{"id":"https://openalex.org/W7225620042","doi":"https://doi.org/10.1073/pnas.2622307123","title":"Targeting of STEAP3 by a selenium D\u2013\u03c0\u2013A photosensitizer that activates ferroptosis","display_name":"Targeting of STEAP3 by a selenium D\u2013\u03c0\u2013A photosensitizer that activates ferroptosis","publication_year":2026,"publication_date":"2026-11-09","ids":{"openalex":"https://openalex.org/W7225620042","doi":"https://doi.org/10.1073/pnas.2622307123","pmid":"https://pubmed.ncbi.nlm.nih.gov/43002678"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2622307123","doi":"https://doi.org/10.1073/pnas.2622307123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2622307123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2622307123","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161337239","display_name":"Zheng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4405278907","display_name":"Jiangsu Collaborative Innovation Center of Biomedical Functional Materials","ror":"https://ror.org/00r94wm54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I152031979","https://openalex.org/I4405278907"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zheng Li","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University","institution_ids":["https://openalex.org/I152031979","https://openalex.org/I4210111013","https://openalex.org/I4405278907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159429355","display_name":"Zhuoying Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4405278907","display_name":"Jiangsu Collaborative Innovation Center of Biomedical Functional Materials","ror":"https://ror.org/00r94wm54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I152031979","https://openalex.org/I4405278907"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhuoying Chen","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University","institution_ids":["https://openalex.org/I152031979","https://openalex.org/I4210111013","https://openalex.org/I4405278907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161318216","display_name":"Yanli Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4405278907","display_name":"Jiangsu Collaborative Innovation Center of Biomedical Functional Materials","ror":"https://ror.org/00r94wm54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I152031979","https://openalex.org/I4405278907"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanli Yang","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University","institution_ids":["https://openalex.org/I152031979","https://openalex.org/I4210111013","https://openalex.org/I4405278907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161321796","display_name":"Xiangjie Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4405278907","display_name":"Jiangsu Collaborative Innovation Center of Biomedical Functional Materials","ror":"https://ror.org/00r94wm54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I152031979","https://openalex.org/I4405278907"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiangjie Luo","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University","institution_ids":["https://openalex.org/I152031979","https://openalex.org/I4210111013","https://openalex.org/I4405278907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021293109","display_name":"Dan Yang","orcid":"https://orcid.org/0000-0002-1852-6858","observed_orcids":["https://orcid.org/0000-0002-1852-6858"]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4405278907","display_name":"Jiangsu Collaborative Innovation Center of Biomedical Functional Materials","ror":"https://ror.org/00r94wm54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I152031979","https://openalex.org/I4405278907"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Yang","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University","institution_ids":["https://openalex.org/I152031979","https://openalex.org/I4210111013","https://openalex.org/I4405278907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027157675","display_name":"Wei Cheng","orcid":"https://orcid.org/0000-0003-1118-1743","observed_orcids":["https://orcid.org/0000-0003-1118-1743","https://orcid.org/0009-0005-5236-0344"]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4405278907","display_name":"Jiangsu Collaborative Innovation Center of Biomedical Functional Materials","ror":"https://ror.org/00r94wm54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I152031979","https://openalex.org/I4405278907"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Cheng","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University","institution_ids":["https://openalex.org/I152031979","https://openalex.org/I4210111013","https://openalex.org/I4405278907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161332623","display_name":"Mingyuan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4405278907","display_name":"Jiangsu Collaborative Innovation Center of Biomedical Functional Materials","ror":"https://ror.org/00r94wm54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I152031979","https://openalex.org/I4405278907"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyuan Sun","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University","institution_ids":["https://openalex.org/I152031979","https://openalex.org/I4210111013","https://openalex.org/I4405278907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003197601","display_name":"Lixian Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4405278907","display_name":"Jiangsu Collaborative Innovation Center of Biomedical Functional Materials","ror":"https://ror.org/00r94wm54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I152031979","https://openalex.org/I4405278907"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lixian Fu","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University","institution_ids":["https://openalex.org/I152031979","https://openalex.org/I4210111013","https://openalex.org/I4405278907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161348419","display_name":"Bing Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Zhang","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology, Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070852723","display_name":"Tony D. James","orcid":"https://orcid.org/0000-0002-4095-2191","observed_orcids":["https://orcid.org/0000-0002-4095-2191"]},"institutions":[{"id":"https://openalex.org/I51601045","display_name":"University of Bath","ror":"https://ror.org/002h8g185","country_code":"GB","type":"education","lineage":["https://openalex.org/I51601045"]},{"id":"https://openalex.org/I75955062","display_name":"Henan Normal University","ror":"https://ror.org/00s13br28","country_code":"CN","type":"education","lineage":["https://openalex.org/I75955062"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Tony D. James","raw_affiliation_strings":["Department of Chemistry, University of Bath","School of Chemistry and Chemical Engineering, Henan Normal University"],"raw_orcid":"https://orcid.org/0000-0002-4095-2191","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Bath","institution_ids":["https://openalex.org/I51601045"]},{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Henan Normal University","institution_ids":["https://openalex.org/I75955062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000215293","display_name":"Jonathan L. Sessler","orcid":"https://orcid.org/0000-0002-9576-1325","observed_orcids":["https://orcid.org/0000-0002-9576-1325"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan L. Sessler","raw_affiliation_strings":["Department of Chemistry, The University of Texas at Austin"],"raw_orcid":"https://orcid.org/0000-0002-9576-1325","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Texas at Austin","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013700497","display_name":"Yong Qian","orcid":"https://orcid.org/0000-0003-3788-3575","observed_orcids":["https://orcid.org/0000-0003-3788-3575"]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I4405278907","display_name":"Jiangsu Collaborative Innovation Center of Biomedical Functional Materials","ror":"https://ror.org/00r94wm54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I152031979","https://openalex.org/I4405278907"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Qian","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University","State Key Laboratory of Pharmaceutical Biotechnology, Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University"],"raw_orcid":"https://orcid.org/0000-0003-3788-3575","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University","institution_ids":["https://openalex.org/I152031979","https://openalex.org/I4210111013","https://openalex.org/I4405278907"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5000215293","https://openalex.org/A5013700497","https://openalex.org/A5159429355","https://openalex.org/A5161318216","https://openalex.org/A5161321796","https://openalex.org/A5161337239"],"corresponding_institution_ids":["https://openalex.org/I152031979","https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I4405278907","https://openalex.org/I86519309","https://openalex.org/I881766915"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"46","first_page":"e2622307123","last_page":"e2622307123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.052000001072883606,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.04989999905228615,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/steap3","display_name":"STEAP3","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.8360000252723694},{"id":"https://openalex.org/keywords/p38-mapk-signaling","display_name":"p38 MAPK signaling","score":0.8190000057220459},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/p53-activation","display_name":"p53 activation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.7979999780654907},{"id":"https://openalex.org/keywords/non-apoptotic-cell-death","display_name":"non-apoptotic cell death","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.8330000042915344},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.8313000202178955},{"id":"https://openalex.org/C20639190","wikidata":"https://www.wikidata.org/wiki/Q2088972","display_name":"Phototoxicity","level":3,"score":0.7211999893188477},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.7027999758720398},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6866000294685364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6247000098228455},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5932000279426575},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.453000009059906},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4341999888420105},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4271000027656555},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.40290001034736633},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3912000060081482},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3837999999523163},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.361299991607666},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.3312000036239624},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3183000087738037},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.3147999942302704},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30630001425743103},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.30079999566078186},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.29089999198913574},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.2892000079154968},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.2757999897003174},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2685999870300293},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.2531999945640564}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012643","descriptor_name":"Selenium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012643","descriptor_name":"Selenium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1073/pnas.2622307123","doi":"https://doi.org/10.1073/pnas.2622307123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2622307123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:43002678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43002678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.2622307123","doi":"https://doi.org/10.1073/pnas.2622307123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2622307123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320311345","display_name":"Henan Normal University","ror":"https://ror.org/00s13br28"},{"id":"https://openalex.org/F4320324852","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760"},{"id":"https://openalex.org/F4320334065","display_name":"National Natural Science Foundation of China-Shandong Joint Fund","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1997183854","https://openalex.org/W2002490399","https://openalex.org/W2072860434","https://openalex.org/W2085791588","https://openalex.org/W2162420845","https://openalex.org/W3017650118","https://openalex.org/W3082333872","https://openalex.org/W3125578060","https://openalex.org/W3217607978","https://openalex.org/W4200007252","https://openalex.org/W4205700101","https://openalex.org/W4210576858","https://openalex.org/W4224215946","https://openalex.org/W4282962800","https://openalex.org/W4290861562","https://openalex.org/W4291652365","https://openalex.org/W4306769755","https://openalex.org/W4366985088","https://openalex.org/W4377826561","https://openalex.org/W4381988222","https://openalex.org/W4385605483","https://openalex.org/W4385635780","https://openalex.org/W4386092828","https://openalex.org/W4388847434","https://openalex.org/W4391693955","https://openalex.org/W4391836528","https://openalex.org/W4391878282","https://openalex.org/W4392018214","https://openalex.org/W4392282159","https://openalex.org/W4394564046","https://openalex.org/W4397045884","https://openalex.org/W4399300218","https://openalex.org/W4399727220","https://openalex.org/W4399807124","https://openalex.org/W4400007655","https://openalex.org/W4401290160","https://openalex.org/W4401854234","https://openalex.org/W4402079330","https://openalex.org/W4403922070","https://openalex.org/W4407908100","https://openalex.org/W4408244269","https://openalex.org/W4411492041","https://openalex.org/W4411748894","https://openalex.org/W4413660618","https://openalex.org/W7161248243","https://openalex.org/W7162205610","https://openalex.org/W7164994337"],"related_works":["https://openalex.org/W7140800536","https://openalex.org/W7153070635","https://openalex.org/W4405865346","https://openalex.org/W7220666089","https://openalex.org/W4388574021","https://openalex.org/W4413786773","https://openalex.org/W4401056086","https://openalex.org/W4403452685","https://openalex.org/W7214080177","https://openalex.org/W4372291697"],"abstract_inverted_index":{"Resistance":[0],"to":[1,50,139],"apoptosis":[2,84,183],"limits":[3],"the":[4,31,100,128],"efficacy":[5,151],"of":[6,35,45,77,108,145],"many":[7],"cancer":[8,182],"therapies.":[9],"Photodynamic":[10],"therapy":[11,172],"(PDT),":[12],"with":[13,59],"its":[14],"spatial":[15],"precision,":[16],"offers":[17],"a":[18,43,56,74,104,166,175],"promising":[19],"strategy":[20],"by":[21,185],"engaging":[22],"nonapoptotic":[23],"cell":[24,78,141],"death":[25,79],"pathways,":[26],"such":[27],"as":[28,55,103,165],"ferroptosis.":[29,96,187],"However,":[30],"direct":[32,105],"molecular":[33,106,168],"targets":[34],"most":[36],"photosensitizers":[37,48],"remain":[38],"undefined.":[39],"Here,":[40],"we":[41],"introduce":[42],"class":[44],"selenium-containing":[46],"D\u2013\u03c0\u2013A":[47],"(PDSe-1":[49],"PDSe-11)":[51],"and":[52,63,132,158,173],"identify":[53],"PDSe-8":[54,72,110,116],"lead":[57],"system":[58],"advantageous":[60],"photophysical":[61],"properties":[62],"potent,":[64],"hypoxia-tolerant":[65],"phototoxicity":[66],"(IC":[67],"50":[68],"=":[69],"53":[70],"nM).":[71],"elicits":[73],"concentration-dependent":[75],"switching":[76],"programs.":[80],"Low":[81],"doses":[82,94],"trigger":[83],"through":[85],"p38":[86],"mitogen-activated":[87],"protein":[88],"kinase":[89],"(MAPK)":[90],"signaling,":[91],"whereas":[92],"higher":[93],"activate":[95],"Competitive":[97],"chemoproteomics":[98],"reveals":[99],"metalloreductase":[101],"STEAP3":[102,118,164],"target":[107,169],"light-activated":[109],"underlying":[111],"this":[112],"switch.":[113],"Upon":[114],"photoirradiation,":[115],"photodegrades":[117],"in":[119,123,148,156,159],"glioblastoma":[120,154],"cells,":[121],"which":[122],"turn":[124],"activates":[125],"p53,":[126],"impairs":[127],"SLC7A11\u2013GPX4":[129],"antioxidant":[130],"axis,":[131],"drives":[133],"lethal":[134],"lipid":[135],"peroxidation,":[136],"ultimately":[137],"leading":[138],"ferroptotic":[140],"death.":[142],"This":[143,161],"mode":[144],"action":[146],"results":[147],"potent":[149],"antitumor":[150],"against":[152],"U87MG":[153],"both":[155],"vitro":[157],"vivo.":[160],"work":[162],"establishes":[163],"key":[167],"for":[170],"photodynamic":[171],"proposes":[174],"mechanistically":[176],"defined":[177],"selenium":[178],"photosensitizer":[179],"that":[180],"overcomes":[181],"resistance":[184],"inducing":[186]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-10T00:00:00"}
