942795","https://openalex.org/W2056399096","https://openalex.org/W2064844197","https://openalex.org/W2065786692","https://openalex.org/W2069076782","https://openalex.org/W2091584326","https://openalex.org/W2129521094","https://openalex.org/W2136343696","https://openalex.org/W2144064311","https://openalex.org/W2157453530","https://openalex.org/W2166494017","https://openalex.org/W2168383581","https://openalex.org/W2310104311","https://openalex.org/W2345395249","https://openalex.org/W2560579106","https://openalex.org/W2613128908","https://openalex.org/W2624271183","https://openalex.org/W2742840075","https://openalex.org/W2755732974","https://openalex.org/W2801432680","https://openalex.org/W2889603863","https://openalex.org/W2899260024","https://openalex.org/W2919506097","https://openalex.org/W2936858900","https://openalex.org/W2974622520","https://openalex.org/W2990346768","https://openalex.org/W3014696958","https://openalex.org/W3037230909","https://openalex.org/W3138633890","https://openalex.org/W3148594962","https://openalex.org/W3183824701","https://openalex.org/W4221036649","https://openalex.org/W4229052120","https://openalex.org/W4285405011","https://openalex.org/W4311679600","https://openalex.org/W4361296881","https://openalex.org/W4385076563","https://openalex.org/W4386474478","https://openalex.org/W4391731066","https://openalex.org/W4394061156","https://openalex.org/W4399807098","https://openalex.org/W4400459661","https://openalex.org/W4401459857","https://openalex.org/W4404444408","https://openalex.org/W4409086566","https://openalex.org/W7118364565"],"related_works":["https://openalex.org/W6940778192","https://openalex.org/W4401459857","https://openalex.org/W4414085760","https://openalex.org/W4389151343","https://openalex.org/W4405916298","https://openalex.org/W4324367529","https://openalex.org/W2033317577","https://openalex.org/W4320035582","https://openalex.org/W4389619562","https://openalex.org/W4408573945"],"abstract_inverted_index":{"Abstract":[0],"Arsenicals":[1],"are":[2],"widespread":[3],"endocrine-disrupting":[4],"contaminants":[5],"in":[6,47,53],"agricultural":[7],"environments":[8],"and":[9,23,52,66,70,113,129,141],"food":[10],"supplies.":[11],"Our":[12],"prior":[13],"work":[14],"has":[15],"linked":[16],"arsenic":[17,139],"exposure":[18],"to":[19,120],"thyroid":[20,44,68,126],"cell":[21,127],"pyroptosis":[22,128],"consequent":[24],"tissue":[25],"injury,":[26],"yet":[27],"the":[28,37,80,143],"underlying":[29],"molecular":[30],"mechanism":[31,137],"remains":[32],"unclear.":[33],"This":[34],"study":[35],"interrogated":[36],"ERRFI1-ErbB1/ERK":[38,144],"axis":[39,145],"mediating":[40],"sodium":[41],"arsenite":[42],"(NaAsO2)-induced":[43],"injury":[45,69],"using":[46],"vivo":[48],"SD":[49],"rat":[50],"models":[51],"vitro":[54],"Nthy-ori":[55,85],"3\u20131":[56,86],"cells.":[57],"In":[58,84],"rats,":[59],"NaAsO2":[60,88,117],"decreased":[61],"ERRFI1,":[62,94],"boosted":[63],"ErbB1/ERK":[64,96,111],"phosphorylation,":[65],"caused":[67],"endocrine":[71,130],"dysfunction;":[72],"these":[73],"adverse":[74],"effects":[75],"were":[76],"partially":[77],"reversed":[78],"by":[79],"ErbB1":[81,102],"inhibitor":[82],"erlotinib.":[83],"cells,":[87],"elicited":[89],"NLRP3":[90,124],"inflammasome-dependent":[91],"pyroptosis,":[92],"repressed":[93],"hyperactivated":[95],"signaling.":[97],"Pharmacological":[98],"bidirectional":[99],"modulation":[100],"of":[101,138],"confirmed":[103],"its":[104],"critical":[105],"role,":[106],"while":[107],"ERRFI1":[108,119],"overexpression":[109],"dampened":[110],"phosphorylation":[112],"mitigated":[114],"pyroptosis.":[115],"Collectively,":[116],"represses":[118],"hyperactivate":[121],"ErbB1/ERK,":[122],"triggering":[123],"inflammasome-mediated":[125],"dysfunction.":[131],"These":[132],"findings":[133],"define":[134],"a":[135,147],"novel":[136],"thyrotoxicity":[140],"identify":[142],"as":[146],"promising":[148],"intervention":[149],"target.":[150]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}