{"id":"https://openalex.org/W7225622161","doi":"https://doi.org/10.1021/jacs.6c19996","title":"Dissecting the Influence of Molecular Charge on Hydrophobicity","display_name":"Dissecting the Influence of Molecular Charge on Hydrophobicity","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225622161","doi":"https://doi.org/10.1021/jacs.6c19996"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.6c19996","doi":"https://doi.org/10.1021/jacs.6c19996","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jacs.6c19996","pdf_url":"https://pubs.acs.org/jacsat/article-pdf/doi/10.1021/jacs.6c19996/69116302/jacs.6c19996.pdf","source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/jacsat/article-pdf/doi/10.1021/jacs.6c19996/69116302/jacs.6c19996.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109794975","display_name":"B. IDDON","orcid":"https://orcid.org/0009-0004-6007-3364","observed_orcids":["https://orcid.org/0009-0004-6007-3364"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ben Iddon","raw_affiliation_strings":["University of Cambridge , , Lensfield Road , ,"],"raw_orcid":"https://orcid.org/0009-0004-6007-3364","affiliations":[{"raw_affiliation_string":"University of Cambridge , , Lensfield Road , ,","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064693777","display_name":"Christopher A. Hunter","orcid":"https://orcid.org/0000-0002-5182-1859","observed_orcids":["https://orcid.org/0000-0002-5182-1859"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christopher A. Hunter","raw_affiliation_strings":["University of Cambridge , , Lensfield Road , ,"],"raw_orcid":"https://orcid.org/0000-0002-5182-1859","affiliations":[{"raw_affiliation_string":"University of Cambridge , , Lensfield Road , ,","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064693777","https://openalex.org/A5109794975"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.06750000268220901,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-charge","display_name":"molecular charge","score":0.9330000281333923},{"id":"https://openalex.org/keywords/hydrophobicity","display_name":"hydrophobicity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cyclodextrins","display_name":"cyclodextrins","score":0.7829999923706055},{"id":"https://openalex.org/keywords/tetraphenylborate","display_name":"tetraphenylborate","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tetraphenylphosphonium","display_name":"tetraphenylphosphonium","score":0.7300000190734863},{"id":"https://openalex.org/keywords/ion-solute-interactions","display_name":"ion-solute interactions","score":0.5419999957084656},{"id":"https://openalex.org/keywords/complexation-thermodynamics","display_name":"complexation thermodynamics","score":0.6460000276565552},{"id":"https://openalex.org/keywords/enthalpy-entropy-compensation","display_name":"enthalpy-entropy compensation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.4830000102519989},{"id":"https://openalex.org/keywords/reversed-phase-hplc-retention","display_name":"reversed-phase HPLC retention","score":0.890999972820282},{"id":"https://openalex.org/keywords/chaotropic-effect","display_name":"chaotropic effect","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9724000096321106},{"id":"https://openalex.org/C102362939","wikidata":"https://www.wikidata.org/wiki/Q417062","display_name":"Chaotropic agent","level":2,"score":0.7770000100135803},{"id":"https://openalex.org/C148093993","wikidata":"https://www.wikidata.org/wiki/Q739398","display_name":"Solvation","level":3,"score":0.7376000285148621},{"id":"https://openalex.org/C90260826","wikidata":"https://www.wikidata.org/wiki/Q899157","display_name":"Hydrophobic effect","level":2,"score":0.6341000199317932},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.5126000046730042},{"id":"https://openalex.org/C166361863","wikidata":"https://www.wikidata.org/wiki/Q7559045","display_name":"Solvophobic","level":3,"score":0.5006999969482422},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.4984999895095825},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.48410001397132874},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.475600004196167},{"id":"https://openalex.org/C2182769","wikidata":"https://www.wikidata.org/wiki/Q62500","display_name":"Ionic bonding","level":3,"score":0.4156000018119812},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.38429999351501465},{"id":"https://openalex.org/C2780709120","wikidata":"https://www.wikidata.org/wiki/Q407189","display_name":"Perchlorate","level":3,"score":0.3741999864578247},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.3700000047683716},{"id":"https://openalex.org/C192552737","wikidata":"https://www.wikidata.org/wiki/Q898797","display_name":"Partition coefficient","level":2,"score":0.36910000443458557},{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.3677000105381012},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.366100013256073},{"id":"https://openalex.org/C137277065","wikidata":"https://www.wikidata.org/wiki/Q2915446","display_name":"Non-covalent interactions","level":4,"score":0.35199999809265137},{"id":"https://openalex.org/C149823470","wikidata":"https://www.wikidata.org/wiki/Q1088326","display_name":"Solvation shell","level":4,"score":0.35190001130104065},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.329800009727478},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3260999917984009},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3075000047683716},{"id":"https://openalex.org/C127160389","wikidata":"https://www.wikidata.org/wiki/Q415608","display_name":"Osmolyte","level":2,"score":0.30160000920295715},{"id":"https://openalex.org/C18705241","wikidata":"https://www.wikidata.org/wiki/Q1128023","display_name":"Conformational isomerism","level":3,"score":0.3000999987125397},{"id":"https://openalex.org/C205188671","wikidata":"https://www.wikidata.org/wiki/Q3803316","display_name":"Isostructural","level":3,"score":0.2874000072479248},{"id":"https://openalex.org/C2776226600","wikidata":"https://www.wikidata.org/wiki/Q6048561","display_name":"Octanol","level":3,"score":0.2854999899864197},{"id":"https://openalex.org/C148506334","wikidata":"https://www.wikidata.org/wiki/Q4476528","display_name":"Taft equation","level":3,"score":0.28029999136924744},{"id":"https://openalex.org/C187428577","wikidata":"https://www.wikidata.org/wiki/Q898396","display_name":"Ionic strength","level":3,"score":0.2793000042438507},{"id":"https://openalex.org/C2776066709","wikidata":"https://www.wikidata.org/wiki/Q188862","display_name":"Cycloalkane","level":3,"score":0.2782999873161316},{"id":"https://openalex.org/C87716614","wikidata":"https://www.wikidata.org/wiki/Q845744","display_name":"Static electricity","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2685999870300293},{"id":"https://openalex.org/C179303850","wikidata":"https://www.wikidata.org/wiki/Q4300362","display_name":"Molecular recognition","level":3,"score":0.2662999927997589},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.2662000060081482},{"id":"https://openalex.org/C120001659","wikidata":"https://www.wikidata.org/wiki/Q219567","display_name":"Hydrophobe","level":2,"score":0.26499998569488525},{"id":"https://openalex.org/C128122844","wikidata":"https://www.wikidata.org/wiki/Q4119007","display_name":"Free-energy relationship","level":4,"score":0.2644999921321869},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.26249998807907104},{"id":"https://openalex.org/C58436429","wikidata":"https://www.wikidata.org/wiki/Q410693","display_name":"Hofmeister series","level":3,"score":0.2567000091075897}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/jacs.6c19996","doi":"https://doi.org/10.1021/jacs.6c19996","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jacs.6c19996","pdf_url":"https://pubs.acs.org/jacsat/article-pdf/doi/10.1021/jacs.6c19996/69116302/jacs.6c19996.pdf","source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/jacs.6c19996","doi":"https://doi.org/10.1021/jacs.6c19996","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jacs.6c19996","pdf_url":"https://pubs.acs.org/jacsat/article-pdf/doi/10.1021/jacs.6c19996/69116302/jacs.6c19996.pdf","source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225622161.pdf","grobid_xml":"https://content.openalex.org/works/W7225622161.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W27727037","https://openalex.org/W1885856887","https://openalex.org/W1965038570","https://openalex.org/W1968179825","https://openalex.org/W1969333766","https://openalex.org/W1974129069","https://openalex.org/W1980963182","https://openalex.org/W1984356759","https://openalex.org/W1991577867","https://openalex.org/W1992210899","https://openalex.org/W1993062133","https://openalex.org/W1993806828","https://openalex.org/W1994177550","https://openalex.org/W1994845758","https://openalex.org/W1996681113","https://openalex.org/W1998359737","https://openalex.org/W2000207131","https://openalex.org/W2000775586","https://openalex.org/W2007588102","https://openalex.org/W2009071379","https://openalex.org/W2012521191","https://openalex.org/W2012931837","https://openalex.org/W2015517515","https://openalex.org/W2016384435","https://openalex.org/W2018989460","https://openalex.org/W2021568364","https://openalex.org/W2021867728","https://openalex.org/W2025383518","https://openalex.org/W2038444883","https://openalex.org/W2039104539","https://openalex.org/W2039867851","https://openalex.org/W2042342269","https://openalex.org/W2046964459","https://openalex.org/W2048344330","https://openalex.org/W2052226480","https://openalex.org/W2054448211","https://openalex.org/W2060871685","https://openalex.org/W2066310963","https://openalex.org/W2066744229","https://openalex.org/W2070783701","https://openalex.org/W2071158076","https://openalex.org/W2071978227","https://openalex.org/W2075320109","https://openalex.org/W2081218966","https://openalex.org/W2081231276","https://openalex.org/W2083838718","https://openalex.org/W2084961342","https://openalex.org/W2085537085","https://openalex.org/W2087962864","https://openalex.org/W2089159346","https://openalex.org/W2090583381","https://openalex.org/W2091240944","https://openalex.org/W2092544374","https://openalex.org/W2093498573","https://openalex.org/W2093933186","https://openalex.org/W2094640259","https://openalex.org/W2100145024","https://openalex.org/W2106491438","https://openalex.org/W2111428753","https://openalex.org/W2127893392","https://openalex.org/W2154063883","https://openalex.org/W2159796302","https://openalex.org/W2161222061","https://openalex.org/W2161260708","https://openalex.org/W2166211830","https://openalex.org/W2316095116","https://openalex.org/W2319397042","https://openalex.org/W2329497228","https://openalex.org/W2339992943","https://openalex.org/W2411159431","https://openalex.org/W2471069319","https://openalex.org/W2746793809","https://openalex.org/W2893559110","https://openalex.org/W2898938799","https://openalex.org/W2899020702","https://openalex.org/W2953300149","https://openalex.org/W2960630151","https://openalex.org/W2975063009","https://openalex.org/W3003427638","https://openalex.org/W3011312667","https://openalex.org/W3125168951","https://openalex.org/W3185783720","https://openalex.org/W3209502510","https://openalex.org/W4248107770","https://openalex.org/W4306764865","https://openalex.org/W4327698179","https://openalex.org/W4385620959","https://openalex.org/W4388131904","https://openalex.org/W4388633157","https://openalex.org/W4401169962","https://openalex.org/W4401994508","https://openalex.org/W4402667587","https://openalex.org/W4409293520","https://openalex.org/W4411012784","https://openalex.org/W4411474794","https://openalex.org/W7157938513","https://openalex.org/W7172302878"],"related_works":["https://openalex.org/W2784342506","https://openalex.org/W1995615847","https://openalex.org/W2115108571","https://openalex.org/W2329497228","https://openalex.org/W2000207131","https://openalex.org/W2323162670","https://openalex.org/W2324473963","https://openalex.org/W3010676288","https://openalex.org/W2245612742","https://openalex.org/W2005129447"],"abstract_inverted_index":{"Abstract":[0],"Interactions":[1],"of":[2,13,19,28,35,48,90,128,138,147,179,183,207,215,233,241],"hydrophobic":[3,33,200],"environments":[4],"and":[5,51,58,61,71,79,100,107,131,160,190,223],"ionic":[6],"solutes":[7,30],"are":[8,102],"important":[9],"in":[10,39,122,204,220],"a":[11,36,62],"range":[12],"biological":[14],"processes,":[15],"but":[16,88,110,126],"the":[17,32,46,91,105,114,129,139,145,153,166,181,205,224],"effect":[18],"molecular":[20],"charge":[21],"on":[22],"hydrophobicity":[23,168],"remains":[24],"opaque.":[25],"The":[26,77,96,227],"interaction":[27],"isostructural":[29],"with":[31,84,165],"cavity":[34],"cyclodextrin":[37],"(\u03b3-CD)":[38],"water":[40],"was":[41,67],"used":[42],"to":[43,150,188],"directly":[44],"compare":[45],"hydrophobicities":[47],"anionic,":[49],"neutral,":[50],"cationic":[52],"species.":[53],"Complex":[54],"formation":[55],"between":[56],"\u03b3-CD":[57,83],"PPh4+,":[59,194],"BPh4\u2013":[60,184],"neutral":[63,80,108,132],"analogue":[64,81,133],"(CPh4":[65],"derivative)":[66],"investigated":[68],"by":[69,199],"ITC":[70],"NMR":[72],"spectroscopy":[73],"at":[74],"different":[75,112,192],"temperatures.":[76],"anion":[78,106,130],"bind":[82],"similar":[85,103,187],"association":[86],"constants,":[87],"binding":[89,127,137],"cation":[92,140],"is":[93,117,134,141,185,196,236],"104-fold":[94],"weaker.":[95],"thermodynamic":[97],"signatures":[98],"\u0394H\u00b0":[99],"\u0394Cp\u00b0":[101],"for":[104,113,157,211,248],"analogue,":[109],"quite":[111,191],"cation.":[115],"There":[116],"almost":[118],"perfect":[119],"entropy-enthalpy":[120],"compensation":[121],"all":[123],"three":[124],"cases,":[125],"enthalpy-driven,":[135],"while":[136],"entropy-driven.":[142],"Substituents":[143],"increase":[144],"affinity":[146],"tetraarylborates":[148],"(up":[149],"108":[151],"M\u20131,":[152],"highest":[154],"reported":[155],"value":[156],"native":[158],"cyclodextrins),":[159],"substituent":[161],"effects":[162],"correlate":[163],"well":[164],"Hansch":[167],"parameter.":[169],"In":[170],"reversed-phase":[171],"HPLC":[172],"experiments":[173,228],"that":[174,230,240],"provide":[175],"an":[176],"alternative":[177],"measure":[178],"hydrophobicity,":[180],"behavior":[182,206],"again":[186],"CPh4":[189],"from":[193],"which":[195],"less":[197],"retained":[198],"stationary":[201],"phases.":[202],"Asymmetry":[203],"ions":[208],"has":[209],"implications":[210],"understanding":[212],"partition":[213],"coefficients":[214],"charged":[216],"compounds,":[217],"dipole":[218],"potentials":[219],"lipid":[221],"membranes,":[222],"chaotropic":[225],"effect.":[226],"indicate":[229],"aqueous":[231],"solvation":[232],"organic":[234,242],"cations":[235],"much":[237],"stronger":[238],"than":[239],"anions":[243],"(by":[244],">20":[245],"kJ":[246],"mol\u20131":[247],"tetraphenyl":[249],"compounds).":[250]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
