{"id":"https://openalex.org/W7225622276","doi":"https://doi.org/10.64898/2026.11.07.765072","title":"Embryonic integrin signaling establishes a program of differential cell elongation in a growing proprioceptive organ","display_name":"Embryonic integrin signaling establishes a program of differential cell elongation in a growing proprioceptive organ","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225622276","doi":"https://doi.org/10.64898/2026.11.07.765072"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.07.765072","doi":"https://doi.org/10.64898/2026.11.07.765072","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.07.765072","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.07.765072","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084693766","display_name":"Praween Kumar Choubey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Praween Kumar Choubey","raw_affiliation_strings":["Department of Genetics and Developmental Biology, The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Developmental Biology, The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054943119","display_name":"A. A. Avetisyan","orcid":"https://orcid.org/0000-0002-1196-8485","observed_orcids":["https://orcid.org/0000-0002-1196-8485"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Adel Avetisyan","raw_affiliation_strings":["Department of Genetics and Developmental Biology, The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology"],"raw_orcid":"https://orcid.org/0000-0002-1196-8485","affiliations":[{"raw_affiliation_string":"Department of Genetics and Developmental Biology, The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077906249","display_name":"Lihi Amit","orcid":"https://orcid.org/0000-0001-7313-1325","observed_orcids":["https://orcid.org/0000-0001-7313-1325"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lihi Amit","raw_affiliation_strings":["Department of Genetics and Developmental Biology, The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Developmental Biology, The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108254333","display_name":"Rina T. Greenblatt Ben-El","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rina T. Greenblatt Ben-El","raw_affiliation_strings":["Department of Genetics and Developmental Biology, The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Developmental Biology, The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000623898","display_name":"Naomi Halachmi","orcid":"https://orcid.org/0000-0002-1409-3303","observed_orcids":["https://orcid.org/0000-0002-1409-3303"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Naomi Halachmi","raw_affiliation_strings":["Department of Genetics and Developmental Biology, The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology"],"raw_orcid":"https://orcid.org/0000-0002-1409-3303","affiliations":[{"raw_affiliation_string":"Department of Genetics and Developmental Biology, The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031074190","display_name":"Adi Salzberg","orcid":"https://orcid.org/0000-0002-0427-9809","observed_orcids":["https://orcid.org/0000-0002-0427-9809"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Adi Salzberg","raw_affiliation_strings":["Department of Genetics and Developmental Biology, The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology"],"raw_orcid":"https://orcid.org/0000-0002-0427-9809","affiliations":[{"raw_affiliation_string":"Department of Genetics and Developmental Biology, The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology","institution_ids":["https://openalex.org/I174306211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031074190"],"corresponding_institution_ids":["https://openalex.org/I174306211"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proprioception","display_name":"proprioception","score":0.7480000257492065},{"id":"https://openalex.org/keywords/integrin-signaling","display_name":"integrin signaling","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cell-elongation","display_name":"cell elongation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/ligament-cells","display_name":"ligament cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cap-cells","display_name":"cap cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.6869999766349792},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.5849999785423279},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thrombospondin","display_name":"thrombospondin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/talin","display_name":"talin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.906000018119812},{"id":"https://openalex.org/keywords/organ-morphogenesis","display_name":"organ morphogenesis","score":0.734000027179718},{"id":"https://openalex.org/keywords/larval-development","display_name":"larval development","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8511999845504761},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6919999718666077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6065999865531921},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5669000148773193},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.47870001196861267},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42170000076293945},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.4018999934196472},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.3450999855995178},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.34380000829696655},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.3337000012397766},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.3294000029563904},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.32019999623298645},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.31529998779296875},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.30570000410079956},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.305400013923645},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2799000144004822},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.26589998602867126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.07.765072","doi":"https://doi.org/10.64898/2026.11.07.765072","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.07.765072","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.07.765072","doi":"https://doi.org/10.64898/2026.11.07.765072","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.07.765072","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2748429854","https://openalex.org/W2800858389","https://openalex.org/W3145622887","https://openalex.org/W2623049553","https://openalex.org/W1964981878","https://openalex.org/W2047396661","https://openalex.org/W1971920524","https://openalex.org/W2092228042","https://openalex.org/W2075742157","https://openalex.org/W2065934118"],"abstract_inverted_index":{"The":[0],"ChO":[1,67],"is":[2,21,43,167,192,235],"a":[3,195,223],"proprioceptive":[4],"sensory":[5],"organ":[6,204,254],"that":[7,71,104,130,185,218,231],"undergoes":[8],"extensive":[9],"morphological":[10],"remodeling":[11],"during":[12,194,200],"larval":[13],"growth.":[14],"A":[15],"key":[16],"feature":[17],"of":[18,25,50,87,98,122,142,154,172,181,189],"this":[19,131,165],"process":[20],"the":[22,83,96,115,119,152,170,186,203,215,245],"dramatic":[23],"elongation":[24,234,252],"cap":[26,88,123,155,250],"cells,":[27,89],"while":[28],"adjacent":[29],"ligament":[30,125,135,146,190,232],"cells":[31,136,147,191],"remain":[32],"short.":[33],"How":[34],"these":[35,228],"contrasting":[36],"growth":[37,162],"behaviors":[38],"are":[39,79],"established":[40,193,241],"and":[41,57,77,92,106,114,124,253],"coordinated":[42],"largely":[44],"unknown.":[45],"Using":[46],"targeted":[47],"RNAi":[48],"screens":[49],"extracellular":[51],"matrix":[52],"(ECM)":[53],"components,":[54,74],"ECM":[55],"receptors,":[56],"their":[58,139,160],"intracellular":[59],"effectors,":[60],"we":[61,102],"identified":[62],"distinct":[63,168],"molecular":[64],"mechanisms":[65],"controlling":[66],"architecture.":[68],"We":[69],"found":[70],"basement":[72],"membrane":[73],"including":[75],"collagens":[76],"laminins,":[78],"required":[80],"to":[81,95,137,148,213],"maintain":[82],"characteristic":[84],"straight":[85],"morphology":[86,188],"whereas":[90],"Thrombospondin":[91,105],"Tiggrin":[93],"contribute":[94],"stability":[97],"cellular":[99,177],"attachments.":[100,178],"Unexpectedly,":[101],"discovered":[103],"an":[107,239],"\u03b1PS2\u03b2PS":[108],"integrin":[109,143,182,208,220],"signaling":[110,144,221],"module,":[111],"comprising":[112],"Talin":[113],"ILK-PINCH-Parvin":[116],"complex,":[117],"regulate":[118],"relative":[120],"lengths":[121],"cells.":[126],"Cell-type-specific":[127],"knockdown":[128],"demonstrated":[129],"pathway":[132],"acts":[133],"within":[134],"restrict":[138],"elongation.":[140],"Disruption":[141],"causes":[145],"elongate":[149],"dramatically":[150],"at":[151],"expense":[153],"cell":[156,233,251],"extension,":[157],"effectively":[158],"reversing":[159],"normal":[161],"behaviors.":[163],"Importantly,":[164],"function":[166],"from":[169],"role":[171],"integrin-associated":[173],"proteins":[174],"in":[175],"maintaining":[176],"Temporal":[179],"manipulation":[180],"expression":[183,209],"revealed":[184],"short":[187],"critical":[196],"developmental":[197,225],"time":[198],"window":[199],"embryogenesis,":[201],"before":[202],"becomes":[205],"functional.":[206],"Restoring":[207],"after":[210],"hatching":[211],"fails":[212],"rescue":[214],"phenotype,":[216],"indicating":[217],"embryonic":[219],"establishes":[222],"persistent":[224],"state.":[226],"Together,":[227],"findings":[229],"reveal":[230],"actively":[236],"restricted":[237],"by":[238],"embryonically":[240],"integrin-dependent":[242],"mechanism,":[243],"providing":[244],"structural":[246],"basis":[247],"for":[248],"subsequent":[249],"maturation.":[255]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
