{"id":"https://openalex.org/W7225621006","doi":"https://doi.org/10.33003/fjs-2026-1024-6321","title":"In Silico Assessment of Gongronema Latifolium Fruit Metabolites as Potential Multi-Target Antidiabetic Leads using Network Pharmacology and Molecular Docking","display_name":"In Silico Assessment of Gongronema Latifolium Fruit Metabolites as Potential Multi-Target Antidiabetic Leads using Network Pharmacology and Molecular Docking","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225621006","doi":"https://doi.org/10.33003/fjs-2026-1024-6321"},"language":"en","primary_location":{"id":"doi:10.33003/fjs-2026-1024-6321","doi":"https://doi.org/10.33003/fjs-2026-1024-6321","is_oa":true,"landing_page_url":"https://doi.org/10.33003/fjs-2026-1024-6321","pdf_url":"https://fjs.fudutsinma.org.ng/index.php/fjs/article/download/6321/4240","source":{"id":"https://openalex.org/S4210224159","display_name":"FUDMA Journal of Sciences","issn_l":"2616-1370","issn":["2616-1370","2645-2944"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4404662838","host_organization_name":"Federal University, Dutsin-Ma","host_organization_lineage":["https://openalex.org/P4404662838"],"host_organization_lineage_names":["Federal University, Dutsin-Ma"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FUDMA Journal of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://fjs.fudutsinma.org.ng/index.php/fjs/article/download/6321/4240","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161332444","display_name":"Victoria Temitope Makanjuola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201292520","display_name":"Bingham University","ror":"https://ror.org/04dbvvk55","country_code":"NG","type":"education","lineage":["https://openalex.org/I201292520"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Victoria Temitope Makanjuola","raw_affiliation_strings":["Department of Biochemistry, Bingham University, Karu, Nasarawa State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Bingham University, Karu, Nasarawa State, Nigeria","institution_ids":["https://openalex.org/I201292520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088541361","display_name":"Gideon Ampoma Gyebi","orcid":"https://orcid.org/0000-0002-1945-1739","observed_orcids":["https://orcid.org/0000-0002-1945-1739"]},"institutions":[{"id":"https://openalex.org/I201292520","display_name":"Bingham University","ror":"https://ror.org/04dbvvk55","country_code":"NG","type":"education","lineage":["https://openalex.org/I201292520"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Gideon Ampoma Gyebi","raw_affiliation_strings":["Department of Biochemistry , Faculty of Science and Technology , Bingham University , Karu , Nasarawa State , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry , Faculty of Science and Technology , Bingham University , Karu , Nasarawa State , Nigeria","institution_ids":["https://openalex.org/I201292520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108279994","display_name":"Chinenye Florence Ogah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201292520","display_name":"Bingham University","ror":"https://ror.org/04dbvvk55","country_code":"NG","type":"education","lineage":["https://openalex.org/I201292520"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Chinenye Florence Ogah","raw_affiliation_strings":["Department of Biochemistry , Faculty of Science and Technology , Bingham University , Karu , Nasarawa State , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry , Faculty of Science and Technology , Bingham University , Karu , Nasarawa State , Nigeria","institution_ids":["https://openalex.org/I201292520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201292520"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"24","first_page":"79","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.08699999749660492,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gongronema-latifolium","display_name":"Gongronema latifolium","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9580000042915344},{"id":"https://openalex.org/keywords/fruit-metabolites","display_name":"fruit metabolites","score":0.7059999704360962},{"id":"https://openalex.org/keywords/multitarget-drug-candidates","display_name":"multi-target drug candidates","score":0.6980000138282776},{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.972000002861023},{"id":"https://openalex.org/keywords/glyceraldehyde-3-phosphate-dehydrogenase","display_name":"glyceraldehyde-3-phosphate dehydrogenase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.6489999890327454},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.7770000100135803},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.6169999837875366},{"id":"https://openalex.org/keywords/drug-likeness","display_name":"drug-likeness","score":0.6129999756813049},{"id":"https://openalex.org/keywords/adme-prediction","display_name":"ADME prediction","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8345999717712402},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6571999788284302},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.557200014591217},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.49779999256134033},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47519999742507935},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4343000054359436},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41190001368522644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3833000063896179},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3765000104904175},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.326200008392334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32260000705718994},{"id":"https://openalex.org/C154137905","wikidata":"https://www.wikidata.org/wiki/Q17816452","display_name":"AKT1","level":4,"score":0.3172000050544739},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29789999127388},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2565999925136566},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2538999915122986}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.33003/fjs-2026-1024-6321","doi":"https://doi.org/10.33003/fjs-2026-1024-6321","is_oa":true,"landing_page_url":"https://doi.org/10.33003/fjs-2026-1024-6321","pdf_url":"https://fjs.fudutsinma.org.ng/index.php/fjs/article/download/6321/4240","source":{"id":"https://openalex.org/S4210224159","display_name":"FUDMA Journal of Sciences","issn_l":"2616-1370","issn":["2616-1370","2645-2944"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4404662838","host_organization_name":"Federal University, Dutsin-Ma","host_organization_lineage":["https://openalex.org/P4404662838"],"host_organization_lineage_names":["Federal University, Dutsin-Ma"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FUDMA Journal of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:fjs.fudutsinma.edu.ng:article/6321","doi":null,"is_oa":true,"landing_page_url":"https://fjs.fudutsinma.org.ng/index.php/index/article/view/6321","pdf_url":null,"source":{"id":"https://openalex.org/S4210224159","display_name":"FUDMA Journal of Sciences","issn_l":"2616-1370","issn":["2616-1370","2645-2944"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4404662838","host_organization_name":"Federal University, Dutsin-Ma","host_organization_lineage":["https://openalex.org/P4404662838"],"host_organization_lineage_names":["Federal University, Dutsin-Ma"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2645-2944","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.33003/fjs-2026-1024-6321","doi":"https://doi.org/10.33003/fjs-2026-1024-6321","is_oa":true,"landing_page_url":"https://doi.org/10.33003/fjs-2026-1024-6321","pdf_url":"https://fjs.fudutsinma.org.ng/index.php/fjs/article/download/6321/4240","source":{"id":"https://openalex.org/S4210224159","display_name":"FUDMA Journal of Sciences","issn_l":"2616-1370","issn":["2616-1370","2645-2944"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4404662838","host_organization_name":"Federal University, Dutsin-Ma","host_organization_lineage":["https://openalex.org/P4404662838"],"host_organization_lineage_names":["Federal University, Dutsin-Ma"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FUDMA Journal of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225621006.pdf","grobid_xml":"https://content.openalex.org/works/W7225621006.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1887624773","https://openalex.org/W2030971064","https://openalex.org/W2103912979","https://openalex.org/W2130479394","https://openalex.org/W2134967712","https://openalex.org/W2135732933","https://openalex.org/W2159675211","https://openalex.org/W2169678694","https://openalex.org/W2558586574","https://openalex.org/W2593436234","https://openalex.org/W2611425558","https://openalex.org/W2886504687","https://openalex.org/W2891165960","https://openalex.org/W2901527454","https://openalex.org/W2946412700","https://openalex.org/W2983166786","https://openalex.org/W2997022986","https://openalex.org/W4206799195","https://openalex.org/W4285269377","https://openalex.org/W4292466704","https://openalex.org/W4316363201","https://openalex.org/W4394688967","https://openalex.org/W4402676710","https://openalex.org/W4403608560","https://openalex.org/W4403627476","https://openalex.org/W4404511387","https://openalex.org/W4404511389","https://openalex.org/W4406846918","https://openalex.org/W4408983060","https://openalex.org/W4409293325","https://openalex.org/W4409528328","https://openalex.org/W4411984628","https://openalex.org/W4413114127","https://openalex.org/W4414095310","https://openalex.org/W4414696071","https://openalex.org/W4417523995","https://openalex.org/W7140101728"],"related_works":["https://openalex.org/W4200554457","https://openalex.org/W4414588477","https://openalex.org/W7117584758","https://openalex.org/W4404364557","https://openalex.org/W7119474463","https://openalex.org/W4360812075","https://openalex.org/W4399366684","https://openalex.org/W4400679290","https://openalex.org/W3092060795","https://openalex.org/W7203932602"],"abstract_inverted_index":{"Background:":[0],"Type":[1],"2":[2,134],"diabetes":[3,135],"mellitus":[4],"(T2DM)":[5],"is":[6,22],"a":[7,68,192],"multifactorial":[8],"disease":[9],"for":[10,54,121,166,177,181,208,239],"which":[11,138],"single-target":[12],"drugs":[13],"are":[14,34,217],"often":[15],"inadequate.":[16],"The":[17,86,162],"fruit":[18,43,125,216,235],"of":[19,49,106,116,137,194,213,233],"Gongronema":[20],"latifolium":[21,124,215],"used":[23],"in":[24,52,240,243],"traditional":[25,231],"Nigerian":[26],"medicine,":[27],"but":[28],"its":[29],"metabolites":[30,88,101,198],"and":[31,57,63,78,81,96,127,141,160,202,204,226,236,242],"molecular":[32],"targets":[33,60,118],"poorly":[35],"described.":[36],"Methods:":[37],"Metabolites":[38,212],"previously":[39],"identified":[40,120,150],"from":[41],"the":[42,122,175,178,188,230,234],"were":[44,61,89,109,119,130,142],"screened":[45],"against":[46,91],"Lipinski's":[47,104],"rule":[48,105],"five":[50],"and,":[51],"SwissADME,":[53],"gastrointestinal":[55],"absorption":[56],"drug-likeness.":[58],"Their":[59],"predicted":[62,218],"intersected":[64],"with":[65,132,171],"T2DM-associated":[66],"genes,":[67,77,153],"protein\u2013protein":[69],"interaction":[70],"network":[71],"was":[72,84,168,184],"analysed":[73],"to":[74,219],"identify":[75],"hub":[76,93,152],"Gene":[79],"Ontology":[80],"KEGG":[82],"enrichment":[83],"performed.":[85],"retained":[87,110],"docked":[90],"two":[92],"targets,":[94,223],"AKT1":[95,167],"GAPDH.":[97],"Results:":[98],"Of":[99],"251":[100],"that":[102],"satisfied":[103],"five,":[107],"241":[108],"after":[111],"SwissADME":[112],"screening.":[113],"A":[114],"total":[115],"1561":[117],"G.":[123,214],"compounds":[126],"6,392":[128],"genes":[129],"associated":[131],"type":[133],"mellitus,":[136],"1,028":[139],"overlapped":[140],"taken":[143],"forward":[144],"as":[145],"common":[146],"targets.":[147,210],"Network":[148],"analysis":[149],"25":[151],"led":[154],"by":[155],"GAPDH,":[156,182],"AKT1,":[157],"TP53,":[158],"INS":[159],"TNF.":[161],"best":[163],"docking":[164],"score":[165,176,193],"\u221211.9":[169],"kcal/mol,":[170,186],"\u22129.4":[172],"kcal/mol":[173],"being":[174],"co-crystallised":[179,189],"ligand;":[180],"it":[183],"\u22129.7":[185],"while":[187],"ligand":[190],"had":[191],"\u22127.0":[195],"kcal/mol.":[196],"Twenty":[197],"outscored":[199],"both":[200,209],"references,":[201],"C20":[203],"C513":[205],"ranked":[206],"highly":[207],"Conclusion:":[211],"engage":[220],"several":[221],"T2DM-relevant":[222],"notably":[224],"insulin-signalling":[225],"inflammatory":[227],"nodes,":[228],"supporting":[229],"use":[232],"prioritising":[237],"candidates":[238],"vitro":[241],"vivo":[244],"validation.":[245]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}